FB2020_01, released Feb 12, 2020

Gene: Dmel\Mrp4

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General Information
Symbol
Dmel\Mrp4
Species
D. melanogaster
Name
Multidrug resistance protein 4
Annotation Symbol
CG14709
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263316
Gene Model Status
Current
Stock Availability
13 publicly available
Enzyme Name (EC)
Adenosinetriphosphatase (3.6.1.3)
Gene Snapshot
Multidrug resistance protein 4 (Mrp4) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in the response to oxidative stress and hypoxia. [Date last reviewed: 2019-09-12]
Other Summaries
Also Known As

dMRP4, BEST:CK01227 , EP3221

Key Links
Genomic Location
Cytogenetic map
86E11-86E11
Sequence location
3R:11,569,250..11,575,937 [+]
Recombination map

3-51

RefSeq locus
NT_033777 REGION:11569250..11575937
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
ATP binding; ATPase activity; ATPase-coupled transmembrane transporter activity
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + H(2)O = ADP + phosphate (3.6.1.3)
Summaries
Gene Group (FlyBase)
ABCC ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY -
The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCC subfamily are full transporters, encoding the functional transporter in one polypeptide. In humans some members of this class are associated with multidrug resistance. (Adapted from FBrf0224053).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Mrp4 or the JBrowse view of Dmel\Mrp4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mrp4-RB
FBtr0302027
NM_141829
4726
1316
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Mrp4-PB
FBpp0291237
147.9
1316
7.64
NP_650086
AAF54656
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mrp4 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
ATPase activity
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
ATPase-coupled transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
determination of adult lifespan
inferred from mutant phenotype
(Huang et al., 2014)
response to anoxia
inferred from mutant phenotype
(Huang and Haddad, 2007)
response to hypoxia
inferred from mutant phenotype
(Huang and Haddad, 2007)
response to oxidative stress
inferred from mutant phenotype
(Huang et al., 2014)
wing disc dorsal/ventral pattern formation
inferred from genetic interaction with FLYBASE:Bx; FB:FBgn0265598, FLYBASE:ap; FB:FBgn0267978
(Bejarano et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
integral component of membrane
inferred from electronic annotation with InterPro:IPR011527, InterPro:IPR036640
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
membrane
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mrp4 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mrp4
Transgenic constructs containing regulatory region of Mrp4
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of larval stage | conditional, with Scer\GAL4da.G32
lethal - all die before end of larval stage | conditional, with Scer\GAL4elav.PU
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
chemical sensitive, with Scer\GAL4da.G32
locomotor behavior defective | progressive (with Mrp4M1)
locomotor behavior defective | progressive (with Mrp4M2)
long lived | RU486 conditional, with Scer\GAL4αTub84B.Switch.PK
neuroanatomy defective | larval stage, with Scer\GAL4elav-C155
oxidative stress response defective
oxidative stress response defective, with Scer\GAL4yolk
oxidative stress response defective (with Mrp4M1)
oxidative stress response defective (with Mrp4M2)
oxidative stress response defective | adult stage | RU486 conditional, with Scer\GAL4Switch1.106
oxidative stress response defective | adult stage | RU486 conditional, with Scer\GAL4αTub84B.Switch.PK
short lived
short lived, with Scer\GAL4da.PU
short lived (with Mrp4M1)
short lived (with Mrp4M2)
short lived | recessive
some die during larval stage | conditional, with Scer\GAL4da.G32
some die during larval stage | conditional, with Scer\GAL4elav.PU
stress response defective, with Scer\GAL4442
stress response defective, with Scer\GAL4Act.PU
stress response defective, with Scer\GAL4da.G32
stress response defective, with Scer\GAL4Ddc.PL
stress response defective, with Scer\GAL4elav.PU
stress response defective (with Mrp4EP3177)
stress response defective (with Mrp4EP3221)
stress response defective (with Mrp4EP3328)
stress response defective (with Mrp4ex621)
stress response defective (with Mrp4ex661)
stress response defective | recessive
Phenotype manifest in
Allele
anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155
intersegmental nerve, with Scer\GAL4elav-C155
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ABCC4
10 of 15
Yes
No
 
Hsap\CFTR
4 of 15
No
Yes
Hsap\ABCC3
3 of 15
No
No
Hsap\ABCC1
2 of 15
No
No
 
Hsap\ABCC2
2 of 15
No
No
Hsap\ABCC5
2 of 15
No
No
 
Hsap\ABCC6
2 of 15
No
No
Hsap\ABCC8
2 of 15
No
No
Hsap\ABCC9
2 of 15
No
No
Hsap\ABCC10
2 of 15
No
No
Hsap\ABCC11
2 of 15
No
No
Hsap\ABCC12
2 of 15
No
No
Hsap\LOC105369239
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Abcc4
11 of 15
Yes
No
Mmus\Cftr
4 of 15
No
Yes
Mmus\Abcc1
2 of 15
No
No
Mmus\Abcc2
2 of 15
No
No
Mmus\Abcc3
2 of 15
No
No
Mmus\Abcc5
2 of 15
No
No
Mmus\Abcc6
2 of 15
No
No
Mmus\Abcc8
2 of 15
No
No
Mmus\Abcc9
2 of 15
No
No
Mmus\Abcc10
2 of 15
No
No
Mmus\Abcc12
2 of 15
No
No
Rattus norvegicus (Norway rat) (12)
Rnor\Abcc4
6 of 13
Yes
No
Rnor\Cftr
3 of 13
No
Yes
Rnor\Abcc2
2 of 13
No
No
Rnor\Abcc5
2 of 13
No
No
Rnor\Abcc6
2 of 13
No
No
Rnor\Abcc8
2 of 13
No
No
Rnor\Abcc10
2 of 13
No
No
Rnor\Abcc1
1 of 13
No
No
Rnor\Abcc3
1 of 13
No
No
Rnor\Abcc9
1 of 13
No
No
Rnor\Abcc12
1 of 13
No
No
Rnor\LOC100912948
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (7)
Xtro\abcc4
5 of 12
Yes
Yes
Xtro\abcc3
2 of 12
No
No
Xtro\cftr
2 of 12
No
Yes
Xtro\abcc1
1 of 12
No
No
Xtro\abcc6
1 of 12
No
No
Xtro\abcc10
1 of 12
No
No
Xtro\LOC100493583
1 of 12
No
Yes
Danio rerio (Zebrafish) (15)
Drer\abcc4
8 of 15
Yes
No
Drer\cftr
4 of 15
No
Yes
Drer\abcc1
2 of 15
No
No
Drer\abcc5
2 of 15
No
No
Drer\abcc6a
2 of 15
No
No
Drer\abcc8
2 of 15
No
No
Drer\abcc9
2 of 15
No
No
Drer\abcc10
2 of 15
No
No
Drer\abcc12
2 of 15
No
No
Drer\abcc13
2 of 15
No
Yes
Drer\abcc3
1 of 15
No
No
Drer\abcc6b.2
1 of 15
No
No
Drer\abcc8b
1 of 15
No
No
Drer\cry1bb
1 of 15
No
No
Drer\fam212aa
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\mrp-6
7 of 15
Yes
No
Cele\mrp-8
3 of 15
No
No
Cele\mrp-1
2 of 15
No
No
Cele\mrp-2
2 of 15
No
No
Cele\mrp-3
2 of 15
No
No
Cele\mrp-4
2 of 15
No
No
Cele\mrp-7
2 of 15
No
No
Cele\cft-1
1 of 15
No
No
Cele\mrp-5
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (15)
Atha\ABCC3
2 of 9
Yes
No
Atha\ABCC4
2 of 9
Yes
No
Atha\ABCC6
2 of 9
Yes
No
Atha\ABCC7
2 of 9
Yes
No
Atha\ABCC11
2 of 9
Yes
No
Atha\ABCC12
2 of 9
Yes
No
Atha\ABCC14
2 of 9
Yes
No
Atha\ABCC1
1 of 9
No
No
Atha\ABCC2
1 of 9
No
No
Atha\ABCC5
1 of 9
No
No
Atha\ABCC8
1 of 9
No
No
Atha\ABCC9
1 of 9
No
No
Atha\ABCC10
1 of 9
No
No
Atha\ABCC13
1 of 9
No
No
Atha\ABCC15
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\YOR1
5 of 15
Yes
No
Scer\YBT1
3 of 15
No
No
Scer\YCF1
3 of 15
No
No
Scer\BPT1
2 of 15
No
No
Scer\NFT1
2 of 15
No
No
Scer\VMR1
2 of 15
No
No
Scer\YKR104W
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\abc2
2 of 12
Yes
No
Spom\abc3
2 of 12
Yes
No
Spom\abc4
1 of 12
No
No
Spom\ybt1
1 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900RY )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Mrp4
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011006
Drosophila simulans
Dsim\GD18764
Drosophila sechellia
Dsec\GM23953
Drosophila erecta
Dere\GG18233
Drosophila yakuba
Dyak\GE24181
Drosophila ananassae
Dana\GF18378
Drosophila pseudoobscura pseudoobscura
Dpse\GA27495
Drosophila persimilis
Dper\GL12397
Drosophila willistoni
Dwil\GK11301
Drosophila virilis
Dvir\GJ11101
Drosophila mojavensis
Dmoj\GI10292
Drosophila mojavensis
Dmoj\GI10294
Drosophila mojavensis
Dmoj\GI10293
Drosophila grimshawi
Dgri\GH17328
Drosophila grimshawi
Dgri\GH23071
Drosophila grimshawi
Dgri\GH17329
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500H3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008620
Musca domestica
House fly
Mdoa\17025036
Musca domestica
House fly
Mdoa\17010600
Musca domestica
House fly
Mdoa\17025039
Musca domestica
House fly
Mdoa\17007546
Musca domestica
House fly
Mdoa\17011900
Musca domestica
House fly
Mdoa\17007545
Musca domestica
House fly
Mdoa\17010601
Musca domestica
House fly
Mdoa\17010739
Glossina morsitans
Tsetse fly
Gmor\GMOY003900
Glossina morsitans
Tsetse fly
Gmor\GMOY009859
Glossina morsitans
Tsetse fly
Gmor\GMOY006234
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11737
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06545
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01726
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06632
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11094
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11095
Mayetiola destructor
Hessian fly
Mdes\Mdes002100
Mayetiola destructor
Hessian fly
Mdes\Mdes001987
Mayetiola destructor
Hessian fly
Mdes\Mdes002094
Mayetiola destructor
Hessian fly
Mdes\Mdes007300
Mayetiola destructor
Hessian fly
Mdes\Mdes000581
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013834
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012395
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005918
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013567
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL018267
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005937
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012386
Anopheles darlingi
American malaria mosquito
Adar\ADAC010113
Anopheles darlingi
American malaria mosquito
Adar\ADAC010688
Anopheles darlingi
American malaria mosquito
Adar\ADAC003507
Anopheles darlingi
American malaria mosquito
Adar\ADAC010108
Anopheles darlingi
American malaria mosquito
Adar\ADAC010689
Anopheles gambiae
Malaria mosquito
Agam\AGAP006427
Anopheles gambiae
Malaria mosquito
Agam\AGAP004603
Anopheles gambiae
Malaria mosquito
Agam\AGAP001775
Anopheles gambiae
Malaria mosquito
Agam\AGAP001777
Anopheles gambiae
Malaria mosquito
Agam\AGAP004602
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008281
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011652
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004604
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016918
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008283
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001310
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00X0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007735
Bombyx mori
Silkmoth
Bmor\BGIBMGA010330
Bombyx mori
Silkmoth
Bmor\BGIBMGA011220
Bombyx mori
Silkmoth
Bmor\BGIBMGA007738
Bombyx mori
Silkmoth
Bmor\BGIBMGA010332
Bombyx mori
Silkmoth
Bmor\BGIBMGA010849
Bombyx mori
Silkmoth
Bmor\BGIBMGA003359
Danaus plexippus
Monarch butterfly
Dple\DPOGS208713-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208066-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208634-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208494-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208084-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208065-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203074-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202687-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008762
Heliconius melpomene
Postman butterfly
Hmel\HMEL015261
Heliconius melpomene
Postman butterfly
Hmel\HMEL003355
Heliconius melpomene
Postman butterfly
Hmel\HMEL011589
Heliconius melpomene
Postman butterfly
Hmel\HMEL003354
Heliconius melpomene
Postman butterfly
Hmel\HMEL011731
Heliconius melpomene
Postman butterfly
Hmel\HMEL003351
Heliconius melpomene
Postman butterfly
Hmel\HMEL014185
Apis florea
Little honeybee
Aflo\2214844468
Apis florea
Little honeybee
Aflo\2589023892
Apis florea
Little honeybee
Aflo\2315419124
Apis florea
Little honeybee
Aflo\2155303284
Apis florea
Little honeybee
Aflo\2379350372
Apis mellifera
Western honey bee
Amel\GB43189
Apis mellifera
Western honey bee
Amel\LOC551061
Apis mellifera
Western honey bee
Amel\GB53134
Apis mellifera
Western honey bee
Amel\GB48573
Apis mellifera
Western honey bee
Amel\GB50195
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18350
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21252
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22500
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14830
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21060
Bombus terrestris
Buff-tailed bumblebee
Bter\15205612
Bombus terrestris
Buff-tailed bumblebee
Bter\15215779
Bombus terrestris
Buff-tailed bumblebee
Bter\15212604
Bombus terrestris
Buff-tailed bumblebee
Bter\15211279
Bombus terrestris
Buff-tailed bumblebee
Bter\15211632
Linepithema humile
Argentine ant
Lhum\LH25761
Linepithema humile
Argentine ant
Lhum\LH22562
Linepithema humile
Argentine ant
Lhum\LH12079
Linepithema humile
Argentine ant
Lhum\LH15915
Linepithema humile
Argentine ant
Lhum\LH22565
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000168
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0000ee
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00011e
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00205d
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002038
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005769
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014001
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007473
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005619
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011110
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005949
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008391
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005944
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005771
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001436
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022099
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001435
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005946
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001437
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04278
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03598
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05102
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03994
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08194
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06255
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08305
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06244
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02982
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03090
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07647
Tribolium castaneum
Red flour beetle
Tcas\TC013751
Tribolium castaneum
Red flour beetle
Tcas\TC014092
Tribolium castaneum
Red flour beetle
Tcas\TC009892
Tribolium castaneum
Red flour beetle
Tcas\TC014383
Tribolium castaneum
Red flour beetle
Tcas\TC009891
Tribolium castaneum
Red flour beetle
Tcas\TC014089
Tribolium castaneum
Red flour beetle
Tcas\TC014589
Tribolium castaneum
Red flour beetle
Tcas\TC014775
Tribolium castaneum
Red flour beetle
Tcas\TC013750
Tribolium castaneum
Red flour beetle
Tcas\TC014403
Tribolium castaneum
Red flour beetle
Tcas\TC014090
Tribolium castaneum
Red flour beetle
Tcas\TC033612
Tribolium castaneum
Red flour beetle
Tcas\TC010434
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15346
Tribolium castaneum
Red flour beetle
Tcas\TC033390
Tribolium castaneum
Red flour beetle
Tcas\TC014091
Tribolium castaneum
Red flour beetle
Tcas\TC008570
Tribolium castaneum
Red flour beetle
Tcas\TC014776
Tribolium castaneum
Red flour beetle
Tcas\TC012253
Tribolium castaneum
Red flour beetle
Tcas\TC034098
Tribolium castaneum
Red flour beetle
Tcas\TC013749
Tribolium castaneum
Red flour beetle
Tcas\TC013752
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_14880
Tribolium castaneum
Red flour beetle
Tcas\TC010962
Pediculus humanus
Human body louse
Phum\PHUM075990
Pediculus humanus
Human body louse
Phum\PHUM351610
Pediculus humanus
Human body louse
Phum\PHUM513390
Rhodnius prolixus
Kissing bug
Rpro\RPRC008610
Rhodnius prolixus
Kissing bug
Rpro\RPRC014278
Cimex lectularius
Bed bug
Clec\CLEC025140
Cimex lectularius
Bed bug
Clec\CLEC011933
Cimex lectularius
Bed bug
Clec\CLEC006400
Cimex lectularius
Bed bug
Clec\CLEC011936
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI23911
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI38602
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004675
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI084147
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI068671
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008842
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006979
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI070177
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007210
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000359
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002363
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008595
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI084024
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005339
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006442
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001507
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004533
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006066
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001390
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01907
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11998
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01434
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09464
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02081
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09949
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02052
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09948
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0183 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008549
Strigamia maritima
European centipede
Smar\SMAR006496
Strigamia maritima
European centipede
Smar\SMAR008548
Strigamia maritima
European centipede
Smar\SMAR006498
Strigamia maritima
European centipede
Smar\SMAR011036
Strigamia maritima
European centipede
Smar\SMAR011133
Strigamia maritima
European centipede
Smar\SMAR011077
Strigamia maritima
European centipede
Smar\SMAR005358
Ixodes scapularis
Black-legged tick
Isca\ISCW007915
Ixodes scapularis
Black-legged tick
Isca\ISCW021900
Ixodes scapularis
Black-legged tick
Isca\ISCW018516
Ixodes scapularis
Black-legged tick
Isca\ISCW019069
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57967.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75623.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82636.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80877.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur16g03480
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g04610
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02300
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02310
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g04410
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g01110
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g07860
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g02060
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02290
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g01950
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g00590
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g05540
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g15310
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02330
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g00280
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g00580
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g07910
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g10390
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02320
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g02240
Tetranychus urticae
Two-spotted spider mite
Turt\tetur40g00010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g00220
Tetranychus urticae
Two-spotted spider mite
Turt\tetur23g02452
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g07880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g07490
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g04360
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g03510
Tetranychus urticae
Two-spotted spider mite
Turt\tetur25g01780
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g15340
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g00360
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g04620
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g02120
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09800
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g04290
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g04300
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g03560
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g15330
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347288
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347281
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00IN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4e
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9e
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mrpl
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc3a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9k
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9f
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9i
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9c
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9h
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sur1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc10a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4d
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_015053gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9j
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-ABCC9g
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9l
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4c
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc1b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc10b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9d
Ciona intestinalis
Vase tunicate
Cint\LOC100185468
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006107
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007551
Gallus gallus
Domestic chicken
Ggal\ABCC4
Gallus gallus
Domestic chicken
Ggal\LOC416599
Gallus gallus
Domestic chicken
Ggal\ABCC9
Gallus gallus
Domestic chicken
Ggal\ABCC2
Gallus gallus
Domestic chicken
Ggal\ABCC3
Gallus gallus
Domestic chicken
Ggal\ABCC10
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015675
Gallus gallus
Domestic chicken
Ggal\ABCC1
Gallus gallus
Domestic chicken
Ggal\ABCC8
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (13)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG4562
7 of 10
CG9270
7 of 10
CG31792
7 of 10
CG31793
7 of 10
l(2)03659
7 of 10
CG5789
6 of 10
CG7627
6 of 10
CG10505
5 of 10
CG11898
5 of 10
rdog
5 of 10
MRP
4 of 10
CG7806
3 of 10
Sur
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 4 )
    Human Ortholog
    Disease
    Evidence
    References
    CFTR; CF transmembrane conductance regulator
    model of  bronchiectasis 1
    IEA
    (FlyBase, 2019-)
    model of  bronchiectasis
    IEA
    (FlyBase, 2019-)
    model of  pancreatitis
    IEA
    (FlyBase, 2019-)
    model of  cystic fibrosis
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ABCC4; ATP binding cassette subfamily C member 4
    10 of 15
    605250
         
        CFTR; CF transmembrane conductance regulator
        4 of 15
        602421
        ABCC3; ATP binding cassette subfamily C member 3
        3 of 15
        604323
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Mrp4
            suppressible
            puc
            (Huang et al., 2014)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            mam
            suppressible
            Mrp4
            (Kankel et al., 2007)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map

            3-51

            Cytogenetic map
            86E11-86E11
            Sequence location
            3R:11,569,250..11,575,937 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            86E11-86E11
            Limits computationally determined from genome sequence between P{PZ}tho1&P{PZ}l(3)0462905275 and P{EP}Lk6EP886
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            3-51

            (FlyBase, 2016)

            3-48.5

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (13)
            Genomic Clones (16)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (23)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: Mrp4 CG14709

                (Huang and Haddad, 2007)
                Source for database merge of

                Source for merge of: BEST:CK01227 CG14709

                (Bayraktaroglu, 2000.11.2)

                Source for merge of: CG14709 BEST:CK02472

                (Rana, 2004.7.8)

                Source for merge of: Mrp4 EP3221

                (Huang and Haddad, 2007)
                Additional comments
                Other Comments

                Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.

                (Kopczynski et al., 1998)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 28 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (10)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (71)