FB2020_06, released Dec 22, 2020

Gene: Dmel\Dscam4

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General Information
Symbol
Dmel\Dscam4
Species
D. melanogaster
Name
Down syndrome cell adhesion molecule 4
Annotation Symbol
CG42330
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263219
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Snapshot
Down syndrome cell adhesion molecule 4 (Dscam4) one of four Dscam paralogs in the D. melanogaster genome. It encodes a homophilic cell adhesion molecule that regulates interactions between dendrites and axons in the visual system. [Date last reviewed: 2019-05-16]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
66C3-66C4
Sequence location
3L:8,238,647..8,282,398 [+]
Recombination map

3-24

RefSeq locus
NT_037436 REGION:8238647..8282398
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables cell-cell adhesion mediator activity
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
enables identical protein binding
inferred from sequence or structural similarity with FLYBASE:Dscam2; FB:FBgn0265296
(FlyBase Curators, 2008--)
Biological Process (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cell adhesion
inferred from sequence or structural similarity with FLYBASE:Dscam2; FB:FBgn0265296
(FlyBase Curators, 2008--)
involved_in dendrite self-avoidance
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in homophilic cell adhesion via plasma membrane adhesion molecules
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in axon
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in integral component of plasma membrane
inferred from sequence model
(Millard et al., 2007)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
DOWN SYNDROME CELL-ADHESION MOLECULES -
The Dscam (Down syndrome cell-adhesion molecule) transmembrane immunoglobulin superfamily proteins regulate axon branching and guidance by mediating both repulsion and adhesion. (Adapted from FBrf0232776, FBrf0145178 and FBrf0193992).
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Dscam4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
(Millard et al., 2007)
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Dscam4-RD
FBtr0299839
NM_001144436
7764
1918
Dscam4-RE
FBtr0299840
NM_001043131
6229
1918
Dscam4-RH
FBtr0299841
NM_001144437
6529
1874
Dscam4-RI
FBtr0333589
NM_001274642
7815
1935
Dscam4-RJ
FBtr0333590
NM_001274643
6454
1935
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Dscam4-PD
FBpp0289117
214.6
1918
6.96
NP_001137908
ACL83263
Dscam4-PE
FBpp0289118
214.6
1918
6.96
NP_001036596
ABI31245
Dscam4-PH
FBpp0289119
209.5
1874
6.86
NP_001137909
ACL83264
Dscam4-PI
FBpp0305766
216.4
1935
6.93
NP_001261571
AGB94266
Dscam4-PJ
FBpp0305767
216.4
1935
6.93
NP_001261572
AGB94267
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1918 aa isoforms: Dscam4-PD, Dscam4-PE
1935 aa isoforms: Dscam4-PI, Dscam4-PJ
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dscam4 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dscam4 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dscam4
Transgenic constructs containing regulatory region of Dscam4
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (28)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DSCAM
13 of 15
Yes
Yes
3  
Hsap\DSCAML1
11 of 15
No
No
2  
Hsap\CNTN2
1 of 15
No
No
0  
Hsap\CNTN4
1 of 15
No
No
Hsap\CNTN6
1 of 15
No
No
Hsap\HSPG2
1 of 15
No
No
Hsap\IGLON5
1 of 15
No
No
Hsap\IGSF9B
1 of 15
No
No
Hsap\IGSF9
1 of 15
No
No
2  
Hsap\KIRREL1
1 of 15
No
No
Hsap\KIRREL2
1 of 15
No
No
Hsap\KIRREL3
1 of 15
No
No
Hsap\LRIT1
1 of 15
No
Yes
Hsap\LRIT3
1 of 15
No
Yes
Hsap\LSAMP
1 of 15
No
No
Hsap\MYPN
1 of 15
No
No
Hsap\NCAM1
1 of 15
No
No
4  
Hsap\NCAM2
1 of 15
No
No
Hsap\NEGR1
1 of 15
No
No
1  
Hsap\NTM
1 of 15
No
No
Hsap\OPCML
1 of 15
No
No
Hsap\PALLD
1 of 15
No
No
Hsap\PAPLN
1 of 15
No
No
Hsap\PTPRQ
1 of 15
No
No
Hsap\SDK1
1 of 15
No
No
Hsap\SDK2
1 of 15
No
No
1  
Hsap\USH2A
1 of 15
No
Yes
Hsap\VSIG10L
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (25)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Dscam
13 of 15
Yes
Yes
1  
Mmus\Dscaml1
10 of 15
No
No
Mmus\Cntn5
1 of 15
No
No
Mmus\Cntn6
1 of 15
No
No
Mmus\Iglon5
1 of 15
No
No
Mmus\Igsf9b
1 of 15
No
No
Mmus\Igsf9
1 of 15
No
No
Mmus\Kirrel2
1 of 15
No
No
1  
Mmus\Kirrel3
1 of 15
No
No
1  
Mmus\Kirrel
1 of 15
No
No
1  
Mmus\Lrit1
1 of 15
No
Yes
Mmus\Lrit3
1 of 15
No
Yes
Mmus\Lsamp
1 of 15
No
No
Mmus\Mypn
1 of 15
No
No
Mmus\Ncam1
1 of 15
No
No
Mmus\Ncam2
1 of 15
No
No
Mmus\Negr1
1 of 15
No
No
Mmus\Nrcam
1 of 15
No
No
Mmus\Ntm
1 of 15
No
No
Mmus\Opcml
1 of 15
No
No
Mmus\Papln
1 of 15
No
No
Mmus\Ptprq
1 of 15
No
No
Mmus\Sdk1
1 of 15
No
No
Mmus\Sdk2
1 of 15
No
No
Mmus\Vstm2l
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (19)
Rnor\Dscam
12 of 13
Yes
Yes
Rnor\Dscaml1
11 of 13
No
No
Rnor\Cntn4
1 of 13
No
No
Rnor\Iglon5
1 of 13
No
No
Rnor\Igsf9b
1 of 13
No
No
Rnor\Igsf9
1 of 13
No
No
Rnor\Kirrel1
1 of 13
No
No
Rnor\Kirrel2
1 of 13
No
No
Rnor\Kirrel3
1 of 13
No
No
Rnor\LOC100360205
1 of 13
No
Yes
Rnor\Lrit1
1 of 13
No
No
Rnor\Lsamp
1 of 13
No
No
Rnor\Ncam1
1 of 13
No
No
Rnor\Ncam2
1 of 13
No
No
Rnor\Nrcam
1 of 13
No
No
2  
Rnor\Ntm
1 of 13
No
No
Rnor\Opcml
1 of 13
No
No
Rnor\Pecam1
1 of 13
No
Yes
Rnor\Sdk2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\dscaml1
6 of 12
Yes
No
Xtro\dscam
4 of 12
No
Yes
Xtro\iglon5
1 of 12
No
No
Xtro\igsf9b
1 of 12
No
No
Xtro\igsf9
1 of 12
No
No
Xtro\kirrel2
1 of 12
No
No
Xtro\lrit3
1 of 12
No
Yes
Xtro\lsamp
1 of 12
No
No
Xtro\ncam2
1 of 12
No
No
Xtro\negr1
1 of 12
No
No
Xtro\ntm
1 of 12
No
No
Xtro\papln
1 of 12
No
No
Danio rerio (Zebrafish) (35)
Drer\dscama
12 of 15
Yes
Yes
Drer\dscamb
10 of 15
No
Yes
Drer\dscaml1
8 of 15
No
No
Drer\robo4
2 of 15
No
No
Drer\cntn3a.1
1 of 15
No
No
Drer\cntn3a.2
1 of 15
No
No
Drer\igsf9a
1 of 15
No
No
Drer\igsf9ba
1 of 15
No
No
Drer\igsf9bb
1 of 15
No
No
Drer\igsf9b
1 of 15
No
No
Drer\itgb4
1 of 15
No
No
Drer\kirrel1b
1 of 15
No
No
Drer\kirrel3a
1 of 15
No
No
Drer\kirrel3b
1 of 15
No
No
Drer\kirrel3l
1 of 15
No
No
Drer\lrit1a
1 of 15
No
Yes
Drer\lrit1b
1 of 15
No
Yes
Drer\lrit3a
1 of 15
No
Yes
Drer\lrit3b
1 of 15
No
No
Drer\ncam1a
1 of 15
No
No
Drer\ncam1b
1 of 15
No
No
Drer\negr1
1 of 15
No
No
Drer\ntm
1 of 15
No
No
Drer\opcml
1 of 15
No
No
Drer\paplna
1 of 15
No
No
Drer\ptprq
1 of 15
No
No
Drer\sdk1a
1 of 15
No
No
Drer\sdk1b
1 of 15
No
No
Drer\sdk2a
1 of 15
No
No
Drer\sdk2b
1 of 15
No
No
Drer\si:ch1073-459j12.1
1 of 15
No
No
Drer\si:dkeyp-75h12.2
1 of 15
No
No
Drer\ush2a
1 of 15
No
Yes
Drer\vstm2l
1 of 15
No
Yes
Drer\zgc:110372
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (21)
Cele\rig-3
2 of 15
Yes
Yes
Cele\zig-2
2 of 15
Yes
No
Cele\zig-3
2 of 15
Yes
No
Cele\zig-4
2 of 15
Yes
No
Cele\C53A5.13
1 of 15
No
Yes
Cele\egl-15
1 of 15
No
No
Cele\him-4
1 of 15
No
No
Cele\igcm-2
1 of 15
No
No
Cele\lad-2
1 of 15
No
No
Cele\let-805
1 of 15
No
Yes
Cele\ncam-1
1 of 15
No
No
Cele\rig-4
1 of 15
No
No
Cele\rig-5
1 of 15
No
No
Cele\rig-6
1 of 15
No
No
Cele\syg-1
1 of 15
No
No
Cele\ver-3
1 of 15
No
No
Cele\wrk-1
1 of 15
No
No
Cele\zig-6
1 of 15
No
Yes
Cele\zig-7
1 of 15
No
Yes
Cele\zig-8
1 of 15
No
No
Cele\zig-11
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919008H )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003712
Drosophila simulans
Dsim\GD14072
Drosophila sechellia
Dsec\GM25036
Drosophila erecta
Dere\GG14294
Drosophila yakuba
Dyak\GE20723
Drosophila ananassae
Dana\GF25109
Drosophila pseudoobscura pseudoobscura
Dpse\GA24633
Drosophila persimilis
Dper\GL22542
Drosophila willistoni
Dwil\GK17189
Drosophila virilis
Dvir\GJ12521
Drosophila mojavensis
Dmoj\GI16778
Drosophila grimshawi
Dgri\GH15500
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915005R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025421
Glossina morsitans
Tsetse fly
Gmor\GMOY011959
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01412
Mayetiola destructor
Hessian fly
Mdes\Mdes006323
Mayetiola destructor
Hessian fly
Mdes\Mdes006325
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003498
Anopheles darlingi
American malaria mosquito
Adar\ADAC003297
Anopheles gambiae
Malaria mosquito
Agam\AGAP007092
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000087
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0AMK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001924
Danaus plexippus
Monarch butterfly
Dple\DPOGS207502-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005580
Heliconius melpomene
Postman butterfly
Hmel\HMEL009433
Apis florea
Little honeybee
Aflo\2875288628
Apis florea
Little honeybee
Aflo\2147508419
Apis florea
Little honeybee
Aflo\2147508259
Apis florea
Little honeybee
Aflo\2163234418
Apis florea
Little honeybee
Aflo\2147508435
Apis mellifera
Western honey bee
Amel\GB49767
Apis mellifera
Western honey bee
Amel\GB45774
Apis mellifera
Western honey bee
Amel\GB54069
Apis mellifera
Western honey bee
Amel\GB55648
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16978
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19596
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21514
Bombus terrestris
Buff-tailed bumblebee
Bter\15214986
Bombus terrestris
Buff-tailed bumblebee
Bter\15212849
Bombus terrestris
Buff-tailed bumblebee
Bter\15215059
Linepithema humile
Argentine ant
Lhum\LH24163
Linepithema humile
Argentine ant
Lhum\LH24161
Linepithema humile
Argentine ant
Lhum\LH11233
Linepithema humile
Argentine ant
Lhum\LH14993
Linepithema humile
Argentine ant
Lhum\LH14992
Linepithema humile
Argentine ant
Lhum\LH24162
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000e6e
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b1f
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001093
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001091
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011929
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013136
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07622
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11317
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07621
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07623
Tribolium castaneum
Red flour beetle
Tcas\TC033567
Tribolium castaneum
Red flour beetle
Tcas\TC003918
Tribolium castaneum
Red flour beetle
Tcas\TC004993
Pediculus humanus
Human body louse
Phum\PHUM572430
Pediculus humanus
Human body louse
Phum\PHUM427190
Pediculus humanus
Human body louse
Phum\PHUM427180
Pediculus humanus
Human body louse
Phum\PHUM031590
Pediculus humanus
Human body louse
Phum\PHUM163340
Rhodnius prolixus
Kissing bug
Rpro\RPRC008073
Rhodnius prolixus
Kissing bug
Rpro\RPRC013561
Rhodnius prolixus
Kissing bug
Rpro\RPRC012156
Cimex lectularius
Bed bug
Clec\CLEC006185
Cimex lectularius
Bed bug
Clec\CLEC006183
Cimex lectularius
Bed bug
Clec\CLEC001146
Cimex lectularius
Bed bug
Clec\CLEC001149
Cimex lectularius
Bed bug
Clec\CLEC011553
Cimex lectularius
Bed bug
Clec\CLEC007902
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004464
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001720
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI088098
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07069
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11064
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18189
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01975
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17659
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08732
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X002X )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010628
Strigamia maritima
European centipede
Smar\SMAR000414
Strigamia maritima
European centipede
Smar\SMAR005060
Strigamia maritima
European centipede
Smar\SMAR005038
Strigamia maritima
European centipede
Smar\SMAR010347
Strigamia maritima
European centipede
Smar\SMAR010787
Strigamia maritima
European centipede
Smar\SMAR014698
Strigamia maritima
European centipede
Smar\SMAR009342
Strigamia maritima
European centipede
Smar\SMAR004329
Strigamia maritima
European centipede
Smar\SMAR000919
Strigamia maritima
European centipede
Smar\SMAR011561
Strigamia maritima
European centipede
Smar\SMAR005057
Strigamia maritima
European centipede
Smar\SMAR005788
Strigamia maritima
European centipede
Smar\SMAR010689
Strigamia maritima
European centipede
Smar\SMAR011672
Strigamia maritima
European centipede
Smar\SMAR013782
Strigamia maritima
European centipede
Smar\SMAR008780
Strigamia maritima
European centipede
Smar\SMAR009392
Strigamia maritima
European centipede
Smar\SMAR010961
Strigamia maritima
European centipede
Smar\SMAR013914
Strigamia maritima
European centipede
Smar\SMAR011548
Strigamia maritima
European centipede
Smar\SMAR007303
Strigamia maritima
European centipede
Smar\SMAR011182
Strigamia maritima
European centipede
Smar\SMAR014353
Strigamia maritima
European centipede
Smar\SMAR010692
Strigamia maritima
European centipede
Smar\SMAR012325
Strigamia maritima
European centipede
Smar\SMAR005787
Strigamia maritima
European centipede
Smar\SMAR013694
Strigamia maritima
European centipede
Smar\SMAR014212
Strigamia maritima
European centipede
Smar\SMAR004313
Strigamia maritima
European centipede
Smar\SMAR010788
Strigamia maritima
European centipede
Smar\SMAR014338
Strigamia maritima
European centipede
Smar\SMAR011726
Strigamia maritima
European centipede
Smar\SMAR010346
Strigamia maritima
European centipede
Smar\SMAR004310
Strigamia maritima
European centipede
Smar\SMAR001994
Strigamia maritima
European centipede
Smar\SMAR010994
Strigamia maritima
European centipede
Smar\SMAR009858
Strigamia maritima
European centipede
Smar\SMAR005058
Strigamia maritima
European centipede
Smar\SMAR000686
Strigamia maritima
European centipede
Smar\SMAR011562
Strigamia maritima
European centipede
Smar\SMAR011320
Strigamia maritima
European centipede
Smar\SMAR011319
Strigamia maritima
European centipede
Smar\SMAR015611
Strigamia maritima
European centipede
Smar\SMAR013749
Strigamia maritima
European centipede
Smar\SMAR011671
Strigamia maritima
European centipede
Smar\SMAR009857
Strigamia maritima
European centipede
Smar\SMAR009349
Strigamia maritima
European centipede
Smar\SMAR013837
Strigamia maritima
European centipede
Smar\SMAR009501
Strigamia maritima
European centipede
Smar\SMAR011727
Strigamia maritima
European centipede
Smar\SMAR009834
Strigamia maritima
European centipede
Smar\SMAR003721
Strigamia maritima
European centipede
Smar\SMAR010629
Ixodes scapularis
Black-legged tick
Isca\ISCW022826
Ixodes scapularis
Black-legged tick
Isca\ISCW017602
Ixodes scapularis
Black-legged tick
Isca\ISCW017597
Ixodes scapularis
Black-legged tick
Isca\ISCW023871
Ixodes scapularis
Black-legged tick
Isca\ISCW001673
Ixodes scapularis
Black-legged tick
Isca\ISCW016099
Ixodes scapularis
Black-legged tick
Isca\ISCW017420
Ixodes scapularis
Black-legged tick
Isca\ISCW001245
Ixodes scapularis
Black-legged tick
Isca\ISCW016844
Ixodes scapularis
Black-legged tick
Isca\ISCW022093
Ixodes scapularis
Black-legged tick
Isca\ISCW019537
Ixodes scapularis
Black-legged tick
Isca\ISCW017407
Ixodes scapularis
Black-legged tick
Isca\ISCW023928
Ixodes scapularis
Black-legged tick
Isca\ISCW020407
Ixodes scapularis
Black-legged tick
Isca\ISCW022837
Ixodes scapularis
Black-legged tick
Isca\ISCW017409
Ixodes scapularis
Black-legged tick
Isca\ISCW010083
Ixodes scapularis
Black-legged tick
Isca\ISCW016847
Ixodes scapularis
Black-legged tick
Isca\ISCW022096
Ixodes scapularis
Black-legged tick
Isca\ISCW022820
Ixodes scapularis
Black-legged tick
Isca\ISCW022831
Ixodes scapularis
Black-legged tick
Isca\ISCW022819
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82055.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75330.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71651.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72780.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82606.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64485.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82057.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78901.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78654.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75331.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70029.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81635.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78043.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72392.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68992.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74747.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81636.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79756.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g02050
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02890
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g01100
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g01590
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g03400
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g02520
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02800
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g00600
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02780
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g02480
Tetranychus urticae
Two-spotted spider mite
Turt\tetur16g02990
Tetranychus urticae
Two-spotted spider mite
Turt\tetur21g02250
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g01130
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g01050
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g00850
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_127336
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43826
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48415
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_262741
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_331991
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44367
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G005W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mlckb
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mlck
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-DscamL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-DscamL_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mlck1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mlck_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Igf_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mlcka
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Igcam/Igcam/Igcam
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-TtnL_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MlckL
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022039
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000012471
Ciona intestinalis
Vase tunicate
Cint\LOC100179969
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000824
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000007314
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006273
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000016138
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004334
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000011708
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000012845
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (55)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Dscam1
6 of 10
Dscam2
5 of 10
Dscam3
5 of 10
bdl
2 of 10
Fas2
2 of 10
tutl
2 of 10
Ama
1 of 10
babos
1 of 10
Bsg
1 of 10
CG7166
1 of 10
CG13506
1 of 10
CG33543
1 of 10
CG34353
1 of 10
CG44153
1 of 10
Cont
1 of 10
DIP-α
1 of 10
DIP-β
1 of 10
DIP-δ
1 of 10
DIP-ε
1 of 10
DIP-η
1 of 10
DIP-γ
1 of 10
DIP-ι
1 of 10
DIP-κ
1 of 10
DIP-θ
1 of 10
DIP-ζ
1 of 10
dpr1
1 of 10
dpr2
1 of 10
dpr3
1 of 10
dpr4
1 of 10
dpr5
1 of 10
dpr6
1 of 10
dpr7
1 of 10
dpr8
1 of 10
dpr9
1 of 10
dpr10
1 of 10
dpr11
1 of 10
dpr12
1 of 10
dpr13
1 of 10
dpr14
1 of 10
dpr15
1 of 10
dpr16
1 of 10
dpr17
1 of 10
dpr18
1 of 10
dpr19
1 of 10
dpr20
1 of 10
dpr21
1 of 10
fipi
1 of 10
ImpL2
1 of 10
kirre
1 of 10
klg
1 of 10
Lac
1 of 10
rst
1 of 10
sdk
1 of 10
Strn-Mlck
1 of 10
wrapper
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DSCAM; DS cell adhesion molecule
    13 of 15
    602523
         
        DSCAML1; DS cell adhesion molecule like 1
        11 of 15
        611782
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Dscam4
            enzyme linked immunosorbent assay
            (Ozkan et al., 2013)
            Summary of Genetic Interactions
            esyN Network Diagram
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map

            3-24

            Cytogenetic map
            66C3-66C4
            Sequence location
            3L:8,238,647..8,282,398 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            66C3-66C4
            Limits computationally determined from genome sequence between P{lacW}l(3)L0139L0139 and P{PZ}Gug03928&P{EP}CG6745EP595b
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            3-24

            (FlyBase, 2016)

            3-19.2

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (17)
            Genomic Clones (31)
            cDNA Clones (33)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Tadros et al., 2016)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of

            Source for merge of: CG13672 CG33274

            (FlyBase Genome Annotators, 2008)

            Source for merge of: CG7060 CG18630

            (FlyBase Genome Annotators, 2004)

            Source for merge of: Dscam4 CG42330

            (Zipursky, 2011.4.20)
            Additional comments

            Annotations CG13672 and CG33274 merged as CG42330 in release 5.9 of the genome annotation.

            (FlyBase Genome Annotators, 2008)

            Annotations CG7060 and CG18630 merged as CG33274 in release 3.2 of the genome annotation, based on BLASTX data.

            (FlyBase Genome Annotators, 2004)
            Other Comments
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 40 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (8)
            Reported As
            Symbol Synonym
            CG13672
            CG18630
            (Vogel et al., 2003)
            CG33274
            (Funada et al., 2007)
            CG42330
            (Ashwal-Fluss et al., 2014, Zipursky, 2011.4.20, Ni et al., 2010.12.1, FlyBase Genome Annotators, 2008)
            CG7060
            (Arbeitman et al., 2004, Vogel et al., 2003)
            CT21829
            (Hynes and Zhao, 2000)
            Dscam4
            (Nazario-Toole et al., 2018, Zhang et al., 2016, Gene Disruption Project members, 2015-, Ozkan et al., 2013, Ozkan et al., 2013, Ozkan et al., 2013, Armitage et al., 2012, Zipursky, 2011.4.20, Hattori et al., 2008, Millard et al., 2007)
            Name Synonyms
            CG13672
            CG33274
            Down syndrome cell adhesion molecule 4
            Secondary FlyBase IDs
            • FBgn0250795
            • FBgn0259232
            • FBgn0035862
            • FBgn0040831
            • FBgn0035864
            • FBgn0035863
            • FBgn0053274
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (50)