DmLpin, dLipin, DmLipin, EP2431
phosphatidate phosphatase activity - transcriptional co-activator - downstream effector mediating effects of insulin and TORC1 signaling on lipid metabolism - influences fat body development and function - affects cellular growth
Shares 5' UTR with upstream gene; observed for only a few of the many alternative transcripts.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lpin using the Feature Mapper tool.
Lpin expression was assayed by immunolocalization on dissected tissues. Within fat body, signal is distributed throughout the cytoplasm but is strongly concentrated in the perinuclear region of adipocytes. In the CNS, signal is strong in the cytoplasm of cells of the brain hemispheres and is also found in peripheral glia. Signal is observed in the visceral musculature around the midgut and testis, where it shows a pattern of striated labeling. In testis, Lpin is not detected in the muscles of the seminal vesicles, ejaculatory duct, or accessory glands. The pattern of striated labeling relative to actin distribution shows that Lpin is concentrated in the A band of the visceral muscles. Lpin is found in the cytoplasm of follicle cells, nurse cells and the oocyte throughout oogenesis and is enriched in the ring canals between nurse cells and in the cytoplasm of migrating border/polar follicle cells. Isoform-specific expression of Lpin in specific developmental stages and tissues was discussed.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Lpin in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Lpin CG8709