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Gene Dmel\SP1029

General Information
Symbol	Dmel\SP1029	Species	D. melanogaster
Name	SP1029	Annotation symbol	CG11956
Feature type	protein_coding_gene	FlyBase ID	FBgn0263236
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99A4-99A6	Sequence location	3R:25,070,683..25,076,173 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene SP1029 is referred to in FlyBase by the symbol Dmel\SP1029 (CG11956, FBgn0263236). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: aminopeptidase activity. There is experimental evidence that it is involved in the biological process: lateral inhibition. 4 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Domain of unknown function DUF3358; Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase; Peptidase M1, membrane alanine aminopeptidase, N-terminal. Gene sequence location is 3R:25070683..25076173.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99A4-99A6   Limits computationally determined from genome sequence between P{PZ}l(3)0470804708 and P{PZ}l(3)0674306743; Left limit from molecular mapping relative to stg (FBrf0073015) Right limit from molecular mapping relative to stg (FBrf0073015)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 99A5-99A6     (Serano, 2000.2.4) 99A-99A     (Edgar et al., 1994)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\SP1029 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated. DGC clone appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) SP1029-RA FBtr0085398  NM_144361   3026   932 SP1029-RB FBtr0085399  NM_170405   3321   932 SP1029-RC FBtr0085400  NM_170406   3158   932 SP1029-RD FBtr0334868  NM_001276136   3198   932
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein SP1029-PA   FBpp0084767   108.0   932   6.57     NP_652618   AAF56884 SP1029-PB   FBpp0084768   108.0   932   6.57     NP_733284   AAG22174 SP1029-PC   FBpp0084769   108.0   932   6.57     NP_733285   AAN14169 SP1029-PD   FBpp0306891   108.0   932   6.57     NP_001263065   AGB96445
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase (IPR001930) Peptidase M1, membrane alanine aminopeptidase, N-terminal (IPR014782) Domain of unknown function DUF3358 (IPR024571)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201175   AA202610   AA264884   AA820603   AA941163   AA941585   AA942391   AA949895   AA951777   AA952186   AE014297 AAF56884   AE014297 AAG22174   AE014297 AAN14169   AF231040 AAF34809   AE014297 AGB96445   AI134071   AI260237   AI293998   AI388803   AI455470   AI514487   AI518880   AI519477   AI519935   AI544197   AW943278   AY051855 AAK93279   BI162451   BI168485   BI171878   BI172333   BI172661   BI213075   BI214986   BI215340   BI227508   BI231337   BI231547   BI231666   BI237953   BI239259   BI239653   BI239901   BI242161   BI242305   BI371456   BI485796   BI486223   BI575879   BI605746   BI613772   BI626212   BP541016   BP552996   BP552997   BT014634   BT133378   CO269725   CO292654   CO295336   CO297643   CO302338   CO306312   CO319834   CO323817   CO324552   EC085334   EC088360   EC212170   EC212988   EC214660   EC217073   EC240243   EC245935   EL872291   EL872292
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q0KI00 Q960U1 Q9NH67
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   dorsal trunk primordium   (Fisher et al., 2012) Comment:reported as dorsal trunk specific anlage embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic maxillary sensory complex   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval dorsal trunk   (Fisher et al., 2012) embryonic/larval visceral branch   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    23 head, virgin 4-day female    18 head, virgin 20-day female    23 head, mated 1-day female    15 head, mated 4-day female    15 head, mated 20-day female    17 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    240 carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    12 ovary, virgin 4-day female    42 ovary, mated 4-day female    38 testis, mated 4-day male    7 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (28) central nervous system, larvae L3  (28) central nervous system, pupae P8    19 head, virgin 1-day female    23 head, virgin 4-day female    18 head, virgin 20-day female    23 head, mated 1-day female    15 head, mated 4-day female    15 head, mated 20-day female    17 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male  (33) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering  (240) carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    12 ovary, virgin 4-day female  (42) ovary, mated 4-day female  (38) testis, mated 4-day male    7 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    23 head, virgin 4-day female    18 head, virgin 20-day female    23 head, mated 1-day female    15 head, mated 4-day female    15 head, mated 20-day female    17 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering  (240) carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    12 ovary, virgin 4-day female    42 ovary, mated 4-day female    38 testis, mated 4-day male    7 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    23 head, virgin 4-day female    18 head, virgin 20-day female    23 head, mated 1-day female    15 head, mated 4-day female    15 head, mated 20-day female    17 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    240 carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    12 ovary, virgin 4-day female    42 ovary, mated 4-day female    38 testis, mated 4-day male    7 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    23 head, virgin 4-day female    18 head, virgin 20-day female    23 head, mated 1-day female    15 head, mated 4-day female    15 head, mated 20-day female    17 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    240 carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    12 ovary, virgin 4-day female    42 ovary, mated 4-day female    38 testis, mated 4-day male    7 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  28 central nervous system, larvae L3  28 central nervous system, pupae P8    19 head, virgin 1-day female    23 head, virgin 4-day female    18 head, virgin 20-day female    23 head, mated 1-day female    15 head, mated 4-day female    15 head, mated 20-day female    17 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male  (33) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering  (240) carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    12 ovary, virgin 4-day female  (42) ovary, mated 4-day female  (38) testis, mated 4-day male    7 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    23 head, virgin 4-day female    18 head, virgin 20-day female    23 head, mated 1-day female    15 head, mated 4-day female    15 head, mated 20-day female    17 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering  (240) carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    12 ovary, virgin 4-day female    42 ovary, mated 4-day female    38 testis, mated 4-day male    7 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    23 head, virgin 4-day female    18 head, virgin 20-day female    23 head, mated 1-day female    15 head, mated 4-day female    15 head, mated 20-day female    17 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    240 carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    12 ovary, virgin 4-day female    42 ovary, mated 4-day female    38 testis, mated 4-day male    7 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    58 embryo 04-06hr    59 embryo 06-08hr    22 embryo 08-10hr    21 embryo 10-12hr    72 embryo 12-14hr    77 embryo 14-16hr    61 embryo 16-18hr    41 embryo 18-20hr    57 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    20 larva L2    64 larva L3 12hr old    28 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    124 white prepupae new    89 white prepupae 12hr    59 white prepupae 24hr    184 pupae 2d postWPP    66 pupae 3d postWPP    85 pupae 4d postWPP    29 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    15 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (48) embryo 02-04hr  (58) embryo 04-06hr  (59) embryo 06-08hr    22 embryo 08-10hr    21 embryo 10-12hr  (72) embryo 12-14hr  (77) embryo 14-16hr  (61) embryo 16-18hr  (41) embryo 18-20hr  (57) embryo 20-22hr    24 embryo 22-24hr    22 larva L1    20 larva L2  (64) larva L3 12hr old  (28) larva L3 puffstage 1-2    7 larva L3 puffstage 3-6  (31) larva L3 puffstage 7-9  (124) white prepupae new  (89) white prepupae 12hr  (59) white prepupae 24hr  (184) pupae 2d postWPP  (66) pupae 3d postWPP  (85) pupae 4d postWPP  (29) adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    15 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    58 embryo 04-06hr    59 embryo 06-08hr    22 embryo 08-10hr    21 embryo 10-12hr    72 embryo 12-14hr    77 embryo 14-16hr    61 embryo 16-18hr    41 embryo 18-20hr    57 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    20 larva L2    64 larva L3 12hr old    28 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9  (124) white prepupae new    89 white prepupae 12hr    59 white prepupae 24hr  (184) pupae 2d postWPP    66 pupae 3d postWPP    85 pupae 4d postWPP    29 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    15 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    58 embryo 04-06hr    59 embryo 06-08hr    22 embryo 08-10hr    21 embryo 10-12hr    72 embryo 12-14hr    77 embryo 14-16hr    61 embryo 16-18hr    41 embryo 18-20hr    57 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    20 larva L2    64 larva L3 12hr old    28 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    124 white prepupae new    89 white prepupae 12hr    59 white prepupae 24hr    184 pupae 2d postWPP    66 pupae 3d postWPP    85 pupae 4d postWPP    29 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    15 adult female 05day    25 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    58 embryo 04-06hr    59 embryo 06-08hr    22 embryo 08-10hr    21 embryo 10-12hr    72 embryo 12-14hr    77 embryo 14-16hr    61 embryo 16-18hr    41 embryo 18-20hr    57 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    20 larva L2    64 larva L3 12hr old    28 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    124 white prepupae new    89 white prepupae 12hr    59 white prepupae 24hr    184 pupae 2d postWPP    66 pupae 3d postWPP    85 pupae 4d postWPP    29 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    15 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (48) embryo 02-04hr  (58) embryo 04-06hr  (59) embryo 06-08hr    22 embryo 08-10hr    21 embryo 10-12hr  (72) embryo 12-14hr  (77) embryo 14-16hr  (61) embryo 16-18hr  (41) embryo 18-20hr  (57) embryo 20-22hr    24 embryo 22-24hr    22 larva L1    20 larva L2  (64) larva L3 12hr old  28 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6  31 larva L3 puffstage 7-9  (124) white prepupae new  (89) white prepupae 12hr  (59) white prepupae 24hr  (184) pupae 2d postWPP  (66) pupae 3d postWPP  (85) pupae 4d postWPP  29 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    15 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    58 embryo 04-06hr    59 embryo 06-08hr    22 embryo 08-10hr    21 embryo 10-12hr    72 embryo 12-14hr    77 embryo 14-16hr    61 embryo 16-18hr    41 embryo 18-20hr    57 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    20 larva L2    64 larva L3 12hr old    28 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9  124 white prepupae new    89 white prepupae 12hr    59 white prepupae 24hr  (184) pupae 2d postWPP    66 pupae 3d postWPP    85 pupae 4d postWPP    29 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    15 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    58 embryo 04-06hr    59 embryo 06-08hr    22 embryo 08-10hr    21 embryo 10-12hr    72 embryo 12-14hr    77 embryo 14-16hr    61 embryo 16-18hr    41 embryo 18-20hr    57 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    20 larva L2    64 larva L3 12hr old    28 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    124 white prepupae new    89 white prepupae 12hr    59 white prepupae 24hr    184 pupae 2d postWPP    66 pupae 3d postWPP    85 pupae 4d postWPP    29 adult male 01day    6 adult male 05day    7 adult male 30day    6 adult female 01day    15 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    70 embryonic 1182-4H    1 embryonic GM2    9 embryonic Kc167    3 embryonic S1    22 embryonic S3    15 leg disc CME L1    78 wing disc CME-W2    51 wing disc ML-DmD8    2 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    58 wing disc ML-DmD21    3 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4  (70) embryonic 1182-4H    1 embryonic GM2    9 embryonic Kc167    3 embryonic S1    22 embryonic S3    15 leg disc CME L1  (78) wing disc CME-W2  (51) wing disc ML-DmD8    2 wing disc ML-DmD9    18 wing disc ML-DmD16-c3  (58) wing disc ML-DmD21    3 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    70 embryonic 1182-4H    1 embryonic GM2    9 embryonic Kc167    3 embryonic S1    22 embryonic S3    15 leg disc CME L1    78 wing disc CME-W2    51 wing disc ML-DmD8    2 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    58 wing disc ML-DmD21    3 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    70 embryonic 1182-4H    1 embryonic GM2    9 embryonic Kc167    3 embryonic S1    22 embryonic S3    15 leg disc CME L1    78 wing disc CME-W2    51 wing disc ML-DmD8    2 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    58 wing disc ML-DmD21    3 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    70 embryonic 1182-4H    1 embryonic GM2    9 embryonic Kc167    3 embryonic S1    22 embryonic S3    15 leg disc CME L1    78 wing disc CME-W2    51 wing disc ML-DmD8    2 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    58 wing disc ML-DmD21    3 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4  (70) embryonic 1182-4H    1 embryonic GM2    9 embryonic Kc167    3 embryonic S1    22 embryonic S3    15 leg disc CME L1  (78) wing disc CME-W2  (51) wing disc ML-DmD8    2 wing disc ML-DmD9    18 wing disc ML-DmD16-c3  (58) wing disc ML-DmD21    3 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    70 embryonic 1182-4H    1 embryonic GM2    9 embryonic Kc167    3 embryonic S1    22 embryonic S3    15 leg disc CME L1    78 wing disc CME-W2    51 wing disc ML-DmD8    2 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    58 wing disc ML-DmD21    3 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    70 embryonic 1182-4H    1 embryonic GM2    9 embryonic Kc167    3 embryonic S1    22 embryonic S3    15 leg disc CME L1    78 wing disc CME-W2    51 wing disc ML-DmD8    2 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    58 wing disc ML-DmD21    3 wing disc ML-DmD32    25 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3  (36) Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (28) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3  (28) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (30) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult  (27) Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3  (36) Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  28 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3  28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  30 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult  27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	BDGP expression data • PC00180
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die, with Scer\GAL4Act5C.PU SP1029KK110719 viable, with Scer\GAL4pnr-MD237 SP1029GD1198 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 SP1029GD1198 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 SP1029GD1198
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of SP1029 Class Mutagen Stocks Known lesion SP1029MB02279 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of SP1029 Class Mutagen Stocks Known lesion SP1029GD1198 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes SP1029KK110719 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SP1029BCDE in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6212 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1198} NA P{KK110719} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}SP1029MB02279 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
NOT aminoacylase activity non-traceable author statement (FlyBase, 1992-) aminopeptidase activity inferred from sequence or structural similarity (Serano, 2000.2.4) metallopeptidase activity inferred from electronic annotation with InterPro:IPR014782 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR014782 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001930 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions SP1029 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0263236
Orthologs
OrthoDB Orthologs (141) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZS9NJ Dipteran inclusive ortholog search EOG634WF3 Insect inclusive ortholog search EOG6D7X1M Arthropod inclusive ortholog search EOG6KSN0Q Metazoa inclusive ortholog search EOG6GR2XN
Orthologs in Drosophila Species (EOG6ZS9NJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\SP1029     Drosophila simulans   Dsim\GD17853 Y   Drosophila sechellia   Dsec\GM12248     Drosophila erecta   Dere\GG12022     Drosophila yakuba   Dyak\GE10459     Drosophila ananassae   Dana\GF22895     Drosophila pseudoobscura pseudoobscura   Dpse\GA26842     Drosophila persimilis   Dper\GL13602     Drosophila willistoni   Dwil\GK22491     Drosophila virilis   Dvir\GJ14226     Drosophila mojavensis   Dmoj\GI22347     Drosophila grimshawi   Dgri\GH14003
Orthologs in non-Drosophila Dipterans (EOG634WF3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012217 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011291 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000885 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014660 Y
Orthologs in non-Dipteran Insects (EOG6D7X1M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC412808 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001189 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15714 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15713 Y Atta cephalotes Leafcutter ant  Acep\ACEP22435 Y Atta cephalotes Leafcutter ant  Acep\ACEP22430 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19985 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20377 Y Linepithema humile Argentine ant  Lhum\LH22823 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23514 Y Solenopsis invicta Red fire ant  Sinv\SINV20306 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI010198 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006366 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007868 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI33244 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI41611 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI089346 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI071951 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI34486 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003165 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI080787 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001203 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI067691 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001092 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI083965 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI067721 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI43770 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI22813 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI22605 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005810 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002583 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010763 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008058 Y Pediculus humanus Human body louse  Phum\PHUM411950 Y Pediculus humanus Human body louse  Phum\PHUM412200 Y Tribolium castaneum Red flour beetle  Tcas\TC004557 Y Tribolium castaneum Red flour beetle  Tcas\TC004952 Y
Orthologs in non-Insect Arthropods (EOG6KSN0Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\RGD1309594 Y Daphnia pulex Water flea  Dpux\Gstm5 Y Daphnia pulex Water flea  Dpux\JGI_V11_302210 Y Daphnia pulex Water flea  Dpux\rpoB Y Daphnia pulex Water flea  Dpux\NAT2 Y Daphnia pulex Water flea  Dpux\Rbp3 Y Daphnia pulex Water flea  Dpux\JGI_V11_203789 Y Daphnia pulex Water flea  Dpux\rbcL Y Daphnia pulex Water flea  Dpux\JGI_V11_329565 Y Daphnia pulex Water flea  Dpux\CO1 Y Daphnia pulex Water flea  Dpux\JGI_V11_302859 Y Daphnia pulex Water flea  Dpux\JGI_V11_331359 Y Daphnia pulex Water flea  Dpux\JGI_V11_115736 Y Daphnia pulex Water flea  Dpux\JGI_V11_64107 Y Daphnia pulex Water flea  Dpux\Mapk1 Y Ixodes scapularis Deer tick  Isca\ISCW006685 Y Ixodes scapularis Deer tick  Isca\ISCW005385 Y
Orthologs in non-Arthropod Metazoa (EOG6GR2XN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\R03G8.6 Y Caenorhabditis elegans Nematode  Cele\T07F10.1 Y Caenorhabditis elegans Nematode  Cele\F49B2.6 Y Caenorhabditis elegans Nematode  Cele\T16G12.1 Y Caenorhabditis elegans Nematode  Cele\R03G8.4 Y Caenorhabditis elegans Nematode  Cele\pam-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027486gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003266gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012295gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003264gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026920gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011978gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015599gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027905gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011869gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023693gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015341gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024032gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019152gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009652gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013660gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028897gn Y Danio rerio Zebrafish  Drer\lnpep Y Danio rerio Zebrafish  Drer\BX005410.2 Y Danio rerio Zebrafish  Drer\anpepb Y Danio rerio Zebrafish  Drer\si:ch211-200o3.4 Y Danio rerio Zebrafish  Drer\zgc:56194 Y Danio rerio Zebrafish  Drer\erap2 Y Danio rerio Zebrafish  Drer\si:ch211-198g19.1 Y Danio rerio Zebrafish  Drer\BX005410.1 Y Danio rerio Zebrafish  Drer\npepps Y Danio rerio Zebrafish  Drer\si:ch211-149p5.1 Y Danio rerio Zebrafish  Drer\enpep Y Danio rerio Zebrafish  Drer\si:dkey-24n17.6 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033249 Y Xenopus tropicalis Western clawed frog  Xtro\lnpep Y Xenopus tropicalis Western clawed frog  Xtro\erap1 Y Xenopus tropicalis Western clawed frog  Xtro\anpep Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032202 Y Xenopus tropicalis Western clawed frog  Xtro\npepps Y Xenopus tropicalis Western clawed frog  Xtro\aqpep Y Xenopus tropicalis Western clawed frog  Xtro\enpep Y Gallus gallus Domestic chicken  Ggal\NPEPPS Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000002318 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000005185 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000008277 Y Gallus gallus Domestic chicken  Ggal\ERAP1 Y Gallus gallus Domestic chicken  Ggal\TRHDE Y Gallus gallus Domestic chicken  Ggal\LNPEP Y Gallus gallus Domestic chicken  Ggal\ENPEP Y Mus musculus House mouse  Mmus\Trhde Y Mus musculus House mouse  Mmus\Lnpep Y Mus musculus House mouse  Mmus\Enpep Y Mus musculus House mouse  Mmus\Npepps Y Mus musculus House mouse  Mmus\Erap1 Y Mus musculus House mouse  Mmus\Anpep Y Mus musculus House mouse  Mmus\4833403I15Rik Y Rattus norvegicus Norway rat  Rnor\Trhde Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000013082 Y Rattus norvegicus Norway rat  Rnor\Erap1 Y Rattus norvegicus Norway rat  Rnor\Npepps Y Rattus norvegicus Norway rat  Rnor\Anpep Y Rattus norvegicus Norway rat  Rnor\Lvrn Y Homo sapiens Human  Hsap\ENSG00000164307 Y Homo sapiens Human  Hsap\ENPEP Y Homo sapiens Human  Hsap\TRHDE Y Homo sapiens Human  Hsap\NPEPPS Y Homo sapiens Human  Hsap\ENSG00000172901 Y Homo sapiens Human  Hsap\ERAP2 Y Homo sapiens Human  Hsap\LNPEP Y Homo sapiens Human  Hsap\ANPEP Y
Human Orthologs (8)
Gene OMIM HGNC Hsap\ENSG00000164307     Hsap\ENPEP     Hsap\TRHDE     Hsap\NPEPPS     Hsap\ENSG00000172901     Hsap\ERAP2     Hsap\LNPEP     Hsap\ANPEP
AAA Orthologs (1) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17853
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	23430 w1118; Mi{ET1}SP1029MB02279
VDRC	v105785 P{KK110719}VIE-260B v3335 w1118; P{GD1198}v3335 v3336 w1118; P{GD1198}v3336
Genomic Clones ( 1 )
	BACR22E21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 65 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35296 RH66772
Other clones	FI20034
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH11421 GH19821 LD02746 LD03883 LD09583 LD25149 LD25789 LD26567 LD28454 LD29272 LD32492 LD39085 LD39787 LD41010 LD47652 LP03957 LP07276 RE01764 RE09235 RE13762 RE14676 RE15196 RE18388 RE20789 RE21162 RE21719 RE22425 RE22972 RE24578 RE34291 RE35695 RE36205 RE36530 RE39418 RE39604 RE58359 RE69141 RE69622 RH32227 RH43009 RH71647
Other clones	53247 55793 66327 79520 118284 144759 CK01.114C.G7 CK01.117C.E4 EK095706 EK170249 EK183939 EK191604 EK194223 EK200704 EK209457 EK250747 EK281005 FGA009H03 FGM222A04 IP04237 LD24417
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53473
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: SP1029 CG11956 (Bayraktaroglu, 2000.8.7) Source for merge of: SP1029 ptls (FlyBase, 1996-)
Additional comments
Other Comments
	Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. (Claridge-Chang et al., 2001) Defined as a transcription unit immediately adjacent to the 3' end of stg. (Edgar et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_144361 NM_170405 NM_170406 NM_001276136 RefSeq (Proteins) • NP_652618 NP_733284 NP_733285 NP_001263065 DDBJ / EMBL / GenBank • AAF34809 AAF56884 AAG22174 AAK93279 AAN14169 AF231040 AGB96445 AI518880 AW943278 AY051855 BI626212 Entrez Gene - A searchable database of RefSeq genes. • 53473 UniProtKB/TrEMBL • Q0KI00 Q9NH67 Q960U1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase (IPR001930) Peptidase M1, membrane alanine aminopeptidase, N-terminal (IPR014782) Domain of unknown function DUF3358 (IPR024571) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00180
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0263236 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53473
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG11956 (Kai et al., 2005, Schulz et al., 2001, Beckstead et al., 2007, Keleman et al., 2009.8.5) ptl (Edgar et al., 1994) ptls   SP1029 (Butchar et al., 2012, Cherbas et al., 2011, Firth and Baker, 2007, Bartkuhn et al., 2009)
Name Synonym	pathless (Edgar et al., 1994) SP1029
Secondary FlyBase IDs
	FBgn0014996 FBgn0039658 FBgn0040282
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Butchar et al., 2012, Genetics 191(4): 1213--1226 New negative feedback regulators of egfr signaling in Drosophila. [FBrf0219175] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Show all research papers ...