α1, Prosalpha6, Proteasome α6 subunit, Proteasome alpha6 subunit, alpha1
Gene model reviewed during 5.49
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). Interacts with PI31.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Prosα1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Prosα1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
CG30382 is an almost exact duplicate of Prosα1. This duplication is not present in close Drosophila species; it may be strain-specific. Following the naming conventions used in FBrf0215459, CG30382 should probably be referred to as 'Prosα1R' / 'Proteasome α1 subunit-related'.
The nomenclature of genes encoding subunits of the 26S proteasome of D. melanogaster have been standardized according to FBrf0215459. These symbols/names largely follow those used already in FlyBase, and largely mirror fly community usage. HOWEVER, note that at least one other nomenclature system exists that is followed by the HUGO Gene Nomenclature Committee (HGNC), for example, with the unfortunate result that several D. melanogaster genes have shared synonyms.
FlyBase curator comment: The gene corresponding to the CG18495 annotation was previously mistakenly renamed to "Prosα6" in FlyBase (this symbol does not appear to have been used in the literature for the CG18495 annotation prior to the mistaken rename in FlyBase). The gene has been renamed to "Prosα1" to reflect the symbol used in the literature. Note that the "Prosα6" symbol has been used in the literature for the gene corresponding to the CG4904 annotation (FBgn0250843), which encodes a different proteasome subunit from that encoded by "Prosα1".