FlyBase Gene Report: Dmel\Acn

General Information

Symbol

Dmel\Acn

Species

D. melanogaster

Name

Acinus

Annotation Symbol

CG10473

Feature Type

protein_coding_gene

FlyBase ID

FBgn0263198

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Acinus (Acn) encodes nuclear protein that, together with the products of a Bin1 and RnpS1, forms the ASAP complex that contributes to the regulation of alternative splicing. The Acn protein also functions in basal, starvation-independent autophagy. [Date last reviewed: 2019-05-16] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Red Book
Interactive Fly

Also Known As

hkl, hook-like, l(2)37Ba, Ba

Key Links

Genomic Location

Cytogenetic map

37B11-37B10

Sequence location

2L:19,045,355..19,048,817 [+]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:19045355..19048817

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:cass; FB:FBgn0286781

(Rigou et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables nucleic acid binding

inferred from electronic annotation with InterPro:IPR000504

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in negative regulation of transposition, DNA-mediated

inferred from mutant phenotype

(Hayashi et al., 2014)

involved_in regulation of autophagy

inferred from mutant phenotype

(Nandi et al., 2014, Haberman et al., 2010)

involved_in RNA splicing

inferred from mutant phenotype

(Hayashi et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in mRNA splicing, via spliceosome

inferred by curator from GO:0071011,GO:0071013

(Herold et al., 2009)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

located_in cytoplasm

inferred from direct assay

(Haberman et al., 2010)

located_in nucleus

inferred from direct assay

(Haberman et al., 2010)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

l(2)37Ba

Variably late lethal; death occurs at larval [l(2)37Ba2], or pupal [l(2)37Ba2, l(2)37Ba4, l(2)37Ba8, l(2)37Ba9] stage with pharate adults; l(2)37Ba2 produces some adults, which are male sterile or female sterile; l(2)37Ba4 produces many adults, which are male or female sterile; l(2)37Bfs1 is a normally viable, female-sterile allele. Melanotic tumors noted in l(2)37Ba4 and l(2)37Ba8; pharate adults display incompletely developed abdominal cuticle in l(2)37Ba2, l(2)37Ba4, and l(2)37Ba8 (Wright, 1987, Adv. Genet. 24: 127-222).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Acn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VJ12)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Acn-RA

FBtr0081145

NM_136091

2884

739

Acn-RB

FBtr0081144

NM_165273

2513

739

Acn-RC

FBtr0336842

NM_001273627

3153

739

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Acn-PA

FBpp0080689

83.7

739

6.66

NP_609935

AAF53746

Acn-PB

FBpp0080688

83.7

739

6.66

NP_724153

AAN11023

Acn-PC

FBpp0307803

83.7

739

6.66

NP_001260556

AGB93091

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

739 aa isoforms: Acn-PA, Acn-PB, Acn-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Acn using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

embryonic central brain glial cell

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

lateral cord glial cell

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

ommatidial precursor cluster

• nucleus

(Haberman et al., 2010)

eye disc morphogenetic furrow

(Haberman et al., 2010)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

located_in cytoplasm

inferred from direct assay

(Haberman et al., 2010)

located_in nucleus

inferred from direct assay

(Haberman et al., 2010)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Acn in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Acn

View exonic expression by tissue for Dmel\Acn

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0263198

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35173/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263198

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086441

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263198

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10473

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 31 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Acn

Transgenic constructs containing regulatory region of Acn

Aberrations (Deficiencies and Duplications) ( 26 )

Inferred from experimentation ( 26 )

Gene disrupted in

Gene not disrupted in

Df(2L)Catsup⁴⁴

(Stathakis et al., 1999)

Df(2L)Catsup⁴⁵

(Stathakis et al., 1999)

Df(2L)Catsup⁴⁶

(Stathakis et al., 1999)

Df(2L)E55

(Stathakis et al., 1995)

Df(2L)NST

(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986)

Df(2L)Sd37

(Wright, 1996, Stathakis et al., 1995)

Df(2L)Sd57

(Wright, 1996, Stathakis et al., 1995)

Df(2L)Sd77

(Wright, 1996, Stathakis et al., 1995)

Df(2L)TE37C-1

(Wright, 1996, Gilbert et al., 1984, Wright et al., 1981)

Df(2L)TE37C-7

(Wright, 1996, Stathakis et al., 1995)

Df(2L)TW137

(Stathakis et al., 1995)

Df(2L)TW203

(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986)

Df(2L)VA12

(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986, Gilbert et al., 1984, Wright et al., 1981)

Df(2L)VA13

(Wright, 1996, Gilbert et al., 1984, Wright et al., 1981)

Df(2L)VA17

(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986, Gilbert et al., 1984, Wright et al., 1981)

Df(2L)VA19

(Wright, 1996, Stathakis et al., 1995)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Acn²

lethal, with Scer\GAL4^Tub.PU

Acn^UAS.Tag:MYC

lethal (with Acn¹)

Acn²⁷

lethal (with Acn²⁷)

Acn¹

lethal (with Df(2L)TW130)

lethal - all die before end of P-stage

Acn⁴

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Acn^GD6985

viable

Acn^fs1

viable, with Scer\GAL4^pnr-MD237

Acn^GD6985

Sterility

Allele

female fertile, with Scer\GAL4^nos.PG

Acn^KK111555

female sterile

female sterile, with Scer\GAL4^nos.PG

Acn^GD6985

female sterile, with Scer\GAL4^VP16.otu

Acn^HMC03673

female sterile | recessive

male sterile

male sterile | recessive

Other Phenotypes

Allele

abnormal eye color | somatic clone

Acn²⁷

abnormal starvation stress response

decreased size | adult stage, with Scer\GAL4^en-e16E

Acn^UAS.cNa

flightless, with Scer\GAL4^Mef2.PR

Acn^GD6985

increased size | adult stage, with Scer\GAL4^Bx-MS1096

increased size | adult stage, with Scer\GAL4^en-e16E

increased size | adult stage, with Scer\GAL4^nub-AC-62

long lived

melanotic mass phenotype

Acn⁴

some die during pharate adult stage

Acn⁴

visible, with Scer\GAL4^GMR.PF

visible | adult stage, with Scer\GAL4^Bx-MS1096

visible | adult stage, with Scer\GAL4^en-e16E

visible | adult stage, with Scer\GAL4^GMR.PF

Acn^UAS.cNa

visible | adult stage, with Scer\GAL4^nub-AC-62

wild-type

Phenotype manifest in

Allele

adult cuticle & abdomen

autophagosome

cuticle & abdomen & pharate adult

embryonic/larval fat body, with Scer\GAL4^Lsp2.PH

Acn^UAS.Tag:MYC

embryonic/larval fat body (with Acn¹)

Acn²⁷

embryonic/larval fat body (with Acn²⁷)

Acn¹

eye, with Scer\GAL4^GMR.PF

eye | heat sensitive, with Scer\GAL4^GMR.PF

Acn^UAS.cNa

eye | somatic clone

Acn²⁷

eye photoreceptor cell | somatic clone

Acn²⁷

melanotic mass

Acn⁴

ommatidium | somatic clone

Acn²⁷

pigment cell | somatic clone

Acn²⁷

wing, with Scer\GAL4^Bx-MS1096

wing, with Scer\GAL4^en-e16E

wing, with Scer\GAL4^nub-AC-62

wing posterior compartment, with Scer\GAL4^en-e16E

Acn^UAS.cNa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ACIN1

10 of 15

Yes

Hsap\KIAA0754

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Acin1

10 of 15

Yes

Rattus norvegicus (Norway rat) (2)

Rnor\Acin1

8 of 13

Yes

Rnor\Safb

1 of 13

Xenopus tropicalis (Western clawed frog) (2)

Xtro\acin1

6 of 12

Yes

Xtro\rsf1

1 of 12

Danio rerio (Zebrafish) (2)

Drer\acin1b

8 of 15

Yes

Drer\acin1a

5 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\acin-1

11 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\AT4G39680

5 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ACIN1; apoptotic chromatin condensation inducer 1

10 of 15

604562

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Acn - Hsap\CDK5

enzymatic study, western blot

(Nandi et al., 2017)

Acn - RnpS1

experimental knowledge based

(Guruharsha et al., 2011)

Acn - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Acn - cass

two hybrid

(Rigou et al., 2009)

Acn - dos

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Acn - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Acn - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Acn

enhanceable

Akt

(Nandi et al., 2014)

Acn

suppressible

Atg1

(Nandi et al., 2014)

Acn

suppressible

Atg5

(Haberman et al., 2010)

Acn

suppressible

Atg7

(Nandi et al., 2014)

Acn

enhanceable

CG15035

(Nandi et al., 2022)

Acn

enhanceable

Dcp-1

(Nandi et al., 2014)

Acn

enhanceable

flw

(Nandi et al., 2022)

Acn

suppressible

hpo

(Tyra et al., 2020)

Acn

enhanceable

mts

(Nandi et al., 2022)

Acn

suppressible

Nil

(Nandi et al., 2022)

Acn

enhanceable

Nil

(Nandi et al., 2022)

Acn

enhanceable

Pp1-13C

(Nandi et al., 2022)

Acn

suppressible

Pp1-Y1

(Nandi et al., 2022)

Acn

suppressible

Pp2B-14D

(Nandi et al., 2022)

Acn

enhanceable

PpD6

(Nandi et al., 2022)

Acn

enhanceable

PpV

(Nandi et al., 2022)

Acn

suppressible

PpV

(Nandi et al., 2022)

Acn

suppressible

PpY-55A

(Nandi et al., 2022)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Dcp-1

suppressible

Acn

(Nandi et al., 2014)

Egfr

suppressible

Acn

(Haberman et al., 2010)

enhanceable

Acn

(Haberman et al., 2010)

Pten

suppressible

Acn

(Haberman et al., 2010)

Tor

suppressible

Acn

(Haberman et al., 2010)

yki

suppressible

Acn

(Tyra et al., 2020)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263198

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0263198

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Apoptotic cleavage of cellular proteins

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

37B11-37B10

Sequence location

2L:19,045,355..19,048,817 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

37B11-37B10

Limits computationally determined from genome sequence between P{lacW}l(2)37Db^k16106&P{lacW}Catsup^k05424 and P{lacW}Ddc^k02104; Left limit from non-inclusion within Df(2L)TW203 (FBrf0044480) Right limit from inclusion within Df(2L)OD15 (FBrf0044480)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-53.6

(Comeron et al., 2012)

2-53.9

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

6102

Acn^fs1/CyO

3388

Acn¹ pr¹/CyO

43414

w^*; P{GSV1}Acn^EP-338

22565

y¹ w^67c23; P{EPgy2}Acn^EY22500

79328

y¹ w^*; TI{CRIMIC.TG4.2}Acn^{CR00866-TG4.2}/SM6a

53676

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03673}attP40

VDRC

v102407

P{KK111555}VIE-260B

v16052

w¹¹¹⁸; P{GD6985}v16052/TM3

v318824

PBac{fTRG01268.sfGFP-TVPTBF}VK00033

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (148)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0263198

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35173

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Nandi et al., 2017, Haberman et al., 2010)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: hkl CG10473

(Haberman, 2007.2.26)

Source for database merge of

Source for merge of: l(2)37Ba CG10473

(FlyBase, 1996-)

Additional comments

Other Comments

Acn is inactivated by cleavage at aspartate[527].

(Nandi et al., 2014)

Mutants show a mild reduction in eye colour and a reduction in trafficking of proteins to lysosomes.

(Haberman and Krämer, 2007)

Located between coordinates -72.3 and -68.1.

(Stathakis et al., 1995)

Variably late lethal; death occurs at larval ^{l(2)37Ba<up>2}</up>, or pupal <up>l(2)37Ba², l(2)37Ba⁴, l(2)37Ba⁸, l(2)37Ba⁹</up> stage with pharate adults; l(2)37Ba² produces some adults, which are male sterile or female sterile; l(2)37Ba⁴ produces many adults, which are male or female sterile; l(2)37Ba^fs1 is a normally viable, female-sterile allele. Melanotic tumors noted in l(2)37Ba⁴ and l(2)37Ba⁸; pharate adults display incompletely developed abdominal cuticle in l(2)37Ba², l(2)37Ba⁴ and l(2)37Ba⁸ (Wright, 1987).

Origin and Etymology

Discoverer

Etymology

The gene is named based on its homology to mammalian "Acinus".

(Haberman et al., 2010)

Identification

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35173

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VJ12

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VJ12

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0263198

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0263198

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35173/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263198

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086441

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263198

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10473

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0263198

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35173

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014271

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG10473

MARRVEL_MODEL - MARRVEL (model organism gene)

35173

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263198

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Apoptotic cleavage of cellular proteins

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

Acinus

(Czech et al., 2013)

Acn

(Nandi et al., 2022, Gene Disruption Project members, 2018-, Wang et al., 2018, Nandi et al., 2017, Sarov et al., 2016, Kwong et al., 2015, Hayashi et al., 2014, Nandi et al., 2014, Czech et al., 2013, de Celis et al., 2013.9.11, Handler et al., 2013, Handler et al., 2013, Kwon et al., 2013)

(Thor and Thomas, 1997, Wright, 1996, McCrady and Tolin, 1994)

CG10437

(Vernooy et al., 2000)

CG10473

(Kolkhof et al., 2017, Ni et al., 2010.12.1, Herold et al., 2009, Keleman et al., 2009.8.5, Rigou et al., 2009, Cakouros et al., 2008, Haberman, 2007.2.26, Molnar et al., 2006, Laviolette et al., 2005)

acn

(Shinoda et al., 2019, Zhang et al., 2018, Nandi et al., 2017)

dAcn

(Haberman et al., 2010)

dacn

(Haberman et al., 2010)

hkl

(Japanese National Institute of Genetics, 2012.5.21, Ashton-Beaucage and Therrien, 2011, Friedman et al., 2011, Herold et al., 2009, Haberman et al., 2008, Haberman, 2007.2.26, Haberman and Krämer, 2007)

l(2)37Ba

(FlyBase, 1996-, McCrady and Tolin, 1994, Wright, 1987)

Name Synonyms

Acinus

(Nandi et al., 2022, Nandi et al., 2014, Handler et al., 2013, Murachelli et al., 2012)

CG10473

Drosophlia homolog of acinus

(Haberman et al., 2010)

Hook-like

(Ye et al., 2010)

acinus

(Haberman et al., 2010)