FlyBase Gene Report: Dmel\CG43373

General Information

Symbol

Dmel\CG43373

Species

D. melanogaster

Name

Annotation Symbol

CG43373

Feature Type

protein_coding_gene

FlyBase ID

FBgn0263131

Gene Model Status

Current

Stock Availability

9 publicly available

Enzyme Name (EC)

Adenylate cyclase (4.6.1.1)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

73A4-73A4

Sequence location

3L:16,491,838..16,543,370 [-]

Recombination map

3-44

RefSeq locus

NT_037436 REGION:16491838..16543370

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables adenylate cyclase activity

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000229373

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in cAMP biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000229373

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in integral component of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

ADENYLATE CYCLASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP = 3',5'-cyclic AMP + diphosphate (4.6.1.1)

Summaries

Gene Group (FlyBase)

ADENYLATE CYCLASES -: Adenylate cyclases catalyze the synthesis of cAMP from ATP, yielding diphosphate as a by-product. (Adapted from FBrf0238856).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG43373 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A8JNU1)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene

nuclear_gene

(FlyBase, 1992-)

protein_coding_gene

(FlyBase, 1992-)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG43373-RB

FBtr0307367

NM_168670

5913

1240

CG43373-RC

FBtr0307368

NM_001104152

6246

1854

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG43373-PB

FBpp0298356

136.8

1240

7.95

NP_730173

AAF49454

CG43373-PC

FBpp0298357

203.8

1854

6.95

NP_001097622

ABW08553

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG43373 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG43373_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG43373 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG43373

View exonic expression by tissue for Dmel\CG43373

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39835/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263131

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036637

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263131

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG43373

Transgenic constructs containing regulatory region of CG43373

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

CG43373^e01330

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG43373^GD13449

viable, with Scer\GAL4^Mef2.PR

CG43373^GD13449

viable, with Scer\GAL4^pnr-MD237

CG43373^GD13449

Sterility

Allele

fertile

CG43373^e01330

Other Phenotypes

Allele

abnormal touch response | larval stage, with Scer\GAL4^ChAT.PU

CG43373^{dsRNA.UAS.cUa}

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (26)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ADCY5

11 of 15

Yes

Hsap\ADCY6

9 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (27)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Adcy5

11 of 15

Yes

Mmus\Adcy6

9 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (28)

Rnor\Adcy5

8 of 13

Yes

Rnor\Adcy6

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\LOC108351033

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (18)

Xtro\adcy6

4 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (34)

Drer\adcy5

11 of 15

Yes

Drer\adcy6a

9 of 15

Yes

Drer\adcy6b

8 of 15

Yes

Drer\adcy1a

2 of 15

Drer\adcy1b

2 of 15

Drer\si:ch211-132f19.7

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:dkey-206f10.1

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (46)

Cele\acy-4

9 of 15

Yes

Cele\gcy-1

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (7)

Atha\AGO1

1 of 9

Yes

Atha\AGO2

1 of 9

Yes

Atha\AGO4

1 of 9

Yes

Atha\AGO5

1 of 9

Yes

Atha\AGO9

1 of 9

Yes

Atha\AGO10

1 of 9

Yes

Atha\AT5G21030

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CYR1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (28)

Gene Symbol

Score

Source

Alignment

rut

4 of 10

Ac3

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

CG43373^KK110535

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-231.UAS}

(Onur et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADCY5; adenylate cyclase 5

11 of 15

600293

ADCY6; adenylate cyclase 6

9 of 15

600294

LETHAL CONGENITAL CONTRACTURE SYNDROME 8; LCCS8

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263131

MIST (protein-protein) - An integrated Molecular Interaction Database

CG43373

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0263131

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-44

Cytogenetic map

73A4-73A4

Sequence location

3L:16,491,838..16,543,370 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

73A4-73A4

Limits computationally determined from genome sequence between P{lacW}l(3)j10E8^j10E8&P{PZ}l(3)10532¹⁰⁵³² and P{PZ}Baldspot⁰²²⁸¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-44

(FlyBase, 2016)

3-39.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

25662

w¹¹¹⁸; Mi{ET1}CG43373^MB08203

41104

y¹ w^*; Mi{MIC}CG43373^MI06631

64884

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05757}attP40

17944

w¹¹¹⁸; PBac{RB}st^e01330 CG43373^e01330 CG42514^e01330

41502

y¹ w^*; Mi{MIC}CG43373^MI05926/TM3, Sb¹ Ser¹

60239

y¹ w^*; Mi{PT-GFSTF.0}CG43373^{MI05926-GFSTF.0}/TM6C, Sb¹ Tb⁺

59501

y¹ w^*; Mi{MIC}CG33158^MI14337 CG42514^MI14337 CG43373^MI14337/TM3, Sb¹ Ser¹

VDRC

v102057

P{KK110535}VIE-260B

v23385

w¹¹¹⁸; P{GD13449}v23385

Genomic Clones (42)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (30)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

GH08173

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0263131

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39835

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG12243 CG4526

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: CG32158 anon-WO0257455.11 anon-WO0118547.377

(FlyBase, 1996-)

Source for merge of: CG12436 CG42513

(FlyBase Genome Annotators, 2011)

Additional comments

Annotations CG12436 and CG42513 merged as CG43373 in release 5.36 of the genome annotation.

(FlyBase Genome Annotators, 2011)

Annotation CG32158 split into CG42513 and CG42514 in release 5.14 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Annotations CG12243, CG4526 merged as CG32158 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG32158 anon-WO0257455.11 anon-WO0118547.377 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R[+] cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39835

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A8JNU1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A8JNU1

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0263131

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39835/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263131

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG43373_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036637

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263131

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0263131

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39835

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033004

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG43373

MARRVEL_MODEL - MARRVEL (model organism gene)

39835

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263131

MIST (protein-protein) - An integrated Molecular Interaction Database

CG43373

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Name Synonyms

Secondary FlyBase IDs

FBgn0036637
FBgn0260387
FBan0032158
FBgn0052158
FBgn0036636

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (35)

The following external sites may use different assemblies or annotations than FlyBase.

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