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Gene Dmel\scrib

General Information
Symbol	Dmel\scrib	Species	D. melanogaster
Name	scribbled	Annotation symbol	CG43398
Feature type	protein_coding_gene	FlyBase ID	FBgn0263289
Gene Model Status	Current	Stock availability	31 publicly available
Also Known As	CG5462, smi97B, scrb, ird15, vart, l(3)j7B3, CG42614, CG31082, l(3)673, CG5467
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	97B9-97C2	Sequence location	3R:22,362,072..22,429,773 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene scribbled is referred to in FlyBase by the symbol Dmel\scrib (CG43398, FBgn0263289). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 27 unique biological process terms, many of which group under: single-organism developmental process; biological regulation; cellular component organization or biogenesis; sensory organ development; post-embryonic organ morphogenesis; establishment of planar polarity; cell proliferation; instar larval development; cell junction organization; establishment or maintenance of bipolar cell polarity. 59 alleles are reported. The phenotypes of these alleles are annotated with: multicellular structure; organ system; organ system subdivision; portion of tissue; sense organ; imaginal precursor; adult; adult segment; thoracic segment; cell cluster organ; cell junction. It has 18 annotated transcripts and 18 annotated polypeptides. Protein features are: Leucine rich repeat 4; Leucine-rich repeat; PDZ domain. Gene sequence location is 3R:22362072..22429773.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles scrib[MI07508]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 97B9-97C2   Limits computationally determined from genome sequence between P{PZ}l(3)rQ197rQ197 and P{lacW}scribj7B3; Limits computationally determined from genome sequence between P{lacW}scribj7B3 and P{lacW}His2AvL1602
Experimentally Determined Cytological Location
Cytogenetic map Notes References 97B-97B     (Bilder, 1999.9.29) 97B8-97B9   (determined by in situ hybridisation)   (Spradling et al., 1999) 97C-97C   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 97B-97B     (Choe et al., 1999) 97C-97C   (determined by in situ hybridisation)   (Deak et al., 1997) 97B-97B   (determined by in situ hybridisation)   (Anholt et al., 1996) 97B8-97B9     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\scrib for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.47 Gene model reviewed during 5.40 Gene model reviewed during 5.49 DGC clone LD43989 appears problematic: incomplete CDS Two sites of polyadenylation reported in FBrf0139743. DGC clone SD05339 appears problematic: incomplete CDS Gene merge based on EST/cDNA. Gene merge based on EST/cDNA and RNA-seq data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) scrib-RA FBtr0308620  NM_170275   7048   1756 scrib-RB FBtr0308621  NM_001043296   7148   1756 scrib-RC FBtr0308624  NM_170277   4752   1247 scrib-RD FBtr0308625  NM_080015   7433   1851 scrib-RH FBtr0308622  NM_001014670   6323   1939 scrib-RI FBtr0308623  NM_001014669   6087   1711 scrib-RJ FBtr0308626  NM_001170274   8891   2426 scrib-RK FBtr0308627  NM_001260389   8667   2331 scrib-RL FBtr0308628  NM_001170275   9438   2585 scrib-RM FBtr0308629  NM_001170276   9153   2490 scrib-RN FBtr0308630  NM_001260390   9372   2554 scrib-RO FBtr0308631  NM_001260391   8538   2515 scrib-RP FBtr0308632  NM_170276   6219   1729 scrib-RQ FBtr0308633  NM_001260392   9414   2577 scrib-RR FBtr0308634  NM_001260393   6636   1951 scrib-RS FBtr0335520  NM_001276058   6905   1859 scrib-RT FBtr0335521  NM_001276059   9224   2444 scrib-RU FBtr0335522  NM_001276060   7178   1766
Additional Transcript Data & Comments
Reported size (kB)	7.2, 6.0, 4.6 (northern blot) (Li et al., 2001) 7.1, 5.9, 4.6 (northern blot) (Ganguly et al., 2003) 6.2 (northern blot) (Bilder and Perrimon, 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein scrib-PA   FBpp0300844   190.2   1756   4.80     NP_733154   AAN14076 scrib-PB   FBpp0300845   190.2   1756   4.80     NP_001036761   ABI31210 scrib-PC   FBpp0300848   136.4   1247   4.78     NP_733156   AAN14078 scrib-PD   FBpp0300849   200.4   1851   4.81     NP_524754   AAF56598 scrib-PH   FBpp0300846   210.2   1939   5.03     NP_001014670   AAX52995 scrib-PI   FBpp0300847   184.7   1711   4.90     NP_001014669   AAX52996 scrib-PJ   FBpp0300850   263.3   2426   4.46     NP_001163745   ACZ95039 scrib-PK   FBpp0300851   253.1   2331   4.45     NP_001247318   AFH06635 scrib-PL   FBpp0300852   280.9   2585   4.54     NP_001163746   ACZ95040 scrib-PM   FBpp0300853   270.6   2490   4.53     NP_001163747   ACZ95041 scrib-PN   FBpp0300854   277.3   2554   5.11     NP_001247319   AFH06636 scrib-PO   FBpp0300855   273.7   2515   4.53     NP_001247320   AFH06637 scrib-PP   FBpp0300856   187.0   1729   4.87     NP_733155   AAN14077 scrib-PQ   FBpp0300857   280.8   2577   4.56     NP_001247321   AFH06638 scrib-PR   FBpp0300858   211.8   1951   5.13     NP_001247322   AFH06639 scrib-PS   FBpp0307488   199.9   1859   4.64     NP_001262987   AGB96367 scrib-PT   FBpp0307489   265.2   2444   5.11     NP_001262988   AGB96368 scrib-PU   FBpp0307490   191.3   1766   4.79     NP_001262989   AGB96369
Additional Polypeptide Data & Comments
Reported size (kDa)	1756 (aa); 210 (kD observed); 195 (kD predicted) (Bilder and Perrimon, 2000) 1756, 1247 (aa); 250, 180 (kD) (Li et al., 2001)
Comments	scrib 1756aa isoform-specific antibodies were raised. (Li et al., 2001) scrib 1247aa isoform-specific antibodies were raised. (Li et al., 2001)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Leucine rich repeat 4 (IPR025875) PDZ domain (IPR001478) Leucine-rich repeat (IPR001611)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140699   AA140700   AA141797   AA392400   AA438816   AA441056   AA441190   AA567428   AA698589   AA801781   AA803512   AA817281   AA942310   AA949316   AA950515   AA978822   AE014297 AAF56598   AE014297 AAN14076   AE014297 AAN14077   AE014297 AAN14078   AE014297 AAX52995   AE014297 AAX52996   AE014297 ABI31210   AE014297 ACZ95039   AE014297 ACZ95040   AE014297 ACZ95041   AF190774 AAF26357   AE014297 AFH06635   AE014297 AFH06636   AE014297 AFH06637   AE014297 AFH06638   AE014297 AFH06639   AE014297 AGB96367   AE014297 AGB96368   AE014297 AGB96369   AI064465   AI108226   AI389526   AI403174   AI404149   AI455067   AI457086   AI511640   AI512224   AI516873   AI516996   AI533495   AI533713   AI945529   AJ252084 CAB70601   AJ271647 CAB71137   AQ034098   AW940245   AW943689   AW944411   AY060469 AAL25508   AY060642 AAL28190   AY069661 AAL39806   AY089684   AY167903 AAO32791   AY167904 AAO32792   AY167905 AAO32793   AY167906 AAO32794   BF503460   BG635821   BG637579   BG638104   BG638833   BI230646   BI353966   BI354852   BI605028   BI614368   BI615815   BI625330   BI638321   BI640889   BP556566   BP556567   BP560210   BP560211   BT015240 AAT94469   BT024946   BT033002   BT125631   CA805856   CK132095   CL527755   CO179664   CO188479   CO189175   CO190321   CO190471   CO190843   CO264360   CO264648   CO266082   CO268984   CO269185   CO272072   CO272785   CO275990   CO279840   CO282458   CO283439   CO286508   CO287912   CO289440   CO295394   CO298024   CO298872   CO300202   CO300384   CO300623   CO304418   CO304445   CO305453   CO306805   CO308391   CO308807   CO308848   CO309734   CO313497   CO313706   CO318209   CO319203   CO321181   CO322093   CO324279   CO325728   CO328106   CO330313   CO331438   CO334056   CO339252   CO339566   CO342819   CO343500   CO343732   CO344297   CZ468864   CZ471107   CZ471128   CZ485056   CZ489656   CZ489657   EC058485   EC061813   EC065329   EC069367   EC072394   EC073564   EC074794   EC075424   EC077727   EC079449   EC080551   EC081533   EC083911   EC084196   EC085134   EC085488   EC088796   EC089867   EC194791   EC195234   EC196311   EC198247   EC200219   EC202501   EC202533   EC206921   EC210596   EC212114   EC214047   EC215579   EC216297   EC217448   EC218089   EC218090   EC219931   EC219981   EC220024   EC220351   EC223978   EC225142   EC225790   EC227606   EC228062   EC232828   EC234398   EC237268   EC237408   EC240989   EC245125   EC249628   EC250427   EC252527   EC253637   EC254325   EC257621   EC258900   EC259759   EC260644   EL883815   EL884898   EL884899   EL885017   EL885018   EL885144   EL885145   EL886780   EL886846   EL886910   EL886975   EL887033   EL887098   EL887158   EL887220   GH949615   GH961754   GH965047   GH973827   GH979905
UniProtKB/Swiss-Prot	Q7KRY7
UniProtKB/TrEMBL	E1JIZ2 E1JIZ0 E1JIZ1 Q8IMR7 Q95SR1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   foregut primordium   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) tracheal primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   Bolwig organ   (Fisher et al., 2012) embryonic dorsal apodeme   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic proventriculus inner layer   (Fisher et al., 2012) embryonic stomatogastric nervous system   (Fisher et al., 2012) adult stage   maxillary palpus   (Ganguly et al., 2003) Johnston organ   (Ganguly et al., 2003) third segment of antenna   (Ganguly et al., 2003) second segment of antenna   (Ganguly et al., 2003) adult brain | restricted   (Ganguly et al., 2003) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late     (Li et al., 2001) embryonic stage 1 -- 11     (Li et al., 2001) Comment:reference states 0-6 hr AEL embryonic stage 1 -- 17     (Li et al., 2001) Comment:reference states 0-24 hr AEL embryonic stage 12 -- 17     (Li et al., 2001) Comment:reference states 9-22 hr AEL larval stage     (Ganguly et al., 2003) larval stage | male     (Ganguly et al., 2003) larval stage | female     (Ganguly et al., 2003) pupal stage     (Li et al., 2001) adult stage     (Li et al., 2001, Ganguly et al., 2003) adult stage | male   organism   (Li et al., 2001)   (Li et al., 2001, Ganguly et al., 2003) adult stage | female   organism   (Li et al., 2001)   (Ganguly et al., 2003, Li et al., 2001)
Additional Descriptive Data
	scrib transcripts are detected in antennae, maxillary palps, Johnston's organ and in restricted cortical regions of the brain. (Ganguly et al., 2003)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | mid -- embryonic stage | late   presumptive embryonic/larval central nervous system   (Li et al., 2001) ventral nerve cord   (Li et al., 2001) adult stage   antenna   (Ganguly et al., 2003) protocerebrum   (Ganguly et al., 2003) adult brain | restricted   (Ganguly et al., 2003) maxillary palpus   (Ganguly et al., 2003) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | mid   neuroblast   (Li et al., 2001) embryonic stage | early   organism | ubiquitous   (Li et al., 2001)   (Li et al., 2001) embryonic stage | late   presumptive embryonic/larval central nervous system   (Li et al., 2001) cell body   (Li et al., 2001) embryonic sensory system   (Li et al., 2001) presumptive embryonic/larval peripheral nervous system   (Li et al., 2001) embryonic stage 1 -- 15     (Li et al., 2001) Comment:reference states 0-12 hr AEL embryonic stage 15 -- 16   pole cell   (Li et al., 2001) gonad   (Li et al., 2001) embryonic stage 15 -- 17     (Li et al., 2001) Comment:reference states 12-24 hr AEL embryonic stage 16 -- 17   neuron   • axon (Li et al., 2001) longitudinal connective   (Li et al., 2001) ventral midline   (Li et al., 2001) ventral nerve cord commissure   (Li et al., 2001)
Additional Descriptive Data
	scrib protein is detected in the brain, especially in the antennal nerves and the ventrolateral and superior medial protocerebrum. It is also widely deposited in the antennae and maxillary palps. (Bilder and Perrimon, 2000, Ganguly et al., 2003) The 1756aa scrib protein isoform is most abundant in the first half of embryogenesis, is present at a low level in 12-24hr embryos, and is nearly undetectable in larvae, pupae and adults on Western blots. Immunostaining reveals that the 1756aa isoform is ubiquitous in early embryos and then becomes preferentially expressed in neuroblasts of the CNS. In later embryos it is expressed intensively in the ventral nerve cord axons and strongly decorates the longitudinal and transverse fibres of the connectives and commissures. It is also detected in midline cells at the anterior and posterior commissures. It is observed at a lower level in some epithelial structures and muscle fibres as well as in the pole cells of the gonads at embryonic stage 15/16. (Li et al., 2001) The 1247aa scrib protein isoform is most abundant in the first half of embryogenesis, is present at a low level in 12-24hr embryos and is nearly undetectable in larvae, pupae and adults on Western blots. Immunolocalization reveals that the 1247aa isoform is expressed in a very different expression pattern from the 1756aa isoform. The 1247aa isoform is expressed in the basal domain of forming blastoderm cells. In late embryos it is expressed in the CNS, preferentially in neuronal cell bodies, and not axons. It is strongly expressed in the projections of the PNS. Double staining with the 22C10 antibody shows that it is expressed in the PNS sensory organs. (Li et al., 2001)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apicolateral plasma membrane inferred from direct assay (Bilder et al., 2000) basolateral plasma membrane inferred from direct assay (Sotillos et al., 2004) fusome inferred from direct assay (Lighthouse et al., 2008) lateral plasma membrane inferred from direct assay (Bilder et al., 2000) neuromuscular junction inferred from direct assay (Kohsaka et al., 2007) septate junction inferred from direct assay (Bilder and Perrimon, 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    15 central nervous system, pupae P8    17 head, virgin 1-day female    14 head, virgin 4-day female    16 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    14 head, mated 20-day female    13 head, mated 1-day male    22 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    15 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    10 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    18 ovary, mated 4-day female    18 testis, mated 4-day male    4 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    15 central nervous system, pupae P8    17 head, virgin 1-day female    14 head, virgin 4-day female    16 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    14 head, mated 20-day female    13 head, mated 1-day male    22 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    15 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    10 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    18 ovary, mated 4-day female    18 testis, mated 4-day male    4 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    15 central nervous system, pupae P8    17 head, virgin 1-day female    14 head, virgin 4-day female    16 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    14 head, mated 20-day female    13 head, mated 1-day male    22 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    15 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    10 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    18 ovary, mated 4-day female    18 testis, mated 4-day male    4 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    15 central nervous system, pupae P8    17 head, virgin 1-day female    14 head, virgin 4-day female    16 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    14 head, mated 20-day female    13 head, mated 1-day male    22 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    15 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    10 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    18 ovary, mated 4-day female    18 testis, mated 4-day male    4 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    15 central nervous system, pupae P8    17 head, virgin 1-day female    14 head, virgin 4-day female    16 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    14 head, mated 20-day female    13 head, mated 1-day male    22 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    15 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    10 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    18 ovary, mated 4-day female    18 testis, mated 4-day male    4 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    15 central nervous system, pupae P8    17 head, virgin 1-day female    14 head, virgin 4-day female    16 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    14 head, mated 20-day female    13 head, mated 1-day male    22 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    15 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    10 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    18 ovary, mated 4-day female    18 testis, mated 4-day male    4 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    15 central nervous system, pupae P8    17 head, virgin 1-day female    14 head, virgin 4-day female    16 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    14 head, mated 20-day female    13 head, mated 1-day male    22 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    15 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    10 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    18 ovary, mated 4-day female    18 testis, mated 4-day male    4 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    15 central nervous system, pupae P8    17 head, virgin 1-day female    14 head, virgin 4-day female    16 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    14 head, mated 20-day female    13 head, mated 1-day male    22 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    15 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    10 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    18 ovary, mated 4-day female    18 testis, mated 4-day male    4 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    32 embryo 04-06hr    23 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    23 embryo 12-14hr    25 embryo 14-16hr    26 embryo 16-18hr    41 embryo 18-20hr    63 embryo 20-22hr    44 embryo 22-24hr    40 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    16 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    12 adult male 05day    16 adult male 30day    16 adult female 01day    13 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr  (32) embryo 04-06hr    23 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    23 embryo 12-14hr    25 embryo 14-16hr  26 embryo 16-18hr  (41) embryo 18-20hr  (63) embryo 20-22hr  (44) embryo 22-24hr  (40) larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    24 white prepupae 24hr  (30) pupae 2d postWPP    16 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    12 adult male 05day    16 adult male 30day    16 adult female 01day    13 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    32 embryo 04-06hr    23 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    23 embryo 12-14hr    25 embryo 14-16hr    26 embryo 16-18hr    41 embryo 18-20hr    63 embryo 20-22hr    44 embryo 22-24hr    40 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    16 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    12 adult male 05day    16 adult male 30day    16 adult female 01day    13 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    32 embryo 04-06hr    23 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    23 embryo 12-14hr    25 embryo 14-16hr    26 embryo 16-18hr    41 embryo 18-20hr    63 embryo 20-22hr    44 embryo 22-24hr    40 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    16 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    12 adult male 05day    16 adult male 30day    16 adult female 01day    13 adult female 05day    12 adult female 30day    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    32 embryo 04-06hr    23 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    23 embryo 12-14hr    25 embryo 14-16hr    26 embryo 16-18hr    41 embryo 18-20hr    63 embryo 20-22hr    44 embryo 22-24hr    40 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    16 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    12 adult male 05day    16 adult male 30day    16 adult female 01day    13 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr  32 embryo 04-06hr    23 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    23 embryo 12-14hr    25 embryo 14-16hr  26 embryo 16-18hr  (41) embryo 18-20hr  (63) embryo 20-22hr  (44) embryo 22-24hr  (40) larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    24 white prepupae 24hr  30 pupae 2d postWPP    16 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    12 adult male 05day    16 adult male 30day    16 adult female 01day    13 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    32 embryo 04-06hr    23 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    23 embryo 12-14hr    25 embryo 14-16hr    26 embryo 16-18hr    41 embryo 18-20hr    63 embryo 20-22hr    44 embryo 22-24hr    40 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    16 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    12 adult male 05day    16 adult male 30day    16 adult female 01day    13 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    32 embryo 04-06hr    23 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    23 embryo 12-14hr    25 embryo 14-16hr    26 embryo 16-18hr    41 embryo 18-20hr    63 embryo 20-22hr    44 embryo 22-24hr    40 larva L1    14 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    16 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    12 adult male 05day    16 adult male 30day    16 adult female 01day    13 adult female 05day    12 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    7 embryonic 1182-4H    25 embryonic GM2    10 embryonic Kc167    8 embryonic S1    10 embryonic S3    9 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    8 ovary OSC    12 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    7 embryonic 1182-4H    25 embryonic GM2    10 embryonic Kc167    8 embryonic S1    10 embryonic S3    9 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3  (59) wing disc ML-DmD21  (33) wing disc ML-DmD32    11 haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    8 ovary OSC    12 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    7 embryonic 1182-4H    25 embryonic GM2    10 embryonic Kc167    8 embryonic S1    10 embryonic S3    9 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    8 ovary OSC    12 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    7 embryonic 1182-4H    25 embryonic GM2    10 embryonic Kc167    8 embryonic S1    10 embryonic S3    9 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    8 ovary OSC    12 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    7 embryonic 1182-4H    25 embryonic GM2    10 embryonic Kc167    8 embryonic S1    10 embryonic S3    9 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    8 ovary OSC    12 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    7 embryonic 1182-4H    25 embryonic GM2    10 embryonic Kc167    8 embryonic S1    10 embryonic S3    9 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3  (59) wing disc ML-DmD21  (33) wing disc ML-DmD32    11 haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    8 ovary OSC    12 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    7 embryonic 1182-4H    25 embryonic GM2    10 embryonic Kc167    8 embryonic S1    10 embryonic S3    9 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    8 ovary OSC    12 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    7 embryonic 1182-4H    25 embryonic GM2    10 embryonic Kc167    8 embryonic S1    10 embryonic S3    9 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    20 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    8 ovary OSC    12 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GH07007
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone scrib1 lethal | larval stage (with scrib1) scribj7B3 lethal | larval stage (with scribj7B3) scrib1 lethal | larval stage | recessive scrib63S15 lethal | pharate adult stage (with scrib1) scrib882 lethal | pharate adult stage (with scrib882) scrib1 lethal | pharate adult stage | recessive scribdt14 lethal | pharate adult stage | somatic clone scrib1 scrib673 scribird15 lethal | P-stage | somatic clone scrib673 lethal | pupal stage, with Scer\GAL4pnr-MD237 scribGD11663 scribGD11666 lethal | pupal stage (with Df(3R)Tl-X) scrib882 scribdt14 lethal | pupal stage (with scrib1) scribdt6 scribdt12 lethal | pupal stage (with scrib673) scrib882 scribdt6 scribdt12 scribdt14 lethal | pupal stage (with scrib882) scrib673 scribdt6 scribird15 lethal | pupal stage (with scribdt6) scrib1 scrib673 scrib882 scribdt14 scribird15 lethal | pupal stage (with scribdt12) scrib1 scrib673 scribird15 lethal | pupal stage (with scribdt14) scrib673 scribdt6 scribird15 lethal | pupal stage (with scribird15) scrib882 scribdt6 scribdt12 scribdt14 lethal | recessive scrib1 scrib673 scribc00019 scribc00119 scribdt6 scribdt12 scribdt14 scribf02351 scribird15 scribj7B3 scribKG04161 scribS042405b lethal | third instar larval stage (with Df(3R)Tl-X) scrib1 scrib673 scribird15 lethal | third instar larval stage (with scrib1) scrib673 scribird15 lethal | third instar larval stage (with scrib673) scrib1 scribird15 lethal | third instar larval stage (with scribird15) scrib1 scrib673 partially lethal - majority die | pupal stage | somatic clone scrib1 partially lethal - majority die | recessive scribS042405b viable scribc06968 scribCA07683 scribEY04509 scribsmi97B viable (with scrib1) scrib5 viable (with scrib5) scrib1 scribjB709 viable (with scrib882) scribdt14 viable (with scribdt14) scrib882 viable (with scribjB709) scrib5 Sterility Allele female fertile | germline clone scrib1 scribc00019 scribf02351 scribKG04161 fertile scribc06968 scribEY04509 Other Phenotypes Allele behavior defective | recessive scribsmi97B cell growth defective | somatic clone scrib1 cell polarity defective | larval stage (with scrib673) scribird15 cell polarity defective | larval stage (with scribird15) scrib673 cell polarity defective | larval stage | recessive scrib673 cell polarity defective | somatic clone scrib1 scribunspecified cell shape defective | larval stage (with scrib673) scribdt6 scribdt12 scribird15 cell shape defective | larval stage (with scribdt6) scrib673 cell shape defective | larval stage (with scribdt12) scrib673 cell shape defective | larval stage (with scribird15) scrib673 cell shape defective | larval stage | recessive scrib673 developmental rate defective | third instar larval stage (with Df(3R)Tl-X) scrib673 scribird15 developmental rate defective | third instar larval stage (with scrib673) scribird15 developmental rate defective | third instar larval stage (with scribird15) scrib673 hyperplasia | recessive scrib1 immune response defective | recessive scribird15 increased cell death | larval stage | somatic clone scribunspecified increased cell death | somatic clone scrib1 increased cell number | larval stage (with scrib673) scribdt6 scribird15 increased cell number | larval stage (with scribdt6) scrib673 increased cell number | larval stage (with scribird15) scrib673 increased cell number | somatic clone scrib1 large body | larval stage | somatic clone scrib673 large body | third instar larval stage (with Df(3R)Tl-X) scrib1 scrib673 scribird15 large body | third instar larval stage (with scrib1) scrib673 scribird15 large body | third instar larval stage (with scrib673) scrib1 scribird15 large body | third instar larval stage (with scribird15) scrib1 scrib673 mitotic cell cycle defective | somatic clone scrib1 scrib673 neuroanatomy defective scrib1 neuroanatomy defective | larval stage scrib673 neuroanatomy defective | larval stage (with Df(3R)Tl-X) scrib673 neuroanatomy defective | somatic clone scribunspecified neurophysiology defective | larval stage scrib673 neurophysiology defective | larval stage (with Df(3R)Tl-X) scrib673 planar polarity defective | larval stage (with scrib1) scribj7B3 planar polarity defective | larval stage (with scribj7B3) scrib1 planar polarity defective | somatic clone scrib1 scrib5 size defective | larval stage (with scrib1) scrib673 size defective | larval stage (with scrib673) scrib1 scrib882 scribdt6 scribdt12 scribdt14 scribird15 size defective | larval stage (with scrib882) scrib673 size defective | larval stage (with scribdt6) scrib673 size defective | larval stage (with scribdt12) scrib673 size defective | larval stage (with scribdt14) scrib673 size defective | larval stage (with scribird15) scrib673 size defective | larval stage | recessive scrib673 size defective | recessive scribj7B3 smell perception defective scribsmi97B smell perception defective | adult stage (with scrib1) scribsmi97B smell perception defective | adult stage (with scrib673) scribsmi97B smell perception defective | adult stage (with scribsmi97B) scrib1 scrib673 smell perception defective | adult stage | female (with Df(3R)Tl-X) scribsmi97B smell perception defective | adult stage | female | recessive scribsmi97B smell perception defective | adult stage | female limited (with scribS042405b) scribsmi97B smell perception defective | adult stage | female limited (with scribsmi97B) scribS042405b smell perception defective | adult stage | female limited | recessive scribsmi97B-2A smell perception defective | adult stage | male (with Df(3R)Tl-X) scribsmi97B smell perception defective | adult stage | male | recessive scribsmi97B smell perception defective | adult stage | male limited | recessive scribsmi97B-15A smell perception defective | larval stage scribsmi97B tumorigenic scrib63S15 tumorigenic | larval stage | somatic clone scrib1 scribunspecified tumorigenic | somatic clone scrib1 scrib673 visible, with Scer\GAL4pnr-MD237 scribGD11663 visible (with scrib1) scrib5 visible (with scrib5) scrib1 scribjB709 visible (with scribjB709) scrib5 visible | recessive | somatic clone scribdt6 wild-type scribhs.PB Phenotype manifest in Allele adherens junction scrib673 adherens junction (with scrib1) scrib673 adherens junction (with scrib673) scrib1 adult head | somatic clone scrib673 scrib1 scribird15 adult Malpighian tubule | somatic clone scrib1 adult thorax (with scrib1) scrib5 adult thorax (with scrib5) scribjB709 scrib1 adult thorax (with scribjB709) scrib5 chaeta (with scrib1) scrib5 chaeta (with scrib5) scribjB709 scrib1 chaeta (with scribjB709) scrib5 egg | maternal effect (with T(Y;3)G75) scribj7B3 embryonic/first instar larval cuticle scribunspecified embryonic/larval brain scrib63S15 scrib1 embryonic/larval fat body scribunspecified embryonic dorsal epidermis | germline clone scribdt6 epithelial cell scrib673 scrib1 epithelial cell (with scrib673) scribdt6 scribird15 scribdt12 epithelial cell (with scribdt6) scrib673 epithelial cell (with scribdt12) scrib673 epithelial cell (with scribird15) scrib673 epithelial cell | embryonic stage scribunspecified eye (with scrib1) scrib5 eye (with scrib5) scribjB709 scrib1 eye (with scribjB709) scrib5 eye | somatic clone scribunspecified scribA128 scrib673 scrib1 scribdt6 scrib5 eye-antennal disc | somatic clone scribunspecified scrib673 scrib1 eye disc | somatic clone scribUU7 scribA128 scrib673 scrib1 eye photoreceptor cell | somatic clone scrib5 follicle cell | cell autonomous | somatic clone scribunspecified imaginal disc scribunspecified scrib63S15 scrib1 lamina scrib1 macrochaeta scribL97C medulla anlage scrib1 mesothoracic tergum, with Scer\GAL4pnr-MD237 scribGD11663 ommatidial precursor cluster scrib673 ommatidium | cell non-autonomous | somatic clone scrib1 ommatidium | somatic clone scrib1 scrib5 organism | third instar larval stage (with scrib1) scribj7B3 organism | third instar larval stage (with scribj7B3) scrib1 photoreceptor cell | somatic clone scribA128 scrib1 rhabdomere | somatic clone scrib5 septate junction scrib673 septate junction (with scrib1) scrib673 septate junction (with scrib673) scrib1 scribdt6 septate junction (with scribdt6) scrib673 synaptic vesicle | larval stage scrib673 synaptic vesicle | larval stage (with Df(3R)Tl-X) scrib673 type I bouton | larval stage scrib673 type I bouton | larval stage (with Df(3R)Tl-X) scrib673 wing disc scribj7B3 scrib673 wing disc (with scrib1) scrib673 wing disc (with scrib673) scrib882 scrib1 scribdt6 scribdt14 scribird15 scribdt12 wing disc (with scrib882) scrib673 wing disc (with scribdt6) scrib673 wing disc (with scribdt12) scrib673 wing disc (with scribdt14) scrib673 wing disc (with scribird15) scrib673 wing disc | somatic clone | third instar larval stage scrib1 wing disc | third instar larval stage (with scrib1) scribj7B3 wing disc | third instar larval stage (with scribj7B3) scrib1 wing hair | somatic clone scrib5
Classical Alleles ( 39 )
For All Classical Alleles Show
Allele of scrib Class Mutagen Stocks Known lesion scribc06968 piggyBac transposase 2 -- scribj7B3 hypomorphic allele - genetic evidence P-element activity 2 Yes scrib673 loss of function allele ethyl methanesulfonate 1 -- scribc03872 piggyBac transposase 1 -- scribc06946 piggyBac transposase 1 -- scribc07109 1 -- scribdt14 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 -- scribdt6 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 -- scribEY04509 P-element activity 1 -- scribf02531 piggyBac transposase 1 -- scribf04986 1 -- scribf06915 piggyBac transposase 1 -- scribKG04161 1 -- scribMI00800 1 -- scribMI01968 1 -- scribMI07508 1 -- scribNP7522 1 -- scrib1 loss of function allele ethyl methanesulfonate 0 -- scrib5 0 -- scrib63S15 X ray ethyl methanesulfonate 0 -- scrib882 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- scribA128 ethyl methanesulfonate 0 -- scribc00019 0 -- scribc00119 piggyBac transposase 0 -- scribCA07683 P-element activity 0 Yes scribdt12 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- scribf02351 0 -- scribird15 loss of function allele ethyl methanesulfonate 0 -- scribjB709 0 -- scribL97C P-element activity 0 Yes scribS042405b hypomorphic allele - genetic evidence Delta2-3 P-element activity 0 Yes scribsmi97B-15A Delta2-3 0 Yes scribsmi97B-16A Delta2-3 0 Yes scribsmi97B-2A Delta2-3 0 Yes scribsmi97B Delta2-3 0 Yes scribunspecified 0 -- scribUU7 ethyl methanesulfonate 0 -- scribvartul P-element activity 0 Yes scribΔG P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of scrib Class Mutagen Stocks Known lesion scribGD11666 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes scribGD11663 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes scribGL00638 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes scribHMS01490 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes scribHMS01993 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes scribJF03229 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes scribKK101128 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes scribKK103936 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes scribKK106065 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes scrib4.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes scribhs.PB in vitro construct - regulatory fusion 0 Yes scribL223Q.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes scribNIG.31082R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes scribNIG.5462R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes scribPDZ.T:Avic\GFP in vitro construct - coding region fusion 0 Yes scribScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes scribScer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes scribΔLRR.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes scribΔLRR.Scer\UAS.P\T.T:Myr-Src42A,T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes scribΔPDZ3.4.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes scribΔPDZs.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC752 (Christensen et al., 2009.2.28) Df(3R)ED6235 (Ryder and Roote, 2004.11.10) Df(3R)Espl10 (Spradling et al., 1999) Df(3R)ME61 (Cook and Carpenter, 2002) Df(3R)ro80b (Wu et al., 2001) Df(3R)Tl84cRPA (Howe et al., 1995) Df(3R)Tl-I (Brumby et al., 2004, Cook and Carpenter, 2002) Df(3R)Tl-P (Spradling et al., 1999, BDGP Project Members, 1994-1999, Thibault et al., 2004, Szeged Stock Center, 1998-, Brumby et al., 2004, Cook and Carpenter, 2002) Df(3R)Tl-X (Roche et al., 2002, Wu et al., 2001, Kidd et al., 1999, Brumby et al., 2004, Zeitler et al., 2004, Ganguly et al., 2003, Cook and Carpenter, 2002, Bilder and Perrimon, 2000) T(2;3)63S15 (Brumby et al., 2004) T(2;3)lt-x13p20 (Howe et al., 1995) T(2;3)lt-x13p89 (Howe et al., 1995) T(2;3)tx-p1 (Howe et al., 1995) T(2;3)tx-p5 (Howe et al., 1995) T(2;3)tx-p15 (Howe et al., 1995) T(2;3)tx-p17 (Howe et al., 1995) T(2;3)tx-p18 (Howe et al., 1995) T(2;3)tx-p19 (Howe et al., 1995) T(2;3)tx-p31 (Howe et al., 1995) T(2;3)tx-x13p100 (Howe et al., 1995)
Not disrupted in	Df(3R)3450 (Brumby et al., 2004) Df(3R)Espl3 (Cook and Carpenter, 2002) Df(3R)ro80b (Cook and Carpenter, 2002, Kidd et al., 1999) Df(3R)XTA1 (Brumby et al., 2004) T(2;3)8r9 (Bilder and Perrimon, 2000) T(2;3)ClassIII (Howe et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11663} NA P{KK101128} NA P{KK106065} NA P{NIG.5462R} NA P{NIG.31082R} NA P{TRiP.GL00638} NA P{TRiP.HMS01490} NA P{TRiP.HMS01993} NA P{TRiP.JF03229} NA P{UASp-myr-scrib.ΔLRR.GFP} NA P{UASp-Scrib4.GFP} NA P{UASp-scrib.GFP} NA P{UASp-scrib.L223Q.GFP} NA P{UASp-scrib.ΔLRR.GFP} NA P{UASp-scrib.ΔPDZ3/4.GFP} NA P{UASp-scrib.ΔPDZs.GFP} NA P{UAS-scrib.B} NA heat-shock construct P{hs-scrib.B} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}scribj7B3 No P{lacW}scribS042405b No P{lArB}scribL97C No P{lArB}scribsmi97B No insertion of mobile activating element P{EPgy2}scribEY04509 NA miscellaneous insertions Mi{MIC}scribMI00800 NA Mi{MIC}scribMI01968 NA Mi{MIC}scribMI07508 NA P{?lArB}scribsmi97B-2A NA P{?lArB}scribsmi97B-15A NA P{}scribvartul NA P{PTT-GA}scribCA07683 NA P{SUPor-P}scribKG04161 NA PBac{PB}scribc00119 NA PBac{PB}scribc03872 NA PBac{PB}scribc06946 NA PBac{PB}scribc06968 NA PBac{PB}scribc07109 NA PBac{WH}scribf02531 NA PBac{WH}scribf04986 NA PBac{WH}scribf06915 NA insertion of enhancer trap binary system P{GawB}scribNP7522 No
Gene Ontology: Function, Process & Cellular Component ( 42 unique terms )
Terms Based on Experimental Evidence ( 34 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with gukh (Mathew et al., 2002)
Biological Process
CV term Evidence References
asymmetric protein localization inferred from mutant phenotype (Albertson and Doe, 2003) cell cycle process inferred from mutant phenotype (Dow et al., 2003) cell morphogenesis inferred from mutant phenotype (Zeitler et al., 2004) cell proliferation inferred from mutant phenotype (Bilder et al., 2000, Uhlirova and Bohmann, 2006) compound eye development inferred from mutant phenotype (Zeitler et al., 2004) dorsal closure inferred from mutant phenotype (Zeitler et al., 2004) establishment of epithelial cell apical/basal polarity inferred from mutant phenotype (Dow et al., 2003) establishment of imaginal disc-derived wing hair orientation inferred from mutant phenotype (Courbard et al., 2009) establishment of ommatidial planar polarity inferred from mutant phenotype (Courbard et al., 2009) establishment or maintenance of apical/basal cell polarity inferred from mutant phenotype (Zeitler et al., 2004) establishment or maintenance of polarity of follicular epithelium inferred from mutant phenotype (Bilder et al., 2000) establishment or maintenance of polarity of larval imaginal disc epithelium inferred from mutant phenotype (Bilder et al., 2000) Malpighian tubule development inferred from mutant phenotype (Zeng et al., 2010, Campbell et al., 2009) morphogenesis of follicular epithelium inferred from mutant phenotype (Bilder et al., 2000) morphogenesis of larval imaginal disc epithelium inferred from mutant phenotype (Bilder et al., 2000) negative regulation of epithelial cell proliferation inferred from mutant phenotype (Zeitler et al., 2004) negative regulation of imaginal disc growth inferred from mutant phenotype (Zeitler et al., 2004) olfactory behavior inferred from mutant phenotype (Ganguly et al., 2003, Anholt et al., 1996) positive regulation of antibacterial peptide biosynthetic process inferred from mutant phenotype (Choe et al., 1999) R3/R4 cell fate commitment inferred from mutant phenotype (Courbard et al., 2009) regulation of endocytosis inferred from mutant phenotype (Igaki et al., 2009) regulation of synapse structure and activity inferred from mutant phenotype (Roche et al., 2002) septate junction assembly inferred from mutant phenotype (Zeitler et al., 2004) stem cell differentiation inferred from mutant phenotype (Zeng et al., 2010) stem cell proliferation inferred from mutant phenotype (Zeng et al., 2010) wing disc morphogenesis inferred from mutant phenotype (Zeitler et al., 2004) zonula adherens assembly inferred from mutant phenotype (Zeitler et al., 2004)
Cellular Component
CV term Evidence References
apicolateral plasma membrane inferred from direct assay (Bilder et al., 2000) basolateral plasma membrane inferred from direct assay (Sotillos et al., 2004) fusome inferred from direct assay (Lighthouse et al., 2008) lateral plasma membrane inferred from direct assay (Bilder et al., 2000) neuromuscular junction inferred from direct assay (Kohsaka et al., 2007) septate junction inferred from direct assay (Bilder and Perrimon, 2000)
Terms Based on Predictions or Assertions ( 12 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
asymmetric protein localization traceable author statement (Wedlich, 2002) dorsal closure traceable author statement (Harden, 2002) establishment or maintenance of epithelial cell apical/basal polarity non-traceable author statement (Johnston and Gallant, 2002) traceable author statement (Humbert et al., 2003, Tepass et al., 2001) establishment or maintenance of polarity of embryonic epithelium traceable author statement (Bilder et al., 2000) gonad development non-traceable author statement (Marhold et al., 2003) morphogenesis of a polarized epithelium traceable author statement (Gibson and Perrimon, 2003) morphogenesis of embryonic epithelium traceable author statement (Bilder et al., 2000) negative regulation of cell proliferation traceable author statement (Humbert et al., 2003) pole cell migration non-traceable author statement (Marhold et al., 2003) regulation of cell cycle non-traceable author statement (Humbert et al., 2003)
Cellular Component
CV term Evidence References
basolateral plasma membrane traceable author statement (Gibson and Perrimon, 2003) septate junction non-traceable author statement (Tepass et al., 2001) traceable author statement (Caruana, 2002, Humbert et al., 2003, Cereijido et al., 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions scrib allele Gene References scrib1 CycE (Brumby et al., 2004) Eb1 (Brumby et al., 2004) l(2)gl (Brumby et al., 2004) l(3)cl-R3 (Brumby and Richardson, 2003) N (Brumby and Richardson, 2003) phyl (Brumby et al., 2004) Ras85D (Brumby and Richardson, 2003, Pagliarini and Xu, 2003) S(CycEJP)2.4 (Brumby et al., 2004) S(CycEJP)2.9 (Brumby et al., 2004) scb (Brumby et al., 2004) scrib5 Eb1 (Brumby et al., 2004) l(2)gl (Brumby et al., 2004) phyl (Brumby et al., 2004) S(CycEJP)2.4 (Brumby et al., 2004) S(CycEJP)2.9 (Brumby et al., 2004) scb (Brumby et al., 2004) scrib63S15 CycE (Brumby et al., 2004) scrib673 crb (Tanentzapf and Tepass, 2003, Bilder et al., 2003) CycE (Brumby et al., 2004) sdt (Tanentzapf and Tepass, 2003) scribsmi97B Cam (Anholt et al., 2003) fax (Anholt et al., 2003) Hk (Anholt et al., 2003) Pino (Fedorowicz et al., 1998) sgg (Anholt et al., 2003) smi51A (Fedorowicz et al., 1998) trp (Anholt et al., 2003) scribunspecified dlg1 (Bilder et al., 2000) l(2)gl (Bilder et al., 2000) Ras85D (Pagliarini and Xu, 2003) unspecified Egfr (Read et al., 2005) kay (Uhlirova and Bohmann, 2006) Ras85D (Uhlirova and Bohmann, 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0263289 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7KRY7
Orthologs
OrthoDB Orthologs (50) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64QTK7 Dipteran inclusive ortholog search EOG6RXZ74 Insect inclusive ortholog search EOG6FQZMW Arthropod inclusive ortholog search EOG62547X Metazoa inclusive ortholog search EOG6TFCCG
Orthologs in Drosophila Species (EOG64QTK7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG12885     Drosophila melanogaster fruit fly  Dmel\scrib     Drosophila melanogaster fruit fly  Dmel\pnr     Drosophila simulans   Dsim\GD21289   Y Drosophila sechellia   Dsec\GM21540   Y Drosophila sechellia   Dsec\GM10328   Y Drosophila erecta   Dere\GG11485   Y Drosophila yakuba   Dyak\GE23676   Y Drosophila ananassae   Dana\GF16442   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA18897   Y Drosophila persimilis   Dper\GL23097   Y Drosophila willistoni   Dwil\GK13318   Y Drosophila mojavensis   Dmoj\GI22874   Y Drosophila grimshawi   Dgri\GH18723   Y
Orthologs in non-Drosophila Dipterans (EOG6RXZ74)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002336 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000054 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006376 Y
Orthologs in non-Dipteran Insects (EOG6FQZMW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53149 Y Apis mellifera Western honey bee  Amel\GB53150 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011031 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15226 Y Atta cephalotes Leafcutter ant  Acep\ACEP19189 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO15562 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14866 Y Linepithema humile Argentine ant  Lhum\LH20400 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24314 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24316 Y Solenopsis invicta Red fire ant  Sinv\SINV14539 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004696 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006516 Y Pediculus humanus Human body louse  Phum\PHUM127710 Y Tribolium castaneum Red flour beetle  Tcas\TC011397 Y
Orthologs in non-Insect Arthropods (EOG62547X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Mrpl14 Y Daphnia pulex Water flea  Dpux\psmb9a Y Ixodes scapularis Deer tick  Isca\ISCW024675 Y Ixodes scapularis Deer tick  Isca\ISCW019590 Y
Orthologs in non-Arthropod Metazoa (EOG6TFCCG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\let-413 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002555gn Y Danio rerio Zebrafish  Drer\lrrc1 Y Danio rerio Zebrafish  Drer\scrib Y Xenopus tropicalis Western clawed frog  Xtro\lrrc1 Y Xenopus tropicalis Western clawed frog  Xtro\scrib Y Gallus gallus Domestic chicken  Ggal\SCRIB Y Gallus gallus Domestic chicken  Ggal\LRRC1 Y Mus musculus House mouse  Mmus\Lrrc1 Y Mus musculus House mouse  Mmus\Scrib Y Rattus norvegicus Norway rat  Rnor\Scrib Y Rattus norvegicus Norway rat  Rnor\Lrrc1 Y Homo sapiens Human  Hsap\ENSG00000180900 Y Homo sapiens Human  Hsap\LRRC1 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000180900     Hsap\LRRC1
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21290 Drosophila sechellia Dsec\GM10329 Drosophila erecta Dere\GG11486 Drosophila yakuba Dyak\GE23677 Drosophila pseudoobscura pseudoobscura Dpse\GA18901 Drosophila willistoni Dwil\GK13319 Drosophila virilis Dvir\GJ14170 Drosophila mojavensis Dmoj\GI22875
Stocks & Reagents
Stocks Listed in FlyBase ( 31 )
Harvard	- PBac{PB}scribc03872 - PBac{PB}scribc06946 - PBac{PB}scribc06968 - PBac{PB}scribc07109 - PBac{WH}scribf02531 - PBac{WH}scribf04986 - PBac{WH}scribf06915
VDRC	v100363 P{KK106065}VIE-260B v102821 P{KK103936}VIE-260B v105412 P{KK101128}VIE-260B v27430 w1118 P{GD11666}v27430 v27424 w1118; P{GD11663}v27424
	More stocks available...
Genomic Clones ( 2 )
	BACR13P17 BACR48G23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 170 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH07007 IP16017 LD43989 RE02389 RH61266 SD05339
Other clones	IP21957 MIP24161
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT19452 GH04901 GH20730 GH23755 GH27459 GH27616 GM12994 GM13360 GM25745 GM28613 HL01174 HL04983 LD11253 LD13173 LD13923 LD16092 LD22510 LD26440 LD28165 LD30341 LD32992 LD43114 LP13352 RE14364 RH43728 RH45643 RH65672 RH70541 SD05630 SD13319 SD20576 SD23914
Other clones	14685 19762 28650 30255 31102 38613 39016 39757 45190 46998 54042 55463 57605 65650 66100 70153 76806 99502 104937 105301 107688 107970 108018 108726 117605 145712 156448 156687 166001 174491 176120 179673 192137 214279.12 214317.60 214415.6 214437.12 214447.14 214533.12 214571.7 272812 283271 bs13h05 CK01.9D.G12 CK01.21A.G5 CK01.35D.D4 CK01.38B.B12 CK01.43B.F10 CK01.50A.A12 CK01.53C.A10 CK01.58D.E4 CK01.76D.D12 CK01.86A.B4 CK01.90C.B10 CK01.120B.B10 CK01.122A.B6 CK01.123B.E1 CK01.145A.B10 CK00392 CK02488 EK040434 EK043333 EK047750 EK048307 EK049909 EK060146 EK063027 EK067132 EK071039 EK093239 EK093817 EK105802 EK108406 EK119337 EK136139 EK138748 EK139814 EK144905 EK160530 EK163302 EK171140 EK174024 EK177606 EK178060 EK178825 EK187203 EK193121 EK197331 EK209732 EK219009 EK233103 EK233764 EK244641 EK244716 EK248662 EK252433 EK257804 EK259422 EK259514 EK270926 EK276617 EK290445 EK294945 EK299742 EK308755 EP01330 EP02256 EP08564 EP15550 EP16906 EP17927 EP19020 ESG0120a.B21_D07 FGM304C06 FGM325C07 IP13466 IP16117 IP16217 IP16317 IP18031 IP18131 IP18231 IP18331 LD15830 LD37377 RP004183442 RP004247011 RP004375283 RP004497010 RP004532196
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44448
Antibody Information
	polyclonal (Li et al., 2001, Bilder and Perrimon, 2000)
Other Information
Discoverer
	L. and Y. Jan.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: scrib CG5462 (Bilder, 2000.3.24) Source for merge of: scrib CG5467 (FlyBase Genome Annotators, 2009) Source for merge of: scrib CG31082 (FlyBase Genome Annotators, 2011) Source for merge of: scrib l(3)c00119 (FlyBase, 1996-) Source for merge of: scrib l(3)j7B3 l(3)673 (Bilder, 1999.9.28) Source for merge of: scrib l(3)S042405 (Bilder and Perrimon, 2000) Source for merge of: scrib smi97B (Ganguly et al., 2001) Source for merge of: scrib vart CG5462 (Mechler, 2000.4.12, Bryant, 2000.5.26)
Additional comments	Annotations CG42614 and CG31082 merged as CG43398 in release 5.39 of the genome annotation. (FlyBase Genome Annotators, 2011) Annotations CG5462 and CG5467 merged as CG42614 in release 5.20 of the genome annotation. (FlyBase Genome Annotators, 2009)
Other Comments
	The LRR region of the scrib product is necessary and sufficient to form a polarized epithelial monolayer, provides significant control of cell proliferation, and also regulates its subcellular localization. (Zeitler et al., 2004) The PDZ domains of the scrib product are not essential for the development of monolayered epithelia but are involved in providing full control over cell proliferation. (Zeitler et al., 2004) scrib is essential for odour guided behaviour. (Ganguly et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) New annotation (CG31082) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) scrib specifically restricts apical membrane determinants to the apical cell surface. (Bilder and Perrimon, 2000) scrib is required for polarisation of the embryonic, imaginal disc and follicular epithelia. scrib acts as a tumour suppressor. (Bilder et al., 2000) Mutations in scrib disrupt cell adhesion, polarity and shape in the ovarian follicular epithelium, the imaginal disc and the embryonic epidermis. (Bilder and Perrimon, 1999) Identification: Isolated in a screen for mutants that failure to induce a Dpt-Ecol\lacZ reporter after E.coli injection. (Choe et al., 1999) Identified during a screen for olfactory mutants. (Anholt et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080015 NM_170275 NM_170276 NM_170277 NM_001014669 NM_001014670 NM_001043296 NM_001170274 NM_001170275 NM_001170276 NM_001260389 NM_001260390 NM_001260391 NM_001260392 NM_001260393 NM_001276058 NM_001276059 NM_001276060 RefSeq (Proteins) • NP_524754 NP_733154 NP_733155 NP_733156 NP_001014669 NP_001014670 NP_001036761 NP_001163745 NP_001163746 NP_001163747 NP_001247318 NP_001247319 NP_001247320 NP_001247321 NP_001247322 NP_001262987 NP_001262988 NP_001262989 DDBJ / EMBL / GenBank • AA140699 AA140700 AA392400 AA441056 AA441190 AA801781 AA803512 AA817281 AA942310 AA949316 AA978822 AAF26357 AAF56598 AAF56598.2 AAL25508 AAL28190 AAL39806 AAN14076 AAN14076.1 AAN14077 AAN14077.1 AAN14078 AAN14078.1 AAN14079 AAO32791 AAO32792 AAO32793 AAO32794 AAT94469 AAX52995 AAX52996 ABI31210 ACZ95039 ACZ95040 ACZ95041 AF190774 AFH06635 AFH06636 AFH06637 AFH06638 AFH06639 AGB96367 AGB96368 AGB96369 AI108226 AI403174 AI404149 AI455067 AI457086 AI511640 AI512224 AI516996 AI533495 AI533713 AI945529 AJ252084 AJ271647 AQ034098 AW940245 AW943689 AW944411 AY060469 AY060642 AY069661 AY167903 AY167904 AY167905 AY167906 BG637579 BG638104 BG638833 BI353966 BT015240 CAB70601 CAB71137 CL527755 CZ468864 CZ471107 CZ471128 CZ485056 CZ489656 CZ489657 Entrez Gene - A searchable database of RefSeq genes. • 44448 318587 UniProtKB/Swiss-Prot • Q7KRY7 UniProtKB/TrEMBL • E1JIZ0 E1JIZ1 E1JIZ2 Q8IMR7 Q95SR1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Leucine rich repeat 4 (IPR025875) PDZ domain (IPR001478) Leucine-rich repeat (IPR001611) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH07007
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0263289 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44448 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7KRY7
Synonyms & Secondary IDs ( 33 )
Reported As
Symbol Synonym	0424/05 (Deak et al., 1997) CG5462 (Hazelett et al., 2009, Klement et al., 2010, Norga et al., 2003, Bryant, 2000.5.26, Mechler, 2000.4.12, Keleman et al., 2009.8.5, Perkins et al., 2009, Mummery-Widmer et al., 2009) CG5467 (Doheny et al., 2008, Keleman et al., 2009.8.5) CG31082 (Keleman et al., 2009.8.5, Yano et al., 2012, Japanese National Institute of Genetics, 2012.5.21) CG42614 (FlyBase Genome Annotators, 2009, Ni et al., 2011.7.19, Azad et al., 2012) CG43398 (FlyBase Genome Annotators, 2011, Ni et al., 2010.12.1) CT17324 (Hynes and Zhao, 2000) ird (Wasserman, 2000) ird15 (Dean et al., 2001, Anholt and Mackay, 2001, Choe et al., 1999, Choe et al., 1999, ) l(3)673 (Kidd et al., 1999, Howe et al., 1995, ) l(3)c00119   l(3)j7B3 (Spradling et al., 1999, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) l(3)S042405 (Szeged Stock Center, 1998-, ) MENE (3R)-F (Menut et al., 2007) Scb (Lecuit, 2004) SCR (Kramer, 2000) scrb (Thomson and Johnson, 2010, Weber et al., 2012) Scrb (Kolsch et al., 2007, Somorjai and Martinez-Arias, 2008) Scrib (Cho et al., 2011, Zeng et al., 2010, Djiane et al., 2011, Egger et al., 2007, Caruana, 2002, Santoni et al., 2002, Le Bivic, 2005, Wei et al., 2005, Guan et al., 2006, Lee et al., 2006, Zhu et al., 2008, Wu and Beitel, 2004, Suzuki and Ohno, 2006, Somorjai and Martinez-Arias, 2008, Romani et al., 2009, Harris and Tepass, 2008, Gorfinkiel and Arias, 2007, Ramachandran et al., 2009, Mendoza-Topaz et al., 2008, Gorczyca et al., 2007, Rolls et al., 2007, Kohsaka et al., 2007, Warner and Longmore, 2009, Laprise et al., 2010, Warner et al., 2010, Azad et al., 2012, Andersen et al., 2012, Mathew et al., 2011) scrib (Li et al., 2011, Brumby et al., 2011, Wu et al., 2010, Goossens et al., 2011, Ohsawa et al., 2011, Grusche et al., 2011, Dow et al., 2003, Grifoni et al., 2004, Zhao et al., 2008, Wirtz-Peitz and Knoblich, 2006, Wodarz and Gonzalez, 2006, Djiane et al., 2005, Tyler et al., 2007, Uhlirova et al., 2005, Mathew et al., 2002, Lu and Bilder, 2005, Zeitler et al., 2004, Guthridge et al., 2007, Mishra and Nigam, 2007, Tountas and Fortini, 2007, Buszczak et al., 2007, Uhlirova and Bohmann, 2006, Chia et al., 2008, Menut et al., 2007, Srivastava et al., 2007, Li et al., 2008, Grzeschik et al., 2007, Firth and Baker, 2007, Albertson et al., 2004, Hauenschild et al., 2008, Junion et al., 2007, Christensen et al., 2009.2.28, Mao and Freeman, 2009, Rhiner et al., 2009, Igaki et al., 2009, Laprise et al., 2009, Courbard et al., 2009, Campbell et al., 2009, Igaki et al., 2006, Igaki et al., 2006, Leong et al., 2009, Li et al., 2009, Siegrist et al., 2010, Grzeschik et al., 2010, Lighthouse et al., 2008, Froldi et al., 2010, Cordero et al., 2010, Rhiner et al., 2010, Menéndez et al., 2010, Fichelson et al., 2010, Bahri et al., 2010, Krahn et al., 2010, Pastor-Pareja et al., 2008, Jiang et al., 2011, Chen et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Nelson et al., 2012, Justiniano et al., 2012, Andersen et al., 2012, Tan et al., 2012, Weber et al., 2012) smi97B (Anholt, 2004, Mackay, 2004, Anholt et al., 2003, Dean et al., 2001, Ganguly et al., 2001, Anholt and Mackay, 2001, Anholt et al., 1996, ) unnamed (Thibault et al., 2004) vart (Bryant, 2000.5.26, Mechler, 2000.4.12, Mechler, 1999.12.23, )
Name Synonym	CG5467   gp150-like (Hynes and Zhao, 2000) immune response deficient 15 (Choe et al., 1999) lethal (3) c00119   Scribble (Mateus and Martinez Arias, 2011, Cho et al., 2011, Thomson and Johnson, 2010, Hatan et al., 2011, Djiane et al., 2011, Swanson et al., 2009, Caruana, 2002, Zhao et al., 2006, Muschalik et al., 2006, Garcia-Mata and Burridge, 2007, Das et al., 2006, Ataman et al., 2006, Swanson and Beitel, 2006, Khoo et al., 2007, Margolis and Borg, 2005, Wu and Beitel, 2004, Rodriguez-Boulan et al., 2004, Suzuki and Ohno, 2006, Das et al., 2008, Kohsaka et al., 2007, Li et al., 2008, Albertson et al., 2004, Harris and Tepass, 2008, Campbell et al., 2009, Gorczyca et al., 2007, Warner and Longmore, 2009, Siegrist et al., 2010, Grzeschik et al., 2010, Warner et al., 2010, Bahri et al., 2010, Andersen et al., 2012) scribble (Li et al., 2011, Newman and Prehoda, 2009, Dow et al., 2003, Grifoni et al., 2004, Zhao et al., 2008, Sambandan et al., 2008, Coffman, 2004, Torban et al., 2004, Polesello and Payre, 2004, Levine, 2004, Humbert et al., 2003, Bryant and Huwe, 2000, Bilder et al., 2000, Muller, 2003, Schober et al., 2002, Mathew et al., 2001, Knust, 2000, Jan and Jan, 2000, Roche et al., 2002, Brumby et al., 2004, Anholt, 2004, Brumby and Richardson, 2003, Santoni et al., 2002, Ganguly et al., 2001, Li et al., 2001, Kramer, 2000, Bilder, 2000.3.24, Bilder and Perrimon, 1999, Uhlirova and Bohmann, 2006, Humbert et al., 2006, Wiggin et al., 2005, Lu and Bilder, 2005, Zeitler et al., 2004, Sahota et al., 2007, Tountas and Fortini, 2007, Guan et al., 2006, Uhlirova and Bohmann, 2006, Pastor-Pareja et al., 2008, Baas et al., 2004, Veeman et al., 2003, Chia et al., 2008, Zhao et al., 2005, Firth and Baker, 2007, Rhiner et al., 2009, Leong et al., 2009, Li et al., 2009, Laprise et al., 2010, Lighthouse et al., 2008, Tamori et al., 2010, Froldi et al., 2010, Cordero et al., 2010, Rhiner et al., 2010, Fichelson et al., 2010, Chen et al., 2012, Justiniano et al., 2012) scribbled (Wu et al., 2010, Grusche et al., 2011, Hazelett et al., 2009, Klement et al., 2010, Bilder and Perrimon, 1999, Srivastava et al., 2007, Hauenschild et al., 2008, Menéndez et al., 2010, Weber et al., 2012) Scribbled (Kolsch et al., 2007, Zhu et al., 2008, Tan et al., 2012) Scribbles (Lecuit, 2004) smell impaired 97B (Anholt et al., 1996) vartul (Mechler, 1999.12.23)
Secondary FlyBase IDs
	FBgn0011401 FBgn0016016 FBgn0016937 FBgn0026178 FBgn0026234 FBgn0028155 FBgn0028975 FBgn0039432 FBgn0039433 FBgn0051082 FBgn0069188 FBgn0261263
References ( 283 )
Generate a list of	All references relating to this gene ( 283 )
List References by type	Research paper  ( 140 ) Supplementary material  ( 7 ) Review  ( 58 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 21 ) Abstract  ( 41 ) FlyBase analysis  ( 6 ) Conference report  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 27 )
	Willoughby et al., 2013, Dis. Model Mech. 6(2): 521--529 An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery. [FBrf0221096] Adamson and Lajeunesse, 2012, ScientificWorldJournal 2012: 347597 A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System. [FBrf0218446] Andersen et al., 2012, Dev. Biol. 363(1): 258--265 Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts. [FBrf0217488] Azad et al., 2012, G3 (Bethesda) 2(10): 1169--1178 Identification of Genes Underlying Hypoxia Tolerance in Drosophila by a P-element Screen. [FBrf0219647] Chen et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(2): 484--489 Tumor suppression by cell competition through regulation of the Hippo pathway. [FBrf0217148] Justiniano et al., 2012, PLoS ONE 7(2): e31417 Loss of the Tumor Suppressor Pten Promotes Proliferation of Drosophila melanogaster Cells In Vitro and Gives Rise to Continuous Cell Lines. [FBrf0217611] Lolo et al., 2012, Cell Rep. 2(3): 526--539 Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes. [FBrf0220993] Nelson et al., 2012, Nat. Cell Biol. 14(5): 518--525 Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size. [FBrf0218197] Tan et al., 2012, PLoS Genet. 8(5): e1002681 MicroRNA-277 Modulates the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats. [FBrf0218227] Verghese et al., 2012, PLoS ONE 7(11): e47173 Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity. [FBrf0219901] Wandler and Guillemin, 2012, PLoS Pathog. 8(10): e1002939 Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila. [FBrf0219744] Weber et al., 2012, Genetics 191(1): 145--162 Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Brumby et al., 2011, Genetics 188(1): 105--125 Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis. [FBrf0213630] Cho et al., 2011, PLoS ONE 6(7): e22703 Wolbachia bacteria reside in host Golgi-related vesicles whose position is regulated by polarity proteins. [FBrf0214605] Djiane et al., 2011, J. Cell Biol. 192(1): 189--200 Su(dx) E3 ubiquitin ligase-dependent and -independent functions of Polychaetoid, the Drosophila ZO-1 homologue. [FBrf0212737] Doggett et al., 2011, BMC Dev. Biol. 11: 57 Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. [FBrf0216618] Goossens et al., 2011, Development 138(8): 1595--1605 The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development. [FBrf0213316] Grusche et al., 2011, Dev. Biol. 350(2): 255--266 The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. [FBrf0212888] Hatan et al., 2011, J. Cell Biol. 192(2): 307--319 The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures. [FBrf0212807] Jiang et al., 2011, Oncogene 30(29): 3248--3260 Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. [FBrf0214488] Li et al., 2011, Fly 5(2): 81--87 Requirements of Lgl in cell differentiation and motility during Drosophila ovarian follicular epithelium morphogenesis. [FBrf0213760] Mateus and Martinez Arias, 2011, PLoS ONE 6(11): e27159 Patterned Cell Adhesion Associated with Tissue Deformations during Dorsal Closure in Drosophila. [FBrf0216560] Mathew et al., 2011, Mol. Cell. Biol. 31(24): 4978--4993 Role for traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. [FBrf0216703] Ohsawa et al., 2011, Dev. Cell 20(3): 315--328 Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila. [FBrf0213219] Oshima and Fehon, 2011, J. Cell Sci. 124(16): 2861--2871 Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large. [FBrf0214577] Rotstein et al., 2011, PLoS ONE 6(12): e28985 Tramtrack is genetically upstream of genes controlling tracheal tube size in Drosophila. [FBrf0217085] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...