FB2025_01 , released February 20, 2025
Gene: Dmel\Tasp1
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General Information
Symbol
Dmel\Tasp1
Species
D. melanogaster
Name
Taspase 1
Annotation Symbol
CG5241
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263602
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
Taspase 1 (Tasp1) encodes a threonine-type endopeptidase involved in spermatogenesis and the defense response to Gram-negative bacteria. [Date last reviewed: 2019-09-19] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)72Dl

Key Links
Genomic Location
Cytogenetic map
72D1-72D4
Sequence location
Recombination map
3-44
RefSeq locus
NT_037436 REGION:16085221..16087525
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables endopeptidase activity
inferred from direct assay
(Capotosti et al., 2007)
enables threonine-type endopeptidase activity
inferred from direct assay
(Wünsch et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables threonine-type endopeptidase activity
inferred from biological aspect of ancestor with PANTHER:PTN000022483
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR037464
(InterPro Project Members, 2004-)
inferred from sequence alignment with HGNC:15859
(Hsieh et al., 2003)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in defense response to Gram-negative bacterium
inferred from mutant phenotype
(Berkey et al., 2009)
involved_in protein processing
inferred from direct assay
(Capotosti et al., 2007)
inferred from mutant phenotype
(Capotosti et al., 2007)
involved_in proteolysis
inferred from direct assay
(Wünsch et al., 2015)
involved_in spermatogenesis
inferred from mutant phenotype
(Lindsley et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein maturation
inferred from biological aspect of ancestor with PANTHER:PTN000022483
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000022481
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Taspase 1 (Tasp1) encodes a threonine-type endopeptidase involved in spermatogenesis and the defense response to Gram-negative bacteria. [Date last reviewed: 2019-09-19]
Gene Group (FlyBase)
TASPASES -
Taspases belong to MEROPS family T2. They are threonine endopeptidases that catalyse cis-cleavage to generate an active heterodimer of alpha and beta subunits, as well as cleavage of aspartyl bonds in other substrates, notably the trx protein in Drosophila and the Mixed-Lineage Leukemia (MLL) protein in humans. (Adapted from FBrf0212858.)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Tasp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VUX9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tasp1-RA
FBtr0075498
NM_140575
1503
365
Tasp1-RB
FBtr0333600
NM_001274991
2159
365
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Tasp1-PA
FBpp0075253
38.7
365
6.57
Q9VUX9
NP_648832
AAF49544
Tasp1-PB
FBpp0305777
38.7
365
6.57
Q9VUX9
NP_001261920
AGB94613
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

365 aa isoforms: Tasp1-PA, Tasp1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tasp1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.82

Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tasp1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tasp1
Transgenic constructs containing regulatory region of Tasp1
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\TASP1
13 of 14
Yes
Yes
Hsap\ASRGL1
3 of 14
No
No
Hsap\AGA
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Tasp1
13 of 14
Yes
Yes
Rnor\Asrgl1
3 of 14
No
No
Rnor\Aga
2 of 14
No
No
Mus musculus (laboratory mouse) (3)
Mmus\Tasp1
12 of 14
Yes
Yes
Mmus\Asrgl1
3 of 14
No
No
Mmus\Aga
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\tasp1
8 of 13
Yes
Yes
Xtro\LOC100486129
2 of 13
No
No
Xtro\agpat3
1 of 13
No
No
Xtro\asrgl1
1 of 13
No
No
Xtro\exd2
1 of 13
No
No
Xtro\mapk8ip1
1 of 13
No
No
Danio rerio (Zebrafish) (6)
Drer\tasp1
13 of 14
Yes
Yes
Drer\asrgl1
3 of 14
No
No
Drer\zgc:153169
3 of 14
No
No
Drer\aga
2 of 14
No
No
Drer\si:ch211-256m1.8
2 of 14
No
No
Drer\si:dkey-103j14.5
2 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\tasp-1
12 of 14
Yes
Yes
Cele\R04B3.2
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (4)
Agam\AgaP_AGAP002531
12 of 12
Yes
Yes
Agam\AgaP_AGAP011098
3 of 12
No
No
Agam\AgaP_AGAP012301
2 of 12
No
No
Agam\AgaP_AGAP004503
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT4G00590
12 of 13
Yes
Yes
Atha\ASPGA1
3 of 13
No
No
Atha\ASPGB1
3 of 13
No
No
Atha\AT5G61540
2 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPAC823.09c
11 of 12
Yes
Yes
Escherichia coli (enterobacterium) (1)
Ecol\iaaA
3 of 11
Yes
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Tasp1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
CG7860
6 of 13
CG4372
4 of 13
CG10474
4 of 13
CG1827
3 of 13
TAF1B
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TASP1; taspase 1
    13 of 14
    608270
      ASRGL1; asparaginase and isoaspartyl peptidase 1
      3 of 14
      609212
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Other Interaction Browsers
          Summary of Genetic Interactions
          esyN Network Diagram
          Other Interaction Browsers
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
          External Data
          Linkouts
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3L
          Recombination map
          3-44
          Cytogenetic map
          72D1-72D4
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          72D1-72D4
          Limits computationally determined from genome sequence between P{lacW}thj5C8&P{PZ}Mbs03802 and P{lacW}SsRβs1939
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          3-44

          (FlyBase, 2016)

          3-38.2

          (Comeron et al., 2012)

          3-[43]

          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (9)
          Genomic Clones (14)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (16)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              The 'l(3)72Dl' (Taspase1) complementation group comprises 11 EMS-induced mutant alleles.

              (Cooper and Kennison, 2011)

              Area matching Drosophila EST AI293141. Probable intron in gene represented by EST AI293141.

              (Davies, 2001.3.15)

              Area matching Drosophila EST AA201987. This EST has sequence similarity to aspariginase genes. Probable intron in gene represented by EST AA201987.

              (Davies, 2001.3.15)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: CG5241 anon-WO0118547.172

              (FlyBase, 1996-)

              Source for merge of: Taspase1 l(3)72Dl

              (Cooper and Kennison, 2011)
              Additional comments

              Source for merge of CG5241 anon-WO0118547.172 was sequence comparison ( date:051113 ).

              (FlyBase, 1996-)
              Nomenclature History
              Source for database identify of

              Source for identity of: Taspase1 CG5241

              (Capotosti et al., 2007)

              Source for identity of: Tasp1 Taspase1

              (Wünsch et al., 2015)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (11)
              Reported As
              Symbol Synonym
              CG5241
              (Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009, Stanyon et al., 2004)
              Tasp1
              (Tang et al., 2024, Fabre et al., 2022)
              Taspase 1
              (Berkey et al., 2009)
              Taspase1
              (Bai et al., 2013, Cooper and Kennison, 2011, FlyBase Curators, 2008-, Hsieh et al., 2003)
              anon-WO0118547.172
              dTasp
              (Wünsch et al., 2015)
              l(3)72Dl
              (Cooper and Kennison, 2011)
              Name Synonyms
              CG5241
              Drosophila Threonine Aspartase1
              (Wünsch et al., 2015)
              Taspase 1
              Taspase1
              (Lindsley et al., 2013, Kong et al., 2010)
              dTaspase1
              (Wünsch et al., 2015)
              lethal (3) 72Dl
              taspase 1
              (Capotosti et al., 2007)
              Secondary FlyBase IDs
              • FBgn0036564
              • FBgn0062192
              • FBgn0005544
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 37 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (42)