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Gene Dmel\Dscam2

General Information
Symbol	Dmel\Dscam2	Species	D. melanogaster
Name	Down syndrome cell adhesion molecule 2	Annotation symbol	CG42256
Feature type	protein_coding_gene	FlyBase ID	FBgn0263218
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	65E6-65E7	Sequence location	3L:7,152,415..7,183,017 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Down syndrome cell adhesion molecule 2 is referred to in FlyBase by the symbol Dmel\Dscam2 (CG42256, FBgn0263218). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: identical protein binding. There is experimental evidence that it is involved in the biological process: neuron projection morphogenesis; homophilic cell adhesion. 12 alleles are reported. The phenotypes of these alleles are annotated with: medulla; mesothoracic tergum. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Fibronectin, type III; Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold. Gene sequence location is 3L:7152415..7183017.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Funada et al., 2007, Europ. J. Neurosci. 25(1): 168--180
FB2012_01	Sequence features HFA08869 BKN46688 HFA10285 HFA11018 BKN25675 BKN32425 BKN30611 HFA11019 HFA10198 Unknown NewRecord NewRecord
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65E6-65E7   Limits computationally determined from genome sequence between P{PZ}corn04202 and P{lacW}Cdc27L7123
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dscam2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	3' UTR contains an ORF that is conserved among close Drosophila species (potential peptide 146 aa in length). Gene merge based on EST/cDNA data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dscam2-RE FBtr0299546  NM_001144425   3463   543 Dscam2-RF FBtr0299547  NM_001144426   3631   752 Dscam2-RG FBtr0299548  NM_168195   6181   1808 Dscam2-RH FBtr0299549  NM_168194   8849   2040 Dscam2-RI FBtr0299550  NM_001043123   6196   1809 Dscam2-RJ FBtr0299551  NM_168196   9940   2074 Dscam2-RK FBtr0299552  NM_001144424   6256   1833 Dscam2-RL FBtr0302123  NM_001169896   6444   1814 Dscam2-RM FBtr0302124  NM_001169897   6196   1813
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dscam2-PE   FBpp0288821   59.1   543   7.22     NP_001137897   ACL83252 Dscam2-PF   FBpp0288822   81.9   752   8.00     NP_001137898   ACL83253 Dscam2-PG   FBpp0288823   198.1   1808   7.49     NP_729224   AAF50600 Dscam2-PH   FBpp0288824   223.5   2040   8.16     NP_729223   AAF50602 Dscam2-PI   FBpp0288825   198.5   1809   7.55     NP_001036588   ABI31239 Dscam2-PJ   FBpp0288826   227.6   2074   8.26     NP_729225   AAF50601 Dscam2-PK   FBpp0288827   201.3   1833   7.70     NP_001137896   ACL83251 Dscam2-PL   FBpp0291333   199.0   1814   7.56     NP_001163367   ACZ94638 Dscam2-PM   FBpp0291334   198.6   1813   7.49     NP_001163368   ACZ94639
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50600   AE014296 AAF50601   AE014296 AAF50602   AE014296 ABI31239   AE014296 ACL83251   AE014296 ACL83252   AE014296 ACL83253   AE014296 ACZ94638   AE014296 ACZ94639   AI106884   AI109023   AI404957   AI406159   AY118274 AAM48303   BF495051   BG632284   BG632379   BI604609   BT022298   BT029121   BT030415   BT083398   BT083399   BT083400   BT126132   CO179099   CO263759   CO287064   CO288517   CO289794   CO304277   CO315050   CO318698   CO333906   CO343889   CO345148   CO345376   EC057665   EC082278   EC195892   EC196389   EC202683   EC203017   EC219007   EC227229   EC229825   EC231506   EC254028   EC259746   EL872686   EL872922   EL878579   EL878667   EL878849   EL884442   EL884443   EL886851   EL887103   EL887163   EV599071
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	E1JI61 E1JI62 Q9VS29
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_14
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Dscam2unspecified viable, with Scer\GAL4pnr-MD237 Dscam2GD111 Dscam2GD10877 Dscam2GD14410 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 Dscam2GD10877 neuroanatomy defective | adult stage Dscam2unspecified neuroanatomy defective | adult stage | somatic clone Dscam2unspecified Phenotype manifest in Allele lamina monopolar neuron L1 | somatic clone Dscam2unspecified medulla Dscam2unspecified mesothoracic tergum, with Scer\GAL4pnr-MD237 Dscam2GD10877
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Dscam2 Class Mutagen Stocks Known lesion Dscam2MB06131 1 -- Dscam2null-1 recombination SCEI endonuclease FLPase 0 Yes Dscam2null-2 recombination SCEI endonuclease FLPase 0 Yes Dscam2null-3 recombination SCEI endonuclease FLPase 0 Yes Dscam2unspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dscam2 Class Mutagen Stocks Known lesion Dscam2GD111 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Dscam2GD10877 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dscam2GD14410 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dscam2A.MtnA in vitro construct - regulatory fusion 0 Yes Dscam2B.MtnA in vitro construct - regulatory fusion 0 Yes Dscam2GD2607 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Dscam2Scer\SceI.RS.cMa in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6111 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data characterization construct P{FRT(Dscam2Scer\SceI.RS.cMa)} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Dscam2MB06131 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
identical protein binding inferred from physical interaction with Dscam2 (Millard et al., 2007)
Biological Process
CV term Evidence References
homophilic cell adhesion inferred from direct assay (Funada et al., 2007, Millard et al., 2007) neuron projection morphogenesis inferred from mutant phenotype (Millard et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
homophilic cell adhesion inferred from sequence or structural similarity with EMBL:AF334384 (FlyBase Genome Annotators, 2002-2003)
Cellular Component
CV term Evidence References
integral to plasma membrane inferred from sequence model (Millard et al., 2007)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene (Millard et al., 2007, )
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dscam2 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0263218
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24786 Dana\GF24788 Dere\GG14991 Dere\GG14992 Dgri\GH14935 Dper\GL24905 Dper\GL24906 Dpse\GA16861 Dpse\GA16863 Dsim\GD17592 Dvir\GJ13649 Dvir\GJ13650 Dwil\GK16751 Dwil\GK19256 Dyak\GE20438 Dyak\GE20439
Curated drosophilid orthologs	Dmir\CG32387 (Thornton, 2005.12.20) Dpse\GA16861   Dpse\GA16863
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	25617 w1118; Mi{ET1}Dscam2MB06131
VDRC	v1100 w1118; P{GD111}v1100 v41890 w1118 P{GD10877}v41890 v1003 w1118; P{GD111}v1003/TM3 v36287 w1118; P{GD14410}v36287/CyO
Genomic Clones ( 1 )
	BACR16I16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 47 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT03867 IP04662 IP15636
Other clones	IP08616 IP15836 RT02363 RT02364 RT02365
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH24836 GH26371 RH70034
Other clones	106952 119371 172958 214345.67 214477.64 CK01.39B.B6 CK01.53C.F4 CK01.74B.C3 CK01.87A.H4 CK01.92B.E12 CK01.107A.B8 CK01.107B.D4 Dmel_neb_006683_0912_3751 EK058410 EK064809 EK068662 EK072052 EK089546 EK238851 EK244243 EK273444 EK308308 EP18310 EP21439 EP21931 GH06134 GH07520 IP04562 IP04762 IP08416 IP08516 IP08716 IP15736 IP18043 IP18243 IP18343
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38788 326212
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG32387 BcDNA:AT03867 (FlyBase, 1996-) Source for merge of: CG32387 CG32389 (FlyBase Genome Annotators, 2008) Source for merge of: Dscam2 CG42256 (Zipursky, 2011.4.20)
Additional comments	Annotations CG32387 and CG32389 merged as CG42256 in release 5.8 of the genome annotation. (FlyBase Genome Annotators, 2008) Source for merge of CG32387 BcDNA:AT03867 was shared cDNA (AT03867) (date:030529). (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)
Other Comments
	Dscam2 is required to restrict the connections formed by individual L1 lamina neurons to single columns in the visual system. (Millard et al., 2007)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168194 NM_168195 NM_168196 NM_001043123 NM_001144424 NM_001144425 NM_001144426 NM_001169896 NM_001169897 RefSeq (Proteins) • NP_729223 NP_729224 NP_729225 NP_001036588 NP_001137896 NP_001137897 NP_001137898 NP_001163367 NP_001163368 DDBJ / EMBL / GenBank • AAF50600 AAF50601 AAF50602 AAM48303 ABI31239 ACL83251 ACL83252 ACL83253 ACZ94638 ACZ94639 AI404957 AY118274 BF495051 Entrez Gene - A searchable database of RefSeq genes. • 38788 UniProtKB/TrEMBL • E1JI61 E1JI62 Q9VS29
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0263218 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38788 326212
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	BcDNA:AT03867   CG8618   CG8619   CG14828   CG17742 (FlyBase Genome Annotators, 2011) CG32387 (Funada et al., 2007, ) CG32389   CG42256 (Zipursky, 2011.4.20, Wasbrough et al., 2010, FlyBase Genome Annotators, 2008) CT14580 (Hynes and Zhao, 2000) CT14584 (Hynes and Zhao, 2000) CT34644 (Hynes and Zhao, 2000) Dscam2 (Zipursky, 2011.4.20, Millard et al., 2010, Millard et al., 2007, Millard et al., 2007, Huang et al., 2008) Dscam-like (Hynes and Zhao, 2000)
Name Synonym	CG32387   CG32389   Down syndrome cell adhesion molecule 2
Secondary FlyBase IDs
	FBgn0035747 FBgn0035748 FBgn0035749 FBgn0052387 FBgn0052389 FBgn0063359 FBgn0250790 FBgn0259141
References ( 27 )
Generate a list of	All references relating to this gene ( 27 )
List References by type	Research paper  ( 4 ) Supplementary material  ( 10 ) Personal communication to FlyBase  ( 4 ) FlyBase analysis  ( 4 ) Computer file  ( 1 ) DNA/RNA sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Millard et al., 2010, Neuron 67(5): 761--768 Drosophila dscam proteins regulate postsynaptic specificity at multiple-contact synapses. [FBrf0211750] Show all research papers ...