hrp40, l(3)j4B4, RRM3, l(3)EP3631, hnRNP A
RNA-binding protein, hnRNP D homolog - mRNA localization and translation are coupled by an interaction between Sqd and the translational repressor protein Bruno - Squid promotes apical cytoplasmic transport and localization of transcripts
Please see the GBrowse view of Dmel\sqd or the JBrowse view of Dmel\sqd for information on other features
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Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.47
4.8, 3.5, 2.3, 1.9, 1.7, 1.5 (northern blot)
321, 308 (aa)
40 (kD observed)
345, 321 (aa); 40 (kD observed); 36, 35 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sqd using the Feature Mapper tool.
Comment: maternally deposited
Isoform-specific expression patterns are observed. Sex-specific expression of alternative transcripts observed.
1.5kb sqd transcripts are expressed predominantly in ovaries.
2.3kb sqd transcripts are expressed predominantly in non-ovarian tissues.
1.9kb sqd transcripts are expressed predominantly in ovaries.
GBrowse - Visual display of RNA-Seq signals
View Dmel\sqd in GBrowse 23-54
3-54
3-51.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
monoclonal antibody
monoclonal
Source for identity of: sqd CG17791
Source for merge of: CR33328 BcDNA:GM03761
Source for merge of: sqd l(3)j4B4
Source for merge of: sqd Rbp3
Source for merge of: CG16901 CG17791
Source for merge of: sqd CR33328
Annotation CG16901 merged with annotation CR33328 in release 5.40 of the genome annotation; CR33328 corresponds to 3' UTR of CG16901.
Annotations CG16901 and CG17791 merged as sqd in release 3 of the genome annotation.
Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.
New annotation (CR33328) in release 3.2 of the genome annotation.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. sqd is required for germ cell viability or early oogenesis.
Phenotypic and molecular characterisation of sqd demonstrates that the RNA-binding gene product plays a central role in establishing egg polarity.
A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.
The distribution of the hnRNP protein sqd on nascent transcripts from polytene chromosomes has been studied.
A sqd cDNA clone has been isolated and sequenced.
