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Gene Dmel\sel

General Information
Symbol	Dmel\sel	Species	D. melanogaster
Name	seele	Annotation symbol	CG12918
Feature type	protein_coding_gene	FlyBase ID	FBgn0263260
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	46D9-46D9	Sequence location	2R:5,938,367..5,939,672 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene seele is referred to in FlyBase by the symbol Dmel\sel (CG12918, FBgn0263260). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: polarity specification of dorsal/ventral axis; regulation of protein processing; maternal specification of dorsal/ventral axis, oocyte, germ-line encoded; regulation of protein secretion. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Domain of unknown function DUF3456. Gene sequence location is 2R:5938367..5939672.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 46D9-46D9   Limits computationally determined from genome sequence between P{lacW}Adamk13906&P{EP}Pka-R2EP2162 and P{PZ}14-3-3ζ07103
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2- (Luschnig et al., 2004)
Left of (cM)
Right of (cM)
Notes	Maps to 2R. (Luschnig et al., 2004)
Gene Model & Products
Please see the GBrowse view of Dmel\sel for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sel-RA FBtr0088433  NM_136703   1012   189
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sel-PA   FBpp0087519   21.3   189   4.32     NP_610547   AAF58856
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Domain of unknown function DUF3456 (IPR021852)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58856   AI113916   AW940363   AY094698 AAM11051   BE976329   BG640473   BI632610   BI633970   BI640532   BP543620   BP543621   BP544032   BP544033   CO183156   CO262606   CO264002   CO267694   CO272424   CO276161   CO278717   CO279676   CO289265   CO290756   CO294346   CO304276   CO313082   CO322135   CO322754   CO338478   CO339769   CZ486792   EC059000   EC060773   EC063970   EC070215   EC071489   EC074437   EC074564   EC085108   EC088345   EC198701   EC202613   EC208682   EC210583   EC232864   EC237117   EC253751   EV597783   GH942228   GH942669   GH942870   GH943141   GH943302   GH945372   GH945812   GH947232   GH947420   GH947687   GH948674   GH950463   GH950781   GH951495   GH951767   GH952055   GH952213   GH952466   GH952768   GH952787   GH953145   GH954783   GH955895   GH956169   GH956698   GH957625   GH957736   GH957820   GH957872   GH959035   GH959300   GH960119   GH963697   GH964693   GH965117   GH966469   GH968608   GH968963   GH969222   GH969769   GH971066   GH971569   GH971775   GH972362   GH973274   GH973738   GH973906   GH974821   GH974902   GH975369   GH976117   GH976443   GH977083   GH977186   GH977713   GH979024   GH980548   GH980647   GH981036   GH981658   GH983155
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JXF7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 11 -- 12   garland cell primordium   (Fisher et al., 2012) plasmatocyte primordium   (Fisher et al., 2012) Comment:reported as plasmatocytes anlage procrystal cell   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic/larval fat body   (Fisher et al., 2012) embryonic/larval garland cell   (Fisher et al., 2012) embryonic/larval salivary gland   (Fisher et al., 2012) embryonic/larval salivary gland body   (Fisher et al., 2012) plasmatocyte   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
endoplasmic reticulum inferred from direct assay (Stein et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    18 head, mated 20-day female    13 head, mated 1-day male    9 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    68 digestive system, 4-day adult    48 digestive system, 20-day adult    31 fat body, larvae L3 wandering    62 fat body, white prepupae    30 fat body, pupae P8    70 carcass, larvae L3 wandering    27 carcass, 1-day adult    19 carcass, 4-day adult    32 carcass, 20-day adult    18 ovary, virgin 4-day female    48 ovary, mated 4-day female    33 testis, mated 4-day male    46 accessory gland, mated 4-day male    190 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    18 head, mated 20-day female    13 head, mated 1-day male    9 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering  (27) salivary gland, white prepupae  (30) digestive system, larvae L3 wandering  (39) digestive system, 1-day adult  (68) digestive system, 4-day adult  (48) digestive system, 20-day adult  (31) fat body, larvae L3 wandering  (62) fat body, white prepupae  (30) fat body, pupae P8  (70) carcass, larvae L3 wandering  (27) carcass, 1-day adult    19 carcass, 4-day adult  (32) carcass, 20-day adult    18 ovary, virgin 4-day female  (48) ovary, mated 4-day female  (33) testis, mated 4-day male  (46) accessory gland, mated 4-day male  (190) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    18 head, mated 20-day female    13 head, mated 1-day male    9 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    68 digestive system, 4-day adult    48 digestive system, 20-day adult    31 fat body, larvae L3 wandering    62 fat body, white prepupae    30 fat body, pupae P8    70 carcass, larvae L3 wandering    27 carcass, 1-day adult    19 carcass, 4-day adult    32 carcass, 20-day adult    18 ovary, virgin 4-day female    48 ovary, mated 4-day female    33 testis, mated 4-day male    46 accessory gland, mated 4-day male  (190) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    18 head, mated 20-day female    13 head, mated 1-day male    9 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    68 digestive system, 4-day adult    48 digestive system, 20-day adult    31 fat body, larvae L3 wandering    62 fat body, white prepupae    30 fat body, pupae P8    70 carcass, larvae L3 wandering    27 carcass, 1-day adult    19 carcass, 4-day adult    32 carcass, 20-day adult    18 ovary, virgin 4-day female    48 ovary, mated 4-day female    33 testis, mated 4-day male    46 accessory gland, mated 4-day male    190 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    18 head, mated 20-day female    13 head, mated 1-day male    9 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    68 digestive system, 4-day adult    48 digestive system, 20-day adult    31 fat body, larvae L3 wandering    62 fat body, white prepupae    30 fat body, pupae P8    70 carcass, larvae L3 wandering    27 carcass, 1-day adult    19 carcass, 4-day adult    32 carcass, 20-day adult    18 ovary, virgin 4-day female    48 ovary, mated 4-day female    33 testis, mated 4-day male    46 accessory gland, mated 4-day male    190 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    18 head, mated 20-day female    13 head, mated 1-day male    9 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering  27 salivary gland, white prepupae  30 digestive system, larvae L3 wandering  (39) digestive system, 1-day adult  (68) digestive system, 4-day adult  (48) digestive system, 20-day adult  31 fat body, larvae L3 wandering  (62) fat body, white prepupae  30 fat body, pupae P8  (70) carcass, larvae L3 wandering  27 carcass, 1-day adult    19 carcass, 4-day adult  32 carcass, 20-day adult    18 ovary, virgin 4-day female  (48) ovary, mated 4-day female  (33) testis, mated 4-day male  (46) accessory gland, mated 4-day male  (190) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    18 head, mated 20-day female    13 head, mated 1-day male    9 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    68 digestive system, 4-day adult    48 digestive system, 20-day adult    31 fat body, larvae L3 wandering    62 fat body, white prepupae    30 fat body, pupae P8    70 carcass, larvae L3 wandering    27 carcass, 1-day adult    19 carcass, 4-day adult    32 carcass, 20-day adult    18 ovary, virgin 4-day female    48 ovary, mated 4-day female    33 testis, mated 4-day male    46 accessory gland, mated 4-day male  (190) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    16 central nervous system, pupae P8    8 head, virgin 1-day female    22 head, virgin 4-day female    11 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    18 head, mated 20-day female    13 head, mated 1-day male    9 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    68 digestive system, 4-day adult    48 digestive system, 20-day adult    31 fat body, larvae L3 wandering    62 fat body, white prepupae    30 fat body, pupae P8    70 carcass, larvae L3 wandering    27 carcass, 1-day adult    19 carcass, 4-day adult    32 carcass, 20-day adult    18 ovary, virgin 4-day female    48 ovary, mated 4-day female    33 testis, mated 4-day male    46 accessory gland, mated 4-day male    190 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    13 embryo 04-06hr    16 embryo 06-08hr    36 embryo 08-10hr    51 embryo 10-12hr    89 embryo 12-14hr    90 embryo 14-16hr    31 embryo 16-18hr    27 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    31 larva L1    49 larva L2    83 larva L3 12hr old    75 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    32 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    31 pupae 2d postWPP    35 pupae 3d postWPP    18 pupae 4d postWPP    19 adult male 01day    46 adult male 05day    35 adult male 30day    32 adult female 01day    19 adult female 05day    37 adult female 30day    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (37) embryo 02-04hr    13 embryo 04-06hr    16 embryo 06-08hr  (36) embryo 08-10hr  (51) embryo 10-12hr  (89) embryo 12-14hr  (90) embryo 14-16hr  (31) embryo 16-18hr  (27) embryo 18-20hr  26 embryo 20-22hr    24 embryo 22-24hr  (31) larva L1  (49) larva L2  (83) larva L3 12hr old  (75) larva L3 puffstage 1-2  (55) larva L3 puffstage 3-6  (34) larva L3 puffstage 7-9  (32) white prepupae new  (33) white prepupae 12hr    23 white prepupae 24hr  (31) pupae 2d postWPP  (35) pupae 3d postWPP    18 pupae 4d postWPP    19 adult male 01day  (46) adult male 05day  (35) adult male 30day  (32) adult female 01day    19 adult female 05day  (37) adult female 30day  (39) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    13 embryo 04-06hr    16 embryo 06-08hr    36 embryo 08-10hr    51 embryo 10-12hr    89 embryo 12-14hr    90 embryo 14-16hr    31 embryo 16-18hr    27 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    31 larva L1    49 larva L2    83 larva L3 12hr old    75 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    32 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    31 pupae 2d postWPP    35 pupae 3d postWPP    18 pupae 4d postWPP    19 adult male 01day    46 adult male 05day    35 adult male 30day    32 adult female 01day    19 adult female 05day    37 adult female 30day    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    13 embryo 04-06hr    16 embryo 06-08hr    36 embryo 08-10hr    51 embryo 10-12hr    89 embryo 12-14hr    90 embryo 14-16hr    31 embryo 16-18hr    27 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    31 larva L1    49 larva L2    83 larva L3 12hr old    75 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    32 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    31 pupae 2d postWPP    35 pupae 3d postWPP    18 pupae 4d postWPP    19 adult male 01day    46 adult male 05day    35 adult male 30day    32 adult female 01day    19 adult female 05day    37 adult female 30day    39 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    13 embryo 04-06hr    16 embryo 06-08hr    36 embryo 08-10hr    51 embryo 10-12hr    89 embryo 12-14hr    90 embryo 14-16hr    31 embryo 16-18hr    27 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    31 larva L1    49 larva L2    83 larva L3 12hr old    75 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    32 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    31 pupae 2d postWPP    35 pupae 3d postWPP    18 pupae 4d postWPP    19 adult male 01day    46 adult male 05day    35 adult male 30day    32 adult female 01day    19 adult female 05day    37 adult female 30day    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (37) embryo 02-04hr    13 embryo 04-06hr    16 embryo 06-08hr  (36) embryo 08-10hr  (51) embryo 10-12hr  (89) embryo 12-14hr  (90) embryo 14-16hr  31 embryo 16-18hr  27 embryo 18-20hr  26 embryo 20-22hr    24 embryo 22-24hr  31 larva L1  (49) larva L2  (83) larva L3 12hr old  (75) larva L3 puffstage 1-2  (55) larva L3 puffstage 3-6  (34) larva L3 puffstage 7-9  32 white prepupae new  (33) white prepupae 12hr    23 white prepupae 24hr  31 pupae 2d postWPP  (35) pupae 3d postWPP    18 pupae 4d postWPP    19 adult male 01day  (46) adult male 05day  (35) adult male 30day  32 adult female 01day    19 adult female 05day  (37) adult female 30day  (39) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    13 embryo 04-06hr    16 embryo 06-08hr    36 embryo 08-10hr    51 embryo 10-12hr    89 embryo 12-14hr    90 embryo 14-16hr    31 embryo 16-18hr    27 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    31 larva L1    49 larva L2    83 larva L3 12hr old    75 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    32 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    31 pupae 2d postWPP    35 pupae 3d postWPP    18 pupae 4d postWPP    19 adult male 01day    46 adult male 05day    35 adult male 30day    32 adult female 01day    19 adult female 05day    37 adult female 30day    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    13 embryo 04-06hr    16 embryo 06-08hr    36 embryo 08-10hr    51 embryo 10-12hr    89 embryo 12-14hr    90 embryo 14-16hr    31 embryo 16-18hr    27 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    31 larva L1    49 larva L2    83 larva L3 12hr old    75 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    32 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    31 pupae 2d postWPP    35 pupae 3d postWPP    18 pupae 4d postWPP    19 adult male 01day    46 adult male 05day    35 adult male 30day    32 adult female 01day    19 adult female 05day    37 adult female 30day    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    150 Schneider line 2 Sg4    145 embryonic 1182-4H    82 embryonic GM2    78 embryonic Kc167    171 embryonic S1    37 embryonic S3    267 leg disc CME L1    180 wing disc CME-W2    57 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    18 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    66 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    109 tumorous blood cells mbn2    136 ovary fGS/OSS    10 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (150) Schneider line 2 Sg4  (145) embryonic 1182-4H  (82) embryonic GM2  (78) embryonic Kc167  (171) embryonic S1  (37) embryonic S3  (267) leg disc CME L1  (180) wing disc CME-W2  (57) wing disc ML-DmD8  (35) wing disc ML-DmD9  (30) wing disc ML-DmD16-c3  (46) wing disc ML-DmD21    18 wing disc ML-DmD32  (41) haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5  (66) mixed discs ML-DmD4-c1  (82) CNS ML-DmBG1-c1  (37) CNS ML-DmBG2-c2  (109) tumorous blood cells mbn2  (136) ovary fGS/OSS    10 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (150) Schneider line 2 Sg4  (145) embryonic 1182-4H    82 embryonic GM2    78 embryonic Kc167  (171) embryonic S1    37 embryonic S3  (267) leg disc CME L1  (180) wing disc CME-W2    57 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    18 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    66 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2  (109) tumorous blood cells mbn2  (136) ovary fGS/OSS    10 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    150 Schneider line 2 Sg4    145 embryonic 1182-4H    82 embryonic GM2    78 embryonic Kc167    171 embryonic S1    37 embryonic S3    267 leg disc CME L1    180 wing disc CME-W2    57 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    18 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    66 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    109 tumorous blood cells mbn2    136 ovary fGS/OSS    10 ovary OSC    4 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    150 Schneider line 2 Sg4    145 embryonic 1182-4H    82 embryonic GM2    78 embryonic Kc167    171 embryonic S1    37 embryonic S3    267 leg disc CME L1    180 wing disc CME-W2    57 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    18 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    66 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    109 tumorous blood cells mbn2    136 ovary fGS/OSS    10 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (150) Schneider line 2 Sg4  (145) embryonic 1182-4H  (82) embryonic GM2  (78) embryonic Kc167  (171) embryonic S1  (37) embryonic S3  (267) leg disc CME L1  (180) wing disc CME-W2  (57) wing disc ML-DmD8  (35) wing disc ML-DmD9  30 wing disc ML-DmD16-c3  (46) wing disc ML-DmD21    18 wing disc ML-DmD32  (41) haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5  (66) mixed discs ML-DmD4-c1  (82) CNS ML-DmBG1-c1  (37) CNS ML-DmBG2-c2  (109) tumorous blood cells mbn2  (136) ovary fGS/OSS    10 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (150) Schneider line 2 Sg4  (145) embryonic 1182-4H    82 embryonic GM2    78 embryonic Kc167  (171) embryonic S1    37 embryonic S3  (267) leg disc CME L1  (180) wing disc CME-W2    57 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    18 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    66 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2  109 tumorous blood cells mbn2  136 ovary fGS/OSS    10 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    150 Schneider line 2 Sg4    145 embryonic 1182-4H    82 embryonic GM2    78 embryonic Kc167    171 embryonic S1    37 embryonic S3    267 leg disc CME L1    180 wing disc CME-W2    57 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    46 wing disc ML-DmD21    18 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    66 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    109 tumorous blood cells mbn2    136 ovary fGS/OSS    10 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    57 Cadmium 50 mM 6 hrs, larvae L3    99 Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    107 Ethanol 10% 3 hrs, larvae L3    90 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    26 Rotenone 2 μg 12 hrs, larvae L3    115 Rotenone 8 μg 12 hrs, larvae L3    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult  (57) Cadmium 50 mM 6 hrs, larvae L3  (99) Cadmium 50 mM 12 hrs, larvae L3  (73) Cadmium 50 mM 48 hrs, 4-day adult  (67) Cadmium 100 mM 48 hrs, 4-day adult  (52) Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult  (45) Zinc 5 mM 12 hrs, larvae L3  (34) Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3  (107) Ethanol 10% 3 hrs, larvae L3  (90) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (37) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (27) Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  (29) Paraquat 10 mM 48 hrs, 4-day adult  26 Rotenone 2 μg 12 hrs, larvae L3  (115) Rotenone 8 μg 12 hrs, larvae L3  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    57 Cadmium 50 mM 6 hrs, larvae L3    99 Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3  107 Ethanol 10% 3 hrs, larvae L3    90 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    26 Rotenone 2 μg 12 hrs, larvae L3  (115) Rotenone 8 μg 12 hrs, larvae L3    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    57 Cadmium 50 mM 6 hrs, larvae L3    99 Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    107 Ethanol 10% 3 hrs, larvae L3    90 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    26 Rotenone 2 μg 12 hrs, larvae L3    115 Rotenone 8 μg 12 hrs, larvae L3    68 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    57 Cadmium 50 mM 6 hrs, larvae L3    99 Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    107 Ethanol 10% 3 hrs, larvae L3    90 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    26 Rotenone 2 μg 12 hrs, larvae L3    115 Rotenone 8 μg 12 hrs, larvae L3    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult  (57) Cadmium 50 mM 6 hrs, larvae L3  (99) Cadmium 50 mM 12 hrs, larvae L3  (73) Cadmium 50 mM 48 hrs, 4-day adult  (67) Cadmium 100 mM 48 hrs, 4-day adult  (52) Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult  (45) Zinc 5 mM 12 hrs, larvae L3  (34) Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3  (107) Ethanol 10% 3 hrs, larvae L3  (90) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (37) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  27 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  29 Paraquat 10 mM 48 hrs, 4-day adult  26 Rotenone 2 μg 12 hrs, larvae L3  (115) Rotenone 8 μg 12 hrs, larvae L3  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    57 Cadmium 50 mM 6 hrs, larvae L3    99 Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3  107 Ethanol 10% 3 hrs, larvae L3    90 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    26 Rotenone 2 μg 12 hrs, larvae L3  115 Rotenone 8 μg 12 hrs, larvae L3    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    57 Cadmium 50 mM 6 hrs, larvae L3    99 Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    107 Ethanol 10% 3 hrs, larvae L3    90 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    26 Rotenone 2 μg 12 hrs, larvae L3    115 Rotenone 8 μg 12 hrs, larvae L3    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_03 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GH10427
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive sel2R-278-38 sel282 viable sel2R-278-38 sel282 selunspecified viable, with Scer\GAL4pnr-MD237 selGD5737 Sterility Allele female sterile | recessive selunspecified Phenotype manifest in Allele denticle belt | maternal effect self04257 filzkorper | maternal effect self04257
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of sel Class Mutagen Stocks Known lesion self04257 piggyBac transposase 1 -- sel282 ethyl methanesulfonate 0 Yes sel2R-278-38 ethyl methanesulfonate 0 -- selunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sel Class Mutagen Stocks Known lesion selGD5737 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes selKK109371 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes selNIG.12918R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes selT:Disc\RFP-mCherry in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)X3 (Stein et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.12918R} NA characterization construct P{sel-mCherry.S} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}EY00918 NA miscellaneous insertions PBac{WH}self04257 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
maternal specification of dorsal/ventral axis, oocyte, germ-line encoded inferred from mutant phenotype (Luschnig et al., 2004) polarity specification of dorsal/ventral axis inferred from mutant phenotype (Stein et al., 2010) regulation of protein processing inferred from mutant phenotype (Stein et al., 2010) regulation of protein secretion inferred from mutant phenotype (Stein et al., 2010)
Cellular Component
CV term Evidence References
endoplasmic reticulum inferred from direct assay (Stein et al., 2010)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
sel - CG11911 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) sel - CG13397 experimental knowledge based (Guruharsha et al., 2011) sel - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sel - CG14826 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sel - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sel - CG2918 experimental knowledge based (Guruharsha et al., 2011) sel - CG3795 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sel - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sel - EndoGI experimental knowledge based (Guruharsha et al., 2011) sel - Fer1HCH experimental knowledge based (Guruharsha et al., 2011) sel - PHGPx experimental knowledge based (Guruharsha et al., 2011) sel - Pdi experimental knowledge based (Guruharsha et al., 2011) sel - Uch experimental knowledge based (Guruharsha et al., 2011) sel - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sel allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0263260
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6WSWX0 Dipteran inclusive ortholog search EOG669R3Z Insect inclusive ortholog search EOG65MM2N Arthropod inclusive ortholog search EOG6JQ2DS Metazoa inclusive ortholog search EOG63JR0C
Orthologs in Drosophila Species (EOG6WSWX0)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\sel     Drosophila simulans   Dsim\GD26011 Y   Drosophila sechellia   Dsec\GM18732     Drosophila sechellia   Dsec\GM20558 Y   Drosophila erecta   Dere\GG25238 Y   Drosophila yakuba   Dyak\GE21841 Y   Drosophila ananassae   Dana\GF12915 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11907 Y   Drosophila persimilis   Dper\GL10560 Y   Drosophila willistoni   Dwil\GK21362 Y   Drosophila virilis   Dvir\GJ22481 Y   Drosophila mojavensis   Dmoj\GI19417 Y   Drosophila grimshawi   Dgri\GH20247 Y
Orthologs in non-Drosophila Dipterans (EOG669R3Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013005   Anopheles gambiae Malaria mosquito  Agam\AGAP008615   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007693
Orthologs in non-Dipteran Insects (EOG65MM2N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC410890   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009186   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11602   Atta cephalotes Leafcutter ant  Acep\ACEP13180   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17253   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18926   Linepithema humile Argentine ant  Lhum\LH25111   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13164   Solenopsis invicta Red fire ant  Sinv\SINV17746   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006838   Bombyx mori Silkmoth  Bmor\BGIBMGA003267   Pediculus humanus Human body louse  Phum\PHUM035170   Tribolium castaneum Red flour beetle  Tcas\TC009499
Orthologs in non-Insect Arthropods (EOG6JQ2DS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_308242   Ixodes scapularis Deer tick  Isca\ISCW010982
Orthologs in non-Arthropod Metazoa (EOG63JR0C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F01F1.15   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002333gn   Danio rerio Zebrafish  Drer\cnpy1   Danio rerio Zebrafish  Drer\cnpy2   Xenopus tropicalis Western clawed frog  Xtro\cnpy2   Xenopus tropicalis Western clawed frog  Xtro\cnpy1   Mus musculus House mouse  Mmus\Cnpy2   Rattus norvegicus Norway rat  Rnor\Cnpy2   Rattus norvegicus Norway rat  Rnor\LOC100364828   Homo sapiens Human  Hsap\ENSG00000257727   Homo sapiens Human  Hsap\ENSG00000144785   Homo sapiens Human  Hsap\CNPY1
Human Orthologs (3)
Gene OMIM HGNC Hsap\ENSG00000257727     Hsap\ENSG00000144785     Hsap\CNPY1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD26011 Drosophila sechellia Dsec\GM20558 Drosophila erecta Dere\GG25238 Drosophila yakuba Dyak\GE21841 Drosophila ananassae Dana\GF12915 Drosophila pseudoobscura pseudoobscura Dpse\GA11907 Drosophila persimilis Dper\GL10560 Drosophila willistoni Dwil\GK21362 Drosophila virilis Dvir\GJ22481 Drosophila mojavensis Dmoj\GI19417 Drosophila grimshawi Dgri\GH20247
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Harvard	- PBac{WH}self04257
VDRC	v105503 P{KK109371}VIE-260B v38082 w1118; P{GD5737}v38082
Genomic Clones ( 1 )
	BACR06J01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 102 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10427
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	SD11495 SD23430 SD26434 SD28191
Other clones	18050 28242 29206 38469 46144 61077 63036 76600 106176 118076 214505.42 bs49d10 CK01.89D.F1 CK01.101D.E9 CK01.124B.D3 CK01.145D.A4 Dmel_neb_008186_0829_3040 EC25020 EK070621 EK075105 EK085917 EK107101 EK119834 EK131322 EK135623 EK137130 EK151527 EK187408 EK188816 EK206630 EK231254 EK244242 EN16906 EP09359 FGC021D12 FGC023G01 RP004004939 RP004015836 RP004048196 RP004049502 RP004051477 RP004054397 RP004073185 RP004084311 RP004089477 RP004108858 RP004134139 RP004139244 RP004139522 RP004143929 RP004147745 RP004149552 RP004153830 RP004157842 RP004164286 RP004169685 RP004194742 RP004205808 RP004208299 RP004211031 RP004213475 RP004226789 RP004229757 RP004231604 RP004235446 RP004239109 RP004239743 RP004251017 RP004254364 RP004256263 RP004256472 RP004258646 RP004258739 RP004281564 RP004299262 RP004302810 RP004319072 RP004327059 RP004344410 RP004354201 RP004356109 RP004373807 RP004376744 RP004384689 RP004398978 RP004407001 RP004411103 RP004418409 RP004436214 RP004444300 RP004447293 RP004452456 RP004478858 RP004494833 RP004500449 RP004510742 RP004549136
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36046
Antibody Information
	polyclonal (Stein et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: sel CG12918 (Stein et al., 2010)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136703 RefSeq (Proteins) • NP_610547 DDBJ / EMBL / GenBank • AAF58856 AAM11051 AI113916 AW940363 AY094698 CZ486792 Entrez Gene - A searchable database of RefSeq genes. • 36046 UniProtKB/TrEMBL • Q7JXF7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Domain of unknown function DUF3456 (IPR021852) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH10427
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0263260 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36046
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG12918 (Stein et al., 2010, Hollien and Weissman, 2006, Keleman et al., 2009.8.5, Cammarato et al., 2011, Japanese National Institute of Genetics, 2012.5.21) sel (Stein et al., 2010, ) Sle (Moussian and Roth, 2005)
Name Synonym	Seele (Stein et al., 2010) seele (Luschnig et al., 2004, Luschnig et al., 2004, )
Secondary FlyBase IDs
	FBgn0033477 FBgn0069083
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 2 ) Supplementary material  ( 8 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Website  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...