Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Two enzyme activities are encoded by Mocs1. MOCS1B orthologous activity is encoded by the final exon and is produced as a bifunctional protein from transcripts using the downstream splice acceptor site for the final intron, which bypasses the stop codon. All transcripts encode the MOCS1A orthologous activity. (FBrf0131302)
Gene model reviewed during 5.46
None of the polypeptides share 100% sequence identity.
Isoform Mocs1a and isoform Mocs1b probably form a heterooligomer.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mocs1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mocs1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Mocs1 CG7858
Source for merge of: Mocs1 lxd
"lxd" probably corresponds to "Mocs1". Mutations in "lxd" have only 10% of the normal molybdenum cofactor activity (FBrf0043787) and "Mocs1" is predicted to encode a protein with a high degree of similarity to molybdenum-binding proteins.
Source for identity of Mocs1 CG7858 was sequence comparison ( date:000509 ).
All alleles noncomplementing.
Expression is enriched in embryonic gonads.
The Mocs1 locus produces a bicistronic transcript containing separate, adjacent open reading frames ("Mocs1A" and "Mocs1B" proteins) and also produces a splice form that fuses these ORFs to produce a single, fused "Mocs1A-B" protein.
Adenine resistant lines were generated with diminished xanthine dehydrogenase activity.
Aldehyde oxidase deficient mutants of lxd have appreciable levels of aldehyde oxidase cross-reacting material in both larval haemolymph and adult extracts.
Rocket immunoelectrophoresis was used to estimate xanthine dehydrogenase cross-reacting material (XDH-CRM). Results show high levels of XDH-CRM in mutant lxd flies, this suggests that the primary effects of the mutant gene is on the function of XDH protein rather than its accumulation.