FB2022_03, released June 9, 2022

Gene: Dmel\SP1029

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General Information
Symbol
Dmel\SP1029
Species
D. melanogaster
Name
SP1029
Annotation Symbol
CG11956
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263236
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
99A6-99A5
Sequence location
Recombination map
3-98
RefSeq locus
NT_033777 REGION:29244961..29250451
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables metalloaminopeptidase activity
inferred from biological aspect of ancestor with PANTHER:PTN000164250
(assigned by GO_Central )
(Gaudet et al., 2011)
enables peptide binding
inferred from biological aspect of ancestor with PANTHER:PTN000164250
(assigned by GO_Central )
(Gaudet et al., 2011)
enables zinc ion binding
inferred from biological aspect of ancestor with PANTHER:PTN000164250
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in peptide catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000164250
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in proteolysis
inferred from biological aspect of ancestor with PANTHER:PTN000164251
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000164250
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
M1 METALLOPEPTIDASES -
M1 metallopeptidases belong to MEROPS family M1. All members of the family act on the N-terminus of polypeptides, many of them being aminopeptidases. The family also contains pyroglutamyl-peptidase II, an omega peptidase that releases pyroglutamate from thyrotropin-releasing hormone, and some dipeptidases. (Adapted from FBrf0239469.)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\SP1029 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q0KI00)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
SP1029-RA
FBtr0085398
NM_144361
3026
932
SP1029-RB
FBtr0085399
NM_170405
3321
932
SP1029-RC
FBtr0085400
NM_170406
3158
932
SP1029-RD
FBtr0334868
NM_001276136
3198
932
SP1029-RE
FBtr0345203
NM_001300651
2981
932
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
SP1029-PA
FBpp0084767
108.0
932
6.57
Q0KI00
NP_652618
AAF56884
SP1029-PB
FBpp0084768
108.0
932
6.57
Q0KI00
NP_733284
AAG22174
SP1029-PC
FBpp0084769
108.0
932
6.57
Q0KI00
NP_733285
AAN14169
SP1029-PD
FBpp0306891
108.0
932
6.57
Q0KI00
NP_001263065
AGB96445
SP1029-PE
FBpp0311398
108.0
932
6.57
Q0KI00
NP_001287580
AHN57579
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

932 aa isoforms: SP1029-PA, SP1029-PB, SP1029-PC, SP1029-PD, SP1029-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SP1029 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\SP1029 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of SP1029
Transgenic constructs containing regulatory region of SP1029
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel6212
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ANPEP
8 of 15
Yes
No
Hsap\ERAP1
5 of 15
No
Yes
Hsap\ERAP2
5 of 15
No
Yes
Hsap\LNPEP
5 of 15
No
Yes
Hsap\LVRN
5 of 15
No
Yes
Hsap\ENPEP
4 of 15
No
No
1  
Hsap\NPEPPS
4 of 15
No
No
Hsap\TRHDE
3 of 15
No
No
Hsap\RNPEP
2 of 15
No
Yes
Hsap\RNPEPL1
2 of 15
No
Yes
Hsap\ANTXR2
1 of 15
No
Yes
Hsap\AOPEP
1 of 15
No
No
Hsap\LOC440434
1 of 15
No
No
Hsap\LOC101929950
1 of 15
No
Yes
Hsap\LTA4H
1 of 15
No
No
Hsap\MIR24-1
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Anpep
8 of 15
Yes
No
Mmus\Lvrn
6 of 15
No
Yes
Mmus\Erap1
5 of 15
No
Yes
Mmus\Lnpep
5 of 15
No
Yes
Mmus\Enpep
4 of 15
No
No
Mmus\Npepps
4 of 15
No
No
Mmus\Trhde
3 of 15
No
No
Mmus\Aopep
2 of 15
No
Yes
Mmus\Rnpepl1
2 of 15
No
Yes
Mmus\Rnpep
2 of 15
No
Yes
Mmus\Lta4h
1 of 15
No
No
Rattus norvegicus (Norway rat) (12)
Rnor\Anpep
7 of 13
Yes
No
Rnor\Erap1
5 of 13
No
Yes
Rnor\Lnpep
5 of 13
No
Yes
Rnor\Lvrn
4 of 13
No
No
Rnor\Npepps
4 of 13
No
No
Rnor\Enpep
3 of 13
No
No
Rnor\Trhde
3 of 13
No
No
Rnor\Npepo
2 of 13
No
Yes
Rnor\Rnpep
2 of 13
No
Yes
Rnor\LOC100910501
1 of 13
No
Yes
Rnor\LOC108348118
1 of 13
No
Yes
Rnor\Lta4h
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\erap1
5 of 12
Yes
Yes
Xtro\lnpep
5 of 12
Yes
Yes
Xtro\anpep
4 of 12
No
Yes
Xtro\lvrn
4 of 12
No
Yes
Xtro\npepps
4 of 12
No
No
Xtro\enpep
3 of 12
No
No
Xtro\c9orf3
2 of 12
No
Yes
Xtro\rnpep
2 of 12
No
Yes
Xtro\lta4h
1 of 12
No
No
Xtro\trhde
1 of 12
No
Yes
Danio rerio (Zebrafish) (17)
Drer\si:ch211-106j24.1
7 of 15
Yes
No
Drer\anpepb
5 of 15
No
No
Drer\erap1a
5 of 15
No
Yes
Drer\erap1b
5 of 15
No
Yes
Drer\erap2
5 of 15
No
Yes
Drer\lnpep
5 of 15
No
Yes
Drer\si:ch211-276a23.5
5 of 15
No
No
Drer\anpepa
4 of 15
No
No
Drer\LOC100004744
4 of 15
No
No
Drer\npepps
4 of 15
No
No
Drer\enpep
3 of 15
No
No
Drer\trhde.1
3 of 15
No
No
Drer\trhde.2
3 of 15
No
No
Drer\rnpep
2 of 15
No
Yes
Drer\rnpepl1
2 of 15
No
Yes
Drer\aopep
1 of 15
No
No
Drer\lta4h
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
Cele\anp-1
6 of 15
Yes
No
Cele\F49B2.6
6 of 15
Yes
No
Cele\pam-1
4 of 15
No
No
Cele\R03G8.4
4 of 15
No
Yes
Cele\R03G8.6
4 of 15
No
No
Cele\T16G12.1
4 of 15
No
Yes
Cele\Y42A5A.1
4 of 15
No
No
Cele\T12E12.6
3 of 15
No
No
Cele\Y67D8C.9
3 of 15
No
No
Cele\AC3.5
2 of 15
No
No
Cele\Y53F4B.20
2 of 15
No
Yes
Cele\ltah-1.1
1 of 15
No
No
Cele\ltah-1.2
1 of 15
No
No
Cele\mnp-1
1 of 15
No
No
Cele\VB0395L.1
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\APM1
2 of 9
Yes
No
Atha\AT1G63770
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\AAP1
3 of 15
Yes
No
Scer\APE2
3 of 15
Yes
No
Scer\TMA108
2 of 15
No
No
Scer\LAP2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\ape2
2 of 12
Yes
No
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (22)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG31445
8 of 10
superdeath
7 of 10
CG8773
6 of 10
CG8774
6 of 10
CG11951
6 of 10
CG32473
6 of 10
CG3502
5 of 10
CG31233
5 of 10
CG31343
5 of 10
Psa
5 of 10
CG2111
4 of 10
CG5849
4 of 10
CG6071
4 of 10
CG7653
4 of 10
CG9806
4 of 10
CG31198
4 of 10
CG46339
4 of 10
CG4467
3 of 10
CG40470
3 of 10
CG42335
3 of 10
CG10602
2 of 10
CR31427
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ANPEP; alanyl aminopeptidase, membrane
    8 of 15
    151530
        ERAP1; endoplasmic reticulum aminopeptidase 1
        5 of 15
        606832
            ERAP2; endoplasmic reticulum aminopeptidase 2
            5 of 15
            609497
                LNPEP; leucyl and cystinyl aminopeptidase
                5 of 15
                151300
                    LVRN; laeverin
                    5 of 15
                    610046
                        ENPEP; glutamyl aminopeptidase
                        4 of 15
                        138297
                             
                            NPEPPS; aminopeptidase puromycin sensitive
                            4 of 15
                            606793
                                TRHDE; thyrotropin releasing hormone degrading enzyme
                                3 of 15
                                606950
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Interactions
                                    Summary of Physical Interactions
                                    esyN Network Diagram
                                    Interactions Browser
                                    Summary of Genetic Interactions
                                    esyN Network Diagram
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    External Data
                                    Linkouts
                                    DroID - A comprehensive database of gene and protein interactions.
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                    External Data
                                    Linkouts
                                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    3R
                                    Recombination map
                                    3-98
                                    Cytogenetic map
                                    99A6-99A5
                                    Sequence location
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    99A6-99A5
                                    Left limit from molecular mapping relative to stg (FBrf0073015) Right limit from molecular mapping relative to stg (FBrf0073015); Limits computationally determined from genome sequence between P{PZ}l(3)0470804708 and P{PZ}l(3)0674306743
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    99A5-99A6
                                    (Serano, 2000.2.4)
                                    99A-99A
                                    (Edgar et al., 1994)
                                    Experimentally Determined Recombination Data
                                    Location

                                    3-98

                                    (FlyBase, 2016)

                                    3-94.8

                                    (Comeron et al., 2012)
                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (6)
                                    Genomic Clones (24)
                                    cDNA Clones (63)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                    Other clones
                                    Drosophila Genomics Resource Center cDNA clones

                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                    cDNA Clones, End Sequenced (ESTs)
                                    BDGP DGC clones
                                    Other clones
                                    RNAi and Array Information
                                    Linkouts
                                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                    Antibody Information
                                    Laboratory Generated Antibodies
                                     
                                    Commercially Available Antibodies
                                     
                                    Other Information
                                    Relationship to Other Genes
                                    Source for database identify of
                                    Source for database merge of

                                    Source for merge of: SP1029 CG11956

                                    (Bayraktaroglu, 2000.8.7)

                                    Source for merge of: SP1029 ptls

                                    (FlyBase, 1996-)
                                    Additional comments
                                    Other Comments

                                    Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

                                    (Claridge-Chang et al., 2001)

                                    Defined as a transcription unit immediately adjacent to the 3' end of stg.

                                    (Edgar et al., 1994)
                                    Origin and Etymology
                                    Discoverer
                                    Etymology
                                    Identification
                                    External Crossreferences and Linkouts ( 58 )
                                    Sequence Crossreferences
                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                    Other crossreferences
                                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                    InterPro - A database of protein families, domains and functional sites
                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                    MARRVEL_MODEL - MARRVEL (model organism gene)
                                    Linkouts
                                    DroID - A comprehensive database of gene and protein interactions.
                                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                    Synonyms and Secondary IDs (5)
                                    Datasets (0)
                                    Study focus (0)
                                    Experimental Role
                                    Project
                                    Project Type
                                    Title
                                    Study result (0)
                                    Result
                                    Result Type
                                    Title
                                    References (53)