FB2020_03, released Jun 16, 2020

Gene: Dmel\CG11000

Open Close
General Information
Symbol
Dmel\CG11000
Species
D. melanogaster
Name
Annotation Symbol
CG11000
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263353
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
83C4-83C4
Sequence location
3R:5,802,328..5,813,258 [+]
Recombination map

3-47.5

RefSeq locus
NT_033777 REGION:5802328..5813258
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
regulation of cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN001023612
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
integral component of membrane
inferred from biological aspect of ancestor with PANTHER:PTN001023612
(assigned by GO_Central )
(Gaudet et al., 2011)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\CG11000 or the JBrowse view of Dmel\CG11000 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG11000-RB
FBtr0113195
NM_001104220
2335
332
CG11000-RC
FBtr0308953
NM_001260007
6816
332
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG11000-PB
FBpp0112107
36.9
332
8.66
NP_001097690
AAF51948
CG11000-PC
FBpp0301052
36.9
332
8.66
NP_001246936
AFH06255
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

332 aa isoforms: CG11000-PB, CG11000-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG11000 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG11000 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG11000
Transgenic constructs containing regulatory region of CG11000
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PLEKHB1
1 of 15
Yes
Yes
Hsap\PLEKHB2
1 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Plekhb1
1 of 15
Yes
Yes
Mmus\Plekhb2
1 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Plekhb1
1 of 13
Yes
Yes
Rnor\Plekhb2
1 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\plekhb2
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (3)
Drer\plekhb2
1 of 15
Yes
Yes
Drer\si:ch211-176g13.7
1 of 15
Yes
Yes
Drer\si:ch1073-83n3.2
1 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\F38B7.3
7 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190BC0 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008678
Drosophila simulans
Dsim\GD19824
Drosophila sechellia
Dsec\GM10843
Drosophila erecta
Dere\GG13056
Drosophila yakuba
Dyak\GE10168
Drosophila ananassae
Dana\GF16355
Drosophila pseudoobscura pseudoobscura
Dpse\GA10701
Drosophila persimilis
Dper\GL24324
Drosophila willistoni
Dwil\GK22540
Drosophila virilis
Dvir\GJ24398
Drosophila mojavensis
Dmoj\GI22364
Drosophila grimshawi
Dgri\GH13168
Drosophila grimshawi
Dgri\GH20286
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507HO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012614
Glossina morsitans
Tsetse fly
Gmor\GMOY000560
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013424
Anopheles darlingi
American malaria mosquito
Adar\ADAC006012
Anopheles gambiae
Malaria mosquito
Agam\AGAP013121
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ013646
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BJI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005134
Bombyx mori
Silkmoth
Bmor\BGIBMGA005133
Danaus plexippus
Monarch butterfly
Dple\DPOGS214726-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008589
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI083609
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BH8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75596.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g01350
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_315864
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map

    3-47.5

    Cytogenetic map
    83C4-83C4
    Sequence location
    3R:5,802,328..5,813,258 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    83C4-83C4
    Limits computationally determined from genome sequence between P{lacW}casj1C2 and P{PZ}lab01241
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-47.5

    (FlyBase, 2016)

    3-44.1

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (9)
    Genomic Clones (28)
    cDNA Clones (20)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: CG31555 BcDNA:HL04389

      (FlyBase, 1996-)

      Source for merge of: CG11000 CG31555

      (FlyBase Genome Annotators, 2011)
      Additional comments

      Annotation CG11000 merged with annotation CG31555 in release 5.40 of the genome annotation; CG31555 corresponds to 3' UTR of CG11000.

      (FlyBase Genome Annotators, 2011)

      Source for merge of CG31555 BcDNA:HL04389 was a shared cDNA ( date:030728 ).

      (FlyBase, 1996-)
      Other Comments

      Annotation CG31555 eliminated in release 5.26 of the genome annotation.

      (FlyBase Genome Annotators, 2010)

      Annotation CG31555 restored in release 5.32 of the genome annotation.

      (FlyBase Genome Annotators, 2010)

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      (Kiger et al., 2003)

      New annotation (CG31555) in release 3 of the genome annotation.

      (FlyBase Genome Annotators, 2002-2003)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 24 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      BcDNA:HL04389
      CG11000
      (Hosono et al., 2015, FlyBase Genome Annotators, 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Zhang et al., 2007)
      CG31555
      (Hosono et al., 2015, FlyBase Genome Annotators, 2010, FlyBase Genome Annotators, 2010, Keleman et al., 2009.8.5)
      Name Synonyms
      Secondary FlyBase IDs
      • FBgn0051555
      • FBgn0047238
      • FBgn0037380
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (27)