FB2022_02, released March 29, 2022

Gene: Dmel\lncRNA:let7C

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General Information
Symbol
Dmel\lncRNA:let7C
Species
D. melanogaster
Name
let-7 Complex
Annotation Symbol
CR43344
Feature Type
lncRNA_gene
FlyBase ID
FBgn0263049
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

let-7-C

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
2-53
RefSeq locus
NT_033779 REGION:18455717..18473132
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in cellular response to ecdysone
inferred from mutant phenotype
(Chawla and Sokol, 2012)
involved_in mushroom body development
inferred from mutant phenotype
(Wu et al., 2012)
involved_in negative regulation of gene expression
inferred from mutant phenotype
(Wu et al., 2012)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Model and Products
    Number of Transcripts
    1
    Number of Unique Polypeptides
    0

    Please see the JBrowse view of Dmel\lncRNA:let7C for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure New Section
    Comments on Gene Model

    miRNA(s) located within the transcribed region of this non-coding RNA gene.

    Gene model reviewed during 5.48

    Sequence Ontology: Class of Gene
    lncRNA_gene
    nuclear_gene
    (FlyBase Genome Annotators, 2011)
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    lncRNA:let7C-RA
    FBtr0306973
    NR_047995
    2449
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lncRNA:let7C using the Feature Mapper tool.

    External Data
    Crossreferences
    Linkouts
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\lncRNA:let7C in GBrowse 2
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Images
    FlyBase Wiki
    Image Based Resources
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 4 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 19 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of lncRNA:let7C
    Transgenic constructs containing regulatory region of lncRNA:let7C
    Aberrations (Deficiencies and Duplications) ( 0 )
    Inferred from experimentation ( 0 )
    Inferred from location ( 0 )
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Other Phenotypes
    Allele
    abnormal locomotor behavior | adult stage | progressive, with Df(2L)let-7-CGKI/lncRNA:let7CKO2
    abnormal locomotor behavior | adult stage | progressive, with Df(2L)let-7-CGKI/lncRNA:let7CKO2, lncRNA:let7C3.3
    abnormal locomotor behavior | adult stage | progressive, with Df(2L)let-7-CGKI/lncRNA:let7CKO2, lncRNA:let7CΔmiRNAs
    abnormal locomotor behavior | adult stage | progressive (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmir-125
    abnormal locomotor behavior | adult stage | progressive (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmir-let7
    abnormal locomotor behavior | adult stage | progressive (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmiRNAs, lncRNA:let7C3.3
    abnormal neuroanatomy, with lncRNA:let7C+tSa
    abnormal neuroanatomy, with lncRNA:let7CKO1
    abnormal neuroanatomy (with lncRNA:let7CKO1)
    abnormal neuroanatomy (with lncRNA:let7CKO2)
    abnormal neuroanatomy | adult stage, with lncRNA:let7CKO1/lncRNA:let7CKO2
    abnormal neuroanatomy | adult stage, with Scer\GAL4ey-OK107
    abnormal neuroanatomy | adult stage (with lncRNA:let7CKO1), with lncRNA:let7CΔmir-125
    abnormal neuroanatomy | adult stage (with lncRNA:let7CKO1), with lncRNA:let7CΔmir-let7
    abnormal neuroanatomy | adult stage (with lncRNA:let7CKO2), with lncRNA:let7CΔmir-125
    abnormal neuroanatomy | adult stage (with lncRNA:let7CKO2), with lncRNA:let7CΔmir-let7
    abnormal neuroanatomy | adult stage | progressive, with Df(2L)let-7-CGKI/lncRNA:let7CKO2
    abnormal neuroanatomy | adult stage | progressive, with Df(2L)let-7-CGKI/lncRNA:let7CKO2, lncRNA:let7C3.3
    abnormal neuroanatomy | adult stage | progressive, with Df(2L)let-7-CGKI/lncRNA:let7CKO2, lncRNA:let7C+tCa
    abnormal neuroanatomy | adult stage | progressive, with Df(2L)let-7-CGKI/lncRNA:let7CKO2, lncRNA:let7CΔmiRNAs
    abnormal neuroanatomy | adult stage | progressive (with Df(2L)let-7-CGKI), with lncRNA:let7C+tCa, lncRNA:let7C3.3
    abnormal neuroanatomy | adult stage | progressive (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmir-125
    abnormal neuroanatomy | adult stage | progressive (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmir-let7
    abnormal neuroanatomy | adult stage | progressive (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmiRNAs, lncRNA:let7C3.3
    abnormal neuroanatomy | dominant
    abnormal neuroanatomy | somatic clone
    decreased cell number | adult stage, with lncRNA:let7CKO1/lncRNA:let7CKO2
    decreased cell number | adult stage (with lncRNA:let7CKO1), with lncRNA:let7CΔmir-125
    decreased cell number | adult stage (with lncRNA:let7CKO1), with lncRNA:let7CΔmir-let7
    decreased cell number | adult stage (with lncRNA:let7CKO2), with lncRNA:let7CΔmir-125
    decreased cell number | adult stage (with lncRNA:let7CKO2), with lncRNA:let7CΔmir-let7
    long lived | female | RU486 conditional, with Scer\GAL4da.Switch.PT
    long lived | female | RU486 conditional, with Scer\GAL4Tub.Switch.PU
    short lived, with Df(2L)let-7-CGKI/lncRNA:let7CKO2
    short lived, with Df(2L)let-7-CGKI/lncRNA:let7CKO2, lncRNA:let7C3.3
    short lived, with Df(2L)let-7-CGKI/lncRNA:let7CKO2, lncRNA:let7CΔmiRNAs
    short lived (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmir-125
    short lived (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmir-let7
    short lived (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmiRNAs
    short lived (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmiRNAs, lncRNA:let7C3.3
    short lived | male | RU486 conditional, with Scer\GAL4Tub.Switch.PU
    Phenotype manifest in
    Allele
    adult brain, with Df(2L)let-7-CGKI/lncRNA:let7CKO2
    adult brain, with Df(2L)let-7-CGKI/lncRNA:let7CKO2, lncRNA:let7C3.3
    adult brain, with Df(2L)let-7-CGKI/lncRNA:let7CKO2, lncRNA:let7C+tCa
    adult brain, with Df(2L)let-7-CGKI/lncRNA:let7CKO2, lncRNA:let7CΔmiRNAs
    adult brain (with Df(2L)let-7-CGKI), with lncRNA:let7C+tCa, lncRNA:let7C3.3
    adult brain (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmir-125
    adult brain (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmir-let7
    adult brain (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmiRNAs, lncRNA:let7C3.3
    adult mushroom body alpha'-lobe, with Scer\GAL4ey-OK107
    adult mushroom body beta'-lobe, with Scer\GAL4ey-OK107
    adult mushroom body gamma-lobe, with Scer\GAL4ey-OK107
    alpha/beta posterior Kenyon cell | adult stage, with lncRNA:let7CKO1/lncRNA:let7CKO2
    alpha/beta posterior Kenyon cell | adult stage (with lncRNA:let7CKO1), with lncRNA:let7CΔmir-125
    alpha/beta posterior Kenyon cell | adult stage (with lncRNA:let7CKO1), with lncRNA:let7CΔmir-let7
    alpha/beta posterior Kenyon cell | adult stage (with lncRNA:let7CKO2), with lncRNA:let7CΔmir-125
    alpha/beta posterior Kenyon cell | adult stage (with lncRNA:let7CKO2), with lncRNA:let7CΔmir-let7
    mushroom body
    mushroom body, with lncRNA:let7C+tSa
    mushroom body, with lncRNA:let7CKO1
    mushroom body (with lncRNA:let7CKO1)
    mushroom body (with lncRNA:let7CKO2)
    mushroom body | somatic clone
    retina, with Df(2L)let-7-CGKI/lncRNA:let7CKO2
    retina (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmir-125
    retina (with Df(2L)let-7-CGKI), with lncRNA:let7CΔmir-let7
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (0)
    No records found.
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (0)
    No records found.
    Rattus norvegicus (Norway rat) (0)
    No records found.
    Xenopus tropicalis (Western clawed frog) (0)
    No records found.
    Danio rerio (Zebrafish) (0)
    No records found.
    Caenorhabditis elegans (Nematode, roundworm) (0)
    No records found.
    Arabidopsis thaliana (thale-cress) (0)
    No records found.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No records found.
    Other Organism Orthologs (via OrthoDB)
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (0)
    No records found.
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Allele
      Disease
      Interaction
      References
      lncRNA:let7CUAS.cSa
      ameliorates  cancer
      modeled by ph-d505, ph-p505
      (Jiang et al., 2018)
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      lncRNA:let7C
      suppressible
      chinmo
      (Chawla et al., 2016, Wu et al., 2012)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      w
      suppressible
      lncRNA:let7C
      (Wu et al., 2012)
      External Data
      Linkouts
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2L
      Recombination map
      2-53
      Cytogenetic map
      36F5-36F5
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      36F5-36F5
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      2-53

      (FlyBase, 2016)

      2-53.3

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (7)
      Genomic Clones (35)
      cDNA Clones (4)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: let-7-C CR43344

                (Sokol et al., 2008)

                Source for identity of: lncRNA:let7C let-7-C

                (FlyBase, 2009-)
                Source for database merge of
                Additional comments

                The three microRNAs let-7, mir-125 and mir-100 are co-transcribed as a single polycistronic miRNA precursor transcript (the "let-7-Complex, let-7-C").

                (Sokol et al., 2008)
                Other Comments

                New annotation (CR43344) in release 5.36 of the genome annotation.

                (FlyBase Genome Annotators, 2011)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 9 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                RNAcentral - A comprehensive ncRNA sequence collection representing all ncRNA types from a broad range of organisms
                Other crossreferences
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Synonyms and Secondary IDs (8)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                References (30)