• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Mrp4

General Information
Symbol	Dmel\Mrp4	Species	D. melanogaster
Name	Multidrug resistance protein 4 ortholog	Annotation symbol	CG14709
Feature type	protein_coding_gene	FlyBase ID	FBgn0263316
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	BEST:CK01227
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	86E11-86E11	Sequence location	3R:7,394,972..7,401,659 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Multidrug resistance protein 4 ortholog is referred to in FlyBase by the symbol Dmel\Mrp4 (CG14709, FBgn0263316). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: response to hypoxia; response to anoxia; wing disc dorsal/ventral pattern formation. 21 alleles are reported. The phenotype of these alleles is annotated with: intersegmental nerve. It has one annotated transcript and one annotated polypeptide. Protein features are: AAA+ ATPase domain; ABC transporter, conserved site; ABC transporter, integral membrane type 1; ABC transporter, transmembrane domain; ABC transporter, transmembrane domain, type 1; ABC transporter-like. Gene sequence location is 3R:7394972..7401659.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86E11-86E11   Limits computationally determined from genome sequence between P{PZ}tho1&P{PZ}l(3)0462905275 and P{EP}Lk6EP886
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mrp4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mrp4-RB FBtr0302027  NM_141829   4726   1316
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mrp4-PB   FBpp0291237   147.9   1316   7.64     NP_650086   AAF54656
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) ABC transporter, transmembrane domain (IPR001140) ABC transporter-like (IPR003439) AAA+ ATPase domain (IPR003593) ABC transporter, transmembrane domain, type 1 (IPR011527) ABC transporter, conserved site (IPR017871) ABC transporter, integral membrane type 1 (IPR017940)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141101   AA141788   AA141798   AE014297 AAF54656   AK277892   AQ073830   BF491569   BG640592   BI612760   BP559110   BP559111   BT031028   CA807713   CC060159   CO152874   CO263690   CO264131   CO275078   CO282369   CO287681   CO297429   CO309544   CO310146   CZ466370   CZ466371   CZ474487   EC062005   EC202016   EC211955   EC221180   EC222400   EC224916   EC231314   EC247836   EC263584
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VGM1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    3 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    33 embryo 16-18hr    42 embryo 18-20hr    43 embryo 20-22hr    23 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    8 pupae 2d postWPP    11 pupae 3d postWPP    9 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr  (33) embryo 16-18hr  (42) embryo 18-20hr  (43) embryo 20-22hr    23 embryo 22-24hr  (36) larva L1    22 larva L2    18 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    8 pupae 2d postWPP    11 pupae 3d postWPP    9 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    33 embryo 16-18hr    42 embryo 18-20hr    43 embryo 20-22hr    23 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    8 pupae 2d postWPP    11 pupae 3d postWPP    9 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    33 embryo 16-18hr    42 embryo 18-20hr    43 embryo 20-22hr    23 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    8 pupae 2d postWPP    11 pupae 3d postWPP    9 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    33 embryo 16-18hr    42 embryo 18-20hr    43 embryo 20-22hr    23 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    8 pupae 2d postWPP    11 pupae 3d postWPP    9 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr  (33) embryo 16-18hr  (42) embryo 18-20hr  (43) embryo 20-22hr    23 embryo 22-24hr  (36) larva L1    22 larva L2    18 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    8 pupae 2d postWPP    11 pupae 3d postWPP    9 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    33 embryo 16-18hr    42 embryo 18-20hr    43 embryo 20-22hr    23 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    8 pupae 2d postWPP    11 pupae 3d postWPP    9 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    33 embryo 16-18hr    42 embryo 18-20hr    43 embryo 20-22hr    23 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    20 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    8 pupae 2d postWPP    11 pupae 3d postWPP    9 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    8 adult male 30day    9 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    43 embryonic 1182-4H    34 embryonic GM2    89 embryonic Kc167    89 embryonic S1    21 embryonic S3    29 leg disc CME L1    48 wing disc CME-W2    75 wing disc ML-DmD8    18 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    100 tumorous blood cells mbn2    88 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (28) Schneider line 2 Sg4  (43) embryonic 1182-4H  (34) embryonic GM2  (89) embryonic Kc167  (89) embryonic S1    21 embryonic S3  (29) leg disc CME L1  (48) wing disc CME-W2  (75) wing disc ML-DmD8    18 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2  (100) tumorous blood cells mbn2  (88) ovary fGS/OSS  (36) ovary OSC    19 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    43 embryonic 1182-4H    34 embryonic GM2    89 embryonic Kc167    89 embryonic S1    21 embryonic S3    29 leg disc CME L1    48 wing disc CME-W2    75 wing disc ML-DmD8    18 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    100 tumorous blood cells mbn2    88 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    43 embryonic 1182-4H    34 embryonic GM2    89 embryonic Kc167    89 embryonic S1    21 embryonic S3    29 leg disc CME L1    48 wing disc CME-W2    75 wing disc ML-DmD8    18 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    100 tumorous blood cells mbn2    88 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    43 embryonic 1182-4H    34 embryonic GM2    89 embryonic Kc167    89 embryonic S1    21 embryonic S3    29 leg disc CME L1    48 wing disc CME-W2    75 wing disc ML-DmD8    18 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    100 tumorous blood cells mbn2    88 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  28 Schneider line 2 Sg4  (43) embryonic 1182-4H  (34) embryonic GM2  (89) embryonic Kc167  (89) embryonic S1    21 embryonic S3  29 leg disc CME L1  (48) wing disc CME-W2  (75) wing disc ML-DmD8    18 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2  (100) tumorous blood cells mbn2  (88) ovary fGS/OSS  (36) ovary OSC    19 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    43 embryonic 1182-4H    34 embryonic GM2    89 embryonic Kc167    89 embryonic S1    21 embryonic S3    29 leg disc CME L1    48 wing disc CME-W2    75 wing disc ML-DmD8    18 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    100 tumorous blood cells mbn2    88 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    43 embryonic 1182-4H    34 embryonic GM2    89 embryonic Kc167    89 embryonic S1    21 embryonic S3    29 leg disc CME L1    48 wing disc CME-W2    75 wing disc ML-DmD8    18 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    100 tumorous blood cells mbn2    88 ovary fGS/OSS    36 ovary OSC    19 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_29 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage | conditional, with Scer\GAL4da.G32 Mrp4EP3177 Mrp4EP3221 Mrp4EP3655 lethal | larval stage | conditional, with Scer\GAL4elav.PU Mrp4EP3177 viable, with Scer\GAL4pnr-MD237 Mrp4GD2920 Other Phenotypes Allele chemical sensitive, with Scer\GAL4da.G32 Mrp4UY4731 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 Mrp4EP3221 stress response defective, with Scer\GAL4442 Mrp4EP3177 stress response defective, with Scer\GAL4Act.PU Mrp4EP430 Mrp4EP3177 Mrp4EP3221 Mrp4EP3655 stress response defective, with Scer\GAL4da.G32 Mrp4EP430 Mrp4EP3177 Mrp4EP3221 Mrp4EP3655 stress response defective, with Scer\GAL4Ddc.PL Mrp4EP3177 stress response defective, with Scer\GAL4elav.PU Mrp4EP3177 Mrp4EP3221 stress response defective (with Mrp4EP3177) Mrp4EP3221 Mrp4EP3328 Mrp4ex621 Mrp4ex661 stress response defective (with Mrp4EP3221) Mrp4EP3177 stress response defective (with Mrp4EP3328) Mrp4EP3177 stress response defective (with Mrp4ex621) Mrp4EP3177 stress response defective (with Mrp4ex661) Mrp4EP3177 stress response defective | recessive Mrp4EP3177 Phenotype manifest in Allele anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155 Mrp4EP3221 intersegmental nerve, with Scer\GAL4elav-C155 Mrp4EP3221
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of Mrp4 Class Mutagen Stocks Known lesion Mrp45-HA-1117 1 -- Mrp4c00326 piggyBac transposase 1 -- Mrp4CB-5620-3 1 -- Mrp4d05358 P-element activity 1 -- Mrp4EY02678b P-element activity 1 -- Mrp4MB09770 1 -- Mrp4NP1346 1 -- Mrp4NP6649 1 -- Mrp4UY4731 P-element activity 1 Yes Mrp4DG29407 0 -- Mrp4EP3177 hypomorphic allele - molecular evidence 0 Yes Mrp4EP3221 P-element activity 0 Yes Mrp4EP3328 hypomorphic allele - molecular evidence 0 Yes Mrp4EP3655 0 Yes Mrp4EP430 P-element activity 0 Yes Mrp4ex11 wild-type allele Delta2-3 0 Yes Mrp4ex31 wild-type allele Delta2-3 0 Yes Mrp4ex621 hypomorphic allele - molecular evidence Delta2-3 0 -- Mrp4ex661 hypomorphic allele - molecular evidence Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mrp4 Class Mutagen Stocks Known lesion Mrp4GD2920 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mrp4KK103940 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6161 (Ryder, 2004.4.26) Df(3R)Exel6276 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP992 NA P{EP}Mrp4EP430 NA P{EP}Mrp4EP3177 NA P{EP}Mrp4EP3221 NA P{EP}Mrp4EP3328 NA P{EP}Mrp4EP3655 NA P{EPgy2}Mrp4EY02678b NA P{GSV1}GSd239GSd239 NA P{GSV1}GSd449GSd449 NA P{GSV1}GSd491GSd491 NA P{Mae-UAS.6.11}Mrp4UY4731 NA P{XP}Mrp4d05358 NA miscellaneous insertions P{PTT-GB}CB04397 NA P{RS3}Mrp4CB-5620-3 NA P{RS5}Mrp45-HA-1117 NA P{UASp-YFP.Rab23.S51N}01 NA P{UASp-YFP.Rab27}14 NA P{wHy}Mrp4DG29407 NA PBac{PB}Mrp4c00326 NA insertion of enhancer trap binary system Mi{ET1}Mrp4MB09770 No P{GawB}Mrp4NP1346 No P{GawB}Mrp4NP6649 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to anoxia inferred from mutant phenotype (Huang and Haddad, 2007) response to hypoxia inferred from mutant phenotype (Huang and Haddad, 2007) wing disc dorsal/ventral pattern formation inferred from genetic interaction with Bx, ap (Bejarano et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATPase activity, coupled to transmembrane movement of substances inferred from sequence or structural similarity with UniProtKB:Q9R1X5 (FlyBase, 1992-) ATP binding inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871 (FlyBase Curators et al., 2004-) organic anion transmembrane transporter activity inferred from sequence or structural similarity with UniProtKB:Q9R1X5 (FlyBase, 1992-)
Biological Process
CV term Evidence References
drug transmembrane transport inferred from sequence or structural similarity with UniProtKB:Q9R1X5 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
ATP-binding cassette (ABC) transporter complex inferred from sequence or structural similarity with UniProtKB:Q9R1X5 (FlyBase, 1992-) integral to membrane inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR011527 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mrp4 allele Gene References unspecified Ppt1 (Buff et al., 2007)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0263316
Orthologs
OrthoDB Orthologs (173) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG634WRB Dipteran inclusive ortholog search EOG6V177S Insect inclusive ortholog search EOG66WX48 Arthropod inclusive ortholog search EOG6DBRVF Metazoa inclusive ortholog search EOG65BD76
Orthologs in Drosophila Species (EOG634WRB)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mrp4     Drosophila sechellia   Dsec\GM23953     Drosophila erecta   Dere\GG18233 Y   Drosophila yakuba   Dyak\GE24181 Y   Drosophila ananassae   Dana\GF18378 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA27495 Y   Drosophila persimilis   Dper\GL12397 Y   Drosophila willistoni   Dwil\GK11301     Drosophila virilis   Dvir\GJ11101     Drosophila virilis   Dvir\GJ11099     Drosophila mojavensis   Dmoj\GI10292     Drosophila mojavensis   Dmoj\GI10294 Y   Drosophila mojavensis   Dmoj\GI10293     Drosophila grimshawi   Dgri\GH17328     Drosophila grimshawi   Dgri\GH23071     Drosophila grimshawi   Dgri\GH17329
Orthologs in non-Drosophila Dipterans (EOG6V177S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013854 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013567 Y Anopheles gambiae Malaria mosquito  Agam\AGAP006427 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016918 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004604 Y
Orthologs in non-Dipteran Insects (EOG66WX48)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43189 Y Apis mellifera Western honey bee  Amel\GB48573 Y Apis mellifera Western honey bee  Amel\GB50195 Y Apis mellifera Western honey bee  Amel\LOC551061 Y Apis mellifera Western honey bee  Amel\GB45278 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005769 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014001 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013995 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005771 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005619 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005939 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001436 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005743 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005949 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005940 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG021419 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007473 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG022099 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008391 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001435 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005946 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001437 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005944 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015638 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20970 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25144 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25142 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25143 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25138 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18076 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25145 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25137 Y Atta cephalotes Leafcutter ant  Acep\ACEP20247 Y Atta cephalotes Leafcutter ant  Acep\ACEP25775 Y Atta cephalotes Leafcutter ant  Acep\ACEP19448 Y Atta cephalotes Leafcutter ant  Acep\ACEP10888 Y Atta cephalotes Leafcutter ant  Acep\ACEP10899 Y Atta cephalotes Leafcutter ant  Acep\ACEP10892 Y Atta cephalotes Leafcutter ant  Acep\ACEP10901 Y Atta cephalotes Leafcutter ant  Acep\ACEP10903 Y Atta cephalotes Leafcutter ant  Acep\ACEP10882 Y Atta cephalotes Leafcutter ant  Acep\ACEP10902 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23510 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13349 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23511 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14835 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23512 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17005 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18589 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23459 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23460 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16445 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23461 Y Linepithema humile Argentine ant  Lhum\LH25761 Y Linepithema humile Argentine ant  Lhum\LH22562 Y Linepithema humile Argentine ant  Lhum\LH22565 Y Linepithema humile Argentine ant  Lhum\LH12079 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18191 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18190 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18184 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11368 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB12060 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18192 Y Solenopsis invicta Red fire ant  Sinv\SINV16600 Y Solenopsis invicta Red fire ant  Sinv\SINV11461 Y Solenopsis invicta Red fire ant  Sinv\SINV15752 Y Solenopsis invicta Red fire ant  Sinv\SINV14284 Y Solenopsis invicta Red fire ant  Sinv\SINV14289 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI23911 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI070177 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007210 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000359 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008595 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI061687 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI38602 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI084024 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001507 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005339 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006442 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004533 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004675 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006979 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008842 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002363 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001390 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007738 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007735 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010849 Y Bombyx mori Silkmoth  Bmor\BGIBMGA003359 Y Pediculus humanus Human body louse  Phum\PHUM075990 Y Pediculus humanus Human body louse  Phum\PHUM513390 Y Tribolium castaneum Red flour beetle  Tcas\TC013751 Y Tribolium castaneum Red flour beetle  Tcas\TC014092 Y Tribolium castaneum Red flour beetle  Tcas\TC009892 Y Tribolium castaneum Red flour beetle  Tcas\TC010434 Y Tribolium castaneum Red flour beetle  Tcas\TC013750 Y Tribolium castaneum Red flour beetle  Tcas\TC009891 Y Tribolium castaneum Red flour beetle  Tcas\TC013749 Y Tribolium castaneum Red flour beetle  Tcas\TC014589 Y Tribolium castaneum Red flour beetle  Tcas\TC014776 Y Tribolium castaneum Red flour beetle  Tcas\TC014775 Y Tribolium castaneum Red flour beetle  Tcas\TC014089 Y Tribolium castaneum Red flour beetle  Tcas\TC014403 Y
Orthologs in non-Insect Arthropods (EOG6DBRVF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_347288 Y Daphnia pulex Water flea  Dpux\Ttc29 Y Ixodes scapularis Deer tick  Isca\ISCW019069 Y
Orthologs in non-Arthropod Metazoa (EOG65BD76)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mrp-2 Y Caenorhabditis elegans Nematode  Cele\mrp-3 Y Caenorhabditis elegans Nematode  Cele\mrp-6 Y Caenorhabditis elegans Nematode  Cele\mrp-1 Y Caenorhabditis elegans Nematode  Cele\mrp-4 Y Caenorhabditis elegans Nematode  Cele\mrp-8 Y Caenorhabditis elegans Nematode  Cele\mrp-7 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002346gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023862gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026395gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021103gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014214gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011617gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020669gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002411gn Y Danio rerio Zebrafish  Drer\ENSDARG00000077243 Y Danio rerio Zebrafish  Drer\ENSDARG00000094901 Y Danio rerio Zebrafish  Drer\ENSDARG00000009582 Y Danio rerio Zebrafish  Drer\abcc4 Y Danio rerio Zebrafish  Drer\abcc2 Y Danio rerio Zebrafish  Drer\BX548046.1 Y Danio rerio Zebrafish  Drer\ENSDARG00000059874 Y Xenopus tropicalis Western clawed frog  Xtro\abcc6 Y Xenopus tropicalis Western clawed frog  Xtro\abcc4 Y Xenopus tropicalis Western clawed frog  Xtro\abcc2 Y Xenopus tropicalis Western clawed frog  Xtro\abcc1 Y Xenopus tropicalis Western clawed frog  Xtro\abcc3 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033617 Y Gallus gallus Domestic chicken  Ggal\ABCC4 Y Gallus gallus Domestic chicken  Ggal\LOC416599 Y Gallus gallus Domestic chicken  Ggal\ABCC2 Y Gallus gallus Domestic chicken  Ggal\ABCC3 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000015675 Y Gallus gallus Domestic chicken  Ggal\ABCC1 Y Mus musculus House mouse  Mmus\ENSMUSG00000020865 Y Mus musculus House mouse  Mmus\Abcc2 Y Mus musculus House mouse  Mmus\Abcc1 Y Mus musculus House mouse  Mmus\Abcc4 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027663 Y Rattus norvegicus Norway rat  Rnor\Abcc1 Y Rattus norvegicus Norway rat  Rnor\Abcc4 Y Rattus norvegicus Norway rat  Rnor\Abcc3 Y Homo sapiens Human  Hsap\ENSG00000108846 Y Homo sapiens Human  Hsap\ABCC4 Y Homo sapiens Human  Hsap\ABCC2 Y Homo sapiens Human  Hsap\ABCC1 Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\ENSG00000108846     Hsap\ABCC4     Hsap\ABCC2     Hsap\ABCC1
AAA Orthologs (6) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG18233 Drosophila yakuba Dyak\GE24181 Drosophila ananassae Dana\GF18378 Drosophila pseudoobscura pseudoobscura Dpse\GA27495 Drosophila persimilis Dper\GL12397 Drosophila mojavensis Dmoj\GI10294
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	29702 w1118; Mi{ET1}Mrp4MB09770 6770 y1 w*; P{Mae-UAS.6.11}Mrp4UY4731 15579 y1 w67c23; P{EPgy2}fabpEY02678a seaEY02678a P{EPgy2}Mrp4EY02678b/TM3, Sb1 Ser1
Harvard	- P{XP}Mrp4d05358 - PBac{PB}Mrp4c00326
Kyoto	123718 w1118; P{RS3}Mrp4CB-5620-3 125084 w1118; P{RS5}Mrp45-HA-1117 114017 w1118; P{GawB}Mrp4NP6649 / TM3, Sb1 Ser1 112636 y* w*; P{GawB}Mrp4NP1346 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v101221 P{KK103940}VIE-260B v6053 w1118; P{GD2920}v6053/TM3
Genomic Clones ( 1 )
	BACR24C01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 25 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD11716
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT28344 RH41717
Other clones	28850 43495 43731 63328 83039 83870 97599 475302 CK01.106D.H4 CK01227 CK02472 EK066501 EK089263 EK116403 EK137554 EK160321 EK216949 EK218350 EK220605 EN00636 ESG019b.E21.1_A03 FGM319A06
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41387
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mrp4 CG14709 (Huang and Haddad, 2007)
Source for database merge of	Source for merge of: BEST:CK01227 CG14709 (Bayraktaroglu, 2000.11.2) Source for merge of: CG14709 BEST:CK02472 (Rana, 2004.7.8) Source for merge of: Mrp4 EP3221 (Huang and Haddad, 2007)
Additional comments
Other Comments
	Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis. (Kopczynski et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141829 RefSeq (Proteins) • NP_650086 DDBJ / EMBL / GenBank • AA141101 AA141788 AAF54656 AQ073830 BG640592 CC060159 CZ466370 CZ466371 CZ474487 Entrez Gene - A searchable database of RefSeq genes. • 41387 UniProtKB/TrEMBL • Q9VGM1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) ABC transporter, transmembrane domain (IPR001140) ABC transporter-like (IPR003439) AAA+ ATPase domain (IPR003593) ABC transporter, transmembrane domain, type 1 (IPR011527) ABC transporter, conserved site (IPR017871) ABC transporter, integral membrane type 1 (IPR017940)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0263316 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41387
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	BEST:CK01227 (Giot et al., 2003, Kamikouchi et al., 2006) BEST:CK02472   CG14709 (Huang and Haddad, 2007, Buszczak et al., 2007, Buff et al., 2007, Zhang et al., 2007, Karpova et al., 2006, Minidorff et al., 2007, Bejarano et al., 2008, Lee et al., 2008, Kankel et al., 2007, Font-Burgada et al., 2008, Simcox et al., 2008, Mayer et al., 2009, Azad et al., 2009, Keleman et al., 2009.8.5) CK01227 (Kopczynski et al., 1998) Dme_CG14709 (Tarnay et al., 2004) dMRP4 (Huang and Haddad, 2007) EP3221   Mrp4   unnamed (Kraut et al., 2001)
Name Synonym	EP3221   Multidrug resistance protein 4 ortholog
Secondary FlyBase IDs
	FBgn0025701 FBgn0037914 FBgn0044463 FBgn0046311
References ( 42 )
Generate a list of	All references relating to this gene ( 42 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 13 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...