FlyBase Gene Report: Dmel\CG43373

ADENYLATE CYCLASES -: Adenylate cyclases catalyze the synthesis of cAMP from ATP, yielding diphosphate as a by-product. (Adapted from FBrf0238856).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\CG43373 or the JBrowse view of Dmel\CG43373 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene

nuclear_gene

(FlyBase, 1992-)

protein_coding_gene

(FlyBase, 1992-)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG43373-RB

FBtr0307367

NM_168670

5913

1240

CG43373-RC

FBtr0307368

NM_001104152

6246

1854

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG43373-PB

FBpp0298356

136.8

1240

7.95

NP_730173

AAF49454

CG43373-PC

FBpp0298357

203.8

1854

6.95

NP_001097622

ABW08553

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG43373 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG43373_1

Linkouts

Gene Ontology (5 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

adenylate cyclase activity

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(assigned by GO_Central )

(Gaudet et al., 2011)

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000938101

(assigned by GO_Central )

(Gaudet et al., 2011)

cAMP biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000938101

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

integral component of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG43373 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG43373

View exonic expression by tissue for Dmel\CG43373

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG43373

Transgenic constructs containing regulatory region of CG43373

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

CG43373^e01330

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG43373^GD13449

viable, with Scer\GAL4^Mef2.PR

CG43373^GD13449

viable, with Scer\GAL4^pnr-MD237

CG43373^GD13449

Sterility

Allele

fertile

CG43373^e01330

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ADCY5

11 of 15

Yes

Hsap\ADCY6

10 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Adcy5

11 of 15

Yes

Mmus\Adcy6

10 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Rattus norvegicus (Norway rat) (8)

Rnor\Adcy6

7 of 13

Yes

Rnor\Adcy5

6 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (5)

Xtro\adcy6

3 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (12)

Drer\adcy5

11 of 15

Yes

Drer\adcy6a

10 of 15

Yes

Drer\adcy6b

9 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

Drer\si:ch211-132f19.7

2 of 15

Drer\si:dkey-206f10.1

2 of 15

Drer\adcy1a

1 of 15

Drer\adcy1b

1 of 15

Drer\adcy8

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\acy-4

9 of 15

Yes

Cele\acy-2

2 of 15

Cele\acy-3

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900JY )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\CG43373

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA28358

Drosophila persimilis

Dper\GL17987

Drosophila willistoni

Dwil\GK17483

Drosophila virilis

Dvir\GJ12611

Drosophila mojavensis

Dmoj\GI16861

Drosophila grimshawi

Dgri\GH15584

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500CF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17008222

Musca domestica

House fly

Mdoa\17015110

Glossina morsitans

Tsetse fly

Gmor\GMOY004130

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01148

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01147

Mayetiola destructor

Hessian fly

Mdes\Mdes015724

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001034

Anopheles darlingi

American malaria mosquito

Adar\ADAC009898

Anopheles gambiae

Malaria mosquito

Agam\AGAP002998

Anopheles gambiae

Malaria mosquito

Agam\AGAP012805

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ007240

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ007241

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00A1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002064

Bombyx mori

Silkmoth

Bmor\BGIBMGA002066

Danaus plexippus

Monarch butterfly

Dple\DPOGS200078-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008507

Heliconius melpomene

Postman butterfly

Hmel\HMEL005819

Apis florea

Little honeybee

Aflo\5158999636

Apis florea

Little honeybee

Aflo\2319609108

Apis mellifera

Western honey bee

Amel\GB41921

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22408

Bombus terrestris

Buff-tailed bumblebee

Bter\15204170

Linepithema humile

Argentine ant

Lhum\LH12172

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002e07

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08635

Tribolium castaneum

Red flour beetle

Tcas\TC033004

Pediculus humanus

Human body louse

Phum\PHUM131860

Rhodnius prolixus

Kissing bug

Rpro\RPRC003743

Cimex lectularius

Bed bug

Clec\CLEC012480

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001747

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09782

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X020K )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011641

Strigamia maritima

European centipede

Smar\SMAR001419

Strigamia maritima

European centipede

Smar\SMAR009363

Ixodes scapularis

Black-legged tick

Isca\ISCW003150

Ixodes scapularis

Black-legged tick

Isca\ISCW002706

Ixodes scapularis

Black-legged tick

Isca\ISCW011601

Stegodyphus mimosarum

African social velvet spider

Smim\KFM59950.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur05g03000

Tetranychus urticae

Two-spotted spider mite

Turt\tetur14g00930

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_318338

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_247897

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_39757

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_48469

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05JR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Adcy3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007235gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Adcy3_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Adcy2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Adcy5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Adcy2_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_018231gn

Ciona intestinalis

Vase tunicate

Cint\rut

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000000490

Gallus gallus

Domestic chicken

Ggal\ADCY8

Gallus gallus

Domestic chicken

Ggal\ADCY5

Gallus gallus

Domestic chicken

Ggal\LOC420934

Gallus gallus

Domestic chicken

Ggal\ADCY1

Gallus gallus

Domestic chicken

Ggal\ADCY7

Gallus gallus

Domestic chicken

Ggal\ADCY3

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (12)

Gene Symbol

Score

Source

Alignment

rut

5 of 10

Ac76E

4 of 10

Ac78C

4 of 10

Ac3

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADCY5; adenylate cyclase 5

11 of 15

600293

DYSKINESIA, FAMILIAL, WITH FACIAL MYOKYMIA; FDFM

ADCY6; adenylate cyclase 6

10 of 15

600294

LETHAL CONGENITAL CONTRACTURE SYNDROME 8; LCCS8

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263131

MIST (protein-protein) - An integrated Molecular Interaction Database

CG43373

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-44

Cytogenetic map

73A3-73A5

Sequence location

3L:16,491,838..16,543,370 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

73A3-73A5

Limits computationally determined from genome sequence between P{lacW}l(3)j10E8^j10E8&P{PZ}l(3)10532¹⁰⁵³² and P{PZ}Baldspot⁰²²⁸¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-44

(FlyBase, 2016)

3-39.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Bloomington

25662

w¹¹¹⁸; Mi{ET1}CG43373^MB08203

41104

y¹ w^*; Mi{MIC}CG43373^MI06631

64884

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05757}attP40

17944

w¹¹¹⁸; PBac{RB}st^e01330 CG43373^e01330 CG42514^e01330

41502

y¹ w^*; Mi{MIC}CG43373^MI05926/TM3, Sb¹ Ser¹

60239

y¹ w^*; Mi{PT-GFSTF.0}CG43373^{MI05926-GFSTF.0}/TM6C, Sb¹ Tb⁺

59501

y¹ w^*; Mi{MIC}CG33158^MI14337 CG42514^MI14337 CG43373^MI14337/TM3, Sb¹ Ser¹

20473

y¹ w^67c23; P{wHy}CG33158^DG23510 CG43373^DG23510 CG42514^DG23510/TM3, Sb¹ Ser¹

VDRC

v102057

P{KK110535}VIE-260B

v23385

w¹¹¹⁸; P{GD13449}v23385

v23386

w¹¹¹⁸; P{GD13449}v23386

Genomic Clones (42)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (30)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

GH08173

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0263131

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39835

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG12243 CG4526

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: CG32158 anon-WO0257455.11 anon-WO0118547.377

(FlyBase, 1996-)

Source for merge of: CG12436 CG42513

(FlyBase Genome Annotators, 2011)

Additional comments

Annotations CG12436 and CG42513 merged as CG43373 in release 5.36 of the genome annotation.

(FlyBase Genome Annotators, 2011)

Annotation CG32158 split into CG42513 and CG42514 in release 5.14 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Annotations CG12243, CG4526 merged as CG32158 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG32158 anon-WO0257455.11 anon-WO0118547.377 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R[+] cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39835

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0263131

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG43373_1

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39835

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033004

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG43373

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263131

MIST (protein-protein) - An integrated Molecular Interaction Database

CG43373

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

(Morrison et al., 2000)

Ago2

(González et al., 2010)

CG12436

(González et al., 2010, Keleman et al., 2009.8.5, Stanyon et al., 2004)

CG32158

(Bellen, 2008.9.12, FlyBase Genome Annotators, 2008, Ueno and Kidokoro, 2008, Gene Disruption Project members and Exelixis, 2005, Bloomington Drosophila Stock Center, 2004.11.6, Kiger et al., 2003, FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

CG42513

(González et al., 2010)

CG43373

(Aradska et al., 2015, Gene Disruption Project members, 2015-, FlyBase Genome Annotators, 2011, Perkins et al., 2009)

Name Synonyms

Secondary FlyBase IDs

FBgn0036637
FBgn0260387
FBan0032158
FBgn0052158
FBgn0036636

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (33)

Report Sections

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