FlyBase Gene Report: Dmel\CG31688

General Information

Symbol

Dmel\CG31688

Species

D. melanogaster

Name

Annotation Symbol

CG31688

Feature Type

protein_coding_gene

FlyBase ID

FBgn0263355

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

38C.52, 38C.49

Key Links

Genomic Location

Cytogenetic map

38C6-38C7

Sequence location

2L:20,426,199..20,447,905 [+]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:20426199..20447905

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG31688 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VIM1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Double stop-codon suppression (UAG, UAA) postulated; FBrf0216941.

Stop-codon suppression (UAG) postulated; FBrf0216884.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG31688-RB

FBtr0273378

NM_001144371

3383

193

CG31688-RD

FBtr0308895

NM_001259176

5400

193

CG31688-RE

FBtr0330203

NM_001273695

3383

204

CG31688-RF

FBtr0330204

NM_136191

3383

714

CG31688-RG

FBtr0330661

NM_001273696

7344

193

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG31688-PB

FBpp0271886

20.6

193

7.27

FBpp0301022

20.6

193

7.27

FBpp0303236

21.8

204

8.26

FBpp0303237

77.7

714

6.34

FBpp0303511

20.6

193

7.27

B7YZX9

NP_001260625

AGB93160

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

193 aa isoforms: CG31688-PB, CG31688-PD, CG31688-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG31688 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.89

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG31688 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG31688

View exonic expression by tissue for Dmel\CG31688

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35314/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263355

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263355

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG31688

Transgenic constructs containing regulatory region of CG31688

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel6046

(Ryder, 2004.4.26)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

CG31688^S506

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

CG31688^GD15488

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

fertile

CG31688^EY00909

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP010138

8 of 12

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\AT1G21065

9 of 13

Yes

Atha\AT1G21060

1 of 13

Yes

Atha\AT1G76620

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPAC4A8.02c

9 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\yjbQ

8 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG31688. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

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Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

CG31688 - stau

anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation

(Laver et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263355

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

38C6-38C7

Sequence location

2L:20,426,199..20,447,905 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

38C6-38C7

Limits computationally determined from genome sequence between P{EP}CG16798^EP401&P{lacW}k07219 and P{lacW}k02501&P{lacW}k14810

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-54.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

20103

y¹ w^67c23; P{EPgy2}CG31688^EY00909

22404

y¹ w^67c23; P{EPgy2}CG31688^EY20598

37191

y¹ w^*; Mi{MIC}CG31688^MI03444/SM6a

Kyoto

112181

w^*; P{GawB}CG31688^NP0428

NIG-Fly

M2L-1302

y¹ w¹¹¹⁸; CG31688^SK1 P{neoFRT}40A/CyO-Tb

M2L-1303

y¹ w¹¹¹⁸; CG31688^SK3 P{neoFRT}40A/CyO-Tb

2LG-1041

y² VhaAC39-1^cho-1 v¹; P{U6-CG31688.NIG.sgRNA}attP40/CyO

VDRC

v102282

P{KK111420}VIE-260B

v103257

P{KK112685}VIE-260B

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (29)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE64176

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0263355

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG11016 CG18597

(FlyBase, 1996-)

Source for merge of: CG11016 CG11017

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: CG31688 CG11019

(FlyBase Genome Annotators, 2011)

Additional comments

CG31687 appears to be a chimeric gene, with the 5' part of the gene derived from cdc23 and the 3' part of the gene derived from CG31688.

(Rogers and Hartl, 2012)

Annotation CG31688 merged with annotation CG11019 in release 5.40 of the genome annotation; CG11019 corresponds to 5' UTR of CG31688.

(FlyBase Genome Annotators, 2011)

"CG31687" is a putative chimeric gene derived from the "cdc23" and "CG31688" genes (where coding sequences of the two parental genes contribute to the coding sequence of the chimeric gene).

(Rogers et al., 2009)

Annotations CG11016 and CG11017 merged as CG31688 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG11016 CG18597 was sequence comparison ( date:001104 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

38C.49

(Butler, 2001, Butler et al., 2001, McGill Drosophila Genome Project, 2001.9.25)

38C.52

(Butler, 2001, Butler et al., 2001, McGill Drosophila Genome Project, 2001.9.25)

CG11016

CG11017

CG11019

(Hosono et al., 2015, Keleman et al., 2009.8.5)

CG18597

(Butler, 2001, Butler et al., 2001)

CG31688

(National Institute of Genetics Fly Stocks, 2022-, FlyBase Genome Annotators, 2019-, Ashwal-Fluss et al., 2014, Kwon et al., 2013, Laver et al., 2013, Malmendal et al., 2013, Hadar et al., 2012, Rogers and Hartl, 2012, FlyBase Genome Annotators, 2011, Jungreis et al., 2011, Zhan et al., 2011, Keleman et al., 2009.8.5, Buszczak et al., 2007, Lawniczak and Begun, 2004)

CG31688-PA

(Rogers et al., 2009)

Name Synonyms

Secondary FlyBase IDs

FBgn0040998
FBgn0051688
FBgn0032861
FBgn0032862
FBgn0040999

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 50 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35314

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VIM1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VIM1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35314/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263355

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263355

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31688

MARRVEL_MODEL - MARRVEL (model organism gene)

35314

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0263355

DroID - A comprehensive database of gene and protein interactions.

FBgn0263355

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0263355

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005961

References (45)

The following external sites may use different assemblies or annotations than FlyBase.

-0.89

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