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Gene Hsap\FUS

General Information
Symbol	Hsap\FUS	Species	H. sapiens
Name	fused in sarcoma	Annotation symbol
Feature type	engineered_foreign_gene	FlyBase ID	FBgn0263319
Gene Model Status	Not Applicable	Stock availability	None publicly available
Also Known As	FUS
Genomic Location
Chromosome (arm)		Recombination map
Cytogenetic map		Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene fused in sarcoma is referred to in FlyBase by the symbol Hsap\FUS (FBgn0263319). It is a engineered_foreign_gene from Homo sapiens. Its molecular function is unknown. The biological processes in which it is involved are not known. 19 alleles are reported. The phenotypes of these alleles are annotated with: eye; retina; A1-7 ventral longitudinal muscle 3; interommatidial bristle; A1-7 ventral longitudinal muscle 4; wing; ommatidium. It has no annotated transcripts. Gene has not been localized to the genome sequence.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC Hsap\FUSScer\UAS.T:Hsap\MYC lethal | pupal stage, with Scer\GAL4Appl.G1a Hsap\FUSR518K.Scer\UAS.T:Ivir\HA1 Hsap\FUSR521C.Scer\UAS.T:Ivir\HA1 Hsap\FUSR521H.Scer\UAS.T:Ivir\HA1 lethal | pupal stage, with Scer\GAL4elav-C155 Hsap\FUSScer\UAS.cMa.T:Ivir\HA1 lethal | pupal stage, with Scer\GAL4VGlut-OK371 Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC Hsap\FUSR521H.Scer\UAS.T:Ivir\HA1 Hsap\FUSScer\UAS.T:Hsap\MYC partially lethal - majority die | heat sensitive, with Scer\GAL4D42 Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC Hsap\FUSScer\UAS.T:Hsap\MYC partially lethal - majority die | heat sensitive, with Scer\GAL4elav.PU Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC Hsap\FUSScer\UAS.T:Hsap\MYC partially lethal - majority live | heat sensitive, with Scer\GAL4Act5C.PU Hsap\FUSΔ32.Scer\UAS.T:Hsap\MYC viable, with Scer\GAL4D42 Hsap\FUSΔ32.Scer\UAS.T:Hsap\MYC viable, with Scer\GAL4elav.PU Hsap\FUSΔ32.Scer\UAS.T:Hsap\MYC Other Phenotypes Allele cell death defective | third instar larval stage, with Scer\GAL4VGlut-OK371 Hsap\FUSScer\UAS.T:Hsap\MYC locomotor behavior defective, with Scer\GAL4VGlut-OK371 Hsap\FUSR518K.Scer\UAS.T:Ivir\HA1 Hsap\FUSR521C.Scer\UAS.T:Ivir\HA1 Hsap\FUSR521H.Scer\UAS.T:Ivir\HA1 locomotor behavior defective | adult stage, with Scer\GAL4D42 Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSΔ32.Scer\UAS.T:Hsap\MYC locomotor behavior defective | RU486 conditional, with Scer\GAL4elav.Switch.PO Hsap\FUSR521C.Scer\UAS.T:Ivir\HA1 Hsap\FUSScer\UAS.T:Ivir\HA1 locomotor behavior defective | third instar larval stage, with Scer\GAL4VGlut-OK371 Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSΔ32.Scer\UAS.T:Hsap\MYC Hsap\FUSΔ32.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC neuroanatomy defective, with Scer\GAL4Rapgap1-OK6 Hsap\FUSScer\UAS.10x.T:Zzzz\FLAG neuroanatomy defective | adult stage | conditional, with Scer\GAL4GMR.PF Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC Hsap\FUSScer\UAS.T:Hsap\MYC neuroanatomy defective | third instar larval stage, with Scer\GAL4VGlut-OK371 Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSΔ32.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC short lived | RU486 conditional, with Scer\GAL4elav.Switch.PO Hsap\FUSR521C.Scer\UAS.T:Ivir\HA1 Hsap\FUSScer\UAS.cMa.T:Ivir\HA1 Hsap\FUSScer\UAS.T:Ivir\HA1 visible, with Scer\GAL4Bx-MS1096 Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC visible | adult stage, with Scer\GAL4Bx-MS1096 Hsap\FUSScer\UAS.T:Hsap\MYC visible | adult stage | conditional, with Scer\GAL4GMR.PF Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC Hsap\FUSScer\UAS.T:Hsap\MYC visible | heat sensitive, with Scer\GAL4GMR.PF Hsap\FUSScer\UAS.cMa.T:Ivir\HA1 Phenotype manifest in Allele A1-7 ventral longitudinal muscle 3, with Scer\GAL4VGlut-OK371 Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC A1-7 ventral longitudinal muscle 4, with Scer\GAL4VGlut-OK371 Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC abdominal segment motor neuron | third instar larval stage, with Scer\GAL4VGlut-OK371 Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC Hsap\FUSΔ32.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Rapgap1-OK6 Hsap\FUSScer\UAS.10x.T:Zzzz\FLAG embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4VGlut-OK371 Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC eye, with Scer\GAL4GMR.PF Hsap\FUSScer\UAS.T:Ivir\HA1 Hsap\FUSR518K.Scer\UAS.T:Ivir\HA1 Hsap\FUSR521C.Scer\UAS.T:Ivir\HA1 Hsap\FUSR521H.Scer\UAS.T:Ivir\HA1 eye | conditional, with Scer\GAL4GMR.PF Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC eye | heat sensitive, with Scer\GAL4GMR.PF Hsap\FUSScer\UAS.cMa.T:Ivir\HA1 interommatidial bristle, with Scer\GAL4GMR.PF Hsap\FUSR518K.Scer\UAS.T:Ivir\HA1 Hsap\FUSR521C.Scer\UAS.T:Ivir\HA1 Hsap\FUSR521H.Scer\UAS.T:Ivir\HA1 interommatidial bristle | heat sensitive, with Scer\GAL4GMR.PF Hsap\FUSScer\UAS.cMa.T:Ivir\HA1 NMJ bouton | third instar larval stage, with Scer\GAL4VGlut-OK371 Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC ommatidium, with Scer\GAL4GMR.PF Hsap\FUSR518K.Scer\UAS.T:Ivir\HA1 Hsap\FUSR521C.Scer\UAS.T:Ivir\HA1 Hsap\FUSR521H.Scer\UAS.T:Ivir\HA1 ommatidium | conditional, with Scer\GAL4GMR.PF Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC retina, with Scer\GAL4GMR.PF Hsap\FUSScer\UAS.T:Ivir\HA1 Hsap\FUSR518K.Scer\UAS.T:Ivir\HA1 Hsap\FUSR521C.Scer\UAS.T:Ivir\HA1 ventral nerve cord | third instar larval stage, with Scer\GAL4VGlut-OK371 Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC Hsap\FUSΔ32.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC wing, with Scer\GAL4Bx-MS1096 Hsap\FUSScer\UAS.T:Hsap\MYC Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Hsap\FUS Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hsap\FUS Class Mutagen Stocks Known lesion Hsap\FUS1-453.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Hsap\FUSNES.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hsap\FUSP525L.10x.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Hsap\FUSR518K.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes Hsap\FUSR521C.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Hsap\FUSR521C.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes Hsap\FUSR521G.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Hsap\FUSR521H.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes Hsap\FUSR522G.10x.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Hsap\FUSScer\UAS.10x.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hsap\FUSScer\UAS.cMa.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hsap\FUSScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hsap\FUSScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hsap\FUSY526F.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Hsap\FUSΔ32.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Hsap\FUSΔ32.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Hsap\FUSΔNES.R518K.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - deletion in vitro construct - coding region fusion 0 Yes Hsap\FUSΔNES.R521C.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes Hsap\FUSΔNES.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	engineered_foreign_gene (FlyBase Curators, 1992-)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hsap\FUS allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Ortholog(s) in Drosophila melanogaster (None identified)
No D. melanogaster orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
Tag or Foreign Gene Data
	Foreign sequence; species == Homo sapiens; gene == FUS; HGNC:4010.
External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
	HGNC • FUS; fused in sarcoma
Linkouts
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	FUS (Miguel et al., 2012, Wang et al., 2011, Lanson et al., 2011) Fus (Xia et al., 2012) FUS/TLS (Chen et al., 2011) hFUS (Wang et al., 2011) Hsap\FUS   TLS (Wang et al., 2011)
Name Synonym	fused in sarcoma (Wang et al., 2011) Fused in sarcoma (Xia et al., 2012) Homo sapiens fused in sarcoma
Secondary FlyBase IDs
References ( 7 )
Research paper	Daigle et al., 2013, Hum. Mol. Genet. 22(6): 1193--1205 RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations. [FBrf0220846] Miguel et al., 2012, Neurobiol. Aging 33(5): 1008.e1--1008.e15 Accumulation of insoluble forms of FUS protein correlates with toxicity in Drosophila. [FBrf0217826] Xia et al., 2012, Mol. Neurodegener. 7: 10 Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS. [FBrf0218020] Chen et al., 2011, Protein Cell 2(6): 477--486 Expression of human FUS protein in Drosophila leads to progressive neurodegeneration. [FBrf0214276] Lanson et al., 2011, Hum. Mol. Genet. 20(13): 2510--2523 A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. [FBrf0213887] Wang et al., 2011, J. Clin. Invest. 121(10): 4118--4126 The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. [FBrf0216240]
FlyBase analysis	FlyBase Curators, 1992-, Summary information describing the origin of tags and foreign genes in FlyBase. Summary information describing the origin of tags and foreign genes in FlyBase. [FBrf0199194]