• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\dar1

General Information
Symbol	Dmel\dar1	Species	D. melanogaster
Name	dendritic arbor reduction 1	Annotation symbol	CG12029
Feature type	protein_coding_gene	FlyBase ID	FBgn0263239
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	63E5-63F3	Sequence location	3L:3,626,352..3,653,442 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dendritic arbor reduction 1 is referred to in FlyBase by the symbol Dmel\dar1 (CG12029, FBgn0263239). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: regulation of dendrite morphogenesis; negative regulation of dendrite morphogenesis. 12 alleles are reported. The phenotype of these alleles is annotated with: dendritic arborizing neuron. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Gene sequence location is 3L:3626352..3653442.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 63E5-63F3   Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634; Left limit from inclusion within Df(3L)GN34 (FBrf0080079) Right limit from non-inclusion within Df(3L)GN19 (FBrf0080079)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dar1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dar1-RB FBtr0113134  NM_001104023   3526   751
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dar1-PB   FBpp0112047   82.3   751   7.80     NP_001097493   AAF47785
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF47785   BT022200   CX309421   CX309461   EC058751   EC197335
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VZN4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   dorsal ridge primordium   (Fisher et al., 2012) epipharynx primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal ridge   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic small intestine   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13   presumptive embryonic/larval peripheral nervous system   (Ye et al., 2011) abdominal dorsal bipolar neuron dbp   (Ye et al., 2011) dendritic arborizing neuron | subset   (Ye et al., 2011) abdominal dorsal multidendritic neuron ddaA   (Ye et al., 2011) abdominal dorsal multidendritic neuron ddaB   (Ye et al., 2011) abdominal dorsal multidendritic neuron ddaC   (Ye et al., 2011) abdominal dorsal multidendritic neuron ddaD   (Ye et al., 2011) abdominal dorsal multidendritic neuron ddaE   (Ye et al., 2011) abdominal dorsal multidendritic neuron ddaF   (Ye et al., 2011)   • nucleus (Ye et al., 2011)
Additional Descriptive Data
	dar1 protein is detected in the peripheral nervous system of stage 13 embryos, in neurons that have more than one primary neurite. These neurons include bipolar neurons (dbp) and dendritic arborizing neurons (ddaA, ddaB, ddaC, ddaD, ddaE and ddaF). (Ye et al., 2011)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    13 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    15 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    4 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    13 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    15 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    4 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    13 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    15 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    4 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    13 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    15 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    4 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    13 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    15 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    4 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    13 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    15 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    4 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    13 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    15 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    4 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    13 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    15 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    4 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	BDGP expression data • IP01101
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive dar1A11 dar1D6 dar1unspecified viable, with Scer\GAL4pnr-MD237 dar1GD13446 Other Phenotypes Allele neuroanatomy defective dar13010 dar13232 neuroanatomy defective, with Scer\GAL4477 dar1Scer\UAS.cYa neuroanatomy defective (with dar13010) dar13232 neuroanatomy defective (with dar13232) dar13010 neuroanatomy defective | somatic clone, with Scer\GAL4477 dar1Scer\UAS.cYa Phenotype manifest in Allele dendritic arborizing neuron dar13010 dar13232 dendritic arborizing neuron, with Scer\GAL4477 dar1Scer\UAS.cYa dendritic arborizing neuron (with dar13010) dar13232 dendritic arborizing neuron (with dar13232) dar13010 dendritic arborizing neuron | somatic clone, with Scer\GAL4477 dar1Scer\UAS.cYa
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of dar1 Class Mutagen Stocks Known lesion dar1A11 1 -- dar1D6 1 Yes dar1f01014 1 -- dar1f06798 1 -- dar13010 FLPase 0 Yes dar13232 FLPase 0 Yes dar1sy diepoxybutane 0 Yes dar1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dar1 Class Mutagen Stocks Known lesion dar1GD13446 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dar1JF03421 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dar1+tYa in vitro construct - regulatory fusion in vitro construct - genomic fragment 0 Yes dar1Scer\UAS.cYa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6097 (Ryder, 2004.4.26) Df(3L)GN34 (Harrison et al., 1995) Df(3L)HR298 (Harrison et al., 1995)
Not disrupted in	Df(3L)C175 (Harrison et al., 1995) Df(3L)GN19 (Harrison et al., 1995) Df(3L)GN34 (Ye et al., 2011) Df(3L)R75 (Ye et al., 2011) Df(3L)TE1 (Harrison et al., 1995) Df(3L)ΔEY01819 (Ye et al., 2011)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-dar1.Y} NA characterization construct P{dar1+tYa} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}dar1f01014 NA PBac{WH}dar1f06798 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from direct assay (Brown et al., 2005)
Biological Process
CV term Evidence References
negative regulation of dendrite morphogenesis inferred from mutant phenotype (Ye et al., 2007) regulation of dendrite morphogenesis inferred from mutant phenotype (Ye et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene (Ye et al., 2007, ) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dar1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0263239
Orthologs
OrthoDB Orthologs (153) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6STSR6 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6T770J Arthropod inclusive ortholog search EOG6TTF0T Metazoa inclusive ortholog search EOG6PS5JW
Orthologs in Drosophila Species (EOG6STSR6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dar1     Drosophila sechellia   Dsec\GM14583 Y   Drosophila erecta   Dere\GG15151 Y   Drosophila yakuba   Dyak\GE21373 Y   Drosophila ananassae   Dana\GF24217 Y   Drosophila persimilis   Dper\GL21001 Y   Drosophila willistoni   Dwil\GK20520 Y   Drosophila virilis   Dvir\GJ12406 Y   Drosophila mojavensis   Dmoj\GI12500 Y   Drosophila grimshawi   Dgri\GH16421 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6T770J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45841 Y Apis mellifera Western honey bee  Amel\GB52090 Y Apis mellifera Western honey bee  Amel\GB45842 Y Apis mellifera Western honey bee  Amel\GB52133 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012904 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG017040 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21746 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17544 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21748 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23627 Y Atta cephalotes Leafcutter ant  Acep\ACEP25041 Y Atta cephalotes Leafcutter ant  Acep\ACEP15814 Y Atta cephalotes Leafcutter ant  Acep\ACEP19659 Y Atta cephalotes Leafcutter ant  Acep\ACEP25043 Y Atta cephalotes Leafcutter ant  Acep\ACEP15823 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO11953 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO22737 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO26808 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO25999 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO26416 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO15513 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14482 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL24279 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13871 Y Linepithema humile Argentine ant  Lhum\LH17698 Y Linepithema humile Argentine ant  Lhum\LH25688 Y Linepithema humile Argentine ant  Lhum\LH23971 Y Linepithema humile Argentine ant  Lhum\LH17368 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18314 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB19805 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18312 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB19804 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13335 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13336 Y Solenopsis invicta Red fire ant  Sinv\SINV23346 Y Solenopsis invicta Red fire ant  Sinv\SINV21799 Y Solenopsis invicta Red fire ant  Sinv\SINV23345 Y Solenopsis invicta Red fire ant  Sinv\SINV21808 Y Solenopsis invicta Red fire ant  Sinv\SINV10616 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI34996 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI23999 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000624 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000499 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002047 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011419 Y Pediculus humanus Human body louse  Phum\PHUM483400 Y Pediculus humanus Human body louse  Phum\PHUM206780 Y Pediculus humanus Human body louse  Phum\PHUM236000 Y Pediculus humanus Human body louse  Phum\PHUM483510 Y Pediculus humanus Human body louse  Phum\PHUM399820 Y Pediculus humanus Human body louse  Phum\PHUM403940 Y Pediculus humanus Human body louse  Phum\PHUM484340 Y Pediculus humanus Human body louse  Phum\PHUM207190 Y Tribolium castaneum Red flour beetle  Tcas\TC006126 Y Tribolium castaneum Red flour beetle  Tcas\TC002119 Y Tribolium castaneum Red flour beetle  Tcas\TC003612 Y Tribolium castaneum Red flour beetle  Tcas\TC003611 Y
Orthologs in non-Insect Arthropods (EOG6TTF0T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Fam3c Y Daphnia pulex Water flea  Dpux\KLF2A Y Daphnia pulex Water flea  Dpux\LRRC59 Y Daphnia pulex Water flea  Dpux\Ap2s1 Y Daphnia pulex Water flea  Dpux\JGI_V11_19818 Y Daphnia pulex Water flea  Dpux\KLF6 Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\ND2 Y Ixodes scapularis Deer tick  Isca\ISCW010690 Y Ixodes scapularis Deer tick  Isca\ISCW016993 Y Ixodes scapularis Deer tick  Isca\ISCW004118 Y Ixodes scapularis Deer tick  Isca\ISCW018441 Y Ixodes scapularis Deer tick  Isca\ISCW016565 Y
Orthologs in non-Arthropod Metazoa (EOG6PS5JW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\klf-1 Y Caenorhabditis elegans Nematode  Cele\klf-2 Y Caenorhabditis elegans Nematode  Cele\klf-3 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015772gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020311gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\Klf7 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017470gn Y Danio rerio Zebrafish  Drer\klf12b Y Danio rerio Zebrafish  Drer\klf15 Y Danio rerio Zebrafish  Drer\klfd Y Danio rerio Zebrafish  Drer\DKEY-222F1.1 Y Danio rerio Zebrafish  Drer\klf2a Y Danio rerio Zebrafish  Drer\si:dkeyp-12a9.2 Y Danio rerio Zebrafish  Drer\klf5b Y Danio rerio Zebrafish  Drer\copeb Y Danio rerio Zebrafish  Drer\klf7a Y Danio rerio Zebrafish  Drer\si:ch211-208m1.2 Y Danio rerio Zebrafish  Drer\klf4 Y Danio rerio Zebrafish  Drer\ENSDARG00000079922 Y Danio rerio Zebrafish  Drer\zgc:136851 Y Danio rerio Zebrafish  Drer\klf12 Y Danio rerio Zebrafish  Drer\klf2b Y Danio rerio Zebrafish  Drer\klf5a Y Xenopus tropicalis Western clawed frog  Xtro\klf5 Y Xenopus tropicalis Western clawed frog  Xtro\klf2 Y Xenopus tropicalis Western clawed frog  Xtro\klf17 Y Xenopus tropicalis Western clawed frog  Xtro\klf8 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000009617 Y Xenopus tropicalis Western clawed frog  Xtro\klf7 Y Xenopus tropicalis Western clawed frog  Xtro\klf4 Y Xenopus tropicalis Western clawed frog  Xtro\klf12 Y Xenopus tropicalis Western clawed frog  Xtro\klf3 Y Xenopus tropicalis Western clawed frog  Xtro\klf15 Y Gallus gallus Domestic chicken  Ggal\LOC422310 Y Gallus gallus Domestic chicken  Ggal\KLF12 Y Gallus gallus Domestic chicken  Ggal\KLF6 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000000373 Y Gallus gallus Domestic chicken  Ggal\KLF2 Y Gallus gallus Domestic chicken  Ggal\KLF7 Y Gallus gallus Domestic chicken  Ggal\KLF15 Y Gallus gallus Domestic chicken  Ggal\KLF3 Y Gallus gallus Domestic chicken  Ggal\KLF5 Y Gallus gallus Domestic chicken  Ggal\KLF1 Y Mus musculus House mouse  Mmus\Klf4 Y Mus musculus House mouse  Mmus\Klf1 Y Mus musculus House mouse  Mmus\Klf15 Y Mus musculus House mouse  Mmus\Klf6 Y Mus musculus House mouse  Mmus\Klf8 Y Mus musculus House mouse  Mmus\Klf5 Y Mus musculus House mouse  Mmus\Klf12 Y Mus musculus House mouse  Mmus\Klf2 Y Mus musculus House mouse  Mmus\Klf7 Y Mus musculus House mouse  Mmus\Klf3 Y Rattus norvegicus Norway rat  Rnor\Klf7 Y Rattus norvegicus Norway rat  Rnor\Klf4 Y Rattus norvegicus Norway rat  Rnor\Klf12 Y Rattus norvegicus Norway rat  Rnor\Klf15 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000008785 Y Rattus norvegicus Norway rat  Rnor\Klf1 Y Rattus norvegicus Norway rat  Rnor\Klf3 Y Rattus norvegicus Norway rat  Rnor\Klf6 Y Rattus norvegicus Norway rat  Rnor\Klf2 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039057 Y Homo sapiens Human  Hsap\KLF15 Y Homo sapiens Human  Hsap\KLF6 Y Homo sapiens Human  Hsap\KLF1 Y Homo sapiens Human  Hsap\KLF7 Y Homo sapiens Human  Hsap\KLF2 Y Homo sapiens Human  Hsap\KLF5 Y Homo sapiens Human  Hsap\KLF8 Y Homo sapiens Human  Hsap\KLF12 Y Homo sapiens Human  Hsap\ENSG00000136826 Y Homo sapiens Human  Hsap\KLF3 Y
Human Orthologs (10)
Gene OMIM HGNC Hsap\KLF15     Hsap\KLF6     Hsap\KLF1     Hsap\KLF7     Hsap\KLF2     Hsap\KLF5     Hsap\KLF8     Hsap\KLF12     Hsap\ENSG00000136826     Hsap\KLF3
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM14583 Drosophila erecta Dere\GG15151 Drosophila yakuba Dyak\GE21373 Drosophila ananassae Dana\GF24217 Drosophila pseudoobscura pseudoobscura Dpse\GA23797 Drosophila persimilis Dper\GL21001 Drosophila willistoni Dwil\GK20520 Drosophila virilis Dvir\GJ12406 Drosophila mojavensis Dmoj\GI12500 Drosophila grimshawi Dgri\GH16421
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	31987 y1 v1; P{TRiP.JF03421}attP2 5164 bw1; dar1D6 st1/TM6B, Tb+ 5163 bw1; dar1A11 st1/TM6B, Tb1
Harvard	- PBac{WH}dar1f01014 - PBac{WH}dar1f06798
VDRC	v26980 w1118; P{GD13446}v26980
Genomic Clones ( 2 )
	BACR09B04 BACR10I10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP01101
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	AM02149 CK01.90C.A6 CK01.128D.C7
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38436
Antibody Information
	polyclonal (Ye et al., 2011)
Other Information
Discoverer
Etymology
Identification
	In a screen for mutations affecting dendritic and/or axonal development in the class IV dendritic arborization (da) neurons. 2 alleles of dar1 have been isolated. (Ye et al., 2007)
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: dar1 CG12029 l(3)63Ed (Ye et al., 2011)
Additional comments
Other Comments
	dar1 belongs to the Kruppel (Kr)-like factor family. (Ye et al., 2011) Mutants have reduced dendritic arbors but normal axonal growth in the class IV dendritic arborization (da) neurons. (Ye et al., 2007) Discussed during genetic analysis of the Ras64B-Rop region. (Harrison et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001104023 RefSeq (Proteins) • NP_001097493 DDBJ / EMBL / GenBank • AAF47785 Entrez Gene - A searchable database of RefSeq genes. • 38436 UniProtKB/TrEMBL • Q9VZN4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP01101
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0263239 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38436
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG12029 (Hoskins et al., 2005, Brown et al., 2005, Perkins et al., 2009) Dar1 (Ye et al., 2011) dar1 (Ye et al., 2007) DAR1 (Veenstra et al., 2008) l(3)63Ed   l(3)SH5 (Harrison et al., 1995)
Name Synonym	ASA-receptor (Veenstra et al., 2008) dendritic arbor reduction 1 (Ye et al., 2007, Ye et al., 2011) lethal (3) 63Ed
Secondary FlyBase IDs
	FBgn0016005 FBgn0035454 FBgn0259102
References ( 20 )
Research paper	Ye et al., 2011, J. Neurosci. 31(9): 3309--3319 Differential regulation of dendritic and axonal development by the novel kruppel-like factor dar1. [FBrf0213162] Veenstra et al., 2008, Cell Tissue Res. 334(3): 499--516 Regulatory peptides in fruit fly midgut. [FBrf0207371] Ye et al., 2007, Cell 130(4): 717--729 Growing dendrites and axons differ in their reliance on the secretory pathway. [FBrf0200877] Brown et al., 2005, Nucleic Acids Res. 33(16): 5181--5189 An Sp1/KLF binding site is important for the activity of a Polycomb group response element from the Drosophila engrailed gene. [FBrf0188187] Hoskins et al., 2005, Nucleic Acids Res. 33(21): e185 Rapid and efficient cDNA library screening by self-ligation of inverse PCR products (SLIP). [FBrf0191341] Vaskova et al., 2000, Genetics 156(1): 229--244 Genetic analysis of the Drosophila 63F early puff: characterization of mutations in E63-1 and maggie, a putative Tom22. [FBrf0130136] Harrison et al., 1995, Genetics 139(4): 1701--1709 A genetic analysis of the 63E-64A genomic region of Drosophila melanogaster: Identification of mutations in a replication factor C subunit. [FBrf0080079]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Harrison, 1999.5.12, 63E-64B mutant stocks. 63E-64B mutant stocks. [FBrf0108507]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705] Li, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126682]