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Gene Dmel\Galt

General Information
Symbol	Dmel\Galt	Species	D. melanogaster
Name	Galactose-1-phosphate uridylyltransferase	Annotation symbol	CG9232
Feature type	protein_coding_gene	FlyBase ID	FBgn0263200
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	26F6-26F6	Sequence location	2L:6,666,264..6,668,031 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Galactose-1-phosphate uridylyltransferase is referred to in FlyBase by the symbol Dmel\Galt (CG9232, FBgn0263200). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: UDP-glucose:hexose-1-phosphate uridylyltransferase activity. It is reported to be involved in the biological process: galactose metabolic process. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Galactose-1-phosphate uridyl transferase, C-terminal; Galactose-1-phosphate uridyl transferase, N-terminal; Galactose-1-phosphate uridyl transferase, class I; Galactose-1-phosphate uridyl transferase, class I His-active site; Histidine triad motif; Histidine triad-like motif. Gene sequence location is 2L:6666264..6668031.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA03161 BKN23070
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26F6-26F6
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Galt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Galt-RA FBtr0079322  NM_135218   1482   350
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Galt-PA   FBpp0078951   40.4   350   6.78     NP_609062   AAF52419
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Galactose-1-phosphate uridyl transferase, class I (IPR001937) Galactose-1-phosphate uridyl transferase, N-terminal (IPR005849) Galactose-1-phosphate uridyl transferase, C-terminal (IPR005850) Histidine triad-like motif (IPR011146) Histidine triad motif (IPR011151) Galactose-1-phosphate uridyl transferase, class I His-active site (IPR019779)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567313   AA803154   AE014134 AAF52419   AI061988   AI063233   AI404081   AI404093   AI516888   AI530956   AW941402   AY089524 AAL90262   BG633430   BH840391   BI352766   BI353527   BI355207   BI372616   BI565048   BI565654   BI569321   BI569322   BI569746   BI584024   BI589891   BI590006   BI590137   BI604603   BI604956   BI605542   BI607176   BI608131   BI608632   BI609668   BI611052   BI615330   BI626188   BI627424   BI628535   BP546115   BP557487   BP557488   BT058003   CO282700   CO291834   CO313763   EC062119   EC088203   EV587462   EV588063   GH751801   GH753651   GH758768   GH770948   GH773342   GH777815   GH798538   GH810074   GH810525   GH810802   GH810945   GH811240   GH815081   GH827109   GH828513   GH832567   GH833977   GH840497   GH841608   GH843319   GH845802   GH852650   GH866383   GH891696   GH897288   GH900022   GH912211   GH920605   GH925557   GH925803   GH928244   GH929194   GH930400   GH932127   GH932776   GH938049
UniProtKB/Swiss-Prot	Q9VMA2
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | chemical conditional (with Df(2L)Exel7027) GaltΔ1AP2 lethal | chemical conditional | larval stage | recessive GaltΔ1AP2 lethal | chemical conditional | recessive GaltΔ1V2 viable, with Scer\GAL4pnr-MD237 GaltGD14162 Other Phenotypes Allele gravitaxis behavior defective | recessive GaltΔ1AP2 GaltΔ1V2 wild-type GaltC2 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Galt Class Mutagen Stocks Known lesion GaltKG00049 P-element activity 1 Yes GaltΔ1AP2 amorphic allele Delta2-3 0 Yes GaltΔ1V2 amorphic allele Delta2-3 0 Yes GaltC2 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Galt Class Mutagen Stocks Known lesion GaltGD14162 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes GaltKK102974 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7027 (Kushner et al., 2010, Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}GaltKG00049 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 1 term )
Molecular Function
CV term Evidence References
UDP-glucose:hexose-1-phosphate uridylyltransferase activity inferred from mutant phenotype (Kushner et al., 2010)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
UDP-glucose:hexose-1-phosphate uridylyltransferase activity inferred from sequence or structural similarity with UniProtKB:P43424 (FlyBase, 1992-) non-traceable author statement (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15) zinc ion binding inferred from electronic annotation with InterPro:IPR001937, InterPro:IPR019779 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
galactose metabolic process inferred from electronic annotation with InterPro:IPR001937, InterPro:IPR005849, InterPro:IPR005850, InterPro:IPR019779 (FlyBase Curators et al., 2004-) non-traceable author statement (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Galt allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0263200
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14459 Dere\GG23600 Dgri\GH13576 Dmoj\GI24150 Dper\GL25591 Dpse\GA21629 Dsec\GM14012 Dsim\GD22556 Dvir\GJ21423 Dwil\GK18097 Dyak\GE18419
Curated drosophilid orthologs	Dpse\GA21629
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	14339 y1 w67c23; P{SUPor-P}GaltKG00049 cupKG00049
VDRC	v100025 P{KK102974}VIE-260B v29088 w1118 P{GD14162}v29088 v29087 w1118; P{GD14162}v29087
Genomic Clones ( 1 )
	BACR25K24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 77 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL01018
Other clones	FI06809
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01016 GH02791 GH23672 GH23685 GH26880 GH27478 GM10317 GM20649 GM24038 GM29931 RE59623 RH01887 RH03407 RH03549 RH03717 RH12304 RH13214 RH14478 RH17147 RH22778 RH44936 RH56969 RH62704 RH63461 RH66742 RH68734 RH70028 RH70463 RH71182 RH74185 SD01761
Other clones	Dmel_neb_010665_0107_1894 Dmel_neb_012710_0074_3093 EK161011 EK198506 EK234019 FGH103A04 FGM309F01 RH01426 RP003022479 RP003027740 RP003032907 RP003083995 RP003094962 RP003096874 RP003097748 RP003106515 RP003110300 RP003125851 RP003165671 RP003181428 RP003192233 RP003208989 RP003218774 RP003292312 RP003296361 RP003312337 RP003339672 RP003372028 RP003376363 RP003407174 RP003419797 RP003424700 RP003441144 RP003450414 RP003486259 RP003495611 RP003524690 RP003543165 RP003569903 RP003577409 RP003588278 RP003603084 RP003609013 RP003680625
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33935
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: GALT CG9232 (Kushner et al., 2010)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135218 RefSeq (Proteins) • NP_609062 DDBJ / EMBL / GenBank • AA567313 AAF52419 AAL90262 AW941402 AY089524 BH840391 Entrez Gene - A searchable database of RefSeq genes. • 33935 UniProtKB/Swiss-Prot • Q9VMA2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Galactose-1-phosphate uridyl transferase, class I (IPR001937) Galactose-1-phosphate uridyl transferase, N-terminal (IPR005849) Galactose-1-phosphate uridyl transferase, C-terminal (IPR005850) Histidine triad-like motif (IPR011146) Histidine triad motif (IPR011151) Galactose-1-phosphate uridyl transferase, class I His-active site (IPR019779)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0263200 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33935
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG9232 (Kushner et al., 2010, Papatsenko et al., 2011, Keleman et al., 2009.8.5, Roxstrom-Lindquist et al., 2004) dGALT (Kushner et al., 2010) Galt   GALT (Kushner et al., 2010, )
Name Synonym	galactose-1-phosphate uridylyltransferase   Galactose-1-phosphate uridylyltransferase   galactose-1P uridylyltransferase (Kushner et al., 2010)
Secondary FlyBase IDs
	FBgn0031845 FBgn0262939
References ( 20 )
Research paper	Papatsenko et al., 2011, PLoS Biol. 9(1): e1000584 Clusters of temporal discordances reveal distinct embryonic patterning mechanisms in Drosophila and anopheles. [FBrf0212907] Kushner et al., 2010, Dis. Model Mech. 3(9-10): 618--627 A Drosophila melanogaster model of classic galactosemia. [FBrf0211713] Inlow and Restifo, 2004, Genetics 166(2): 835--881 Molecular and comparative genetics of mental retardation. [FBrf0174714] Roxstrom-Lindquist et al., 2004, EMBO Rpts 5(2): 207--212 Parasite-specific immune response in adult Drosophila melanogaster: a genomic study. [FBrf0167559] Giannakou and Dow, 2001, J. exp. Biol. 204(21): 3703--3716 Characterization of the Drosophila melanogaster alkali-metal/proton exchanger (NHE) gene family. [FBrf0141626]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Protein sequence record	Swiss-Prot Project Members, 2003.9.15, UniProtKB: Q9VMA2 Probable galactose-1-phosphate uridylyltransferase (EC 2.7.7.12) (Gal-1-P uridylyltransferase) (UDP-glucose--hexose-1-phosphate uridylyltransferase). [FBrf0158234]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126677]