FB2025_05 , released December 11, 2025
Gene: Dmel\hppy
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General Information
Symbol
Dmel\hppy
Species
D. melanogaster
Name
happyhour
Annotation Symbol
CG7097
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263395
Gene Model Status
Current
Stock Availability
24 publicly available
Gene Summary
happyhour (hppy) encodes the Drosophila orthologue of MAP4K3, a Ser/Thr Kinase belonging to the Germinal Center Kinase I family of Ste20-related kinases. The function of hppy has being linked to the Egfr, Hippo and Tor signalling pathways. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

MAP4K3, EP-704

Key Links
Genomic Location
Cytogenetic map
56C1-56C4
Sequence location
Recombination map
2-88
RefSeq locus
NT_033778 REGION:19178738..19227193
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (21 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein kinase activity
inferred from genetic interaction with FLYBASE:Tsc1; FB:FBgn0290397
(Findlay et al., 2007)
enables protein serine/threonine kinase activity
inferred from direct assay
(Li et al., 2015, Zheng et al., 2015)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441, InterPro:IPR021160
(InterPro Project Members, 2004-)
enables MAP kinase kinase kinase kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001220960
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR021160
(InterPro Project Members, 2004-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR000719
(InterPro Project Members, 2004-)
Biological Process (15 terms)
Terms Based on Experimental Evidence (14 terms)
CV Term
Evidence
References
involved_in apoptotic process
inferred from direct assay
(Lam et al., 2010)
involved_in behavioral response to ethanol
inferred from mutant phenotype
(Corl et al., 2009)
involved_in Golgi organization
inferred from mutant phenotype
(Zacharogianni et al., 2011)
involved_in JNK cascade
inferred from direct assay
(Lam et al., 2010)
involved_in negative regulation of epidermal growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:aop; FB:FBgn0000097
(Corl et al., 2009)
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Corl et al., 2009)
involved_in positive regulation of apoptotic process
inferred from mutant phenotype
(Resnik-Docampo and de Celis, 2011)
involved_in positive regulation of cell size
inferred from mutant phenotype
(Resnik-Docampo and de Celis, 2011)
involved_in positive regulation of hippo signaling
inferred from genetic interaction with FLYBASE:wts; FB:FBgn0011739
(Zheng et al., 2015)
inferred from mutant phenotype
(Li et al., 2015)
involved_in positive regulation of JNK cascade
inferred from mutant phenotype
(Resnik-Docampo and de Celis, 2011)
involved_in positive regulation of TOR signaling
inferred from genetic interaction with FLYBASE:Tsc1; FB:FBgn0290397
(Findlay et al., 2007)
involved_in positive regulation of TORC1 signaling
inferred from genetic interaction with FLYBASE:mTor; FB:FBgn0021796
(Resnik-Docampo and de Celis, 2011)
inferred from genetic interaction with FLYBASE:RagC-D; FB:FBgn0033272
(Resnik-Docampo and de Celis, 2011)
inferred from genetic interaction with FLYBASE:path; FB:FBgn0036007
(Resnik-Docampo and de Celis, 2011)
inferred from genetic interaction with FLYBASE:slif; FB:FBgn0037203
(Resnik-Docampo and de Celis, 2011)
inferred from genetic interaction with FLYBASE:RagA-B; FB:FBgn0037647
(Resnik-Docampo and de Celis, 2011)
inferred from genetic interaction with FLYBASE:Rheb; FB:FBgn0041191
(Resnik-Docampo and de Celis, 2011)
inferred from genetic interaction with FLYBASE:S6k; FB:FBgn0283472
(Resnik-Docampo and de Celis, 2011)
involved_in regulation of cell size
inferred from mutant phenotype
(Bryk et al., 2010)
involved_in regulation of growth rate
inferred from mutant phenotype
(Bryk et al., 2010)
involved_in triglyceride homeostasis
inferred from mutant phenotype
(Bryk et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in intracellular signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN004698611
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Resnik-Docampo and de Celis, 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN004698611
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
happyhour (hppy) encodes the Drosophila orthologue of MAP4K3, a Ser/Thr Kinase belonging to the Germinal Center Kinase I family of Ste20-related kinases. The function of hppy has being linked to the Egfr, Hippo and Tor signalling pathways. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
GERMINAL CENTER KINASES -
Germinal center kinases (GCKs) are serine/threonine kinases characterised by an N-terminal STE20 kinase domain. They have diverse roles in signaling pathways; some are MAPK kinase kinase kinases, activating MAPK kinase kinases. (Adapted from FBrf0225276 and FBrf0228279).
Pathway (FlyBase)
POSITIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).
NEGATIVE REGULATORS OF EGFR SIGNALING PATHWAY -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Summary (Interactive Fly)

a MAP4K3 that regulates TOR activity detected by phosphorylation of S6K and 4EBP - required for amino acids to stimulate TOR complex activity - binds physically to the Rag GTPases - promotes caspase-dependent apoptosis

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\hppy for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A1ZBH7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
hppy-RA
FBtr0086504
NM_166335
5080
1218
hppy-RB
FBtr0086503
NM_137555
4267
947
hppy-RC
FBtr0340454
NM_001299675
4330
968
hppy-RD
FBtr0340455
NM_001299676
5041
1205
hppy-RE
FBtr0340456
NM_001299677
4228
934
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
hppy-PA
FBpp0085692
132.4
1218
7.56
A1ZBH7
NP_725863
AAF57595
hppy-PB
FBpp0085691
105.2
947
7.75
A1ZBH8
NP_611399
AAM70845
hppy-PC
FBpp0309396
107.5
968
8.00
A0A0B4LGY8
NP_001286604
AHN56399
hppy-PD
FBpp0309397
130.8
1205
7.62
A0A0B4LFV0
NP_001286605
AHN56400
hppy-PE
FBpp0309398
103.6
934
7.92
A0A0B4LFQ3
NP_001286606
AHN56401
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hppy using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.07

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
pole plasm

Comment: maternally deposited

(Fisher et al., 2012)
organism

Comment: maternally deposited

(Fisher et al., 2012)
third instar larval stage
wing disc | ubiquitous
(Resnik-Docampo and de Celis, 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
wing disc | ubiquitous
(Resnik-Docampo and de Celis, 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Resnik-Docampo and de Celis, 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\hppy in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 27 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of hppy
Transgenic constructs containing regulatory region of hppy
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene disrupted in
Df(2R)Exel6069
(Ryder, 2004.4.26)
Df(2R)P34
(Bradley and Andrew, 2001)
Gene not disrupted in
Df(2R)enaGC10
(Bradley and Andrew, 2001)
Inferred from location ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of pupal stage, with Scer\GAL4Act.PU
lethal - all die before end of pupal stage, with Scer\GAL4da.G32
partially lethal - majority die | nutrition conditional, with Scer\GAL4Tub.PU
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.Tag:NLS(Unk)
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with hppy1V2)
viable (with hppy2G1)
viable (with hppy4T1)
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
fertile
Other Phenotypes
Allele
abnormal developmental rate | larval stage
abnormal developmental rate | recessive
abnormal neuroanatomy | pupal stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.Tag:NLS(Unk)
abnormal size, with Scer\GAL4nub-AC-62
abnormal size | adult stage
abnormal size | recessive | nutrition conditional
abnormal starvation stress response | adult stage, with Scer\GAL4Cg.PU
chemical resistant
chemical sensitive, with Scer\GAL4elav-C155
decreased cell number, with Scer\GAL4nub-AC-62
decreased cell size, with Scer\GAL4nub-AC-62
decreased cell size (with Df(2R)Exel6069)
decreased cell size (with hppy1V2)
decreased cell size (with hppy2G1)
decreased cell size (with hppy4T1)
decreased cell size (with hppyEP-704)
decreased cell size | adult stage
decreased cell size | recessive | nutrition conditional
increased cell death, with Scer\GAL4e22c
increased cell death | cell autonomous, with Scer\GAL4ap-md544
increased cell death | cell autonomous, with Scer\GAL4nub-AC-62
increased occurrence of cell division | larval stage, with Scer\GAL4en.PU
majority die during P-stage | nutrition conditional, with Scer\GAL4Tub.PU
short lived
short lived | calorie restriction conditional, with Scer\GAL4Cg.PU
some die during pupal stage, with Scer\GAL4Act.PU
some die during pupal stage, with Scer\GAL4da.G32
visible
visible, with Scer\GAL4dpp.3KK
visible, with Scer\GAL4en.PU
Phenotype manifest in
Allele
axon | pupal stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.Tag:NLS(Unk)
embryonic/larval fat body, with Scer\GAL4ppl.PP
gamma Kenyon cell | pupal stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.Tag:NLS(Unk)
wing
wing, with Scer\GAL4da.G32
wing, with Scer\GAL4dpp.3KK
wing, with Scer\GAL4e22c
wing, with Scer\GAL4Ilp2.PR
wing, with Scer\GAL4nub-AC-62
wing margin bristle, with Scer\GAL4e22c
wing vein, with Scer\GAL4e22c
wing vein | ectopic, with Scer\GAL4nub-AC-62
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (78)
Hsap\MAP4K3
13 of 14
Yes
Yes
Hsap\MAP4K5
12 of 14
No
Yes
Hsap\MAP4K2
9 of 14
No
Yes
Hsap\MAP4K1
6 of 14
No
Yes
2  
Hsap\AKT1
1 of 14
No
No
1  
Hsap\AKT2
1 of 14
No
No
5  
Hsap\AURKA
1 of 14
No
No
Hsap\BUB1B-PAK6
1 of 14
No
No
Hsap\CAMK1D
1 of 14
No
No
1  
Hsap\CAMK1G
1 of 14
No
No
Hsap\CDKL1
1 of 14
No
No
3  
Hsap\DAPK3
1 of 14
No
No
Hsap\EIF2AK1
1 of 14
No
No
1  
Hsap\EIF2AK2
1 of 14
No
No
2  
Hsap\EIF2AK3
1 of 14
No
No
1  
Hsap\LOC407835
1 of 14
No
No
Hsap\MAP2K1
1 of 14
No
No
Hsap\MAP2K2
1 of 14
No
No
Hsap\MAP2K3
1 of 14
No
No
1  
Hsap\MAP2K4
1 of 14
No
No
Hsap\MAP2K5
1 of 14
No
No
Hsap\MAP2K6
1 of 14
No
No
1  
Hsap\MAP2K7
1 of 14
No
No
Hsap\MAP3K1
1 of 14
No
Yes
Hsap\MAP3K2
1 of 14
No
No
Hsap\MAP3K3
1 of 14
No
No
Hsap\MAP3K5
1 of 14
No
No
Hsap\MAP3K8
1 of 14
No
No
Hsap\MAP3K12
1 of 14
No
No
Hsap\MAP3K14
1 of 14
No
Yes
Hsap\MAP3K15
1 of 14
No
No
Hsap\MAP3K19
1 of 14
No
No
Hsap\MAP4K4
1 of 14
No
No
Hsap\MAPK7
1 of 14
No
No
Hsap\MINK1
1 of 14
No
No
2  
Hsap\MYO3A
1 of 14
No
No
Hsap\MYO3B
1 of 14
No
No
Hsap\NEK2
1 of 14
No
No
Hsap\NEK3
1 of 14
No
No
Hsap\NEK4
1 of 14
No
No
Hsap\NEK5
1 of 14
No
No
Hsap\NEK7
1 of 14
No
No
Hsap\NEK8
1 of 14
No
No
Hsap\NEK9
1 of 14
No
No
1  
Hsap\NRK
1 of 14
No
No
Hsap\NUAK2
1 of 14
No
No
2  
Hsap\OXSR1
1 of 14
No
No
Hsap\PAK1
1 of 14
No
No
Hsap\PAK2
1 of 14
No
No
Hsap\PAK3
1 of 14
No
No
Hsap\PAK4
1 of 14
No
No
Hsap\PAK5
1 of 14
No
No
Hsap\PAK6
1 of 14
No
No
Hsap\PKMYT1
1 of 14
No
No
Hsap\PRKCH
1 of 14
No
No
Hsap\PRKCQ
1 of 14
No
No
Hsap\PSKH1
1 of 14
No
No
Hsap\RPS6KA1
1 of 14
No
No
Hsap\SGK1
1 of 14
No
No
Hsap\SLK
1 of 14
No
No
6  
Hsap\STK3
1 of 14
No
No
1  
Hsap\STK4
1 of 14
No
No
2  
Hsap\STK10
1 of 14
No
No
Hsap\STK17A
1 of 14
No
No
Hsap\STK24
1 of 14
No
No
Hsap\STK25
1 of 14
No
No
1  
Hsap\STK26
1 of 14
No
No
Hsap\STK32B
1 of 14
No
No
Hsap\STK36
1 of 14
No
No
1  
Hsap\STK39
1 of 14
No
No
Hsap\STRADA
1 of 14
No
No
1  
Hsap\STRADB
1 of 14
No
No
1  
Hsap\TAOK1
1 of 14
No
No
Hsap\TAOK2
1 of 14
No
No
4  
Hsap\TAOK3
1 of 14
No
No
Hsap\TNIK
1 of 14
No
No
Hsap\WEE1
1 of 14
No
No
Hsap\WEE2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (57)
Rnor\Map4k3
13 of 14
Yes
Yes
Rnor\Map4k5
12 of 14
No
Yes
Rnor\Map4k2
9 of 14
No
Yes
Rnor\Map4k1
6 of 14
No
Yes
Rnor\Akt1
1 of 14
No
No
Rnor\Akt2
1 of 14
No
No
Rnor\Camk1g
1 of 14
No
No
Rnor\Cdc42bpg
1 of 14
No
No
Rnor\Cdkl3
1 of 14
No
No
Rnor\Eif2ak1
1 of 14
No
No
Rnor\Eif2ak2
1 of 14
No
No
Rnor\Eif2ak3
1 of 14
No
No
Rnor\LOC100911229
1 of 14
No
No
Rnor\LOC102551633
1 of 14
No
No
Rnor\Map3k8
1 of 14
No
Yes
Rnor\Map3k14
1 of 14
No
Yes
Rnor\Map4k4
1 of 14
No
No
Rnor\Melk
1 of 14
No
Yes
Rnor\Mink1
1 of 14
No
No
Rnor\Myo3a
1 of 14
No
No
Rnor\Myo3b
1 of 14
No
No
Rnor\Nek3
1 of 14
No
No
Rnor\Nek4
1 of 14
No
No
Rnor\Nek7
1 of 14
No
No
Rnor\Nrk
1 of 14
No
No
Rnor\Nuak2
1 of 14
No
No
Rnor\Oxsr1
1 of 14
No
No
Rnor\Pak1
1 of 14
No
No
Rnor\Pak2
1 of 14
No
No
Rnor\Pak3
1 of 14
No
No
Rnor\Pak4
1 of 14
No
No
Rnor\Pak5
1 of 14
No
No
Rnor\Pak6
1 of 14
No
No
Rnor\Pkmyt1
1 of 14
No
No
Rnor\Plk2
1 of 14
No
No
Rnor\Plk3
1 of 14
No
No
Rnor\Prkch
1 of 14
No
No
Rnor\Prkcq
1 of 14
No
No
Rnor\RGD1562638
1 of 14
No
No
Rnor\Rps6ka1
1 of 14
No
No
Rnor\Slk
1 of 14
No
No
Rnor\Stk3
1 of 14
No
No
Rnor\Stk4
1 of 14
No
No
Rnor\Stk10
1 of 14
No
No
Rnor\Stk24
1 of 14
No
No
Rnor\Stk25
1 of 14
No
No
Rnor\Stk26
1 of 14
No
No
Rnor\Stk32b
1 of 14
No
No
Rnor\Stk33
1 of 14
No
No
Rnor\Stk36
1 of 14
No
No
Rnor\Stk39
1 of 14
No
No
Rnor\Taok1
1 of 14
No
No
Rnor\Taok2
1 of 14
No
No
Rnor\Taok3
1 of 14
No
No
Rnor\Tesk2
1 of 14
No
No
Rnor\Tnik
1 of 14
No
No
Rnor\Wee1
1 of 14
No
No
Mus musculus (laboratory mouse) (51)
Mmus\Map4k3
12 of 14
Yes
Yes
Mmus\Map4k5
11 of 14
No
Yes
Mmus\Map4k2
9 of 14
No
Yes
Mmus\Map4k1
5 of 14
No
Yes
Mmus\4921509C19Rik
1 of 14
No
No
Mmus\Akt1
1 of 14
No
No
Mmus\Akt2
1 of 14
No
No
Mmus\Camk1g
1 of 14
No
No
Mmus\Cdkl4
1 of 14
No
No
Mmus\Eif2ak1
1 of 14
No
No
Mmus\Eif2ak2
1 of 14
No
No
Mmus\Eif2ak3
1 of 14
No
No
Mmus\Gm14147
1 of 14
No
No
Mmus\Gm14151
1 of 14
No
No
Mmus\Map3k6
1 of 14
No
No
Mmus\Map3k8
1 of 14
No
No
Mmus\Map3k14
1 of 14
No
Yes
Mmus\Map3k15
1 of 14
No
No
Mmus\Map4k4
1 of 14
No
No
Mmus\Mink1
1 of 14
No
No
Mmus\Myo3a
1 of 14
No
No
Mmus\Myo3b
1 of 14
No
No
Mmus\Nek3
1 of 14
No
No
Mmus\Nek4
1 of 14
No
No
Mmus\Nek7
1 of 14
No
No
Mmus\Nrk
1 of 14
No
No
Mmus\Oxsr1
1 of 14
No
No
Mmus\Pak1
1 of 14
No
No
Mmus\Pak2
1 of 14
No
No
Mmus\Pak3
1 of 14
No
No
Mmus\Pak5
1 of 14
No
No
Mmus\Pak6
1 of 14
No
No
Mmus\Pkmyt1
1 of 14
No
No
Mmus\Prkch
1 of 14
No
No
Mmus\Prkcq
1 of 14
No
No
Mmus\Rps6ka1
1 of 14
No
No
Mmus\Slk
1 of 14
No
No
Mmus\Stk3
1 of 14
No
No
Mmus\Stk4
1 of 14
No
No
Mmus\Stk10
1 of 14
No
No
Mmus\Stk24
1 of 14
No
No
Mmus\Stk25
1 of 14
No
No
Mmus\Stk26
1 of 14
No
No
Mmus\Stk36
1 of 14
No
No
Mmus\Stk39
1 of 14
No
No
Mmus\Strada
1 of 14
No
No
Mmus\Taok1
1 of 14
No
No
Mmus\Taok2
1 of 14
No
No
Mmus\Taok3
1 of 14
No
No
Mmus\Tnik
1 of 14
No
No
Mmus\Wee1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (46)
Xtro\map4k3
11 of 13
Yes
Yes
Xtro\map4k5
10 of 13
No
Yes
Xtro\a2ml1
9 of 13
No
Yes
Xtro\braf
1 of 13
No
No
Xtro\camk1
1 of 13
No
No
Xtro\dapk3
1 of 13
No
No
Xtro\eif2ak2
1 of 13
No
No
Xtro\garem2
1 of 13
No
Yes
Xtro\gpha2
1 of 13
No
No
Xtro\itsn1
1 of 13
No
No
Xtro\LOC100486125
1 of 13
No
No
Xtro\LOC100486333
1 of 13
No
No
Xtro\LOC100498055
1 of 13
No
No
Xtro\map2k1
1 of 13
No
No
Xtro\map3k1
1 of 13
No
Yes
Xtro\map3k2
1 of 13
No
No
Xtro\map3k8
1 of 13
No
Yes
Xtro\map3k19
1 of 13
No
No
Xtro\map4k1
1 of 13
No
Yes
Xtro\map4k4
1 of 13
No
No
Xtro\mapk7
1 of 13
No
No
Xtro\melk
1 of 13
No
Yes
Xtro\nek5
1 of 13
No
No
Xtro\nek9
1 of 13
No
No
Xtro\neu4
1 of 13
No
No
Xtro\nrk
1 of 13
No
No
Xtro\nuak1
1 of 13
No
No
Xtro\pak2
1 of 13
No
No
Xtro\pak3
1 of 13
No
No
Xtro\pak4
1 of 13
No
No
Xtro\pkr2
1 of 13
No
No
Xtro\plk5
1 of 13
No
No
Xtro\pskh1
1 of 13
No
No
Xtro\rheb
1 of 13
No
No
Xtro\rock1
1 of 13
No
No
Xtro\smim18
1 of 13
No
No
Xtro\stk3
1 of 13
No
No
Xtro\stk4
1 of 13
No
No
Xtro\stk10
1 of 13
No
No
Xtro\stk32c
1 of 13
No
No
Xtro\stk39
1 of 13
No
No
Xtro\stradb
1 of 13
No
No
Xtro\taok1
1 of 13
No
No
Xtro\taok2
1 of 13
No
No
Xtro\ulk3
1 of 13
No
No
Xtro\wee2
1 of 13
No
No
Danio rerio (Zebrafish) (72)
Drer\map4k3b
13 of 14
Yes
Yes
Drer\map4k3a
12 of 14
No
Yes
Drer\map4k5
12 of 14
No
Yes
Drer\map4k2
9 of 14
No
Yes
Drer\map4k6
9 of 14
No
Yes
Drer\akt2
1 of 14
No
No
Drer\arf2b
1 of 14
No
No
Drer\braf
1 of 14
No
No
Drer\camk1da
1 of 14
No
No
Drer\camk1gb
1 of 14
No
No
Drer\camk2d1
1 of 14
No
No
Drer\eif2ak2
1 of 14
No
No
Drer\LOC100536197
1 of 14
No
No
Drer\LOC101883459
1 of 14
No
Yes
Drer\LOC107980443
1 of 14
No
No
Drer\map2k2a
1 of 14
No
No
Drer\map2k2b
1 of 14
No
No
Drer\map3k3
1 of 14
No
No
Drer\map3k5
1 of 14
No
No
Drer\map3k8
1 of 14
No
No
Drer\map3k14a
1 of 14
No
Yes
Drer\map3k15
1 of 14
No
No
Drer\map3k19
1 of 14
No
No
Drer\map4k4
1 of 14
No
No
Drer\mast1b
1 of 14
No
No
Drer\mink1
1 of 14
No
No
Drer\myo3a
1 of 14
No
No
Drer\myo3b
1 of 14
No
No
Drer\nek1
1 of 14
No
No
Drer\nek2
1 of 14
No
No
Drer\nek4
1 of 14
No
No
Drer\nek8
1 of 14
No
No
Drer\nek12
1 of 14
No
No
Drer\oxsr1a
1 of 14
No
No
Drer\oxsr1b
1 of 14
No
No
Drer\pak1
1 of 14
No
No
Drer\pak2a
1 of 14
No
No
Drer\pak2b
1 of 14
No
No
Drer\pak4
1 of 14
No
No
Drer\pak5
1 of 14
No
No
Drer\pak6b
1 of 14
No
No
Drer\pkz
1 of 14
No
No
Drer\plk2a
1 of 14
No
No
Drer\prkcab
1 of 14
No
No
Drer\rps6ka1
1 of 14
No
No
Drer\sgk2b
1 of 14
No
No
Drer\sgk3
1 of 14
No
No
Drer\si:ch211-1i11.3
1 of 14
No
No
Drer\si:ch211-195b13.1
1 of 14
No
No
Drer\si:dkey-81j8.6
1 of 14
No
No
Drer\si:dkey-192d15.2
1 of 14
No
No
Drer\si:zfos-2326c3.2
1 of 14
No
No
Drer\slka
1 of 14
No
No
Drer\slkb
1 of 14
No
No
Drer\stk3
1 of 14
No
No
Drer\stk10
1 of 14
No
No
Drer\stk24a
1 of 14
No
No
Drer\stk24b
1 of 14
No
No
Drer\stk25a
1 of 14
No
No
Drer\stk25b
1 of 14
No
No
Drer\stk26
1 of 14
No
No
Drer\stk36
1 of 14
No
No
Drer\stk39
1 of 14
No
No
Drer\taok1a
1 of 14
No
No
Drer\taok1b
1 of 14
No
No
Drer\taok2a
1 of 14
No
No
Drer\taok2b
1 of 14
No
No
Drer\taok3a
1 of 14
No
No
Drer\taok3b
1 of 14
No
No
Drer\tnika
1 of 14
No
No
Drer\wee1
1 of 14
No
No
Drer\wee2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (35)
Cele\gck-2
13 of 14
Yes
Yes
Cele\akt-1
1 of 14
No
No
Cele\C03B1.5
1 of 14
No
No
Cele\cst-1
1 of 14
No
No
Cele\cst-2
1 of 14
No
No
Cele\gck-1
1 of 14
No
No
Cele\gck-3
1 of 14
No
No
Cele\gck-4
1 of 14
No
No
Cele\jkk-1
1 of 14
No
No
Cele\kin-4
1 of 14
No
No
Cele\kin-18
1 of 14
No
No
Cele\kin-29
1 of 14
No
No
Cele\mak-1
1 of 14
No
No
Cele\max-2
1 of 14
No
No
Cele\mek-1
1 of 14
No
No
Cele\mek-2
1 of 14
No
No
Cele\mig-15
1 of 14
No
No
Cele\mkk-4
1 of 14
No
No
Cele\nsy-1
1 of 14
No
No
Cele\pak-1
1 of 14
No
No
Cele\pak-2
1 of 14
No
No
Cele\pkc-2
1 of 14
No
No
Cele\R06A10.4
1 of 14
No
No
Cele\sek-1
1 of 14
No
No
Cele\sek-3
1 of 14
No
No
Cele\sek-4
1 of 14
No
No
Cele\sek-5
1 of 14
No
No
Cele\sek-6
1 of 14
No
No
Cele\sgk-1
1 of 14
No
No
Cele\strd-1
1 of 14
No
No
Cele\unc-51
1 of 14
No
No
Cele\wee-1.1
1 of 14
No
No
Cele\wee-1.3
1 of 14
No
No
Cele\wnk-1
1 of 14
No
No
Cele\Y38E10A.8
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (29)
Agam\AgaP_AGAP010837
12 of 12
Yes
Yes
Agam\AgaP_AGAP000310
1 of 12
No
No
Agam\AgaP_AGAP000477
1 of 12
No
No
Agam\AgaP_AGAP001103
1 of 12
No
No
Agam\AgaP_AGAP001790
1 of 12
No
No
Agam\AgaP_AGAP001867
1 of 12
No
No
Agam\AgaP_AGAP001950
1 of 12
No
No
Agam\AgaP_AGAP002371
1 of 12
No
No
Agam\AgaP_AGAP002647
1 of 12
No
No
Agam\AgaP_AGAP002686
1 of 12
No
No
Agam\AgaP_AGAP002986
1 of 12
No
No
Agam\AgaP_AGAP003040
1 of 12
No
No
Agam\AgaP_AGAP003180
1 of 12
No
No
Agam\AgaP_AGAP003201
1 of 12
No
No
Agam\AgaP_AGAP003202
1 of 12
No
No
Agam\AgaP_AGAP003365
1 of 12
No
No
Agam\AgaP_AGAP004239
1 of 12
No
No
Agam\AgaP_AGAP006044
1 of 12
No
No
Agam\AgaP_AGAP006340
1 of 12
No
No
Agam\AgaP_AGAP006715
1 of 12
No
No
Agam\AgaP_AGAP007805
1 of 12
No
No
Agam\AgaP_AGAP009730
1 of 12
No
No
Agam\AgaP_AGAP009961
1 of 12
No
No
Agam\AgaP_AGAP010551
1 of 12
No
No
Agam\AgaP_AGAP010874
1 of 12
No
No
Agam\AgaP_AGAP011099
1 of 12
No
No
Agam\AgaP_AGAP011710
1 of 12
No
No
Agam\AgaP_AGAP012499
1 of 12
No
No
Agam\AgaP_AGAP013266
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (57)
Atha\SIK1
4 of 13
Yes
No
Atha\AT3G15220
2 of 13
No
No
Atha\ATMAP4K ALPHA1
2 of 13
No
No
Atha\AT1G18160
1 of 13
No
No
Atha\AT1G23700
1 of 13
No
No
Atha\AT1G45160
1 of 13
No
No
Atha\AT1G70430
1 of 13
No
No
Atha\AT1G79640
1 of 13
No
No
Atha\AT2G37840
1 of 13
No
No
Atha\AT3G10540
1 of 13
No
No
Atha\AT3G53930
1 of 13
No
No
Atha\AT4G10730
1 of 13
No
No
Atha\AT4G14480
1 of 13
No
No
Atha\AT4G24100
1 of 13
No
No
Atha\AT5G14720
1 of 13
No
No
Atha\AT5G18700
1 of 13
No
No
Atha\AT5G21222
1 of 13
No
No
Atha\CDPK6
1 of 13
No
No
Atha\CIPK4
1 of 13
No
No
Atha\CIPK7
1 of 13
No
No
Atha\CIPK12
1 of 13
No
No
Atha\CIPK19
1 of 13
No
No
Atha\CIPK20
1 of 13
No
No
Atha\CIPK23
1 of 13
No
No
Atha\CPK6
1 of 13
No
No
Atha\CPK16
1 of 13
No
No
Atha\CPK18
1 of 13
No
No
Atha\CPK26
1 of 13
No
No
Atha\CPK28
1 of 13
No
No
Atha\CPK29
1 of 13
No
No
Atha\CPK31
1 of 13
No
No
Atha\CPK33
1 of 13
No
No
Atha\GCN2
1 of 13
No
No
Atha\MAP3KA
1 of 13
No
No
Atha\MAPKKK6
1 of 13
No
No
Atha\MAPKKK7
1 of 13
No
No
Atha\MAPKKK9
1 of 13
No
No
Atha\MEK1
1 of 13
No
No
Atha\MKK2
1 of 13
No
No
Atha\MKK3
1 of 13
No
No
Atha\MKK6
1 of 13
No
No
Atha\MKK7
1 of 13
No
No
Atha\MPK6
1 of 13
No
No
Atha\NEK1
1 of 13
No
No
Atha\NEK2
1 of 13
No
No
Atha\NEK3
1 of 13
No
No
Atha\NEK4
1 of 13
No
No
Atha\NEK6
1 of 13
No
No
Atha\NP1
1 of 13
No
No
Atha\NP2
1 of 13
No
No
Atha\NP3
1 of 13
No
No
Atha\PDK1
1 of 13
No
No
Atha\PEPKR2
1 of 13
No
No
Atha\S6K2
1 of 13
No
No
Atha\SIP4
1 of 13
No
No
Atha\WEE1
1 of 13
No
No
Atha\YDA
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (17)
Scer\KIC1
2 of 13
Yes
No
Scer\BCK1
1 of 13
No
No
Scer\CDC15
1 of 13
No
No
Scer\CLA4
1 of 13
No
No
Scer\FUS3
1 of 13
No
No
Scer\HSL1
1 of 13
No
No
Scer\KCC4
1 of 13
No
No
Scer\MKK1
1 of 13
No
No
Scer\MKK2
1 of 13
No
No
Scer\PBS2
1 of 13
No
No
Scer\SKM1
1 of 13
No
No
Scer\SPS1
1 of 13
No
No
Scer\SSK2
1 of 13
No
No
Scer\STE7
1 of 13
No
No
Scer\STE20
1 of 13
No
No
Scer\TPK2
1 of 13
No
No
Scer\YPK1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (7)
Spom\nak1
2 of 12
Yes
No
Spom\ppk11
2 of 12
Yes
No
Spom\sid1
2 of 12
Yes
No
Spom\cdc7
1 of 12
No
Yes
Spom\ppk2
1 of 12
No
No
Spom\shk1
1 of 12
No
No
Spom\shk2
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:hppy. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (32)
fray
3 of 13
GckIII
3 of 13
Slik
3 of 13
hpo
2 of 13
mbt
2 of 13
msn
2 of 13
Pak
2 of 13
Stlk
2 of 13
Tao
2 of 13
Akt
1 of 13
aPKC
1 of 13
Cdkl
1 of 13
CG32944
1 of 13
dop
1 of 13
Dsor1
1 of 13
hep
1 of 13
inaC
1 of 13
JIL-1
1 of 13
lic
1 of 13
Mkk4
1 of 13
Myt1
1 of 13
Nek2
1 of 13
niki
1 of 13
ninaC
1 of 13
Pak3
1 of 13
par-1
1 of 13
PEK
1 of 13
Pka-C3
1 of 13
Pkc98E
1 of 13
polo
1 of 13
SAK
1 of 13
wnd
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
hppyKK101460
exacerbates  retinitis pigmentosa
modeled by ninaEG69D.UAS
(Chow et al., 2016)
hppy17-51
model of  alcohol use disorder
is ameliorated by aru8.128
(Eddison et al., 2011)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3
13 of 14
604921
      MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5
      12 of 14
      604923
          MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2
          9 of 14
          603166
              MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1
              6 of 14
              601983
                   
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  Summary of Genetic Interactions
                  Interaction Browsers
                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                  Please look at the allele data for full details of the genetic interactions
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  hppy
                  enhanceable
                  Akt
                  (Resnik-Docampo and de Celis, 2011)
                  hppy
                  suppressible
                  aru
                  (Eddison et al., 2011)
                  hppy
                  suppressible
                  bsk
                  (Lam et al., 2010)
                  hppy
                  suppressible
                  Buffy
                  (Lam et al., 2010)
                  hppy
                  suppressible
                  Diap1
                  (Resnik-Docampo and de Celis, 2011)
                  hppy
                  enhanceable
                  mTor
                  (Resnik-Docampo and de Celis, 2011)
                  hppy
                  enhanceable
                  Pi3K92E
                  (Resnik-Docampo and de Celis, 2011)
                  hppy
                  suppressible
                  puc
                  (Resnik-Docampo and de Celis, 2011)
                  hppy
                  enhanceable
                  puc
                  (Resnik-Docampo and de Celis, 2011)
                  hppy
                  enhanceable
                  RagC-D
                  (Resnik-Docampo and de Celis, 2011)
                  hppy
                  enhanceable
                  raptor
                  (Resnik-Docampo and de Celis, 2011)
                  hppy
                  suppressible
                  S6k
                  (Resnik-Docampo and de Celis, 2011)
                  hppy
                  enhanceable
                  S6k
                  (Resnik-Docampo and de Celis, 2011)
                  hppy
                  suppressible
                  Tsc1|gig
                  (Lam et al., 2010)
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Akt
                  enhanceable
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  aop
                  enhanceable
                  hppy
                  (Corl et al., 2009)
                  Egfr
                  suppressible
                  hppy
                  (Corl et al., 2009)
                  Egfr
                  enhanceable
                  hppy
                  (Corl et al., 2009)
                  gig
                  suppressible
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  mTor
                  enhanceable
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  mTor
                  suppressible
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  ninaE
                  enhanceable
                  hppy
                  (Chow et al., 2016)
                  path
                  suppressible
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  path
                  enhanceable
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  Pi3K92E
                  enhanceable
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  Pten
                  suppressible
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  RacGAP84C
                  enhanceable
                  hppy
                  (Raymond et al., 2004)
                  RagA-B
                  suppressible
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  RagA-B
                  enhanceable
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  RagC-D
                  enhanceable
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  raptor
                  enhanceable
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  S6k
                  enhanceable
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  slif
                  enhanceable
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  slif
                  suppressible
                  hppy
                  (Resnik-Docampo and de Celis, 2011)
                  External Data
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Signaling Pathways (FlyBase)
                  Metabolic Pathways
                  FlyBase
                  External Links
                  External Data
                  Linkouts
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  Class of Gene
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  2R
                  Recombination map
                  2-88
                  Cytogenetic map
                  56C1-56C4
                  Sequence location
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  56C1-56C4
                  Limits computationally determined from genome sequence between P{PZ}ena02029&P{lacW}corak08713 and P{lacW}htsk06121
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  56C1-56C4
                  (Oh et al., 2003)
                  Experimentally Determined Recombination Data
                  Location

                  2-88

                  (FlyBase, 2016)

                  2-93.8

                  (Comeron et al., 2012)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (24)
                  Genomic Clones (49)
                  cDNA Clones (86)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequenced
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Zheng et al., 2015, Resnik-Docampo and de Celis, 2011)
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      JNK signaling is required for hppy-mediated cell death.

                      (Lam et al., 2010)

                      hppy expression enhances phosphorylation of Thor.

                      (Lam et al., 2010)

                      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                      (Kiger et al., 2003)

                      1 allele of l(2)SH1261 recovered in a P-insertion screen.

                      (Oh et al., 2003)
                      Relationship to Other Genes
                      Source for database merge of

                      Source for merge of: hppy EP-704

                      (Resnik-Docampo and de Celis, 2011)

                      Source for merge of: CG7097 anon-WO0153538.68

                      (FlyBase, 1996-)

                      Source for merge of: hppy l(2)SH1261

                      (Bryk et al., 2010)
                      Additional comments

                      Source for merge of CG7097 anon-WO0153538.68 was sequence comparison ( date:051113 ).

                      (FlyBase, 1996-)
                      Nomenclature History
                      Source for database identify of

                      Source for identity of: hppy CG7097

                      (Corl et al., 2009)
                      Nomenclature comments
                      Etymology

                      The gene is named "happyhour" because its mutation results in flies being able to imbibe significantly more alcohol than wild-type controls before succumbing to its sedating effects.

                      (Corl et al., 2009)
                      Synonyms and Secondary IDs (15)
                      Reported As
                      Symbol Synonym
                      CG7097
                      (National Institute of Genetics Fly Stocks, 2022-, Ashwal-Fluss et al., 2014, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Murray et al., 2012, Ni et al., 2011.7.19, Resnik-Docampo and de Celis, 2011, Zacharogianni et al., 2011, Bryk et al., 2010, Ni et al., 2010.12.1, Corl et al., 2009, Delpire, 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Findlay et al., 2007, Riedl et al., 2007, Molnar et al., 2006, Raymond et al., 2004)
                      CG7097/hppy
                      (Yin et al., 2013)
                      EP-704
                      (Molnar et al., 2006)
                      GLK/KHS1
                      (Morrison et al., 2000)
                      Hppy
                      (Cho and Jiang, 2021, Hou and Pei, 2021, Cho et al., 2018, Richardson and Portela, 2017, Meng et al., 2016, Narayanan and Rothenfluh, 2016, Li et al., 2015, Zheng et al., 2015)
                      MAP4K3
                      (van Soldt and Cardoso, 2020, Ahmad et al., 2018, Resnik-Docampo and de Celis, 2011, Bryk et al., 2010)
                      anon-WO0153538.68
                      hppy
                      (Chvilicek et al., 2024, Wu et al., 2024, Datta et al., 2023, O'Farrell et al., 2023, Havula et al., 2022, Karam et al., 2022, Marcogliese et al., 2022, Sheardown et al., 2022, Port et al., 2020, Highfill et al., 2019, Meltzer et al., 2019, Palmer et al., 2018, Park et al., 2017, Chow et al., 2016, Gene Disruption Project members, 2016-, Kuleesha et al., 2016, Levinson and Cagan, 2016, Duff et al., 2015, Grotewiel and Bettinger, 2015, Sopko et al., 2014, de Celis et al., 2013.9.11, Rodriguez et al., 2012, Devineni et al., 2011, Eddison et al., 2011, Friedman et al., 2011, Resnik-Docampo and de Celis, 2011, Corl et al., 2009)
                      l(2)SH1261
                      l(2)SH2 1261
                      (Oh et al., 2002.3.25)
                      Name Synonyms
                      CG7097
                      Gene 2
                      (Bradley and Andrew, 2001)
                      Happy Hour
                      (Narayanan and Rothenfluh, 2016)
                      Happyhour
                      (Chen et al., 2020, Zheng et al., 2015)
                      happyhour
                      (Resnik-Docampo and de Celis, 2011, Lam et al., 2010, Corl et al., 2009)
                      lethal (2) SH1261
                      Secondary FlyBase IDs
                      • FBgn0065486
                      • FBgn0259477
                      • FBgn0045883
                      • FBgn0034421
                      • FBgn0263255
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 63 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                      References (113)