FB2020_06, released Dec 22, 2020

Gene: Dmel\dar1

Open Close
General Information
Symbol
Dmel\dar1
Species
D. melanogaster
Name
dendritic arbor reduction 1
Annotation Symbol
CG12029
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263239
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
dendritic arbor reduction 1 (dar1) encodes a transcription factor in the Kruppel-like factor family. It determines the multipolar morphology of neurons by promoting the growth of dendrites (but not axons), in part by controlling the expression of regulators of microtubules and microtubule-based transport. [Date last reviewed: 2019-03-07]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
63E5-63E6
Sequence location
3L:3,626,352..3,653,442 [+]
Recombination map

3-8

RefSeq locus
NT_037436 REGION:3626352..3653442
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables sequence-specific DNA binding
inferred from direct assay
(Brown et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(assigned by GO_Central )
(Gaudet et al., 2011)
enables DNA-binding transcription factor activity
inferred from sequence or structural similarity with MGI:MGI:1338056
(Ye et al., 2011)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in negative regulation of microtubule depolymerization
inferred from mutant phenotype
(Ye et al., 2011)
involved_in negative regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Ye et al., 2011)
involved_in positive regulation of dendrite extension
inferred from mutant phenotype
(Wang et al., 2015)
involved_in positive regulation of dendrite morphogenesis
inferred from mutant phenotype
(Wang et al., 2015, Ye et al., 2011, Ye et al., 2007)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Wang et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with MGI:MGI:1338056
(Ye et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Ye et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in chromatin
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the krueppel C2H2-type zinc-finger protein family. (Q9VZN4)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SP1/KLF TRANSCRIPTION FACTORS -
The Sp1/KLF (Sp1-like/Kruppel-like factors) family of zinc finger proteins are DNA binding proteins. They can act as activators or repressors and some members bind sequences within Polycomb Response Elements (PREs). (Adapted from FBrf0188187).
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Protein Function (UniProtKB)
Transcriptional regulator which promotes dendrite growth by suppressing, either directly or indirectly, the expression of the microtubule-severing protein spas (PubMed:21368042). Determines multipolar neuron morphology in postmitotic neurons by positively regulating the expression of genes involved in nuclear positioning including several dynein genes and the nuclear migration protein nudC (PubMed:26490864).
(UniProt, Q9VZN4)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\dar1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
gene
(Ye et al., 2007)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dar1-RB
FBtr0113134
NM_001104023
3526
751
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
dar1-PB
FBpp0112047
82.3
751
7.80
NP_001097493
AAF47785
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dar1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13
presumptive embryonic/larval peripheral nervous system
(Ye et al., 2011)
abdominal dorsal bipolar neuron dbp
(Ye et al., 2011)
dendritic arborizing neuron | subset
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaA
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaB
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaC
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaD
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaE
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaF
(Ye et al., 2011)
• nucleus
(Ye et al., 2011)
Additional Descriptive Data

dar1 protein is detected in the peripheral nervous system of stage 13 embryos, in neurons that have more than one primary neurite. These neurons include bipolar neurons (dbp) and dendritic arborizing neurons (ddaA, ddaB, ddaC, ddaD, ddaE and ddaF).

(Ye et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Ye et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\dar1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dar1
Transgenic constructs containing regulatory region of dar1
Deletions and Duplications ( 8 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4477
neuroanatomy defective, with Scer\GAL4eve.RN2
neuroanatomy defective, with Scer\GAL4P2.4.Pdf
neuroanatomy defective (with dar13010)
neuroanatomy defective (with dar13232)
neuroanatomy defective | larval stage | somatic clone
neuroanatomy defective | somatic clone
neuroanatomy defective | somatic clone, with Scer\GAL4477
Phenotype manifest in
Allele
adult Pdf neuron, with Scer\GAL4P2.4.Pdf
dendrite | supernumerary, with Scer\GAL4eve.RN2
dendrite | supernumerary, with Scer\GAL4P2.4.Pdf
dendritic arborizing neuron
dendritic arborizing neuron, with Scer\GAL4477
dendritic arborizing neuron (with dar13010)
dendritic arborizing neuron (with dar13232)
dendritic arborizing neuron | somatic clone
dendritic arborizing neuron | somatic clone, with Scer\GAL4477
embryonic/larval motor neuron, with Scer\GAL4eve.RN2
larval multidendritic class III neuron | somatic clone
larval multidendritic class I neuron | somatic clone
larval multidendritic class IV neuron | larval stage | somatic clone
larval multidendritic class IV neuron | somatic clone
neurite | supernumerary, with Scer\GAL4eve.RN2
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\KLF5
4 of 15
Yes
No
Hsap\KLF14
2 of 15
No
Yes
Hsap\KLF17
2 of 15
No
No
Hsap\KLF18
2 of 15
No
Yes
Hsap\KLF1
1 of 15
No
No
Hsap\KLF2
1 of 15
No
No
Hsap\KLF3
1 of 15
No
No
1  
Hsap\KLF4
1 of 15
No
No
Hsap\KLF6
1 of 15
No
No
1  
Hsap\KLF7
1 of 15
No
No
1  
Hsap\KLF8
1 of 15
No
No
Hsap\KLF10
1 of 15
No
No
Hsap\KLF12
1 of 15
No
No
1  
Hsap\KLF16
1 of 15
No
Yes
Hsap\SP1
1 of 15
No
No
0  
Hsap\SP3
1 of 15
No
No
0  
Hsap\SP5
1 of 15
No
No
Hsap\WT1
1 of 15
No
Yes
Hsap\ZNF316
1 of 15
No
Yes
Hsap\ZNF367
1 of 15
No
Yes
Hsap\ZNF853
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Klf5
6 of 15
Yes
Yes
Mmus\Klf3
2 of 15
No
No
Mmus\Klf8
2 of 15
No
No
Mmus\Klf12
2 of 15
No
No
Mmus\Klf17
2 of 15
No
No
Mmus\Zfp352
2 of 15
No
No
Mmus\Klf1
1 of 15
No
No
Mmus\Klf2
1 of 15
No
No
Mmus\Klf4
1 of 15
No
No
Mmus\Klf6
1 of 15
No
No
Mmus\Klf10
1 of 15
No
No
Mmus\Klf14
1 of 15
No
Yes
Mmus\Klf16
1 of 15
No
Yes
Mmus\Sp1
1 of 15
No
No
Mmus\Sp3
1 of 15
No
No
Mmus\Sp5
1 of 15
No
No
Mmus\Wt1
1 of 15
No
Yes
Mmus\Zfp367
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (14)
Rnor\Klf5
4 of 13
Yes
Yes
Rnor\Klf17
2 of 13
No
No
Rnor\Zfp352
2 of 13
No
No
Rnor\Zfp353
2 of 13
No
Yes
Rnor\Klf1
1 of 13
No
No
Rnor\Klf2
1 of 13
No
No
Rnor\Klf3
1 of 13
No
No
Rnor\Klf4
1 of 13
No
No
Rnor\Klf6
1 of 13
No
No
Rnor\Klf8
1 of 13
No
No
Rnor\Klf12
1 of 13
No
No
Rnor\Klf14
1 of 13
No
No
Rnor\Wt1
1 of 13
No
Yes
Rnor\Zfp367
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (8)
Xtro\znf534
4 of 12
Yes
Yes
Xtro\klf5
2 of 12
No
Yes
Xtro\klf6
1 of 12
No
Yes
Xtro\klf7
1 of 12
No
No
Xtro\klf8
1 of 12
No
Yes
Xtro\klf12
1 of 12
No
Yes
Xtro\sp1
1 of 12
No
No
Xtro\sp5
1 of 12
No
No
Danio rerio (Zebrafish) (23)
Drer\klf5l
7 of 15
Yes
Yes
Drer\klf5a
5 of 15
No
Yes
Drer\klf5b
3 of 15
No
No
Drer\klf6b
2 of 15
No
No
Drer\klf12a
2 of 15
No
No
Drer\sp5a
2 of 15
No
No
Drer\klf1
1 of 15
No
No
Drer\klf2a
1 of 15
No
No
Drer\klf2b
1 of 15
No
No
Drer\klf3
1 of 15
No
No
Drer\klf6a
1 of 15
No
No
Drer\klf7a
1 of 15
No
No
Drer\klf7b
1 of 15
No
No
Drer\klf8
1 of 15
No
No
Drer\klf12b
1 of 15
No
No
Drer\klf17
1 of 15
No
No
Drer\sp1
1 of 15
No
No
Drer\sp3a
1 of 15
No
No
Drer\sp3b
1 of 15
No
No
Drer\sp5b
1 of 15
No
No
Drer\sp5l
1 of 15
No
No
Drer\wt1a
1 of 15
No
Yes
Drer\wt1b
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\klf-2
7 of 15
Yes
Yes
Cele\klf-1
4 of 15
No
Yes
Cele\sptf-2
2 of 15
No
No
Cele\hbl-1
1 of 15
No
No
Cele\klf-3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\FZF1
2 of 15
Yes
No
Scer\SWI5
2 of 15
Yes
Yes
Scer\ACE2
1 of 15
No
Yes
Scer\COM2
1 of 15
No
Yes
Scer\CRZ1
1 of 15
No
No
Scer\RGM1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ace2
1 of 12
Yes
Yes
Spom\hsr1
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190AJJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007529
Drosophila simulans
Dsim\GD29486
Drosophila sechellia
Dsec\GM14583
Drosophila erecta
Dere\GG15151
Drosophila yakuba
Dyak\GE21373
Drosophila ananassae
Dana\GF24217
Drosophila pseudoobscura pseudoobscura
Dpse\GA23797
Drosophila persimilis
Dper\GL21001
Drosophila willistoni
Dwil\GK20520
Drosophila virilis
Dvir\GJ12406
Drosophila mojavensis
Dmoj\GI12500
Drosophila grimshawi
Dgri\GH16421
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506EQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Mayetiola destructor
Hessian fly
Mdes\Mdes014761
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0N2W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002047
Bombyx mori
Silkmoth
Bmor\BGIBMGA000499
Bombyx mori
Silkmoth
Bmor\BGIBMGA011419
Danaus plexippus
Monarch butterfly
Dple\DPOGS204925-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206047-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203386-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL003963
Heliconius melpomene
Postman butterfly
Hmel\HMEL002817
Apis florea
Little honeybee
Aflo\2688683860
Apis florea
Little honeybee
Aflo\4198523524
Apis florea
Little honeybee
Aflo\2819733380
Apis mellifera
Western honey bee
Amel\GB52090
Apis mellifera
Western honey bee
Amel\GB52133
Apis mellifera
Western honey bee
Amel\GB45842
Apis mellifera
Western honey bee
Amel\GB45841
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22461
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16234
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25748
Bombus terrestris
Buff-tailed bumblebee
Bter\15209668
Bombus terrestris
Buff-tailed bumblebee
Bter\15213335
Bombus terrestris
Buff-tailed bumblebee
Bter\15215589
Linepithema humile
Argentine ant
Lhum\LH25688
Linepithema humile
Argentine ant
Lhum\LH23971
Linepithema humile
Argentine ant
Lhum\LH17698
Linepithema humile
Argentine ant
Lhum\LH17368
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00236c
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0009ce
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001ee0
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012904
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG017040
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014890
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08410
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09845
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09844
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12304
Tribolium castaneum
Red flour beetle
Tcas\TC033960
Tribolium castaneum
Red flour beetle
Tcas\TC032433
Tribolium castaneum
Red flour beetle
Tcas\TC032606
Pediculus humanus
Human body louse
Phum\PHUM236000
Pediculus humanus
Human body louse
Phum\PHUM207190
Pediculus humanus
Human body louse
Phum\PHUM484340
Pediculus humanus
Human body louse
Phum\PHUM483510
Pediculus humanus
Human body louse
Phum\PHUM483400
Pediculus humanus
Human body louse
Phum\PHUM206780
Pediculus humanus
Human body louse
Phum\PHUM403940
Rhodnius prolixus
Kissing bug
Rpro\RPRC013234
Rhodnius prolixus
Kissing bug
Rpro\RPRC002307
Cimex lectularius
Bed bug
Clec\CLEC005259
Cimex lectularius
Bed bug
Clec\CLEC000374
Cimex lectularius
Bed bug
Clec\CLEC010043
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI34996
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI23999
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000624
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06577
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06576
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06582
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05782
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0NBV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007231
Strigamia maritima
European centipede
Smar\SMAR000131
Strigamia maritima
European centipede
Smar\SMAR008306
Strigamia maritima
European centipede
Smar\SMAR002408
Ixodes scapularis
Black-legged tick
Isca\ISCW016993
Ixodes scapularis
Black-legged tick
Isca\ISCW016565
Ixodes scapularis
Black-legged tick
Isca\ISCW018441
Ixodes scapularis
Black-legged tick
Isca\ISCW016130
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71234.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67703.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61425.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59632.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72243.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g01330
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g03720
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g00210
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g04760
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g11740
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_27999
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_243802
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48391
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_310992
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_55379
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_51551
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G1BN0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klf2/4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klf13
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klf7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klf3/8/12
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klf11
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006082
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000014976
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001563
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000014590
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000012142
Gallus gallus
Domestic chicken
Ggal\LOC422310
Gallus gallus
Domestic chicken
Ggal\KLF12
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028383
Gallus gallus
Domestic chicken
Ggal\KLF6
Gallus gallus
Domestic chicken
Ggal\KLF10
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000373
Gallus gallus
Domestic chicken
Ggal\KLF2
Gallus gallus
Domestic chicken
Ggal\KLF7
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026928
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027374
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026590
Gallus gallus
Domestic chicken
Ggal\KLF11
Gallus gallus
Domestic chicken
Ggal\KLF3
Gallus gallus
Domestic chicken
Ggal\KLF5
Gallus gallus
Domestic chicken
Ggal\KLF1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (17)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG42741
6 of 10
luna
4 of 10
btd
3 of 10
Sp1
3 of 10
cbt
2 of 10
Klf15
2 of 10
Spps
2 of 10
Cf2
1 of 10
CG3065
1 of 10
CG4360
1 of 10
CG10462
1 of 10
hkb
1 of 10
l(3)neo38
1 of 10
mamo
1 of 10
odd
1 of 10
sr
1 of 10
zf30C
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    KLF5; Kruppel like factor 5
    4 of 15
    602903
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        dar1 - AOX1
        two hybrid
        (Hu et al., 2017.6.13)
        dar1 - CG30324
        two hybrid
        (Hu et al., 2017.6.13)
        dar1 - CG31955
        two hybrid array
        (Shokri et al., 2019)
        dar1 - Mst84Dd
        two hybrid
        (Hu et al., 2017.6.13)
        dar1 - Mst87F
        two hybrid
        (Hu et al., 2017.6.13)
        dar1 - Sgt
        two hybrid
        (Hu et al., 2017.6.13)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        dar1
        suppressible
        nudC
        (Wang et al., 2015)
        dar1
        suppressible
        nudE
        (Wang et al., 2015)
        dar1
        suppressible
        sw
        (Wang et al., 2015)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        kn
        suppressible
        dar1
        (Ye et al., 2011)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map

        3-8

        Cytogenetic map
        63E5-63E6
        Sequence location
        3L:3,626,352..3,653,442 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        63E5-63E6
        Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-8

        (FlyBase, 2016)

        3-7.2

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (11)
        Genomic Clones (29)
        cDNA Clones (2)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Ye et al., 2011)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of

            Source for merge of: dar1 CG12029 l(3)63Ed

            (Ye et al., 2011)
            Additional comments
            Other Comments

            dar1 belongs to the Kruppel (Kr)-like factor family.

            (Ye et al., 2011)

            Mutants have reduced dendritic arbors but normal axonal growth in the class IV dendritic arborization (da) neurons.

            (Ye et al., 2007)

            Discussed during genetic analysis of the Ras64B-Rop region.

            (Harrison et al., 1995)
            Origin and Etymology
            Discoverer
            Etymology
            Identification

            In a screen for mutations affecting dendritic and/or axonal development in the class IV dendritic arborization (da) neurons. 2 alleles of dar1 have been isolated.

            (Ye et al., 2007)
            External Crossreferences and Linkouts ( 17 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            Synonyms and Secondary IDs (7)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (40)