FB2020_06, released Dec 22, 2020

Gene: Dmel\smash

Open Close
General Information
Symbol
Dmel\smash
Species
D. melanogaster
Name
smallish
Annotation Symbol
CG43427
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263346
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
82D1-82D2
Sequence location
3R:4,659,579..4,712,193 [+]
Recombination map

3-47.1

RefSeq locus
NT_033777 REGION:4659579..4712193
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
8

Please see the JBrowse view of Dmel\smash for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model includes transcripts encoding non-overlapping portions of the full CDS

Gene model reviewed during 5.40

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Gene model includes transcripts encoding non-overlapping portions of the full CDS.

Alternative translation stop created by use of multiphasic reading frames within coding region.

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011, Stapleton et al., 2006)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
smash-RE
FBtr0308849
NM_169014
5335
1372
smash-RF
FBtr0308850
NM_169015
5897
1372
smash-RG
FBtr0308851
NM_176399
5552
1372
smash-RH
FBtr0308852
NM_001144532
6180
1493
smash-RI
FBtr0308853
NM_141231
3810
889
smash-RJ
FBtr0308854
NM_176400
4163
849
smash-RM
FBtr0308855
NM_001144533
6075
1533
smash-RN
FBtr0308856
NM_001259982
6282
648
smash-RO
FBtr0308857
NM_001259983
7012
1541
smash-RP
FBtr0308858
NM_001259984
7014
1501
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
smash-PE
FBpp0301004
149.3
1372
6.11
NP_730864
AAF52104
smash-PF
FBpp0301005
149.3
1372
6.11
NP_730865
AAF52105
smash-PG
FBpp0301006
149.3
1372
6.11
NP_788576
AAO41500
smash-PH
FBpp0301007
164.5
1493
5.72
NP_001138004
ACL83463
smash-PI
FBpp0301008
98.8
889
6.26
NP_649488
AAF52102
smash-PJ
FBpp0301009
94.4
849
6.24
NP_788577
AAO41501
smash-PM
FBpp0301010
168.9
1533
5.76
NP_001138005
ACL83464
smash-PN
FBpp0301011
70.9
648
5.51
NP_001246911
AFH06230
smash-PO
FBpp0301012
169.8
1541
5.81
NP_001246912
AFH06231
smash-PP
FBpp0301013
165.4
1501
5.83
NP_001246913
AFH06232
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1372 aa isoforms: smash-PE, smash-PF, smash-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\smash using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult fat body

Comment: cyclical, peak ZT17-20

(Xu et al., 2011)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
hindgut proper primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior spiracle primordium

Comment: reported as posterior spiracle specific anlage

(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval posterior spiracle
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic dorsal apodeme
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic esophagus
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic ventral apodeme
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 14
embryonic/larval epidermis
(Beati et al., 2018)
embryonic stage 13
embryonic/larval foregut
(Beati et al., 2018)
embryonic/larval Malpighian tubule
(Beati et al., 2018)
amnioserosa
(Beati et al., 2018)
embryonic/larval trachea
(Beati et al., 2018)
embryonic stage 15
embryonic/larval hindgut
(Beati et al., 2018)
embryonic/larval salivary gland
(Beati et al., 2018)
embryonic/larval visceral muscle
(Beati et al., 2018)
embryonic/larval posterior spiracle
(Beati et al., 2018)
embryonic stage 17
embryonic/larval somatic muscle
(Beati et al., 2018)
pharyngeal muscle
(Beati et al., 2018)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

smash protein is detectable from embryonic stage 5 on in all ectodermally-derived epithelia, including epidermis, foregut, hindgut, Malpighian tubules, salivary glands, amnioserosa, and the tracheal tree. It is also observed in somatic, pharyngeal, and visceral muscles. No expression is observed in neuroblasts and their descendents.

(Beati et al., 2018)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\smash in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 27 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of smash
Transgenic constructs containing regulatory region of smash
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of larval stage, with Scer\GAL4αTub84B.PL
lethal - all die before end of P-stage, with Scer\GAL4αTub84B.PL
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
cell shape defective | adult stage | cell autonomous | somatic clone, with Scer\GAL4Act5C.PP
increased cell death | larval stage, with Scer\GAL4GMR.PS
increased occurrence of cell division | larval stage, with Scer\GAL4GMR.PS
majority die during larval stage, with Scer\GAL4αTub84B.PL
size defective | embryonic stage, with Scer\GAL4btl.PS
small body | adult stage, with Scer\GAL4αTub84B.PL
some die during embryonic stage, with Scer\GAL4αTub84B.PL
some die during pupal stage, with Scer\GAL4αTub84B.PL
visible | adult stage, with Scer\GAL4GMR.PS
Phenotype manifest in
Allele
cuticle | embryonic stage, with Scer\GAL4αTub84B.PL
eye, with Scer\GAL4GMR.PS
eye disc, with Scer\GAL4GMR.PS
oocyte associated follicular epithelium | adult stage | cell autonomous | somatic clone, with Scer\GAL4Act5C.PP
tracheal lumen | embryonic stage, with Scer\GAL4btl.PS
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (24)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\LIMCH1
3 of 15
Yes
Yes
Hsap\LMO7
2 of 15
No
Yes
Hsap\AJUBA
1 of 15
No
No
Hsap\FBLIM1
1 of 15
No
No
Hsap\FHL1
1 of 15
No
Yes
Hsap\FHL2
1 of 15
No
No
Hsap\FHL3
1 of 15
No
No
Hsap\FHL5
1 of 15
No
No
Hsap\LIMD1
1 of 15
No
No
1  
Hsap\LIMS1
1 of 15
No
No
Hsap\LIMS2
1 of 15
No
No
Hsap\LIMS3
1 of 15
No
No
Hsap\LIMS4
1 of 15
No
No
Hsap\LMCD1
1 of 15
No
No
1  
Hsap\PRICKLE1
1 of 15
No
No
Hsap\PRICKLE2
1 of 15
No
No
Hsap\PRICKLE3
1 of 15
No
No
1  
Hsap\PRICKLE4
1 of 15
No
No
Hsap\SCEL
1 of 15
No
Yes
Hsap\TES
1 of 15
No
No
Hsap\TRIP6
1 of 15
No
No
Hsap\WTIP
1 of 15
No
No
Hsap\ZNF185
1 of 15
No
Yes
Hsap\ZYX
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (26)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Limch1
3 of 15
Yes
Yes
Mmus\Lmo7
2 of 15
No
Yes
Mmus\Ajuba
1 of 15
No
No
Mmus\Fblim1
1 of 15
No
No
Mmus\Fhl1
1 of 15
No
Yes
Mmus\Fhl2
1 of 15
No
No
Mmus\Fhl3
1 of 15
No
No
Mmus\Fhl4
1 of 15
No
Yes
Mmus\Fhl5
1 of 15
No
No
Mmus\Gm4907
1 of 15
No
No
Mmus\Limd1
1 of 15
No
No
Mmus\Lims1
1 of 15
No
No
Mmus\Lims2
1 of 15
No
No
Mmus\Lmcd1
1 of 15
No
No
Mmus\Lpp
1 of 15
No
No
Mmus\Peak1
1 of 15
No
Yes
Mmus\Prickle1
1 of 15
No
No
Mmus\Prickle2
1 of 15
No
No
Mmus\Prickle3
1 of 15
No
No
Mmus\Prickle4
1 of 15
No
No
Mmus\Scel
1 of 15
No
Yes
Mmus\Tes
1 of 15
No
No
Mmus\Trip6
1 of 15
No
No
Mmus\Wtip
1 of 15
No
No
Mmus\Zfp185
1 of 15
No
Yes
Mmus\Zyx
1 of 15
No
No
Rattus norvegicus (Norway rat) (20)
Rnor\Limch1
2 of 13
Yes
Yes
Rnor\Ajuba
1 of 13
No
No
Rnor\Fblim1
1 of 13
No
No
Rnor\Fhl1
1 of 13
No
Yes
Rnor\Fhl2
1 of 13
No
No
Rnor\Fhl3
1 of 13
No
No
Rnor\Fhl5
1 of 13
No
No
Rnor\Limd1
1 of 13
No
No
Rnor\Lims1
1 of 13
No
No
Rnor\Lims2
1 of 13
No
No
Rnor\Lmcd1
1 of 13
No
No
Rnor\Lpp
1 of 13
No
No
Rnor\Prickle1
1 of 13
No
No
Rnor\Prickle2
1 of 13
No
No
Rnor\Prickle3
1 of 13
No
No
Rnor\Prickle4
1 of 13
No
No
Rnor\Scel
1 of 13
No
Yes
Rnor\Tesl
1 of 13
No
No
Rnor\Trip6
1 of 13
No
No
Rnor\Zyx
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (13)
Xtro\limch1
2 of 12
Yes
Yes
Xtro\lmo7
2 of 12
Yes
Yes
Xtro\fhl1
1 of 12
No
Yes
Xtro\fhl2
1 of 12
No
No
Xtro\fhl3
1 of 12
No
No
Xtro\fhl5
1 of 12
No
No
Xtro\lims1
1 of 12
No
No
Xtro\lmcd1
1 of 12
No
No
Xtro\lpp
1 of 12
No
No
Xtro\prickle1
1 of 12
No
No
Xtro\prickle2
1 of 12
No
No
Xtro\scel
1 of 12
No
Yes
Xtro\tes
1 of 12
No
No
Danio rerio (Zebrafish) (31)
Drer\limch1a
3 of 15
Yes
Yes
Drer\limch1b
2 of 15
No
Yes
Drer\lmo7a
2 of 15
No
Yes
Drer\lmo7b
2 of 15
No
Yes
Drer\ajuba
1 of 15
No
No
Drer\fblim1
1 of 15
No
No
Drer\fhl1a
1 of 15
No
Yes
Drer\fhl1b
1 of 15
No
Yes
Drer\fhl2a
1 of 15
No
No
Drer\fhl2b
1 of 15
No
No
Drer\fhl3a
1 of 15
No
Yes
Drer\fhl3b
1 of 15
No
Yes
Drer\fhl5
1 of 15
No
Yes
Drer\limd1a
1 of 15
No
No
Drer\limd1b
1 of 15
No
No
Drer\lims1
1 of 15
No
No
Drer\lims2
1 of 15
No
No
Drer\lmcd1
1 of 15
No
No
Drer\LOC101882453
1 of 15
No
Yes
Drer\lpp
1 of 15
No
No
Drer\prickle1a
1 of 15
No
No
Drer\prickle1b
1 of 15
No
No
Drer\prickle2a
1 of 15
No
No
Drer\prickle2b
1 of 15
No
No
Drer\prickle3
1 of 15
No
No
Drer\scel
1 of 15
No
Yes
Drer\tes
1 of 15
No
No
Drer\trip6
1 of 15
No
No
Drer\wtip
1 of 15
No
No
Drer\znf185
1 of 15
No
Yes
Drer\zyx
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\lim-8
4 of 15
Yes
Yes
Cele\lim-9
1 of 15
No
No
Cele\pin-2
1 of 15
No
No
Cele\prkl-1
1 of 15
No
No
Cele\tes-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\RGA1
1 of 15
Yes
No
Scer\RGA2
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902K9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010219
Drosophila simulans
Dsim\GD19746
Drosophila sechellia
Dsec\GM10772
Drosophila sechellia
Dsec\GM10773
Drosophila erecta
Dere\GG12563
Drosophila yakuba
Dyak\GE25434
Drosophila ananassae
Dana\GF18910
Drosophila pseudoobscura pseudoobscura
Dpse\GA30203
Drosophila persimilis
Dper\GL22331
Drosophila persimilis
Dper\GL22332
Drosophila willistoni
Dwil\GK12820
Drosophila virilis
Dvir\GJ23955
Drosophila mojavensis
Dmoj\GI23771
Drosophila grimshawi
Dgri\GH19501
Drosophila grimshawi
Dgri\GH19500
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500DD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014781
Glossina morsitans
Tsetse fly
Gmor\GMOY001569
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13120
Mayetiola destructor
Hessian fly
Mdes\Mdes009895
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007290
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015493
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00G0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc5a3_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_023916gn
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
esn
1 of 10
jub
1 of 10
pk
1 of 10
stck
1 of 10
Tes
1 of 10
Zyx
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    smashGD10286
    ameliorates  tauopathy
    modeled by Hsap\MAPTR406W.UAS
    (Butzlaff et al., 2015)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    LIMCH1; LIM and calponin homology domains 1
    3 of 15
    617750
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        smash - Src42A
        anti tag coimmunoprecipitation, anti tag western blot
        (Beati et al., 2018)
        smash - baz
        nuclear magnetic resonance, predetermined participant, anti tag coimmunoprecipitation, western blot, two hybrid
        (Beati et al., 2018)
        smash - cno
        nuclear magnetic resonance, predetermined participant
        (Beati et al., 2018)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        smash
        enhanceable
        bocks
        (Tanaka et al., 2019)
        smash
        suppressible
        Diap1
        (Tanaka et al., 2019)
        smash
        enhanceable
        Ote
        (Tanaka et al., 2019)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        bocks
        enhanceable
        smash
        (Tanaka et al., 2019)
        Ote
        enhanceable
        smash
        (Tanaka et al., 2019)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map

        3-47.1

        Cytogenetic map
        82D1-82D2
        Sequence location
        3R:4,659,579..4,712,193 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        82D1-82D2
        Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-47.1

        (FlyBase, 2016)

        3-44.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (18)
        Genomic Clones (36)
        cDNA Clones (100)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Tanaka et al., 2019, Beati et al., 2018)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: smash CG43427

        (Beati et al., 2018)
        Source for database merge of

        Source for merge of: CG1054 CG14653

        (FlyBase Genome Annotators, 2002-2003)

        Source for merge of: CG31534 anon-WO0140519.95

        (FlyBase, 1996-)

        Source for merge of: CG18253 CG1055

        (FlyBase, 1996-)

        Source for merge of: CG31531 CG31534

        (FlyBase Genome Annotators, 2011)
        Additional comments

        shk may correspond to CG43427: the P{PZ}shk1 insertion maps within the transcription unit.

        (Gene Disruption Project members, 2015.10.8)

        Annotations CG31531 and CG31534 merged as CG43427 in release 5.40 of the genome annotation.

        (FlyBase Genome Annotators, 2011)

        Merge supported by RNA-seq junction and RNA-seq expression data.

        (FlyBase Genome Annotators, 2011)

        Annotations CG1054 and CG14653 merged as CG31531 in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)

        Annotations CG1055, CG18253 merged as CG31534 in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)

        Source for merge of CG31534 anon-WO0140519.95 was sequence comparison ( date:051113 ).

        (FlyBase, 1996-)

        Source for merge of CG18253 CG1055 was a shared cDNA ( date:010720 ).

        (FlyBase, 1996-)
        Other Comments

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)
        Origin and Etymology
        Discoverer
        Etymology

        Named 'smallish' because overexpression results in almost complete lethality with very rare escaper flies that are strongly reduced in size.

        (Beati et al., 2018)
        Identification
        External Crossreferences and Linkouts ( 79 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (11)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (60)