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Gene Dyak\Lhr

General Information
Symbol	Dyak\Lhr	Species	D. yakuba
Name		Annotation symbol	GE11661
Feature type	protein_coding_gene	FlyBase ID	FBgn0263276
Gene Model Status	Current	Stock availability	None publicly available
Also Known As	Lhr
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map		Sequence location	2R:18,148,499..18,149,476 [-]
Genomic Maps	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dyak\Lhr (GE11661, FBgn0263276). It is a protein_coding_gene from Drosophila yakuba. An electronic pipeline based on InterPro domains suggests that it has the molecular function: DNA binding. The biological processes in which it is involved are not known. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: BESS motif. Gene sequence location is 2R:18148499..18149476.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dyak\Lhr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dyak\Lhr-RA FBtr0258179  XM_002092410   978   325
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dyak\Lhr-PA   FBpp0256671   37.3   325   6.57     XP_002092446   EDW92158
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BESS motif (IPR004210)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name CM000158 EDW92158
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A0PKB0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Dyak\Lhr Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dyak\Lhr Class Mutagen Stocks Known lesion Dyak\LhrC.Scer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR004210 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene (Brideau et al., 2007) nuclear_gene (Drosophila 12 Genomes Consortium, 2008) protein_coding_gene (Drosophila 12 Genomes Consortium, 2008)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dyak\Lhr allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (1) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64J340 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Ortholog(s) in Drosophila melanogaster (EOG64J340)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Lhr Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (1) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila melanogaster Dmel\Lhr
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Dyak\Lhr Dyak\GE11661 (Brideau and Barbash, 2011)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • XM_002092410 RefSeq (Proteins) • XP_002092446 DDBJ / EMBL / GenBank • EDW92158 Entrez Gene - A searchable database of RefSeq genes. • 6531649 UniProtKB/TrEMBL • A0PKB0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BESS motif (IPR004210) GLEANR • dyak_GLEANR_11975
Linkouts
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	dyak_GLEANR_11975 (Drosophila 12 Genomes Consortium, 2008) Dyak\GE11661 (Drosophila 12 Genomes Consortium, 2008) Dyak\Lhr   GE11661 (Drosophila 12 Genomes Consortium, 2008) Lhr (Maheshwari and Barbash, 2012, Brideau and Barbash, 2011, Brideau et al., 2007) LHR (Brideau and Barbash, 2008)
Name Synonym
Secondary FlyBase IDs
	FBgn0086226 FBgn0229457
References ( 7 )
Research paper	Maheshwari and Barbash, 2012, Genetics 192(2): 683--691 An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is functionally relevant. [FBrf0219506] Brideau and Barbash, 2011, BMC Evol. Biol. 11: 57 Functional conservation of the Drosophila hybrid incompatibility gene Lhr. [FBrf0213263] Drosophila 12 Genomes Consortium et al., 2007, Nature 450(7167): 203--218 Evolution of genes and genomes on the Drosophila phylogeny. [FBrf0200326]
Personal communication to FlyBase	Drosophila 12 Genomes Consortium, 2008, personal communication to FlyBase Symbols and class of gene information for the GLEANR consensus sequences of the 11 sequenced non-melanogaster Drosophila species (Drosophila ananassae, erecta, grimshawi, mojavensis, persimilis, pseudoobscura, sechellia, simulans, willistoni, virilis and yakuba). [FBrf0202436] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Abstract	Brideau and Barbash, 2008, A. Dros. Res. Conf. 49: 706A Investigating the interactions between the hybrid incompatibility protein LHR and heterochromatic proteins HP1 and HP6. [FBrf0203570] Brideau et al., 2007, A. Dros. Res. Conf. 48: 718A Investigating interactions between HP1 and the hybrid incompatibility protein LHR. [FBrf0198303]