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General Information
Symbol
Dmel\scrib
Species
D. melanogaster
Name
scribble
Annotation Symbol
CG43398
Feature Type
FlyBase ID
FBgn0263289
Gene Model Status
Stock Availability
Gene Snapshot
scribble (scrib) encodes a scaffolding protein that is part of the conserved machinery regulating apicobasal polarity. It acts with the products of dlg1 and l(2)gl to distinguish the basolateral domain of epithelial cells and neuroblasts, via reciprocally antagonistic interactions with the aPKC/par-6 complex that impacts vesicle trafficking. The product of scrib also organizes synaptic architecture and is implicated in learning and memory. [Date last reviewed: 2019-03-14]
Also Known As
scribbled, smi97B, scrb, ird15, vart
Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:26,536,350..26,604,051 [+]
Recombination map
3-91
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the LAP (LRR and PDZ) protein family. (Q7KRY7)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
-
Summaries
Protein Function (UniProtKB)
Required for polarization of the embryonic, imaginal disk and follicular epithelia. Specifically restricts apical membrane determinants to the apical cell surface; acts to exclude crb from the basolateral domain and define adherens junction position. Regulates cellular growth and differentiation; acts as a tumor suppressor. Essential for odor guided behavior.
(UniProt, Q7KRY7)
Summary (Interactive Fly)
scaffolding protein with multiple PDZ and LLR regions - functions to localize junctional components in the determination of epithelial cell apicobasal polarity - acts with and to distinguish the basolateral domain of epithelial cells and neuroblasts - exhibits antagonistic interactions with the aPKC/Par-6 complex that impacts vesicle trafficking - organizes synaptic architecture and is implicated in learning and memory
Gene Model and Products
Number of Transcripts
18
Number of Unique Polypeptides
17

Please see the GBrowse view of Dmel\scrib or the JBrowse view of Dmel\scrib for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.47
Gene model reviewed during 5.39
Gene model reviewed during 5.49
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.40
Two sites of polyadenylation reported in FBrf0139743.
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0308620
7048
1756
FBtr0308621
7148
1756
FBtr0308624
4752
1247
FBtr0308625
7433
1851
FBtr0308622
6323
1939
FBtr0308623
6087
1711
FBtr0308626
8891
2426
FBtr0308627
8667
2331
FBtr0308628
9438
2585
FBtr0308629
9153
2490
FBtr0308630
9372
2554
FBtr0308631
8538
2515
FBtr0308632
6219
1729
FBtr0308633
9414
2577
FBtr0308634
6636
1951
FBtr0335520
6905
1859
FBtr0335521
9224
2444
FBtr0335522
7178
1766
Additional Transcript Data and Comments
Reported size (kB)
7.1, 5.9, 4.6 (northern blot)
7.2, 6.0, 4.6 (northern blot)
6.2 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0300844
190.2
1756
4.80
FBpp0300845
190.2
1756
4.80
FBpp0300848
136.4
1247
4.78
FBpp0300849
200.4
1851
4.81
FBpp0300846
210.2
1939
5.03
FBpp0300847
184.7
1711
4.90
FBpp0300850
263.3
2426
4.46
FBpp0300851
253.1
2331
4.45
FBpp0300852
280.9
2585
4.54
FBpp0300853
270.6
2490
4.53
FBpp0300854
277.3
2554
5.11
FBpp0300855
273.7
2515
4.53
FBpp0300856
187.0
1729
4.87
FBpp0300857
280.8
2577
4.56
FBpp0300858
211.8
1951
5.13
FBpp0307488
199.9
1859
4.64
FBpp0307489
265.2
2444
5.11
FBpp0307490
191.3
1766
4.79
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1756 aa isoforms: scrib-PA, scrib-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
1756, 1247 (aa); 250, 180 (kD)
1756 (aa); 210 (kD observed); 195 (kD predicted)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scrib using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (62 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:gukh; FB:FBgn0026239
Terms Based on Predictions or Assertions (0 terms)
Biological Process (46 terms)
Terms Based on Experimental Evidence (36 terms)
CV Term
Evidence
References
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (12 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001900149
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001900149
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
non-traceable author statement
Cellular Component (15 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002508426
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002508426
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001900149
(assigned by GO_Central )
colocalizes_with postsynaptic membrane
inferred from biological aspect of ancestor with PANTHER:PTN001900149
(assigned by GO_Central )
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001900149
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 0-6 hr AEL

Comment: reference states 0-24 hr AEL

Comment: reference states 9-22 hr AEL

Additional Descriptive Data
scrib transcripts are detected in antennae, maxillary palps, Johnston's organ and in restricted cortical regions of the brain.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 0-12 hr AEL

Comment: reference states 12-24 hr AEL

Additional Descriptive Data
scrib protein is localized to the epithelial septate junction at the boundary of the apical and basolateral cell surfaces.
scrib protein is detected in the brain, especially in the antennal nerves and the ventrolateral and superior medial protocerebrum. It is also widely deposited in the antennae and maxillary palps.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\scrib in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 44 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 36 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of scrib
Transgenic constructs containing regulatory region of scrib
Deletions and Duplications ( 25 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
7 of 15
Yes
Yes
 
 
6 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
Yes
6 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (9)
5 of 13
Yes
Yes
3 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (7)
2 of 12
Yes
Yes
2 of 12
Yes
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
9 of 15
Yes
Yes
3 of 15
No
Yes
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
9 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (71)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
1 of 15
Yes
No
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
1 of 12
Yes
No
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919005A )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500AV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W005D )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0056 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01EF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (8)
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 4 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-91
Cytogenetic map
Sequence location
3R:26,536,350..26,604,051 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
97B9-97C2
Limits computationally determined from genome sequence between P{PZ}l(3)rQ197rQ197 and P{lacW}scribj7B3; Limits computationally determined from genome sequence between P{lacW}scribj7B3 and P{lacW}His2AvL1602
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
97B8-97B9
(determined by in situ hybridisation)
97C-97C
(determined by in situ hybridisation)
97B-97B
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (39)
Genomic Clones (61)
cDNA Clones (126)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of
Source for merge of: scrib l(3)c00119
Source for merge of: scrib l(3)j7B3 l(3)673
Source for merge of: scrib l(3)S042405
Source for merge of: scrib CG5462
Source for merge of: scrib vart CG5462
Source for merge of: scrib smi97B
Source for merge of: scrib CG5467
Source for merge of: scrib CG31082
Additional comments
Annotations CG42614 and CG31082 merged as CG43398 in release 5.39 of the genome annotation.
Annotations CG5462 and CG5467 merged as CG42614 in release 5.20 of the genome annotation.
Other Comments
scrib is required for proper forgetting of olfactory memories.
The LRR region of the scrib product is necessary and sufficient to form a polarized epithelial monolayer, provides significant control of cell proliferation, and also regulates its subcellular localization.
The PDZ domains of the scrib product are not essential for the development of monolayered epithelia but are involved in providing full control over cell proliferation.
scrib is essential for odour guided behaviour.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
New annotation (CG31082) in release 3 of the genome annotation.
scrib specifically restricts apical membrane determinants to the apical cell surface.
scrib is required for polarisation of the embryonic, imaginal disc and follicular epithelia. scrib acts as a tumour suppressor.
Mutations in scrib disrupt cell adhesion, polarity and shape in the ovarian follicular epithelium, the imaginal disc and the embryonic epidermis.
Identification: Isolated in a screen for mutants that failure to induce a Dpt-Ecol\lacZ reporter after E.coli injection.
Identified during a screen for olfactory mutants.
Origin and Etymology
Discoverer
L. and Y. Jan.
Etymology
Named 'scribble' because embryos that are maternally and zygotically mutant for the gene produce a corrugated cuticular surface that is riddled with holes.
Identification
External Crossreferences and Linkouts ( 153 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
ApoDroso - Functional genomic database for photoreceptor development, survival and function
DroID - A comprehensive database of gene and protein interactions.
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (33)
Reported As
Symbol Synonym
MENE (3R)-F
Scrib
(Bonello and Peifer, 2019, Khadilkar and Tanentzapf, 2019, Ma et al., 2019, Nakajima et al., 2019, Yadav and Srikrishna, 2019, Caria et al., 2018, Carmena, 2018, Brüser and Bogdan, 2017, Golub et al., 2017, Lang and Munro, 2017, Richardson and Portela, 2017, Tamori and Deng, 2017, Clavería and Torres, 2016, Flores-Benitez and Knust, 2016, Padash Barmchi et al., 2016, Roman-Fernandez and Bryant, 2016, Schimizzi et al., 2016, Yadav et al., 2016, Bell et al., 2015, Cao et al., 2015, Carvalho et al., 2015, Felix et al., 2015, Irvine and Harvey, 2015, O'Keefe et al., 2015, Peterson and Krasnow, 2015, Turkel et al., 2015, Amoyel and Bach, 2014, Bätz et al., 2014, Wang et al., 2014, Chen and Zhang, 2013, Chintapalli et al., 2013, Khan et al., 2013, Pastor-Pareja and Xu, 2013, Yu and Guan, 2013, Andersen et al., 2012, Azad et al., 2012, Kelsom and Lu, 2012, Liu et al., 2012, Muñoz-Soriano et al., 2012, Tepass, 2012, Cho et al., 2011, Djiane et al., 2011, Genevet and Tapon, 2011, Laprise, 2011, Laprise and Tepass, 2011, Mathew et al., 2011, Miles et al., 2011, Zhao et al., 2011, Laprise et al., 2010, Warner et al., 2010, Zeng et al., 2010, Ramachandran et al., 2009, Romani et al., 2009, Warner and Longmore, 2009, Harris and Tepass, 2008, Mendoza-Topaz et al., 2008, Somorjai and Martinez-Arias, 2008, Zhu et al., 2008, Egger et al., 2007, Gorczyca et al., 2007, Gorfinkiel and Arias, 2007, Kohsaka et al., 2007, Rolls et al., 2007, Guan et al., 2006, Lee et al., 2006, Suzuki and Ohno, 2006, Le Bivic, 2005, Wei et al., 2005, Wu and Beitel, 2004, Caruana, 2002, Santoni et al., 2002)
l(3)c00119
scrib
(Baker et al., 2019, Mirzoyan et al., 2019, Parvy et al., 2019, Pinal et al., 2019, Strassburger et al., 2019, Sun et al., 2019, Sun et al., 2019, Xu et al., 2019, Zhang et al., 2019, Cong et al., 2018, Courgeon et al., 2018, de Vreede et al., 2018, Donohoe et al., 2018, Enomoto et al., 2018, Katsukawa et al., 2018, La Fortezza et al., 2018, Parvy et al., 2018, Richardson and Portela, 2018, Sotillos et al., 2018, Zoranovic et al., 2018, Aw et al., 2017, Baker, 2017, Banerjee and Roy, 2017, Jacqueline et al., 2017, Katheder et al., 2017, Ma et al., 2017, Ma et al., 2017, Muzzopappa et al., 2017, Pérez et al., 2017, Resnik-Docampo et al., 2017, Yamamoto et al., 2017, Aigouy and Le Bivic, 2016, Atkins et al., 2016, Carbone et al., 2016, Cheng et al., 2016, Cloud-Richardson et al., 2016, Gene Disruption Project members, 2016-, Ma et al., 2016, Moreira and Morais-de-Sá, 2016, Tamori et al., 2016, Andersen et al., 2015, Aradska et al., 2015, Bosch et al., 2015, Doggett et al., 2015, Enomoto et al., 2015, Enomoto et al., 2015, Feng and Martin, 2015, Figueroa-Clarevega and Bilder, 2015, Gailite et al., 2015, Grifoni and Bellosta, 2015, Keder et al., 2015, Külshammer et al., 2015, Matthews et al., 2015, Richardson, 2015.3.11, Ashwal-Fluss et al., 2014, Chabu and Xu, 2014, Johnston, 2014, Kim and Choe, 2014, Liang et al., 2014, Ma et al., 2014, Skwarek et al., 2014, Stickel and Su, 2014, Tipping and Perrimon, 2014, Wang et al., 2014, Westholm et al., 2014, Bangi, 2013, Brown et al., 2013, Harbison et al., 2013, Hirabayashi et al., 2013, Hombría and Serras, 2013, Khan et al., 2013, Khoo et al., 2013, Külshammer and Uhlirova, 2013, Levayer and Moreno, 2013, Ma et al., 2013, Ma et al., 2013, Nakajima et al., 2013, Tamori and Deng, 2013, Willoughby et al., 2013, Yoshigi et al., 2013, Zoranovic et al., 2013, Adamson and Lajeunesse, 2012, Andersen et al., 2012, Aranjuez et al., 2012, Chen et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Justiniano et al., 2012, Nelson et al., 2012, Tan et al., 2012, Weber et al., 2012, Brumby et al., 2011, Goossens et al., 2011, Grusche et al., 2011, Jiang et al., 2011, Kanda et al., 2011, Li et al., 2011, Miles et al., 2011, Ohsawa et al., 2011, Bahri et al., 2010, Cordero et al., 2010, Fichelson et al., 2010, Froldi et al., 2010, Grzeschik et al., 2010, Krahn et al., 2010, Menéndez et al., 2010, Rhiner et al., 2010, Siegrist et al., 2010, Wu et al., 2010, Campbell et al., 2009, Christensen et al., 2009.2.28, Courbard et al., 2009, Igaki et al., 2009, Laprise et al., 2009, Leong et al., 2009, Li et al., 2009, Mao and Freeman, 2009, Rhiner et al., 2009, Chia et al., 2008, Hauenschild et al., 2008, Li et al., 2008, Lighthouse et al., 2008, Pastor-Pareja et al., 2008, Zhao et al., 2008, Buszczak et al., 2007, Firth and Baker, 2007, Grzeschik et al., 2007, Guthridge et al., 2007, Junion et al., 2007, Menut et al., 2007, Mishra and Nigam, 2007, Srivastava et al., 2007, Tountas and Fortini, 2007, Tyler et al., 2007, Igaki et al., 2006, Igaki et al., 2006, Uhlirova and Bohmann, 2006, Wirtz-Peitz and Knoblich, 2006, Wodarz and Gonzalez, 2006, Djiane et al., 2005, Lu and Bilder, 2005, Uhlirova et al., 2005, Albertson et al., 2004, Grifoni et al., 2004, Zeitler et al., 2004, Dow et al., 2003, Mathew et al., 2002)
Name Synonyms
CG5467
Scribbles
immune response deficient 15
lethal (3) c00119
smell impaired 97B
Secondary FlyBase IDs
  • FBgn0261263
  • FBgn0026178
  • FBgn0011401
  • FBgn0016016
  • FBgn0016937
  • FBgn0026234
  • FBgn0028155
  • FBgn0028975
  • FBgn0039432
  • FBgn0069188
  • FBgn0039433
  • FBgn0051082
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (490)