• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Prosα1

General Information
Symbol	Dmel\Prosα1	Species	D. melanogaster
Name	Proteasome α1 subunit	Annotation symbol	CG18495
Feature type	protein_coding_gene	FlyBase ID	FBgn0263121
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	Prosalpha1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	43E18-43E18	Sequence location	2R:3,714,808..3,716,181 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Proteasome α1 subunit is referred to in FlyBase by the symbol Dmel\Prosα1 (CG18495, FBgn0263121). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: response to DNA damage stimulus. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Proteasome A-type subunit; Proteasome, alpha-subunit, conserved site; Proteasome, subunit alpha/beta. Gene sequence location is 2R:3714808..3716181.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 43E18-43E18   Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 43E18-43E18     (Oh et al., 2003) 43E-43F     (Belote, 1999.4.21)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Prosα1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Prosα1-RA FBtr0088896  NM_165565   885   244 Prosα1-RB FBtr0088895  NM_080098   967   244
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Prosα1-PA   FBpp0087970   27.2   244   7.77     NP_724614   AAF59183 Prosα1-PB   FBpp0087969   27.2   244   7.77     NP_524837   AAF59184
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Proteasome A-type subunit (IPR023332) Proteasome, alpha-subunit, conserved site (IPR000426) Proteasome, subunit alpha/beta (IPR001353)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439039   AA696882   AE013599 AAF59183   AE013599 AAF59184   AB082840   AF144749 AAD33944   AI064453   AI257875   AI296309   AI296503   AI405961   AI515374   AI531340   AQ073487   AW944233   AY118637 AAM50006   AY231750   BE975999   BE976020   BF487246   BF487340   BF494721   BG634685   BG635818   BG635819   BG639370   BI163727   BI165261   BI165673   BI235553   BI236488   BI366528   BI372403   BI569833   BI640443   BP540894   BP541396   BP543087   BP543088   BP545845   BP546226   BP546470   BP548005   BP548919   BP548920   BP556582   BP556583   BP557338   BP559056   BP559057   BP559366   BP559367   BQ103655   CK605346   CK605347   CK660678   CO153490   CO154825   CO181561   CO262855   CO274555   CO274640   CO308670   CO311173   CO317402   CO321350   CO323001   EC066284   EC085949   EC086694   EC195353   EC196727   EC198149   EC223608   EC225196   EC226977   EC250913   EC262549   EC266359   EC267427   EL879412   EL882341   EL887327   EL887439   EL887468   EL887506   EV575131   EV580065   GH942242   GH945890   GH948558   GH954045   GH959764   GH963763   GH963835   GH963912   GH964698   GH965445   GH967089   GH967810   GH968812   GH971282   GH977039   GH980371   GH981875
UniProtKB/Swiss-Prot	Q9XZJ4
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Prosα1SH2342 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Prosα1 Class Mutagen Stocks Known lesion Prosα1EP2318 P-element activity 1 -- Prosα1SH2342 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Prosα1 Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Prosα1EP2318 NA insertion of enhancer trap P{lacW}Prosα1SH2342 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
endopeptidase activity non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) threonine-type endopeptidase activity inferred from electronic annotation with InterPro:IPR001353, InterPro:IPR023332 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR000426 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
proteasome core complex non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) proteasome core complex, alpha-subunit complex inferred from electronic annotation with InterPro:IPR000426 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Prosα1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0263121
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA14960   Dyak\GE23574
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	17043 w1118; P{EP}Prosα1EP2318/CyO
Genomic Clones ( 1 )
	BACR04B09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 90 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD02332
Other clones	yak-em_Prosalpha6
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03444 AT21976 AT22113 AT30981 GH04884 GH26123 GM08626 LD13474 LP10168 LP10435 LP19455 RE03210 RE05116 RE05612 RE31412 RE32547 RE52084 RE59355 RH01991 SD13316 SD13317 SD23301
Other clones	12761 61974 63574 73610 100848 156145 163334 194662 522464 524162 571333 bs46d07 bs46e06 CK01.54C.D7 CK01.102D.A12 Dmel_dig_014085_0664_2963 Dmel_dig_017193_0707_2846 EC14545 EK086534 EK114453 EK114808 EK185510 EK189359 EK223659 EK259057 EK267927 EN02058 EN04859 FGA008G06 FGC001B12 FGC018E11 FGH001B07 FGH104B07 FGH106G04 FGH123A05 FGM002F02 FGM304D03 FGM308G04 FGM318F03 FGM320E04 IP09392 IP12117 IP18440 IP18640 IP18740 LD47174 LP06364 RP004120336 RP004197291 RP004224000 RP004226177 RP004241715 RP004258246 RP004303757 RP004414670 RP004449731 RP004462695 RP004472005 RP004493096 RP004500082 RP004509414 RP004511631 RP004511843 RP004553083 UT01861 UUGC1065
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45780
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Prosα1 CG18495 (Bayraktaroglu, 2000.4.7) Source for merge of: Prosα1 l(2)SH2342 (Chang et al., 2011)
Additional comments	FlyBase curator comment: The gene corresponding to the CG18495 annotation was previously mistakenly renamed to "Prosα6" in FlyBase (this symbol does not appear to have been used in the literature for the CG18495 annotation prior to the mistaken rename in FlyBase). The gene has been renamed to "Prosα1" to reflect the symbol used in the literature. Note that the "Prosα6" symbol has been used in the literature for the gene corresponding to the CG4904 annotation (FBgn0250843), which encodes a different proteasome subunit from that encoded by "Prosα1". (FlyBase, 1992-)
Other Comments
	2 alleles of l(2)SH2342 recovered in a P-insertion screen. (Oh et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080098 NM_165565 RefSeq (Proteins) • NP_524837 NP_724614 DDBJ / EMBL / GenBank • AAD33944 AAF59183 AAF59184 AAM50006 AB082840 AF144749 AI531340 AQ073487 AW944233 AY118637 Entrez Gene - A searchable database of RefSeq genes. • 45780 UniProtKB/Swiss-Prot • Q9XZJ4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Proteasome A-type subunit (IPR023332) Proteasome, alpha-subunit, conserved site (IPR000426) Proteasome, subunit alpha/beta (IPR001353)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0263121 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45780
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	18495 (Ravi et al., 2009) CG18495 (Chang et al., 2011, Mount, 2001.8.14, Barbash and Lorigan, 2007, Bayraktaroglu, 2000.4.7, Ma et al., 2002, Cammarato et al., 2011) l(2)SH2 2342 (Oh et al., 2002.3.26) l(2)SH2342   Prosalpha1 (Barbash and Lorigan, 2007) prosalpha1 (Firth and Baker, 2007) Prosalpha6 (Barbash and Lorigan, 2007) Prosα1 (Bayraktaroglu, 2000.4.7, Ma et al., 2002) Prosα6 (McDermott and Kliman, 2008) PSA6_DROME (Storm and Sonnhammer, 2003)
Name Synonym	20s proteasome (Speese et al., 2003) 20S proteasome (Bohm et al., 2000) 20S proteasome subunit alpha1 (Belote, 1999.4.21) lethal (2) SH2342   Proteasome alpha6 subunit (Harbison et al., 2005, Cammarato et al., 2011) Proteasome α1 subunit (Chang et al., 2011) Proteasome α6 subunit
Secondary FlyBase IDs
	FBgn0026781 FBgn0033228 FBgn0065188
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 2 ) Personal communication to FlyBase  ( 4 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 2 )
Recent research papers ( 3 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Chang et al., 2011, PLoS Genet. 7(2): e1001288 Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model. [FBrf0213008] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...