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FB2021_04, released August 17, 2021

Gene: Dmel\Lpin

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General Information
Symbol
Dmel\Lpin
Species
D. melanogaster
Name
Lipin
Annotation Symbol
CG8709
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263593
Gene Model Status
Current
Stock Availability
11 publicly available
Enzyme Name (EC)
Phosphatidate phosphatase (3.1.3.4)
Gene Summary
Lipin (Lpin) encodes a protein that plays a central role in fat body function and energy metabolism. It works as a phosphatidate phosphatase required for normal insulin pathway signaling. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DmLpin, dLipin, DmLipin, EP2431

Key Links
Genomic Location
Cytogenetic map
44B4-44B5
Sequence location
2R:8,136,986..8,156,654 [-]
Recombination map
2-58
RefSeq locus
NT_033778 REGION:8136986..8156654
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables phosphatidate phosphatase activity
inferred from mutant phenotype
(Schmitt et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables phosphatidate phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN000256564
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with MGI:MGI:1891340
(Valente et al., 2010)
enables transcription coactivator activity
inferred from sequence or structural similarity with MGI:MGI:1891340
(Valente et al., 2010)
inferred from biological aspect of ancestor with PANTHER:PTN000953144
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (16 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in cellular response to insulin stimulus
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Schmitt et al., 2015)
involved_in cellular response to starvation
inferred from mutant phenotype
(Schmitt et al., 2015)
involved_in imaginal disc-derived wing margin morphogenesis
inferred from mutant phenotype
(Duy Binh et al., 2019)
involved_in imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Liu et al., 2011)
involved_in lipid homeostasis
inferred from mutant phenotype
(Ugrankar et al., 2011)
involved_in positive regulation of insulin receptor signaling pathway
inferred from mutant phenotype
(Schmitt et al., 2015)
involved_in positive regulation of phosphatidylinositol 3-kinase signaling
inferred from mutant phenotype
(Schmitt et al., 2015)
involved_in regulation of cellular ketone metabolic process
inferred from mutant phenotype
(Ugrankar et al., 2011)
involved_in regulation of DNA damage checkpoint
inferred from mutant phenotype
(Duy Binh et al., 2019)
involved_in regulation of fatty acid metabolic process
inferred from mutant phenotype
(Ugrankar et al., 2011)
involved_in response to starvation
inferred from mutant phenotype
(Ugrankar et al., 2011)
involved_in triglyceride biosynthetic process
inferred from mutant phenotype
(Ugrankar et al., 2011)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in cellular lipid metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000256564
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cellular response to insulin stimulus
inferred from biological aspect of ancestor with PANTHER:PTN000953144
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in fatty acid catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000256565
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000953144
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of transcription by RNA polymerase II
inferred from sequence or structural similarity with MGI:MGI:1891340
(Valente et al., 2010)
involved_in triglyceride biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000256565
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Ugrankar et al., 2011, Valente et al., 2010)
located_in cytosol
inferred from direct assay
(Schmitt et al., 2015)
located_in female germline ring canal inner rim
inferred from direct assay
(Valente et al., 2010)
located_in nucleus
inferred from direct assay
(Schmitt et al., 2015, Ugrankar et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000256565
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate (3.1.3.4)
Predictions / Assertions
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate (3.1.3.4)
Summaries
Gene Snapshot
Lipin (Lpin) encodes a protein that plays a central role in fat body function and energy metabolism. It works as a phosphatidate phosphatase required for normal insulin pathway signaling. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
Positive Regulators of Insulin-like Receptor Signaling Pathway -
Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Negative Regulators of BMP Signaling Pathway -
Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
Gene Group (FlyBase)
LIPID PHOSPHATE PHOSPHATASES -
Lipid phosphate phosphatases (LPP) are integral membrane proteins, with six putative transmembrane domains, that catalyze the dephosphorylation of a variety of lipid phosphates. (Adapted from FBrf0191316 and PMID:25814022).
Summary (Interactive Fly)

phosphatidate phosphatase activity - transcriptional co-activator - downstream effector mediating effects of insulin and TORC1 signaling on lipid metabolism - influences fat body development and function - affects cellular growth

Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
9

Please see the JBrowse view of Dmel\Lpin for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Shares 5' UTR with upstream gene; observed for only a few of the many alternative transcripts.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Lpin-RA
FBtr0088815
NM_136515
3996
1089
Lpin-RB
FBtr0113055
NM_001103758
4088
1035
Lpin-RC
FBtr0303573
NM_001201945
4085
1034
Lpin-RD
FBtr0303574
NM_001201946
4106
1088
Lpin-RE
FBtr0303575
NM_001201947
3867
1045
Lpin-RG
FBtr0303577
NM_001201949
3351
1016
Lpin-RH
FBtr0303578
NM_001201950
3858
1043
Lpin-RJ
FBtr0303580
NM_001201952
3187
962
Lpin-RK
FBtr0303583
NM_001201953
4461
1035
Lpin-RL
FBtr0303584
NM_001201954
3959
992
Lpin-RM
FBtr0303585
NM_001201955
4369
1089
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Lpin-PA
FBpp0087891
120.9
1089
4.47
NP_610359
AAF59125
Lpin-PB
FBpp0111968
114.8
1035
4.72
NP_001097228
ABV53728
Lpin-PC
FBpp0292606
114.7
1034
4.72
NP_001188874
ADV37123
Lpin-PD
FBpp0292607
120.8
1088
4.47
NP_001188875
ADV37124
Lpin-PE
FBpp0292608
115.9
1045
4.41
NP_001188876
ADV37125
Lpin-PG
FBpp0292610
112.7
1016
4.45
NP_001188878
ADV37127
Lpin-PH
FBpp0292611
115.6
1043
4.47
NP_001188879
ADV37128
Lpin-PJ
FBpp0292613
106.6
962
4.71
NP_001188881
ADV37130
Lpin-PK
FBpp0292616
114.8
1035
4.72
NP_001188882
ADV37131
Lpin-PL
FBpp0292617
110.0
992
4.63
NP_001188883
ADV37132
Lpin-PM
FBpp0292618
120.9
1089
4.47
NP_001188884
ADV37133
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1089 aa isoforms: Lpin-PA, Lpin-PM
1035 aa isoforms: Lpin-PB, Lpin-PK
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lpin using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 7 -- 8
mesectoderm anlage | subset
(Kearney et al., 2004)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
midline ventral glial cell
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
larval midline neuron
(Kearney et al., 2004)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Valente et al., 2010)
third instar larval stage
embryonic/larval central nervous system
(Valente et al., 2010)
embryonic/larval fat body
(Valente et al., 2010)
embryonic/larval Malpighian tubule
(Valente et al., 2010)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval central nervous system
(Valente et al., 2010)
embryonic/larval fat body
(Valente et al., 2010)
embryonic/larval Malpighian tubule
(Valente et al., 2010)
adult stage | male
testis
(Valente et al., 2010)
adult stage | female
ovary
(Valente et al., 2010)
Additional Descriptive Data

Isoform-specific expression of Lpin in specific developmental stages and tissues was discussed.

(Valente et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval Malpighian tubule
(Ugrankar et al., 2011)
third instar larval stage
embryonic/larval fat body
(Ugrankar et al., 2011)
embryonic/larval midgut
(Ugrankar et al., 2011)
ring gland
(Ugrankar et al., 2011)
gastric caecum
(Ugrankar et al., 2011)
imaginal disc
(Ugrankar et al., 2011)
peripheral glial cell
(Valente et al., 2010)
embryonic/larval visceral muscle
(Valente et al., 2010)
embryonic/larval adipose system
(Valente et al., 2010)
embryonic/larval central nervous system
(Valente et al., 2010)
adult stage
adult fat body
(Ugrankar et al., 2011)
adult midgut
(Ugrankar et al., 2011)
adult Malpighian tubule
(Ugrankar et al., 2011)
ring gland
(Ugrankar et al., 2011)
gastric caecum
(Ugrankar et al., 2011)
adult stage | female
nurse cell
(Ugrankar et al., 2011)
follicle cell
(Ugrankar et al., 2011)
oogenesis
nurse cell
(Valente et al., 2010)
oocyte
(Valente et al., 2010)
follicle cell
(Valente et al., 2010)
ring canal
(Valente et al., 2010)
polar follicle cell
(Valente et al., 2010)
border follicle cell
(Valente et al., 2010)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Valente et al., 2010)
third instar larval stage
embryonic/larval central nervous system
(Valente et al., 2010)
embryonic/larval fat body
(Valente et al., 2010)
embryonic/larval Malpighian tubule
(Valente et al., 2010)
adult stage | male
testis
(Valente et al., 2010)
adult stage | female
ovary
(Valente et al., 2010)
Additional Descriptive Data

Lpin expression was assayed by immunolocalization on dissected tissues. Within fat body, signal is distributed throughout the cytoplasm but is strongly concentrated in the perinuclear region of adipocytes. In the CNS, signal is strong in the cytoplasm of cells of the brain hemispheres and is also found in peripheral glia. Signal is observed in the visceral musculature around the midgut and testis, where it shows a pattern of striated labeling. In testis, Lpin is not detected in the muscles of the seminal vesicles, ejaculatory duct, or accessory glands. The pattern of striated labeling relative to actin distribution shows that Lpin is concentrated in the A band of the visceral muscles. Lpin is found in the cytoplasm of follicle cells, nurse cells and the oocyte throughout oogenesis and is enriched in the ring canals between nurse cells and in the cytoplasm of migrating border/polar follicle cells. Isoform-specific expression of Lpin in specific developmental stages and tissues was discussed.

(Valente et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Ugrankar et al., 2011, Valente et al., 2010)
located_in cytosol
inferred from direct assay
(Schmitt et al., 2015)
located_in female germline ring canal inner rim
inferred from direct assay
(Valente et al., 2010)
located_in nucleus
inferred from direct assay
(Schmitt et al., 2015, Ugrankar et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Lpin in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Lpin
Transgenic constructs containing regulatory region of Lpin
Aberrations (Deficiencies and Duplications) ( 3 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | P-stage (with Df(2R)Exel7095)
lethal - all die before end of larval stage, with Scer\GAL4αTub84B.PL
partially lethal - majority die (with Df(2R)NCX10)
partially lethal - majority die | late third instar larval stage | recessive
partially lethal - majority die | pharate adult stage | recessive
partially lethal - majority die | P-stage | recessive
partially lethal - majority die | third instar larval stage (with Df(2R)Exel7095)
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4DJ761
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
semi-sterile | recessive
Other Phenotypes
Allele
abnormal cell shape | larval stage, with Scer\GAL4Tub.PU
abnormal cell shape | larval stage (with Df(2R)Exel7095)
abnormal cell size | larval stage, with Scer\GAL4Tub.PU
abnormal developmental rate | recessive | wandering third instar larval stage
abnormal neuroanatomy | larval stage, with Scer\GAL4elav-C155
abnormal starvation stress response, with Scer\GAL4DJ761
abnormal starvation stress response, with Scer\GAL4Lsp2.3.1
abnormal starvation stress response, with Scer\GAL4Switch1.106
decreased cell size | cell autonomous | larval stage | somatic clone, with Scer\GAL4Tub.PU
increased cell size | larval stage (with Df(2R)Exel7095)
some die during larval stage, with Scer\GAL4αTub84B.PL
some die during larval stage (with Df(2R)Exel7095)
some die during P-stage (with Df(2R)NCX10)
some die during P-stage | heat sensitive
visible | adult stage, with Scer\GAL4eya.enh1+E+2
Phenotype manifest in
Allele
anterior crossvein | ectopic, with Scer\GAL4ap-md544
anterior fascicle & synapse, with Scer\GAL4elav-C155
autophagosome (with Df(2R)Exel7095)
embryonic/larval brain | larval stage
embryonic/larval fat body, with Scer\GAL4Cg.PA
embryonic/larval fat body, with Scer\GAL4αTub84B.PL
embryonic/larval fat body (with Df(2R)Exel7095)
embryonic/larval fat body | cell autonomous | larval stage | somatic clone, with Scer\GAL4Tub.PU
embryonic/larval fat body | larval stage, with Scer\GAL4Tub.PU
embryonic/larval fat body | larval stage (with Df(2R)Exel7095)
eye, with Scer\GAL4eya.enh1+E+2
germline cell | male, with Scer\GAL4ptc-559.1
larval intersegmental nerve, with Scer\GAL4elav-C155
lipid droplet, with Scer\GAL4Cg.PA
lipid droplet (with Df(2R)Exel7095)
lipid droplet | cell autonomous | larval stage | somatic clone, with Scer\GAL4Tub.PU
lipid droplet | larval stage, with Scer\GAL4Cg.PA
lipid droplet | larval stage (with Df(2R)Exel7095)
lipid droplet | larval stage | heat sensitive
mitochondrial crista (with Df(2R)Exel7095)
mitochondrial inner membrane (with Df(2R)Exel7095)
mitochondrial outer membrane (with Df(2R)Exel7095)
mitochondrion (with Df(2R)Exel7095)
nucleus (with Df(2R)Exel7095)
nucleus | cell autonomous | larval stage | somatic clone, with Scer\GAL4Tub.PU
nucleus | larval stage (with Df(2R)Exel7095)
wing vein, with Scer\GAL4ap-md544
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\LPIN3
13 of 15
Yes
Yes
Hsap\LPIN1
12 of 15
No
Yes
Hsap\LPIN2
12 of 15
No
Yes
Hsap\PITPNA
1 of 15
No
No
Hsap\PITPNB
1 of 15
No
No
1  
Hsap\PITPNC1
1 of 15
No
No
Hsap\PITPNM1
1 of 15
No
No
Hsap\PITPNM2
1 of 15
No
No
Hsap\PITPNM3
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Lpin3
12 of 15
Yes
Yes
Mmus\Lpin1
11 of 15
No
Yes
Mmus\Lpin2
11 of 15
No
Yes
Mmus\Pitpna
1 of 15
No
No
Mmus\Pitpnb
1 of 15
No
No
Mmus\Pitpnc1
1 of 15
No
No
Mmus\Pitpnm1
1 of 15
No
No
Mmus\Pitpnm2
1 of 15
No
No
Mmus\Pitpnm3
1 of 15
No
No
Rattus norvegicus (Norway rat) (8)
Rnor\Lpin2
11 of 13
Yes
Yes
Rnor\Lpin3
10 of 13
No
Yes
Rnor\Lpin1
9 of 13
No
Yes
Rnor\Pitpna
1 of 13
No
No
Rnor\Pitpnb
1 of 13
No
No
Rnor\Pitpnm1
1 of 13
No
No
Rnor\Pitpnm2
1 of 13
No
No
Rnor\Pitpnm3
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (8)
Xtro\lpin1
7 of 12
Yes
Yes
Xtro\lpin2
7 of 12
Yes
Yes
Xtro\lpin3
6 of 12
No
Yes
Xtro\pitpnb.2
1 of 12
No
No
Xtro\pitpnb
1 of 12
No
No
Xtro\pitpnc1
1 of 12
No
No
Xtro\pitpnc1
1 of 12
No
No
Xtro\pitpnm3
1 of 12
No
No
Danio rerio (Zebrafish) (11)
Drer\lpin1
12 of 15
Yes
Yes
Drer\lpin2
10 of 15
No
Yes
Drer\si:ch73-21k16.1
5 of 15
No
Yes
Drer\zgc:123305
5 of 15
No
Yes
Drer\pitpnaa
1 of 15
No
No
Drer\pitpnab
1 of 15
No
No
Drer\pitpnbl
1 of 15
No
No
Drer\pitpnc1a
1 of 15
No
No
Drer\pitpnc1b
1 of 15
No
No
Drer\pitpnm3
1 of 15
No
No
Drer\plrdgb
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\lpin-1
14 of 15
Yes
Yes
Cele\pitp-1
1 of 15
No
No
Cele\Y54F10AR.1
1 of 15
No
No
Cele\Y71G12B.17
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\PAH1
7 of 9
Yes
Yes
Atha\PAH2
5 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\PAH1
12 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\ned1
9 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901Q1 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006718
Drosophila simulans
Dsim\GD10183
Drosophila sechellia
Dsec\GM20717
Drosophila erecta
Dere\GG10671
Drosophila yakuba
Dyak\GE23267
Drosophila ananassae
Dana\GF11207
Drosophila pseudoobscura pseudoobscura
Dpse\GA21271
Drosophila persimilis
Dper\GL17376
Drosophila willistoni
Dwil\GK23042
Drosophila virilis
Dvir\GJ20221
Drosophila mojavensis
Dmoj\GI20267
Drosophila grimshawi
Dgri\GH19981
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501PH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023867
Glossina morsitans
Tsetse fly
Gmor\GMOY006125
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12100
Mayetiola destructor
Hessian fly
Mdes\Mdes008154
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005175
Anopheles darlingi
American malaria mosquito
Adar\ADAC007165
Anopheles gambiae
Malaria mosquito
Agam\AGAP007636
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002060
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00NL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002643
Danaus plexippus
Monarch butterfly
Dple\DPOGS201743-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006697
Apis florea
Little honeybee
Aflo\2161481444
Apis mellifera
Western honey bee
Amel\GB50941
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25688
Bombus terrestris
Buff-tailed bumblebee
Bter\15213895
Linepithema humile
Argentine ant
Lhum\LH15028
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0025a1
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004650
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08787
Tribolium castaneum
Red flour beetle
Tcas\TC010029
Pediculus humanus
Human body louse
Phum\PHUM407130
Rhodnius prolixus
Kissing bug
Rpro\RPRC010599
Cimex lectularius
Bed bug
Clec\CLEC002347
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI065855
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07458
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X042Q )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010626
Ixodes scapularis
Black-legged tick
Isca\ISCW006345
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65557.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur25g00800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_321858
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G067Z )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lpin2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lpin
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016625gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000011418
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
rdgBβ
1 of 10
rdgB
1 of 10
vib
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    LPIN1; lipin 1
    model of  myoglobinuria
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    LpinGD14004
    ameliorates  congenital generalized lipodystrophy
    modeled by Seipinnull
    (Tian et al., 2011)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    LPIN3; lipin 3
    13 of 15
    605520
        LPIN1; lipin 1
        12 of 15
        605518
        LPIN2; lipin 2
        12 of 15
        605519
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Lpin - rl
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Lpin
          enhanceable
          Tor
          (Schmitt et al., 2015)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Dad
          suppressible
          Lpin
          (Liu et al., 2011)
          Dd
          suppressible
          Lpin
          (Liu et al., 2011)
          Seipin
          suppressible
          Lpin
          (Tian et al., 2011)
          Torsin
          suppressible
          Lpin
          (Grillet et al., 2016)
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Positive Regulators of Insulin-like Receptor Signaling Pathway -
          Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
          Negative Regulators of BMP Signaling Pathway -
          Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
          Metabolic Pathways
          External Data
          Linkouts
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-58
          Cytogenetic map
          44B4-44B5
          Sequence location
          2R:8,136,986..8,156,654 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          44B4-44B5
          Limits computationally determined from genome sequence between P{lacW}Vps28k16503 and P{EP}kermitEP493
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          2-58

          (FlyBase, 2016)

          2-57.4

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (11)
          Genomic Clones (30)
          cDNA Clones (88)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Petrovsky et al., 2018, Ugrankar et al., 2011, Valente et al., 2010)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: Lpin CG8709

          (Valente et al., 2010)
          Source for database merge of

          Source for merge of: CG8709 anon-WO0118547.133

          (FlyBase, 1996-)

          Source for merge of: Lpin EP2431

          (Liu et al., 2011)
          Additional comments

          "CG8709" may correspond to "Scim23". Sequence analysis off ends of P{SUPor-P} in Scim insertion mutant places "Scim23" near/in "CG8709".

          (Dobie and Karpen, 2001.4.18)

          Source for merge of CG8709 anon-WO0118547.133 was sequence comparison ( date:051113 ).

          (FlyBase, 1996-)
          Other Comments

          Area matching Drosophila EST AA698481.

          (Davies, 2001.3.15)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 83 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DRscDB
          EMBL-EBI Single Cell Expression Atlas
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (11)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (88)