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Gene Dmel\CG43373

General Information
Symbol	Dmel\CG43373	Species	D. melanogaster
Name		Annotation symbol	CG43373
Feature type	protein_coding_gene	FlyBase ID	FBgn0263131
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	CG32158, CG12436
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	73A4-73A5	Sequence location	3L:16,484,938..16,536,318 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG43373 (FBgn0263131). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: adenylate cyclase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: cyclic nucleotide biosynthetic process; intracellular signal transduction. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Adenylate cyclase-like; Adenylyl cyclase class-3/4/guanylyl cyclase; Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site. Gene sequence location is 3L:16484938..16536318.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 73A4-73A5   Limits computationally determined from genome sequence between P{lacW}l(3)j10E8j10E8&P{PZ}l(3)1053210532 and P{PZ}Baldspot02281
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG43373 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-seq exon junction(s) not annotated. Gene split based on protein alignment (BLASTX) data. Gene merge based on RNA-Seq data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG43373-RB FBtr0307367  NM_168670   5761   1240 CG43373-RC FBtr0307368  NM_001104152   6094   1854
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG43373-PB   FBpp0298356   136.8   1240   7.95     NP_730173   AAF49454 CG43373-PC   FBpp0298357   203.8   1854   6.95     NP_001097622   ABW08553
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Adenylyl cyclase class-3/4/guanylyl cyclase (IPR001054) Adenylate cyclase-like (IPR009398) Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site (IPR018297)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567907   AA695692   AA697760   AA698362   AA802528   AE014296 AAF49454   AE014296 ABW08553   AY060438   AY113223   BF496745   BF500093   BF506434   BG632956   BG634848   BG640765   BI631121   BT099558   CA804002   CA806764   CA807388   CO152804   CO274228   CO294766   CO314969   CZ470699   EC052897   EC056501   EC247471   GH291243   GH838357   GH840315   GH881328   GH889653   GH924658   GH933977
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VV68 A8JNU1 Q9VV69
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    5 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    5 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    5 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    5 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    5 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    5 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    5 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    5 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_14
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG43373e01330 viable, with Scer\GAL4pnr-MD237 CG43373GD13449 Sterility Allele fertile CG43373e01330 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of CG43373 Class Mutagen Stocks Known lesion CG43373c06449 piggyBac transposase 1 -- CG43373DG23510 1 -- CG43373e01330 piggyBac transposase 1 -- CG43373MB08203 1 -- CG43373MI05926 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG43373 Class Mutagen Stocks Known lesion CG43373GD13449 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG43373KK110535 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}CG43373MI05926 NA P{wHy}CG33158DG23510 NA PBac{PB}CG43373c06449 NA PBac{RB}ste01330 NA insertion of enhancer trap binary system Mi{ET1}CG43373MB08203 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
adenylate cyclase activity inferred from electronic annotation with InterPro:IPR009398 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
cyclic nucleotide biosynthetic process inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR009398, InterPro:IPR018297 (FlyBase Curators et al., 2004-) intracellular signal transduction inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR009398 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene (FlyBase, 1992-) protein_coding_gene (FlyBase, 1992-)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG43373 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0263131
Orthologs
OrthoDB Orthologs (71) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6V701X Dipteran inclusive ortholog search EOG60GCZR Insect inclusive ortholog search EOG6MSBT9 Arthropod inclusive ortholog search EOG62BVQP Metazoa inclusive ortholog search EOG63NM5J
Orthologs in Drosophila Species (EOG6V701X)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG43373     Drosophila simulans   Dsim\GD12464     Drosophila sechellia   Dsec\GM24393     Drosophila erecta   Dere\GG15877     Drosophila yakuba   Dyak\GE22216     Drosophila ananassae   Dana\GF10525     Drosophila pseudoobscura pseudoobscura   Dpse\GA28358     Drosophila persimilis   Dper\GL17987     Drosophila willistoni   Dwil\GK17483     Drosophila virilis   Dvir\GJ12611     Drosophila mojavensis   Dmoj\GI16861     Drosophila grimshawi   Dgri\GH15584
Orthologs in non-Drosophila Dipterans (EOG60GCZR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001034   Anopheles gambiae Malaria mosquito  Agam\AGAP002998   Anopheles gambiae Malaria mosquito  Agam\AGAP012805   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007240   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007241
Orthologs in non-Dipteran Insects (EOG6MSBT9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41921   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12475   Atta cephalotes Leafcutter ant  Acep\ACEP14478   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14325   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15243   Linepithema humile Argentine ant  Lhum\LH12172   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23286   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23290   Solenopsis invicta Red fire ant  Sinv\SINV16695   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001747   Bombyx mori Silkmoth  Bmor\BGIBMGA002064   Bombyx mori Silkmoth  Bmor\BGIBMGA002066   Pediculus humanus Human body louse  Phum\PHUM131860   Tribolium castaneum Red flour beetle  Tcas\TC010893
Orthologs in non-Insect Arthropods (EOG62BVQP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Taspase1   Ixodes scapularis Deer tick  Isca\ISCW011601
Orthologs in non-Arthropod Metazoa (EOG63NM5J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\acy-4 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007235gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023604gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017988gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007236gn Y Danio rerio Zebrafish  Drer\ENSDARG00000043141 Y Danio rerio Zebrafish  Drer\ENSDARG00000017437 Y Danio rerio Zebrafish  Drer\adcy6b Y Danio rerio Zebrafish  Drer\adcy1b Y Danio rerio Zebrafish  Drer\ENSDARG00000077145 Y Danio rerio Zebrafish  Drer\adcy8 Y Danio rerio Zebrafish  Drer\ENSDARG00000091342 Y Danio rerio Zebrafish  Drer\si:dkey-206f10.1 Y Danio rerio Zebrafish  Drer\adcy6a Y Danio rerio Zebrafish  Drer\adcy1a Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000024163 Y Xenopus tropicalis Western clawed frog  Xtro\adcy3 Y Xenopus tropicalis Western clawed frog  Xtro\adcy6 Y Xenopus tropicalis Western clawed frog  Xtro\adcy1 Y Gallus gallus Domestic chicken  Ggal\ADCY8 Y Gallus gallus Domestic chicken  Ggal\ADCY5 Y Gallus gallus Domestic chicken  Ggal\ADCY1 Y Gallus gallus Domestic chicken  Ggal\ADCY3 Y Mus musculus House mouse  Mmus\Adcy6 Y Mus musculus House mouse  Mmus\ENSMUSG00000022840 Y Mus musculus House mouse  Mmus\Adcy1 Y Mus musculus House mouse  Mmus\Adcy8 Y Mus musculus House mouse  Mmus\Adcy3 Y Rattus norvegicus Norway rat  Rnor\Adcy8 Y Rattus norvegicus Norway rat  Rnor\Adcy1 Y Rattus norvegicus Norway rat  Rnor\Adcy3 Y Rattus norvegicus Norway rat  Rnor\Adcy5 Y Rattus norvegicus Norway rat  Rnor\Adcy6 Y Homo sapiens Human  Hsap\ENSG00000174233 Y Homo sapiens Human  Hsap\ADCY5 Y Homo sapiens Human  Hsap\ADCY1 Y Homo sapiens Human  Hsap\ADCY8 Y Homo sapiens Human  Hsap\ADCY3 Y
Human Orthologs (5)
Gene OMIM HGNC Hsap\ENSG00000174233     Hsap\ADCY5     Hsap\ADCY1     Hsap\ADCY8     Hsap\ADCY3
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG15876 Drosophila yakuba Dyak\GE22215 Drosophila ananassae Dana\GF10524 Drosophila pseudoobscura pseudoobscura Dpse\GA11632 Drosophila persimilis Dper\GL17985 Drosophila willistoni Dwil\GK17482 Drosophila mojavensis Dmoj\GI16860 Drosophila grimshawi Dgri\GH15583
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	25662 w1118; Mi{ET1}CG43373MB08203 17944 w1118; PBac{RB}ste01330 CG43373e01330 CG42514e01330 41502 y1 w*; Mi{MIC}CG43373MI05926/TM3, Sb1 Ser1 20473 y1 w67c23; P{wHy}CG33158DG23510 CG43373DG23510 CG42514DG23510/TM3, Sb1 Ser1
Harvard	- PBac{PB}CG43373c06449
VDRC	v102057 P{KK110535}VIE-260B v23385 w1118; P{GD13449}v23385 v23386 w1118; P{GD13449}v23386
Genomic Clones ( 1 )
	BACR08H06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 31 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT09365 GM17804 LD46618
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08894 AT10653 AT14901 AT31208 GH17161 GM04306 HL01974 HL03116 HL04341 RH60534 SD11911
Other clones	78400 DMG5-chr3L.28.001.pred.a EC052897 EC056501 EK113606 EK207625 EK238626 EN00461 ESG014d.E21_G05 ESG017c.E21_H06 ESG0111c.B21_G04 RP003358360 RP003432680 RP003484550 RP003507249 RP003535516 RP003552397
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39835
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG12243 CG4526 (FlyBase Genome Annotators, 2002-2003) Source for merge of: CG12436 CG42513 (FlyBase Genome Annotators, 2011) Source for merge of: CG32158 anon-WO0257455.11 anon-WO0118547.377 (FlyBase, 1996-)
Additional comments	Annotations CG12436 and CG42513 merged as CG43373 in release 5.36 of the genome annotation. (FlyBase Genome Annotators, 2011) Annotation CG32158 split into CG42513 and CG42514 in release 5.14 of the genome annotation. (FlyBase Genome Annotators, 2008) Annotations CG12243, CG4526 merged as CG32158 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of CG32158 anon-WO0257455.11 anon-WO0118547.377 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R[+] cell morphology. (Kiger et al., 2003, Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168670 NM_001104152 RefSeq (Proteins) • NP_730173 NP_001097622 DDBJ / EMBL / GenBank • AA567907 AA802528 AAF49453 AAF49454 ABW08553 BF496745 BF500093 BF506434 BG634848 BI631121 CZ470699 Entrez Gene - A searchable database of RefSeq genes. • 39835 39838 UniProtKB/TrEMBL • A8JNU1 Q9VV68 Q9VV69
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Adenylyl cyclase class-3/4/guanylyl cyclase (IPR001054) Adenylate cyclase-like (IPR009398) Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site (IPR018297)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0263131 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39835
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	AC (Morrison et al., 2000) Ago2 (González et al., 2010) CG12436 (Keleman et al., 2009.8.5, González et al., 2010) CG32158 (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-, Kiger et al., 2003, Bellen, 2008.9.12, Gene Disruption Project members and Exelixis, 2005, FlyBase Genome Annotators, 2008, Bloomington Drosophila Stock Center, 2004.11.6, Ueno and Kidokoro, 2008) CG42513 (González et al., 2010) CG43373 (FlyBase Genome Annotators, 2011)
Name Synonym
Secondary FlyBase IDs
	FBan0032158 FBgn0036636 FBgn0036637 FBgn0052158 FBgn0260387
References ( 20 )
Research paper	González et al., 2010, PLoS Genet. 6(4): e1000905 Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. [FBrf0210506] Ueno and Kidokoro, 2008, Europ. J. Neurosci. 28(10): 1956--1966 Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. [FBrf0206345]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231] Morrison et al., 2000, J. Cell Biol. 150(2): Table S1. Drosophila protein kinases and phosphatases. [FBrf0132098]
Personal communication to FlyBase	Bellen, 2012.9.7, set1005.xml set1005.xml [FBrf0219418] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Bellen, 2008.9.12, set814.xml set814.xml [FBrf0205645] Myrick et al., 2008.12.2, Alignment of P{wHy} collection to current genome. Alignment of P{wHy} collection to current genome. [FBrf0206273] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Genome Annotators, 2011, Changes affecting gene model number or type in release 5.36 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.36 of the annotated D.melanogaster genome. [FBrf0213141] FlyBase Genome Annotators, 2008, Changes affecting gene model number or type in release 5.14 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.14 of the annotated D.melanogaster genome. [FBrf0206130] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]