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Gene Dmel\Mocs1

General Information
Symbol	Dmel\Mocs1	Species	D. melanogaster
Name	Molybdenum cofactor synthesis 1 ortholog	Annotation symbol	CG33048
Feature type	protein_coding_gene	FlyBase ID	FBgn0263241
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	mocsI, CG7858
Genomic Location
Chromosome (arm)	3L	Recombination map	3-34.5
Cytogenetic map	68A4-68A5	Sequence location	3L:11,063,626..11,066,448 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Molybdenum cofactor synthesis 1 ortholog is referred to in FlyBase by the symbol Dmel\Mocs1 (CG33048, FBgn0263241). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: 4 iron, 4 sulfur cluster binding; metal ion binding; catalytic activity. Based on sequence similarity, it is predicted to be involved in the biological process: Mo-molybdopterin cofactor biosynthetic process. 25 alleles are reported. The phenotype of these alleles is annotated with: pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Aldolase-type TIM barrel; Elongator protein 3/MiaB/NifB; MoaA/nifB/pqqE, iron-sulphur binding, conserved site; Molybdenum cofactor biosynthesis C; Molybdenum cofactor biosynthesis C, bacterial-type; Molybdenum cofactor biosynthesis protein A; Molybdenum cofactor synthesis C-terminal; Molybdopterin cofactor biosynthesis C (MoaC) domain; Radical SAM. Gene sequence location is 3L:11063626..11066448.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	lxd: low xanthine dehydrogenase Homozygotes exhibit little or no activity of four molybdenum hydroxylases, i.e., 25% normal levels of xanthine dehydrogenase (XDH) activity (Keller and Glassman), 12% normal aldehyde oxidase (AO) activity (Courtright, 1967, Genetics 57: 25-39), no pyridoxal oxidase (PO) (Keller and Glassman) and 5-10% normal levels of sulfite oxidase (SO) (Bogaart and Bernini, 1981, Biochem. Genet. 19: 929-46) (2% according to Schott, Baldwin and Finnerty). Residual activity of AO and XDH thermolabile (Schott, Baldwin and Finnerty). These reduced activities not accompanied by comparable reductions in the levels of crossreacting material (CRM) indicating that the structural genes for the enzymes are still being expressed (Glassman, Shinoda, Duke, and Collins, 1968, Ann. N.Y. Acad. Sci. 151: 263-73; Browder, Wilkes, and Tucker, 1982, Biochem. Genet. 20: 111-24 and 125-32; Warner, Watts, and Finnerty, 1980, Mol. Gen. Genet. 180: 449-53). lxd+ postulated to be involved in production of an enzyme cofactor (Glassman et al., 1968); dietary molybdenum shown to increase specific activity of AO and XDH in flies homozygous for some, but not all, lxd alleles (Duke, Rushing, and Glassman, 1975, Biochem. Genet. 13: 53-64). lxd homozygotes shown to have only 10% normal molybdenum cofactor activity (Schott, Baldwin, and Finnerty). Tungsten, a known antagonist of molybdemum cofactor, shown to mimic lxd in wild type (Warner and Finnerty, 1981, Mol. Gen. Genet. 184: 92-96) and to exacerbate the effects of lxd (Bentley, Williamson, and Oliver, 1981, Can. J. Genet. Cytol. 23: 597-609). The maternal effects of cin and mal are suppressed in cin lxd and mal lxd offspring of cin/+ and mal/+ mothers respectively; dietary molybdenum counteracts the suppression; lxd also suppresses complementation between various pairs of partially complementing mal alleles (Courtright, 1975, Mol. Gen. Genet. 142: 231-38). Dietary tungsten produces brown eye color in lxd flies, which normally have red eyes; used to select new lxd alleles (Bentley, Williamson, and Oliver); allopurinol used in the same way (Schott, Baldwin, and Finnerty).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 68A4-68A5   Limits computationally determined from genome sequence between P{PZ}klu09036 and P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4; Left limit from inclusion within Df(3L)lxd8 (FBrf0044475) Right limit from non-inclusion within Df(3L)h76 (FBrf0044430)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-34.5 (Schott et al., 1986) 3-33 (Keller and Glassman, 1964)
Left of (cM)	sens (Keller and Glassman, 1964) Sod rs (Schott et al., 1986)
Right of (cM)	cur (Schott et al., 1986) se (Keller and Glassman, 1964)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mocs1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Gene model reviewed during 5.45 Low-frequency RNA-Seq exon junction(s) not annotated. Two enzyme activities are encoded by @Mocs1@. MOCS1B orthologous activity is encoded by the final exon and is produced as a bifunctional protein from transcripts using the downstream splice acceptor site for the final intron, which bypasses the stop codon. All transcripts encode the MOCS1A orthologous activity. (FBrf0131302)
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mocs1-RA FBtr0076204  NM_176317   2232   385 Mocs1-RC FBtr0076205  NM_176316   2178   565
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mocs1-PA   FBpp0075934   43.7   385   9.92     NP_788495   AAF50108 Mocs1-PC   FBpp0075935   63.3   565   9.53     NP_788494   AAN11896
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • MoaA/nifB/pqqE, iron-sulphur binding, conserved site (IPR000385) Molybdopterin cofactor biosynthesis C (MoaC) domain (IPR002820) Elongator protein 3/MiaB/NifB (IPR006638) Radical SAM (IPR007197) Molybdenum cofactor synthesis C-terminal (IPR010505) Molybdenum cofactor biosynthesis protein A (IPR013483) Aldolase-type TIM barrel (IPR013785) Molybdenum cofactor biosynthesis C (IPR023045) Molybdenum cofactor biosynthesis C, bacterial-type (IPR023046)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50108   AE014296 AAN11896   AC006562   AC096692   AF214021 AAF67855   AF214021 AAF67856   AF214027 AAF67862   AI293256   AY077688 AAL87446   BP553327   BT024947   CO187436   CO309045   CO321198   CZ489890   EC089175   EC229525   EL884340   EL884459   EL884588   GH851983
UniProtKB/Swiss-Prot	Q8IQF1
UniProtKB/TrEMBL	Q8I688 Q9NIG2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    2 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    14 digestive system, 4-day adult    14 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    11 ovary, mated 4-day female    10 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    2 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    14 digestive system, 4-day adult    14 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    11 ovary, mated 4-day female    10 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    2 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    14 digestive system, 4-day adult    14 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    11 ovary, mated 4-day female    10 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    2 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    14 digestive system, 4-day adult    14 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    11 ovary, mated 4-day female    10 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    2 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    14 digestive system, 4-day adult    14 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    11 ovary, mated 4-day female    10 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    2 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    14 digestive system, 4-day adult    14 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    11 ovary, mated 4-day female    10 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    2 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    14 digestive system, 4-day adult    14 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    11 ovary, mated 4-day female    10 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    2 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    14 digestive system, 4-day adult    14 digestive system, 20-day adult    15 fat body, larvae L3 wandering    4 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    11 ovary, mated 4-day female    10 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    14 larva L1    11 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    10 embryonic 1182-4H    10 embryonic GM2    14 embryonic Kc167    29 embryonic S1    10 embryonic S3    4 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    7 ovary fGS/OSS    4 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    10 embryonic 1182-4H    10 embryonic GM2    14 embryonic Kc167  (29) embryonic S1    10 embryonic S3    4 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    7 ovary fGS/OSS    4 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    10 embryonic 1182-4H    10 embryonic GM2    14 embryonic Kc167    29 embryonic S1    10 embryonic S3    4 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    7 ovary fGS/OSS    4 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    10 embryonic 1182-4H    10 embryonic GM2    14 embryonic Kc167    29 embryonic S1    10 embryonic S3    4 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    7 ovary fGS/OSS    4 ovary OSC    5 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    10 embryonic 1182-4H    10 embryonic GM2    14 embryonic Kc167    29 embryonic S1    10 embryonic S3    4 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    7 ovary fGS/OSS    4 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    10 embryonic 1182-4H    10 embryonic GM2    14 embryonic Kc167  29 embryonic S1    10 embryonic S3    4 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    7 ovary fGS/OSS    4 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    10 embryonic 1182-4H    10 embryonic GM2    14 embryonic Kc167    29 embryonic S1    10 embryonic S3    4 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    7 ovary fGS/OSS    4 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    10 embryonic 1182-4H    10 embryonic GM2    14 embryonic Kc167    29 embryonic S1    10 embryonic S3    4 leg disc CME L1    13 wing disc CME-W2    16 wing disc ML-DmD8    6 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    7 ovary fGS/OSS    4 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_20 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts	BDGP expression data • IP15954
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Mocs13b Mocs110 Mocs111 Mocs112 Mocs114 Mocs1ck viable Mocs11 Mocs14 Mocs15 Mocs17 Mocs113 Mocs116 Other Phenotypes Allele eye color defective | recessive Mocs11 Phenotype manifest in Allele pigment cell Mocs11
Classical Alleles ( 22 )
For All Classical Alleles Show
Allele of Mocs1 Class Mutagen Stocks Known lesion Mocs11 spontaneous 1 -- Mocs1d03517 1 -- Mocs1f03019 1 -- Mocs110 ethyl methanesulfonate 0 -- Mocs111 ethyl methanesulfonate 0 -- Mocs112 ethyl methanesulfonate 0 -- Mocs113 ethyl methanesulfonate 0 -- Mocs114 ethyl methanesulfonate 0 -- Mocs116 ethyl methanesulfonate 0 Yes Mocs12a ethyl methanesulfonate 0 -- Mocs13a ethyl methanesulfonate 0 -- Mocs13b X ray 0 -- Mocs14 X ray 0 Yes Mocs15 ethyl methanesulfonate 0 -- Mocs17 X ray 0 Yes Mocs1c spontaneous 0 -- Mocs1cb spontaneous natural population 0 -- Mocs1ck X ray 0 -- Mocs1d spontaneous 0 -- Mocs1f07115 piggyBac transposase 0 -- Mocs1h9 0 Yes Mocs1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mocs1 Class Mutagen Stocks Known lesion Mocs1GL01549 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mocs1GD12495 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Mocs1NIG.7858R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(3L)h9 (Zhang et al., 2003)
Disrupted in	Df(3L)h1 (Campbell et al., 1986) Df(3L)h5 (Campbell et al., 1986) Df(3L)h8 (Campbell et al., 1986) Df(3L)h9 (Staveley et al., 1991, Campbell et al., 1986) Df(3L)kluXR19 (Makunin et al., 2002) Df(3L)lxd2 (Crosby and Meyerowitz, 1986, Schott et al., 1986) Df(3L)lxd6 (Crosby and Meyerowitz, 1986, Schott et al., 1986) Df(3L)lxd8 (Makunin et al., 2002, Crosby and Meyerowitz, 1986, Staveley et al., 1991, Schott et al., 1986) Df(3L)lxd9 (Makunin et al., 2002, Crosby and Meyerowitz, 1986, Schott et al., 1986, Campbell et al., 1986, Staveley et al., 1991) Df(3L)lxd15 (Schott et al., 1986) Df(3L)rl-3 (Makunin et al., 2002) Df(3L)rl-5 (Makunin et al., 2002) Df(3L)vin2 (Schott et al., 1986) Df(3L)vin5 (Schott et al., 1986, Crosby and Meyerowitz, 1986) Df(3L)vin66 (Schott et al., 1986)
Not disrupted in	Df(3L)h2 (Campbell et al., 1986, Staveley et al., 1991) Df(3L)h76 (Makunin et al., 2002, Staveley et al., 1991, Campbell et al., 1986) Df(3L)l3 (Campbell et al., 1986, Staveley et al., 1991) Df(3L)rr-2 (Makunin et al., 2002) Df(3L)rr-6 (Makunin et al., 2002) Df(3L)rr-9 (Makunin et al., 2002) Df(3L)vin3 (Crosby and Meyerowitz, 1986) Df(3L)vin4 (Crosby and Meyerowitz, 1986, Schott et al., 1986) Df(3L)vin6 (Crosby and Meyerowitz, 1986) Df(3L)vin7 (Crosby and Meyerowitz, 1986) Df(3L)X61 (Staveley et al., 1991) Df(3L)X66 (Staveley et al., 1991)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12495} NA P{NIG.7858R} NA P{TRiP.GL01549} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP1155 NA P{EP}EP3688 NA P{XP}Mocs1d03517 NA miscellaneous insertions P{CaryP}attP2 NA P{PTT-GB}CB04106 NA P{SUPor-P}KG05225 NA PBac{WH}Mocs1f03019 NA PBac{WH}Mocs1f07115 NA insertion of enhancer trap binary system P{GAL4}beluy1 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
4 iron, 4 sulfur cluster binding inferred from electronic annotation with InterPro:IPR000385, InterPro:IPR010505 (FlyBase Curators et al., 2004-) catalytic activity inferred from electronic annotation with InterPro:IPR000385, InterPro:IPR006638, InterPro:IPR007197, InterPro:IPR013785 (FlyBase Curators et al., 2004-) metal ion binding inferred from electronic annotation with InterPro:IPR000385, InterPro:IPR013483 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
Mo-molybdopterin cofactor biosynthetic process inferred from sequence or structural similarity with EMBL:AF034374 (FlyBase Genome Annotators, 2002-2003) non-traceable author statement (Gray, 1999.12.10, Tahoe, 2002.1.30)
Cellular Component
CV term Evidence References
molybdopterin synthase complex inferred from electronic annotation with InterPro:IPR010505 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Mocs1 - CG11109 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mocs1 - CG18004 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Mocs1 - CG5577 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mocs1 allele Gene References lxdunspecified cin (Courtright, 1975) mal (Courtright, 1975)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0263241
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6J9NJV Dipteran inclusive ortholog search EOG67D9QR Insect inclusive ortholog search EOG60CGCK Arthropod inclusive ortholog search EOG6SXKV2 Metazoa inclusive ortholog search EOG6F554P
Orthologs in Drosophila Species (EOG6J9NJV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mocs1     Drosophila simulans   Dsim\GD14280 Y   Drosophila sechellia   Dsec\GM25246 Y   Drosophila erecta   Dere\GG15474 Y   Drosophila yakuba   Dyak\GE21783 Y   Drosophila ananassae   Dana\GF10488 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17248 Y   Drosophila persimilis   Dper\GL16733 Y   Drosophila willistoni   Dwil\GK11297 Y   Drosophila virilis   Dvir\GJ13645 Y   Drosophila mojavensis   Dmoj\GI11448 Y   Drosophila grimshawi   Dgri\GH14930 Y
Orthologs in non-Drosophila Dipterans (EOG67D9QR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000126   Anopheles gambiae Malaria mosquito  Agam\AGAP006072   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006606
Orthologs in non-Dipteran Insects (EOG60CGCK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55466   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014284   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17878   Atta cephalotes Leafcutter ant  Acep\ACEP21548   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14930   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21314   Linepithema humile Argentine ant  Lhum\LH15814   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20625   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20624   Acyrthosiphon pisum Pea aphid  Apim\ACYPI067455   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006449   Bombyx mori Silkmoth  Bmor\BGIBMGA009187   Pediculus humanus Human body louse  Phum\PHUM338330   Tribolium castaneum Red flour beetle  Tcas\TC000610
Orthologs in non-Insect Arthropods (EOG6SXKV2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_305942   Daphnia pulex Water flea  Dpux\Cmc1   Daphnia pulex Water flea  Dpux\Cytb   Ixodes scapularis Deer tick  Isca\ISCW010699   Ixodes scapularis Deer tick  Isca\ISCW024228
Orthologs in non-Arthropod Metazoa (EOG6F554P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F49E2.1   Caenorhabditis elegans Nematode  Cele\F49H6.5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010557gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022414gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009491gn   Danio rerio Zebrafish  Drer\ENSDARG00000078479   Xenopus tropicalis Western clawed frog  Xtro\mocs1   Gallus gallus Domestic chicken  Ggal\MOCS1   Mus musculus House mouse  Mmus\Mocs1   Rattus norvegicus Norway rat  Rnor\Mocs1   Homo sapiens Human  Hsap\MOCS1
Human Orthologs (1)
Gene OMIM HGNC Hsap\MOCS1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14280 Drosophila sechellia Dsec\GM25246 Drosophila erecta Dere\GG15474 Drosophila yakuba Dyak\GE21783 Drosophila ananassae Dana\GF10488 Drosophila pseudoobscura pseudoobscura Dpse\GA17248 Drosophila persimilis Dper\GL16733 Drosophila willistoni Dwil\GK11297 Drosophila virilis Dvir\GJ13645 Drosophila mojavensis Dmoj\GI11448 Drosophila grimshawi Dgri\GH14930
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	581 ru1 Mocs11 by1 43204 y1 sc* v1; P{TRiP.GL01549}attP40
Harvard	- P{XP}Mocs1d03517 - PBac{WH}Mocs1f03019
Genomic Clones ( 1 )
	BACR48O03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP15954
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH16403
Other clones	156824 CK01.34C.C3 EK029310 EK259958 EK290464 FGM223H01 IP15654 IP15754 IP15854 RP003004927
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39238
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mocs1 CG7858 (FlyBase, 1996-)
Source for database merge of	Source for merge of: Mocs1 lxd (FlyBase, 1992-)
Additional comments	"lxd" probably corresponds to "Mocs1". Mutations in "lxd" have only 10% of the normal molybdenum cofactor activity (FBrf0043787) and "Mocs1" is predicted to encode a protein with a high degree of similarity to molybdenum-binding proteins. (Makunin et al., 2002) Source for identity of Mocs1 CG7858 was sequence comparison (date:000509). (FlyBase, 1996-) All alleles noncomplementing.
Other Comments
	Expression is enriched in embryonic gonads. (Shigenobu et al., 2006) The Mocs1 locus produces a bicistronic transcript containing separate, adjacent open reading frames ("Mocs1A" and "Mocs1B" proteins) and also produces a splice form that fuses these ORFs to produce a single, fused "Mocs1A-B" protein. (Gray, 2000.8.1) Adenine resistant lines were generated with diminished xanthine dehydrogenase activity. (Ho et al., 1992) Mutations in lxd simultaneously effect the activity of four molybdoenzymes; ry, Aldox-1, Po and sulfite oxidase. (Schott et al., 1986) Aldehyde oxidase deficient mutants of lxd have appreciable levels of aldehyde oxidase cross-reacting material in both larval haemolymph and adult extracts. (Browder et al., 1982) Rocket immunoelectrophoresis was used to estimate xanthine dehydrogenase cross-reacting material (XDH-CRM). Results show high levels of XDH-CRM in mutant lxd flies, this suggests that the primary effects of the mutant gene is on the function of XDH protein rather than its accumulation. (Browder et al., 1982) Mutations of lxd exhibit the reduced levels of sulfite oxidase activity compared to wild-type flies. Reduced levels of xanthine dehydrogenase, aldehyde oxidase and alcohol dehydrogenase are also present. (Bogaart and Bernini, 1981)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_176316 NM_176317 RefSeq (Proteins) • NP_788494 NP_788495 DDBJ / EMBL / GenBank • AAF50108 AAF50108.2 AAF67855 AAF67856 AAF67862 AAL87446 AAN11896 AAN11896.1 AAN11897 AAN11897.1 AC006562 AC096692 AF214021 AF214027 AI293256 AY077688 CZ489890 Entrez Gene - A searchable database of RefSeq genes. • 39238 UniProtKB/Swiss-Prot • Q8IQF1 UniProtKB/TrEMBL • Q8I688 Q9NIG2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • MoaA/nifB/pqqE, iron-sulphur binding, conserved site (IPR000385) Molybdopterin cofactor biosynthesis C (MoaC) domain (IPR002820) Elongator protein 3/MiaB/NifB (IPR006638) Radical SAM (IPR007197) Molybdenum cofactor synthesis C-terminal (IPR010505) Molybdenum cofactor biosynthesis protein A (IPR013483) Aldolase-type TIM barrel (IPR013785) Molybdenum cofactor biosynthesis C (IPR023045) Molybdenum cofactor biosynthesis C, bacterial-type (IPR023046) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP15954
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0263241 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39238
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG7858 (Makunin et al., 2002, Zhang et al., 2003, ) CG33048 (Zhang et al., 2003, Ni et al., 2010.12.1) lxd   Mocs1 (Ruden et al., 2009, Shigenobu et al., 2006, Girard et al., 2006, Buszczak et al., 2007, Japanese National Institute of Genetics, 2012.5.21) Mocs1A   MOCS1A (Gray and Nicholls, 2000) Mocs1A-B   Mocs1B   MOCS1B (Gray and Nicholls, 2000) mocsI (Makunin et al., 2002) MocsI (Markstein et al., 2008) MOCSI (Gray, 2000.8.1) Mosc1A+Mosc1B (Misra et al., 2002)
Name Synonym	low xanthine dehydrogenase   Mocs1   Molybdenum cofactor synthesis 1 ortholog
Secondary FlyBase IDs
	FBgn0002572 FBgn0036122 FBgn0063910 FBgn0063911 FBgn0063912
References ( 53 )
Generate a list of	All references relating to this gene ( 53 )
List References by type	Research paper  ( 29 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 3 ) FlyBase analysis  ( 4 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 2 ) Book  ( 1 )
Recent research papers (0)
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Recent reviews (0)
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