FB2019_05, released Oct 15, 2019

Gene: Dmel\Acsl

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General Information
Symbol
Dmel\Acsl
Species
D. melanogaster
Name
Acyl-CoA synthetase long-chain
Annotation Symbol
CG8732
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263120
Gene Model Status
Current
Stock Availability
33 publicly available
Enzyme Name (EC)
Long-chain-fatty-acid--CoA ligase (6.2.1.3)
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As
l(2)44DEa, dAcsl, l(2)k05304, l(2)05847, lethal (2) 44DEa
Key Links
Genomic Location
Cytogenetic map
44D3-44D6
Sequence location
2R:8,665,813..8,683,022 [+]
Recombination map
2-59
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
palmitoyl-CoA ligase activity
Predictions / Assertions
long-chain fatty acid-CoA ligase activity
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA (6.2.1.3)
Summaries
Gene Group (FlyBase)
ACYL-COA SYNTHETASES -
Acyl-coenzyme A (CoA) synthetases catalyze the "activation" of fatty acids by their thioesterification to CoA. This is the initial reaction in fatty acid metabolism, allowing their participation in many fundamental anabolic and catabolic pathways. (Adapted from FBrf0237395).
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\Acsl or the JBrowse view of Dmel\Acsl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Sequence Ontology: Class of Gene
gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Acsl-RA
FBtr0088699
NM_170615
3704
715
Acsl-RB
FBtr0088700
NM_143777
3677
715
Acsl-RC
FBtr0088701
NM_170616
3117
707
Acsl-RD
FBtr0100426
NM_001014512
3452
717
Acsl-RE
FBtr0100427
NM_001014511
3852
715
Acsl-RF
FBtr0100428
NM_001014510
3409
707
Acsl-RG
FBtr0100429
NM_001014509
3534
707
Acsl-RH
FBtr0100430
NM_001014508
3887
715
Acsl-RI
FBtr0100431
NM_001014507
3353
707
Acsl-RJ
FBtr0333001
NM_001273881
3061
728
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Acsl-PA
FBpp0087779
80.4
715
8.35
NP_724695
AAG22300
Acsl-PB
FBpp0087780
80.4
715
8.35
NP_652034
AAF59061
Acsl-PC
FBpp0087781
79.4
707
8.59
NP_724696
AAM68830
Acsl-PD
FBpp0099845
80.6
717
8.61
NP_001014512
AAX52717
Acsl-PE
FBpp0099846
80.4
715
8.35
NP_001014511
AAX52718
Acsl-PF
FBpp0099847
79.4
707
8.59
NP_001014510
AAX52720
Acsl-PG
FBpp0099848
79.4
707
8.59
NP_001014509
AAX52721
Acsl-PH
FBpp0099849
80.4
715
8.35
NP_001014508
AAX52719
Acsl-PI
FBpp0099850
79.4
707
8.59
NP_001014507
AAX52722
Acsl-PJ
FBpp0305216
81.8
728
8.43
NP_001260810
AGB93343
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

715 aa isoforms: Acsl-PA, Acsl-PB, Acsl-PE, Acsl-PH
707 aa isoforms: Acsl-PC, Acsl-PF, Acsl-PG, Acsl-PI
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Acsl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (15 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
palmitoyl-CoA ligase activity
inferred from mutant phenotype
(Huang et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
long-chain fatty acid-CoA ligase activity
inferred from sequence or structural similarity with HGNC:3570,HGNC:3571
(Faust et al., 2012)
Biological Process (9 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
axon guidance
inferred from mutant phenotype
(Zhang et al., 2009)
chemical synaptic transmission
inferred from mutant phenotype
(Liu et al., 2011)
long-chain fatty-acyl-CoA biosynthetic process
inferred from mutant phenotype
(Huang et al., 2016)
nervous system development
inferred from mutant phenotype
(Zhang et al., 2009)
phosphatidylglycerol biosynthetic process
inferred from mutant phenotype
(Huang et al., 2016)
positive regulation of sequestering of triglyceride
inferred from mutant phenotype
(Zhang et al., 2009)
segmentation
inferred from mutant phenotype
(Zhang et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
fatty acid biosynthetic process
traceable author statement
(Watkins et al., 2007)
long-chain fatty acid metabolic process
inferred from sequence or structural similarity with HGNC:3570,HGNC:3571
(Faust et al., 2012)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
axon
inferred from direct assay
(O'Sullivan et al., 2012)
cytoplasm
inferred from direct assay
(Zhang et al., 2011, Zhang et al., 2009)
endoplasmic reticulum
inferred from direct assay
(Huang et al., 2016, Zhang et al., 2009)
peroxisome
inferred from direct assay
(Huang et al., 2016)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
organism | ubiquitous
(Zhang et al., 2011)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Acsl transcripts are deposited maternally in early embryos.
(Zhang et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous
(Zhang et al., 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Acsl protein is ubiquitously distributed in early embryos.
(Zhang et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
axon
inferred from direct assay
(O'Sullivan et al., 2012)
cytoplasm
inferred from direct assay
(Zhang et al., 2011, Zhang et al., 2009)
endoplasmic reticulum
inferred from direct assay
(Huang et al., 2016, Zhang et al., 2009)
peroxisome
inferred from direct assay
(Huang et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Acsl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 37 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Acsl
Transgenic constructs containing regulatory region of Acsl
Deletions and Duplications ( 12 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Acsl1)
lethal (with Acsl8)
lethal (with Acsl05847)
lethal | recessive
lethal - all die before end of embryonic stage
lethal - all die before end of first instar larval stage | recessive
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage | recessive
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
embryonic/larval segmentation phenotype (with Df(2R)H3E1)
embryonic/larval segmentation phenotype | maternal effect | recessive
embryonic/larval segmentation phenotype | recessive
mitotic cell cycle defective | recessive
neuroanatomy defective | larval stage
neuroanatomy defective | larval stage (with Acsl8)
neuroanatomy defective | larval stage (with Acsl05847)
neuroanatomy defective | larval stage (with AcslKO)
neuroanatomy defective | third instar larval stage (with Acsl8)
neuroanatomy defective | third instar larval stage (with Acslk10313)
neurophysiology defective (with Acsl05847)
neurophysiology defective (with AcslKO)
pain response defective | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
some die during embryonic stage
some die during first instar larval stage | recessive
some die during larval stage | recessive
some die during pharate adult stage | recessive
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
A2 neuron (with Acsl8)
A2 neuron (with Acsl05847)
A2 neuron (with AcslKO)
A3 neuron (with Acsl8)
A3 neuron (with Acsl05847)
A3 neuron (with AcslKO)
A4 neuron (with Acsl8)
A4 neuron (with Acsl05847)
A4 neuron (with AcslKO)
A5 neuron (with Acsl8)
A5 neuron (with Acsl05847)
A5 neuron (with AcslKO)
A6 neuron (with Acsl8)
A6 neuron (with Acsl05847)
A6 neuron (with AcslKO)
A7 neuron (with Acsl8)
A7 neuron (with Acsl05847)
A7 neuron (with AcslKO)
bouton (with Acsl05847)
bouton (with AcslKO)
embryonic/larval brain | third instar larval stage (with Acsl8)
embryonic/larval brain | third instar larval stage (with Acslk10313)
embryonic/larval neuromuscular junction (with Acsl05847)
embryonic/larval neuromuscular junction (with AcslKO)
embryonic abdominal segment 1
embryonic abdominal segment 1 | maternal effect
embryonic abdominal segment 2
embryonic abdominal segment 2 (with Df(2R)H3E1)
embryonic abdominal segment 2 | maternal effect
embryonic abdominal segment 3
embryonic abdominal segment 3 (with Df(2R)H3E1)
embryonic abdominal segment 3 | maternal effect
embryonic abdominal segment 4
embryonic abdominal segment 4 (with Df(2R)H3E1)
embryonic abdominal segment 4 | maternal effect
embryonic abdominal segment 5
embryonic abdominal segment 5 | maternal effect
embryonic abdominal segment 6
embryonic abdominal segment 6 (with Df(2R)H3E1)
embryonic abdominal segment 6 | maternal effect
embryonic abdominal segment 7
embryonic abdominal segment 7 (with Df(2R)H3E1)
embryonic abdominal segment 7 | maternal effect
embryonic abdominal segment (with Df(2R)H3E1)
ganglion mother cell | larval stage
lamina anlage glial cell (with Acsl8)
lamina anlage glial cell (with Acslk10313)
lamina plexus (with Acsl8)
lamina plexus (with Acslk10313)
larval abdominal segment 6 (with Acsl05847)
larval abdominal segment 6 (with AcslKO)
larval abdominal segment 7 (with Acsl05847)
larval abdominal segment 7 (with AcslKO)
larval neuroblast | larval stage
medulla anlage (with Acsl8)
medulla anlage (with Acslk10313)
mesothoracic tergum, with Scer\GAL4pnr-MD237
neuromuscular junction (with Acsl8)
neuromuscular junction (with Acsl05847)
neuromuscular junction (with AcslKO)
NMJ bouton (with Acsl8)
NMJ bouton (with Acsl05847)
NMJ bouton (with AcslKO)
rhabdomere | conditional, with Scer\GAL4GMR.PF
rhabdomere | somatic clone | conditional
segmental nerve (with Acsl05847)
segmental nerve (with AcslKO)
synapse (with Acsl05847)
synapse (with AcslKO)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ACSL3
15 of 15
Yes
Yes
 
 
Hsap\ACSL4
14 of 15
No
Yes
 
 
Hsap\ACSL1
2 of 15
No
No
Hsap\ACSL5
2 of 15
No
No
Hsap\ACSL6
2 of 15
No
No
Hsap\ACSBG1
1 of 15
No
No
Hsap\ACSBG2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Acsl3
14 of 15
Yes
Yes
Mmus\Acsl4
13 of 15
No
Yes
Mmus\Acsl1
2 of 15
No
No
Mmus\Acsl5
2 of 15
No
No
Mmus\Acsl6
2 of 15
No
No
Mmus\1700061G19Rik
1 of 15
No
No
Mmus\Acsbg1
1 of 15
No
No
Mmus\Acsbg2
1 of 15
No
No
Rattus norvegicus (Norway rat) (8)
Rnor\Acsl3
13 of 13
Yes
Yes
Rnor\Acsl4
12 of 13
No
Yes
Rnor\Acsl1
2 of 13
No
No
Rnor\Acsbg1
1 of 13
No
No
Rnor\Acsbg2
1 of 13
No
No
Rnor\Acsl5
1 of 13
No
No
Rnor\Acsl6
1 of 13
No
No
Rnor\LOC316124
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\acsl4
6 of 12
Yes
Yes
Xtro\acsl3
2 of 12
No
Yes
Xtro\acsbg1
1 of 12
No
No
Xtro\acsbg2
1 of 12
No
No
Xtro\acsl1
1 of 12
No
No
Xtro\acsl5
1 of 12
No
No
Xtro\acsl6
1 of 12
No
No
Danio rerio (Zebrafish) (11)
Drer\acsl3a
12 of 15
Yes
Yes
Drer\acsl3b
12 of 15
Yes
Yes
Drer\acsl4b
12 of 15
Yes
Yes
Drer\acsl4a
9 of 15
No
Yes
Drer\acsl1a
2 of 15
No
No
Drer\acsl1b
2 of 15
No
No
Drer\acsl2
2 of 15
No
No
Drer\acsl5
2 of 15
No
No
Drer\acsl6
2 of 15
No
No
Drer\acsbg1
1 of 15
No
No
Drer\acsbg2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\acs-4
14 of 15
Yes
Yes
Cele\acs-17
11 of 15
No
Yes
Cele\acs-5
2 of 15
No
No
Cele\acs-13
2 of 15
No
No
Cele\acs-3
1 of 15
No
No
Cele\acs-15
1 of 15
No
No
Cele\acs-18
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (9)
Atha\LACS8
9 of 9
Yes
Yes
Atha\LACS9
8 of 9
No
Yes
Atha\AT4G11030
1 of 9
No
No
Atha\LACS1
1 of 9
No
No
Atha\LACS2
1 of 9
No
No
Atha\LACS3
1 of 9
No
No
Atha\LACS4
1 of 9
No
No
Atha\LACS6
1 of 9
No
No
Atha\LACS7
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\FAA4
14 of 15
Yes
Yes
Scer\FAA1
13 of 15
No
Yes
Scer\FAA3
12 of 15
No
Yes
Scer\FAA2
2 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\lcf1
11 of 12
Yes
Yes
Spom\lcf2
10 of 12
No
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190308 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Acsl
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006783
Drosophila simulans
Dsim\GD10588
Drosophila sechellia
Dsec\GM21055
Drosophila erecta
Dere\GG23376
Drosophila yakuba
Dyak\GE19217
Drosophila ananassae
Dana\GF12373
Drosophila pseudoobscura pseudoobscura
Dpse\GA21288
Drosophila persimilis
Dper\GL17113
Drosophila willistoni
Dwil\GK21733
Drosophila virilis
Dvir\GJ21833
Drosophila mojavensis
Dmoj\GI18805
Drosophila grimshawi
Dgri\GH20089
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501PQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013967
Musca domestica
House fly
Mdoa\17027426
Glossina morsitans
Tsetse fly
Gmor\GMOY000234
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09753
Mayetiola destructor
Hessian fly
Mdes\Mdes005907
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010991
Anopheles darlingi
American malaria mosquito
Adar\ADAC008564
Anopheles gambiae
Malaria mosquito
Agam\AGAP003623
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019378
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015739
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02EM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003788
Danaus plexippus
Monarch butterfly
Dple\DPOGS210140-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211042-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011608
Apis florea
Little honeybee
Aflo\2275604292
Apis mellifera
Western honey bee
Amel\GB42732
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12345
Bombus terrestris
Buff-tailed bumblebee
Bter\15206492
Linepithema humile
Argentine ant
Lhum\LH11911
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001ab7
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011024
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06117
Tribolium castaneum
Red flour beetle
Tcas\TC014440
Pediculus humanus
Human body louse
Phum\PHUM509490
Rhodnius prolixus
Kissing bug
Rpro\RPRC009774
Cimex lectularius
Bed bug
Clec\CLEC012849
Cimex lectularius
Bed bug
Clec\CLEC012848
Cimex lectularius
Bed bug
Clec\CLEC012850
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001408
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04144
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02C9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002471
Ixodes scapularis
Black-legged tick
Isca\ISCW003216
Ixodes scapularis
Black-legged tick
Isca\ISCW004612
Ixodes scapularis
Black-legged tick
Isca\ISCW000319
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77727.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78781.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur34g00700
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g13820
Tetranychus urticae
Two-spotted spider mite
Turt\tetur34g00980
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g02620
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_207639
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_213488
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307390
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02F4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Acyl/CoA/Synth
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Acs13
Gallus gallus
Domestic chicken
Ggal\ACSL4
Gallus gallus
Domestic chicken
Ggal\ACSL3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG3961
3 of 10
bgm
1 of 10
hll
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ACSL3; acyl-CoA synthetase long chain family member 3
15 of 15
602371
       
      ACSL4; acyl-CoA synthetase long chain family member 4
      14 of 15
      300157
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Dmel gene
      Ortholog showing functional complementation
      Supporting References
      Acsl
      Hsap\ACSL3
      (Zhang et al., 2009)
      Acsl
      Hsap\ACSL4
      (Liu et al., 2014, Liu et al., 2011, Zhang et al., 2009)
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Acsl - Cnx99A
      experimental knowledge based
      (Guruharsha et al., 2011)
      Acsl - Mpcp2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Acsl - Rtnl1
      anti tag coimmunoprecipitation, western blot
      (O'Sullivan et al., 2012)
      Acsl - fax
      experimental knowledge based
      (Guruharsha et al., 2011)
      Acsl - msk
      experimental knowledge based
      (Guruharsha et al., 2011)
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Acsl
      enhanceable
      Dad
      (Liu et al., 2014)
      Acsl
      enhanceable
      kni
      (Zhang et al., 2011)
      Acsl
      enhanceable
      Kr
      (Zhang et al., 2011)
      Acsl
      enhanceable
      Rab11
      (Liu et al., 2014)
      Acsl
      suppressible
      tkv
      (Liu et al., 2014)
      Acsl
      suppressible
      wit
      (Liu et al., 2014)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      l(1)sc
      enhanceable
      Acsl
      (Rottgen et al., 1998)
      N
      enhanceable
      Acsl
      (Rottgen et al., 1998)
      peb
      suppressible
      Acsl
      (Wilk et al., 2004)
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Gene Group - Pathway Membership (FlyBase)
      External Data
      Linkouts
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map
      2-59
      Cytogenetic map
      44D3-44D6
      Sequence location
      2R:8,665,813..8,683,022 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      44D3-44D6
      Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      44D3-44D6
      (Oh et al., 2003)
      44F1-44F2
      (determined by in situ hybridisation) 44E1--2 (determined by in situ hybridisation)
      (Spradling et al., 1999)
      44E-44E
      (determined by in situ hybridisation)
      (Amorim et al., 1995)
      24D5-24D6
      44D6--8 44D8--E1
      (BDGP Project Members, 1994-1999)
      Experimentally Determined Recombination Data
      Location
      2-59
      (FlyBase, 2016)
      2-57.8
      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (33)
      Genomic Clones (17)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (174)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      polyclonal
      (Zhang et al., 2009)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: Acsl l(2)44DEa
      (Zhang et al., 2009)
      Source for database merge of
      Source for merge of: l(2)05847 l(2)k05304
      (Dockendorff et al., 2000)
      Source for merge of: l(2)44DEa CG8732
      (Misra, 2000.11.18)
      Source for merge of: l(2)44DEa anon-WO0172774.173
      (FlyBase, 1996-)
      Source for merge of: Acsl l(2)SH0465
      (Liu et al., 2011)
      Additional comments
      Source for merge of l(2)44DEa anon-WO0172774.173 was sequence comparison ( date:051113 ).
      (FlyBase, 1996-)
      Other Comments
      FlyBase Curator comment: 'Acsl' identified as 'FCS' by BLASTing the 'FCS' primer sequences given in the Supplementary Methods.
      (Bauer et al., 2009)
      11 alleles of l(2)SH0465 recovered in a P-insertion screen.
      (Oh et al., 2003)
      Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
      (Harvie et al., 1998)
      l(2)44DEa may be involved in keeping sister chromatids together or stabilizing the microtubule contact with centromeres.
      (Amorim et al., 1995)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 87 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Linkouts
      ApoDroso - Functional genomic database for photoreceptor development, survival and function
      DroID - A comprehensive database of gene and protein interactions.
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (25)
      Reported As
      Symbol Synonym
      7447
      (Harvie et al., 1998)
      ACSL1
      (de Paula et al., 2018, Trindade de Paula et al., 2016)
      ACSL3
      (Wilfling et al., 2013)
      Acsl
      (Ge et al., 2019, Hughes and Simmonds, 2019, Jia et al., 2019, Raza et al., 2019, Gene Disruption Project members, 2018-, Levis, 2018.8.30, Walls et al., 2018, Yeung et al., 2018, Paiardi et al., 2017, Transgenic RNAi Project members, 2017-, Huang et al., 2016, Gene Disruption Project members, 2015-, Van Bortle et al., 2015, Liu et al., 2014, Toshima et al., 2014, Faust et al., 2012, O'Sullivan et al., 2012, Rodriguez et al., 2012, Neumüller et al., 2011, Zhang and Wang, 2010.11.5, Zhang et al., 2009)
      CG8732
      (Kolkhof et al., 2017, Hosono et al., 2015, Krahmer et al., 2013, Wilfling et al., 2013, Chambers et al., 2012, Christis and Munro, 2012, Faust et al., 2012, Jaspers et al., 2012, Cammarato et al., 2011, Sala et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Guo et al., 2008, Quinones-Coello, 2007, Watkins et al., 2007, Cermelli et al., 2006, Montooth et al., 2006, Oba et al., 2005, Scherzer et al., 2003, Seegmiller et al., 2002)
      FACS
      (Lee et al., 2013, Guo et al., 2008)
      FCS
      (Bauer et al., 2009)
      anon-WO0172774.173
      dAcsl
      (Liu et al., 2011, Zhang et al., 2011, Kühnlein, 2010, Zhang et al., 2009)
      dFAC
      (Lee et al., 2010)
      l(2)05847
      (Rottgen et al., 1998, Amorim et al., 1995)
      l(2)44DEa
      (Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Siddiqui et al., 2012, Smibert et al., 2012, Liu and Lehmann, 2008, Li et al., 2007, Minidorff et al., 2007, Quinones-Coello, 2007, Stuart et al., 2007, Watkins et al., 2007, Cermelli et al., 2006, FlyBase, 1992-)
      l(2)7447
      (Harvie, 1997.6.4)
      l(2)SH0465
      l(2)SH2 0465
      (Oh et al., 2002.3.22)
      l(2)k05304
      (Dockendorff et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)
      Name Synonyms
      Acyl-CoA synthetase long-chain
      Fatty acyl CoA synthetase
      (Rawson, 2003, Seegmiller et al., 2002, Seegmiller et al., 2002)
      Fatty acyl-CoA synthetase
      (Dobrosotskaya et al., 2002)
      Long-chain acyl-CoA synthetase
      (Zhang et al., 2009)
      fatty acyl coenzyme A (CoA) synthetase
      (Lee et al., 2010)
      fatty acyl-CoA synthetase
      (Bauer et al., 2009)
      lethal (2) 44DEa
      (Jaspers et al., 2012, Cammarato et al., 2011)
      lethal (2) SH0465
      long-chain acyl-CoA synthetase
      (Zhang et al., 2011)
      Secondary FlyBase IDs
      • FBgn0010609
      • FBgn0022182
      • FBgn0033318
      • FBgn0046428
      • FBgn0065770
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (120)