FlyBase Gene Report: Hsap\FUS

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

caz

Hsap\FUS

(Baldwin et al., 2016, Wang et al., 2011)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hsap\FUS - GstO2

enzymatic study, western blot

(Cha et al., 2022)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

(FlyBase Curators, 1992-)

Stocks and Reagents

Stocks (1)

Bloomington

90872

w¹¹¹⁸; M{UAS-hFUS.M}ZH-51C

Other Comments

Transgenic flies expressing the Hsap\FUS gene recapitulate key features of the FUS proteinopathy.

(Chen et al., 2011)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

ALS6

(HGNC Curators and FlyBase Curators, 2013-)

FUS

(Victor Atoki et al., 2025, Lescouzères and Patten, 2024, Kour et al., 2023, An et al., 2022, Anoar et al., 2021, Fortuna et al., 2021, Jantrapirom et al., 2021, Liguori et al., 2021, Matsukawa et al., 2021, Sanjay et al., 2021, Yamaguchi et al., 2021, Bolus et al., 2020, Cha et al., 2020, Gogia et al., 2020, Kankel et al., 2020, Ramesh et al., 2020, Casci et al., 2019, Lo Piccolo et al., 2019, Walters et al., 2019, Anderson et al., 2018, Bakthavachalu et al., 2018, Bogaert et al., 2018, Deng et al., 2018, Guo et al., 2018, Kim et al., 2018, Machamer et al., 2018, Markmiller et al., 2018, Marrone et al., 2018, Matsumoto et al., 2018, Pons et al., 2018, Steyaert et al., 2018, Uechi et al., 2018, Yamamoto et al., 2018, Ishiguro et al., 2017, Mirra et al., 2017, Zhu et al., 2017, Baldwin et al., 2016, Chen et al., 2016, Chen et al., 2016, Matsukawa et al., 2016, Deng et al., 2015, Joardar et al., 2015, Periz et al., 2015, Sreedharan et al., 2015, He et al., 2014, Machamer et al., 2014, Daigle et al., 2013, HGNC Curators and FlyBase Curators, 2013-, Scaramuzzino et al., 2013, Shahidullah et al., 2013, Miguel et al., 2012, Reinhardt et al., 2012, Chen et al., 2011, Lanson et al., 2011, Wang et al., 2011)

FUS/TLS

(Chen et al., 2011)

FUS1

(HGNC Curators and FlyBase Curators, 2013-)

Fus

(Xia et al., 2012)

HNRNPP2

(HGNC Curators and FlyBase Curators, 2013-)

Hsap\FUS

(Layalle et al., 2021, Franz et al., 2019)

TLS

(HGNC Curators and FlyBase Curators, 2013-, Wang et al., 2011)

hFUS

(Hegde and Srivastava, 2022, Yamamoto et al., 2018, Lo Piccolo et al., 2017, Chen et al., 2016, Tio et al., 2016, Wang et al., 2011)

hFUS/TLS

(Zhou and Xu, 2024)

hnRNP-P2

(HGNC Curators and FlyBase Curators, 2013-)

Name Synonyms

FUS RNA binding protein

(HGNC Curators and FlyBase Curators, 2013-)

Fused in Sarcoma

(Shahidullah et al., 2013)

Fused in sarcoma

(Xia et al., 2012)

Fused in sarcoma/Translated in liposarcoma

(Chen et al., 2011)

Homo sapiens fused in sarcoma

amyotrophic lateral sclerosis 6

(HGNC Curators and FlyBase Curators, 2013-)

fused in sarcoma

(Ishiguro et al., 2017, HGNC Curators and FlyBase Curators, 2013-, Scaramuzzino et al., 2013, Shahidullah et al., 2013, Wang et al., 2011)

fusion (involved in t(12;16) in malignant liposarcoma)

(HGNC Curators and FlyBase Curators, 2013-)

fusion, derived from t(12;16) malignant liposarcoma

(HGNC Curators and FlyBase Curators, 2013-)

heterogeneous nuclear ribonucleoprotein P2

(HGNC Curators and FlyBase Curators, 2013-)

translocated in liposarcoma

(HGNC Curators and FlyBase Curators, 2013-)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 7 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

2521

Other crossreferences

Ensembl_Homo_sapiens -

ENSG00000089280

HUGO Gene Nomenclature Committee -

FUS; FUS RNA binding protein

MARRVEL - MARRVEL (human gene)

OMIM_GENE - Online Mendelian Inheritance in Man (Genes)

FUS RNA-BINDING PROTEIN; FUS

OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)

References (92)

Report Sections