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FB2025_05
,
released December 11, 2025
dChx1, Chx1, Vsx, lincRNA.S8688, dVsx1
homeodomain transcription factors - markers for the brain central neuroendocrine system termed the pars intercerebralis that expresses the hormones Drosophila insulin-like peptide (Dilp), FMRF, and myomodulin
Please see the JBrowse view of Dmel\Vsx1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.51
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vsx1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Vsx1 is expressed at embryonic stage 9 in two bilaterally symmetric domains in the procephalic neurectoderm. These divide into two domains, those that will give rise to the pharynx, and those that will become the pars intercerebralis. It is detected at embryonic stage 12 in the presumptive pharynx, pars intercerebralis, and optic placode. At stage 13 it is detected in the ventral nerve cord and at stages 15-17 in several regions of the CNS including the pars intercerebralis and mushroom body.
Vsx1 protein is detected at embryonic stage 12 in the presumptive pharynx, pars intercerebralis, and optic placode. It is detected at stage 13 in the ventral nerve cord and at stages 15-17 in several regions of the CNS including the pars intercerebralis and mushroom body.
Vsx1 protein is expressed embryonically in the pars intercerebralis, ventral nerve cord, pharynx, optic anlage, and isolated cells in the brain. In the visual system, it is first expressed in the preinvagination optic placode. After invagination, it is expressed in approximately 12 cells in the center of each optic anlage. By the first instar larval stage, it is detected in approximately 9 cells in the central region of the outer optic anlage. In third instar larvae, it is found in a small central population of outer optic anlage epithelial precursors and not in the neuroblasts. A second domain of expression is observed in the nascent medulla cortex. In late third instar larvae, Vsx1 protein is expressed in a subset of neurons in the medulla cortex and continues to be expressed in pupae and adults. It is coexpressed with Vsx2 in 20% of the cells of the medulla cortex.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Vsx1 in JBrowse1-12
1-14.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Vsx1 is required for cell proliferation in the optic lobe anlage.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Identification: Identified on the basis of sequence similarity to murine Chx10.
Source for merge of: Vsx1 Chx1
Source for identity of: Vsx1 CG4136
