FB2025_01 , released February 20, 2025
Gene: Dmel\Mocs1
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General Information
Symbol
Dmel\Mocs1
Species
D. melanogaster
Name
Molybdenum cofactor synthesis 1
Annotation Symbol
CG33048
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263241
Gene Model Status
Current
Stock Availability
10 publicly available
Enzyme Name (EC)
GTP 3',8-cyclase (4.1.99.22)
cyclic pyranopterin monophosphate synthase (4.6.1.17)
Gene Summary
Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP. (UniProt, Q8IQF1)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

lxd

Key Links
Genomic Location
Cytogenetic map
68A4-68A4
Sequence location
Recombination map
3-34
RefSeq locus
NT_037436 REGION:11070526..11073348
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables 4 iron, 4 sulfur cluster binding
inferred from electronic annotation with InterPro:IPR000385, InterPro:IPR010505
(InterPro Project Members, 2004-)
enables catalytic activity
inferred from electronic annotation with InterPro:IPR000385, InterPro:IPR006638, InterPro:IPR007197
(InterPro Project Members, 2004-)
enables cyclic pyranopterin monophosphate synthase activity
inferred from sequence or structural similarity with UniProtKB:Q9NZB8-5
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000539172
(GO Reference Genome Project, 2011-)
enables GTP 3',8'-cyclase activity
inferred from biological aspect of ancestor with PANTHER:PTN000539172
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:Q9NZB8-5
(Gene Ontology Curators, 2002-)
enables metal ion binding
inferred from electronic annotation with InterPro:IPR000385, InterPro:IPR013483
(InterPro Project Members, 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in inter-male aggressive behavior
inferred from mutant phenotype
(Ramin et al., 2019)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in iron-sulfur cluster assembly
traceable author statement
(Marelja et al., 2018)
involved_in Mo-molybdopterin cofactor biosynthetic process
inferred from sequence or structural similarity with UniProtKB:Q9NZB8
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000539172
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR002820, InterPro:IPR023045, InterPro:IPR036522
(InterPro Project Members, 2004-)
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR036522
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in mitochondrial matrix
traceable author statement
(Marelja et al., 2018)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
cyclic pyranopterin monophosphate synthase activity
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate (4.6.1.17)
RHEA 49580: GTP 3',8'-cyclase activity
GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+) (4.1.99.22)
RHEA 49576:
Summaries
Gene Group (FlyBase)
GTP 3',8'-CYCLASES -
GTP 3',8'-cyclases catalyze the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. (Adapted from PMID:25697423).
CYCLIC PYRANOPTERIN MONOPHOSPHATE SYNTHASES -
Cyclic pyranopterin monophosphate synthases catalyze the synthesis of cyclic pyranopterin phosphate with the release of pyrophosphate. (Adapted from FBrf0238856).
Protein Function (UniProtKB)
Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.
(UniProt, Q8IQF1)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
lxd: low xanthine dehydrogenase
Homozygotes exhibit little or no activity of four molybdenum hydroxylases, i.e., 25% normal levels of xanthine dehydrogenase (XDH) activity (Keller and Glassman), 12% normal aldehyde oxidase (AO) activity (Courtright, 1967, Genetics 57: 25-39), no pyridoxal oxidase (PO) (Keller and Glassman) and 5-10% normal levels of sulfite oxidase (SO) (Bogaart and Bernini, 1981, Biochem. Genet. 19: 929-46) (2% according to Schott, Baldwin and Finnerty). Residual activity of AO and XDH thermolabile (Schott, Baldwin and Finnerty). These reduced activities not accompanied by comparable reductions in the levels of crossreacting material (CRM) indicating that the structural genes for the enzymes are still being expressed (Glassman, Shinoda, Duke, and Collins, 1968, Ann. N.Y. Acad. Sci. 151: 263-73; Browder, Wilkes, and Tucker, 1982, Biochem. Genet. 20: 111-24 and 125-32; Warner, Watts, and Finnerty, 1980, Mol. Gen. Genet. 180: 449-53). lxd+ postulated to be involved in production of an enzyme cofactor (Glassman et al., 1968); dietary molybdenum shown to increase specific activity of AO and XDH in flies homozygous for some, but not all, lxd alleles (Duke, Rushing, and Glassman, 1975, Biochem. Genet. 13: 53-64). lxd homozygotes shown to have only 10% normal molybdenum cofactor activity (Schott, Baldwin, and Finnerty). Tungsten, a known antagonist of molybdemum cofactor, shown to mimic lxd in wild type (Warner and Finnerty, 1981, Mol. Gen. Genet. 184: 92-96) and to exacerbate the effects of lxd (Bentley, Williamson, and Oliver, 1981, Can. J. Genet. Cytol. 23: 597-609). The maternal effects of cin and mal are suppressed in cin lxd and mal lxd offspring of cin/+ and mal/+ mothers respectively; dietary molybdenum counteracts the suppression; lxd also suppresses complementation between various pairs of partially complementing mal alleles (Courtright, 1975, Mol. Gen. Genet. 142: 231-38). Dietary tungsten produces brown eye color in lxd flies, which normally have red eyes; used to select new lxd alleles (Bentley, Williamson, and Oliver); allopurinol used in the same way (Schott, Baldwin, and Finnerty).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Mocs1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8IQF1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Two enzyme activities are encoded by Mocs1. MOCS1B orthologous activity is encoded by the final exon and is produced as a bifunctional protein from transcripts using the downstream splice acceptor site for the final intron, which bypasses the stop codon. All transcripts encode the MOCS1A orthologous activity. (FBrf0131302)

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mocs1-RA
FBtr0076204
NM_176317
2232
385
Mocs1-RC
FBtr0076205
NM_176316
2178
565
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Mocs1-PA
FBpp0075934
43.7
385
9.92
NP_788495
AAF50108
Mocs1-PC
FBpp0075935
63.3
565
9.53
Q8IQF1
NP_788494
AAN11896
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Isoform Mocs1a and isoform Mocs1b probably form a heterooligomer.

(UniProt, Q8IQF1)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mocs1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.26

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
wing disc
(Organista et al., 2015)
adult stage
adult brain | restricted
(Ramin et al., 2019)
superior medial protocerebrum | intense
(Ramin et al., 2019)
adult antennal lobe | intense
(Ramin et al., 2019)
adult gnathal ganglion | intense
(Ramin et al., 2019)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Mocs1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 23 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mocs1
Transgenic constructs containing regulatory region of Mocs1
Aberrations (Deficiencies and Duplications) ( 27 )
Inferred from experimentation ( 27 )
Gene partially disrupted in
Df(3L)h9
(Zhang et al., 2003)
Gene disrupted in
Df(3L)h1
(Campbell et al., 1986)
Df(3L)h5
(Campbell et al., 1986)
Df(3L)h8
(Campbell et al., 1986)
Df(3L)h9
(Staveley et al., 1991, Campbell et al., 1986)
Df(3L)kluXR19
(Makunin et al., 2002)
Df(3L)lxd2
(Crosby and Meyerowitz, 1986, Schott et al., 1986)
Df(3L)lxd6
(Crosby and Meyerowitz, 1986, Schott et al., 1986)
Df(3L)lxd8
(Makunin et al., 2002, Staveley et al., 1991, Crosby and Meyerowitz, 1986, Schott et al., 1986)
Df(3L)lxd9
(Makunin et al., 2002, Staveley et al., 1991, Campbell et al., 1986, Crosby and Meyerowitz, 1986, Schott et al., 1986)
Df(3L)lxd15
(Schott et al., 1986)
Df(3L)rl-3
(Makunin et al., 2002)
Df(3L)rl-5
(Makunin et al., 2002)
Df(3L)vin2
(Schott et al., 1986)
Df(3L)vin5
(Crosby and Meyerowitz, 1986, Schott et al., 1986)
Df(3L)vin66
(Schott et al., 1986)
Gene not disrupted in
Df(3L)h2
(Staveley et al., 1991, Campbell et al., 1986)
Df(3L)h76
(Makunin et al., 2002, Staveley et al., 1991, Campbell et al., 1986)
Df(3L)l3
(Staveley et al., 1991, Campbell et al., 1986)
Df(3L)rr-2
(Makunin et al., 2002)
Df(3L)rr-6
(Makunin et al., 2002)
Df(3L)rr-9
(Makunin et al., 2002)
Df(3L)vin3
(Crosby and Meyerowitz, 1986)
Df(3L)vin4
(Crosby and Meyerowitz, 1986, Schott et al., 1986)
Df(3L)vin6
(Crosby and Meyerowitz, 1986)
Df(3L)vin7
(Crosby and Meyerowitz, 1986)
Df(3L)X61
(Staveley et al., 1991)
Df(3L)X66
(Staveley et al., 1991)
Inferred from location ( 9 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\MOCS1
12 of 14
Yes
Yes
Hsap\RSAD2
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Mocs1
14 of 14
Yes
Yes
Rnor\Rsad2
1 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Mocs1
14 of 14
Yes
Yes
Mmus\Rsad2
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\mocs1
8 of 13
Yes
Yes
Xtro\gfi1b
1 of 13
No
No
Xtro\rsad2
1 of 13
No
Yes
Danio rerio (Zebrafish) (2)
Drer\mocs1
10 of 14
Yes
Yes
Drer\rsad2
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\F49H6.5
13 of 14
Yes
Yes
Cele\moc-5
13 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP006072
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\CNX2
12 of 13
Yes
Yes
Atha\CNX3
4 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (4)
Ecol\moaA
10 of 11
Yes
Yes
Ecol\moaC
2 of 11
No
Yes
Ecol\thiH
1 of 11
No
Yes
Ecol\ydeM
1 of 11
No
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Mocs1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    MOCS1; molybdenum cofactor synthesis 1
    model of  molybdenum cofactor deficiency type A
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MOCS1; molybdenum cofactor synthesis 1
    12 of 14
    603707
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Mocs1 - CG18004
    experimental knowledge based
    (Guruharsha et al., 2011)
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    cin
    enhanceable
    Mocs1
    (Courtright, 1975)
    mal
    enhanceable
    Mocs1
    (Courtright, 1975)
    External Data
    Subunit Structure (UniProtKB)
    Isoform Mocs1a and isoform Mocs1b probably form a heterooligomer.
    (UniProt, Q8IQF1 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
    KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-34
    Cytogenetic map
    68A4-68A4
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    68A4-68A4
    Limits computationally determined from genome sequence between P{PZ}klu09036 and P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-34

    (FlyBase, 2016)

    3-28.4

    (Comeron et al., 2012)

    3-34.5

    (Schott et al., 1986)

    3-33

    (Keller and Glassman, 1964)
    Left of (cM)
    (Schott et al., 1986)
    (Keller and Glassman, 1964)
    Right of (cM)
    (Schott et al., 1986)
    (Keller and Glassman, 1964)
    Notes
    Stocks and Reagents
    Stocks (10)
    Genomic Clones (22)
    cDNA Clones (6)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          Expression is enriched in embryonic gonads.

          (Shigenobu et al., 2006)

          The Mocs1 locus produces a bicistronic transcript containing separate, adjacent open reading frames ("Mocs1A" and "Mocs1B" proteins) and also produces a splice form that fuses these ORFs to produce a single, fused "Mocs1A-B" protein.

          (Gray, 2000.8.1)

          Adenine resistant lines were generated with diminished xanthine dehydrogenase activity.

          (Ho et al., 1992)

          Mutations in lxd simultaneously effect the activity of four molybdoenzymes; ry, Aldox-1, Po and sulfite oxidase.

          (Schott et al., 1986)

          Aldehyde oxidase deficient mutants of lxd have appreciable levels of aldehyde oxidase cross-reacting material in both larval haemolymph and adult extracts.

          (Browder et al., 1982)

          Rocket immunoelectrophoresis was used to estimate xanthine dehydrogenase cross-reacting material (XDH-CRM). Results show high levels of XDH-CRM in mutant lxd flies, this suggests that the primary effects of the mutant gene is on the function of XDH protein rather than its accumulation.

          (Browder et al., 1982)

          Mutations of lxd exhibit the reduced levels of sulfite oxidase activity compared to wild-type flies. Reduced levels of xanthine dehydrogenase, aldehyde oxidase and alcohol dehydrogenase are also present.

          (Bogaart and Bernini, 1981)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: Mocs1 lxd

          (FlyBase, 1992-)
          Additional comments

          "lxd" probably corresponds to "Mocs1". Mutations in "lxd" have only 10% of the normal molybdenum cofactor activity (FBrf0043787) and "Mocs1" is predicted to encode a protein with a high degree of similarity to molybdenum-binding proteins.

          (Makunin et al., 2002)

          Source for identity of Mocs1 CG7858 was sequence comparison ( date:000509 ).

          (FlyBase, 1996-)

          All alleles noncomplementing.

          Nomenclature History
          Source for database identify of

          Source for identity of: Mocs1 CG7858

          (FlyBase, 1996-)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (18)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 64 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
          References (74)