FB2021_02, released April 13, 2021

Gene: Dmel\Lpt

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General Information
Symbol
Dmel\Lpt
Species
D. melanogaster
Name
Lost PHDs of trr
Annotation Symbol
CG5591
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263667
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Lost PHDs of trr (Lpt) encodes a core component of COMPASS-like nuclear receptor coactivator complexes. It is involved in histone methylation and dpp/BMP signaling regulation. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)
All Summaries
Also Known As

cmi, cara mitad

Key Links
Genomic Location
Cytogenetic map
60A9-60A9
Sequence location
2R:23,898,561..23,903,661 [+]
Recombination map
2-105
RefSeq locus
NT_033778 REGION:23898561..23903661
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (18 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Chauhan et al., 2013, Chauhan et al., 2012)
enables histone binding
inferred from direct assay
(Chauhan et al., 2012)
enables nuclear receptor coactivator activity
inferred from direct assay
(Chauhan et al., 2012)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables histone binding
inferred from biological aspect of ancestor with PANTHER:PTN002505160
(assigned by GO_Central )
(Gaudet et al., 2011)
enables histone methyltransferase activity (H3-K4 specific)
inferred from biological aspect of ancestor with PANTHER:PTN002505160
(assigned by GO_Central )
(Gaudet et al., 2011)
enables transcription coactivator activity
inferred from biological aspect of ancestor with PANTHER:PTN002505160
(assigned by GO_Central )
(Gaudet et al., 2011)
enables zinc ion binding
inferred from sequence model
(Ying et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in cellular response to ecdysone
inferred from mutant phenotype
(Chauhan et al., 2012)
involved_in ecdysis, chitin-based cuticle
inferred from mutant phenotype
(Chauhan et al., 2012)
involved_in ecdysone receptor-mediated signaling pathway
inferred from genetic interaction with FLYBASE:EcR; FB:FBgn0000546
(Chauhan et al., 2012)
inferred from genetic interaction with FLYBASE:usp; FB:FBgn0003964
(Chauhan et al., 2012)
inferred from genetic interaction with FLYBASE:trr; FB:FBgn0023518
(Chauhan et al., 2012)
involved_in histone H3-K4 methylation
inferred from direct assay
(Mohan et al., 2011)
involved_in imaginal disc-derived wing vein morphogenesis
inferred from mutant phenotype
(Chauhan et al., 2013)
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
(Chauhan et al., 2013)
involved_in imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Chauhan et al., 2012)
involved_in positive regulation of histone H3-K9 trimethylation
inferred from mutant phenotype
(Chauhan et al., 2012)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Chauhan et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN002505160
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
colocalizes_with chromatin
inferred from direct assay
(Chauhan et al., 2013)
part_of ecdysone receptor holocomplex
inferred from physical interaction with FLYBASE:EcR; FB:FBgn0000546, FLYBASE:usp; FB:FBgn0003964
(Chauhan et al., 2012)
part_of MLL3/4 complex
inferred from direct assay
(Mohan et al., 2011)
located_in polytene chromosome
inferred from direct assay
(Mohan et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of MLL3/4 complex
inferred from biological aspect of ancestor with PANTHER:PTN002505160
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Lost PHDs of trr (Lpt) encodes a core component of COMPASS-like nuclear receptor coactivator complexes. It is involved in histone methylation and dpp/BMP signaling regulation. [Date last reviewed: 2019-09-12]
Gene Group (FlyBase)
TRR COMPLEX -
The Trithorax-related (Trr) complex is a COMPASS-like complex that mediates the methylation of histone H3K4 and demethylation of histone H3K27. (Adapted from FBrf0216343 and FBrf0218498).
HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS -
The High mobility group box (HMGB) transcription factors are sequence-specific DNA binding proteins that regulate transcription. The HMGB proteins have a characteristic L-shaped HMGB domain of about 80 amino acid residues, which binds the DNA minor groove and induce DNA bending. The HMGB domains are found in one or more copies and are involved in the regulation of DNA-dependent processes such as transcription, replication and chromatin remodeling. (Adapted from FBrf0194706, FBrf0108466, PMID:24086078 and PMID:23153957).
OTHER PROTEIN-LYSINE N-METHYLTRANSFERASES -
The 'Other protein-lysine N-methyltransferases' is a collection of protein-lysine N-methyltransferases that do not fit into any of the other major groups.
Summary (Interactive Fly)

PHD zinc finger protein - cofactor for Trithorax-related - associates with EcR-USP receptor and is required for hormone-dependent transcription - required for proper global trimethylation of H3K4

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Lpt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
gene
(FlyBase, 1992-)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Lpt-RA
FBtr0072134
NM_138003
4608
1482
Lpt-RB
FBtr0343298
NM_001299863
4596
1478
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Lpt-PA
FBpp0072043
164.5
1482
6.98
NP_611847
AAF47094
Lpt-PB
FBpp0309963
164.0
1478
7.03
NP_001286792
AHN56587
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lpt using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
imaginal disc
(Chauhan et al., 2012)
pupal stage
wing vein
(Chauhan et al., 2013)
wing cell
(Chauhan et al., 2013)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with chromatin
inferred from direct assay
(Chauhan et al., 2013)
part_of ecdysone receptor holocomplex
inferred from physical interaction with FLYBASE:EcR; FB:FBgn0000546, FLYBASE:usp; FB:FBgn0003964
(Chauhan et al., 2012)
part_of MLL3/4 complex
inferred from direct assay
(Mohan et al., 2011)
located_in polytene chromosome
inferred from direct assay
(Mohan et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Lpt in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Lpt
Transgenic constructs containing regulatory region of Lpt
Aberrations (Deficiencies and Duplications) ( 4 )
Inferred from experimentation ( 4 )
Gene disrupted in
Df(2R)Exel6080
(Ryder, 2004.4.26)
Df(2R)or-BR11
(Chauhan et al., 2012)
Gene partially disrupted in
Df(2R)Lpt1
(Chauhan et al., 2012)
Df(2R)Lpt2
(Chauhan et al., 2012)
Inferred from location ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4unspecified
lethal (with Df(2R)BSC610)
lethal - all die before end of larval stage
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die, with Scer\GAL4unspecified
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal body color, with Scer\GAL4unspecified
abnormal locomotor behavior | larval stage
increased cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
melanotic necrosis | larval stage
some die during larval stage
some die during pharate adult stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4C-765
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult midgut epithelium | adult stage | somatic clone, with Scer\GAL4Tub.PU
antenna, with Scer\GAL4ey.PU
embryonic/larval hemocyte | increased number, with Scer\GAL469B
eye, with Scer\GAL469B
eye, with Scer\GAL4ey.PU
head, with Scer\GAL4ey.PU
intestinal stem cell | adult stage | somatic clone, with Scer\GAL4Tub.PU
mouth hook
sex comb | ectopic, with Scer\GAL469B
trichogen cell, with Scer\GAL4pnr-MD237
wing blade posterior compartment, with Scer\GAL4en-e16E
wing vein, with Scer\GAL4C-765
wing vein, with Scer\GAL4en-e16E
wing vein | ectopic, with Scer\GAL4C-765
wing vein | ectopic, with Scer\GAL4en-e16E
wing vein | P-stage, with Scer\GAL469B
wing vein L2, with Scer\GAL4C-765
wing vein L5, with Scer\GAL4C-765
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (32)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\KMT2C
7 of 15
Yes
No
Hsap\KMT2D
7 of 15
Yes
No
Hsap\LOC107985798
2 of 15
No
Yes
Hsap\ASH1L
1 of 15
No
No
Hsap\BAZ1A
1 of 15
No
No
Hsap\BAZ1B
1 of 15
No
No
Hsap\BAZ2A
1 of 15
No
No
Hsap\BAZ2B
1 of 15
No
No
Hsap\BPTF
1 of 15
No
No
Hsap\BRD2
1 of 15
No
No
1  
Hsap\BRD3
1 of 15
No
No
Hsap\BRD4
1 of 15
No
No
Hsap\BRD8
1 of 15
No
No
Hsap\BRDT
1 of 15
No
No
Hsap\CREBBP
1 of 15
No
No
Hsap\DIDO1
1 of 15
No
No
Hsap\EP300
1 of 15
No
No
Hsap\KAT2A
1 of 15
No
No
1  
Hsap\KAT2B
1 of 15
No
No
1  
Hsap\KMT2E
1 of 15
No
No
Hsap\LOC105378260
1 of 15
No
Yes
Hsap\NSD1
1 of 15
No
No
Hsap\NSD2
1 of 15
No
No
Hsap\NSD3
1 of 15
No
No
Hsap\PBRM1
1 of 15
No
No
Hsap\PHF20
1 of 15
No
No
Hsap\PHF20L1
1 of 15
No
No
Hsap\SETD1A
1 of 15
No
No
Hsap\SETD1B
1 of 15
No
No
Hsap\SETD2
1 of 15
No
No
Hsap\SETD5
1 of 15
No
No
1  
Hsap\TBRG1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (32)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Kmt2c
7 of 15
Yes
No
Mmus\Kmt2d
7 of 15
Yes
No
Mmus\4933408B17Rik
1 of 15
No
No
Mmus\Ash1l
1 of 15
No
No
Mmus\Baz1b
1 of 15
No
No
Mmus\Baz2a
1 of 15
No
No
Mmus\Baz2b
1 of 15
No
No
Mmus\Bptf
1 of 15
No
No
Mmus\Brd2
1 of 15
No
No
Mmus\Brd3
1 of 15
No
No
Mmus\Brd4
1 of 15
No
No
Mmus\Brd8
1 of 15
No
No
Mmus\Brdt
1 of 15
No
No
Mmus\Cecr2
1 of 15
No
No
Mmus\Crebbp
1 of 15
No
No
Mmus\Dido1
1 of 15
No
No
Mmus\Ep300
1 of 15
No
No
Mmus\Kat2a
1 of 15
No
No
Mmus\Kat2b
1 of 15
No
No
Mmus\Kmt2e
1 of 15
No
No
Mmus\Nsd1
1 of 15
No
No
Mmus\Nsd2
1 of 15
No
No
Mmus\Nsd3
1 of 15
No
No
Mmus\Pbrm1
1 of 15
No
No
Mmus\Phf3
1 of 15
No
No
Mmus\Phf20l1
1 of 15
No
No
Mmus\Setd1a
1 of 15
No
No
Mmus\Setd1b
1 of 15
No
No
Mmus\Setd2
1 of 15
No
No
Mmus\Setd5
1 of 15
No
No
Mmus\Spocd1
1 of 15
No
No
Mmus\Tbrg1
1 of 15
No
No
Rattus norvegicus (Norway rat) (13)
Rnor\Kmt2c
3 of 13
Yes
Yes
Rnor\Kmt2d
2 of 13
No
Yes
Rnor\Baz1a
1 of 13
No
No
Rnor\Baz1b
1 of 13
No
No
Rnor\Brd2
1 of 13
No
No
Rnor\Brd3
1 of 13
No
No
Rnor\Brd4
1 of 13
No
No
Rnor\Brd8
1 of 13
No
No
Rnor\Cecr2
1 of 13
No
No
Rnor\Crebbp
1 of 13
No
No
Rnor\Kat2a
1 of 13
No
No
Rnor\Pbrm1
1 of 13
No
No
Rnor\Tbrg1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (19)
Xtro\kmt2c
3 of 12
Yes
No
Xtro\kmt2d
3 of 12
Yes
No
Xtro\baz1a
1 of 12
No
No
Xtro\baz1b
1 of 12
No
No
Xtro\baz2a
1 of 12
No
No
Xtro\baz2b
1 of 12
No
No
Xtro\bptf
1 of 12
No
No
Xtro\brd2
1 of 12
No
No
Xtro\brd3
1 of 12
No
No
Xtro\brd4
1 of 12
No
No
Xtro\brd8
1 of 12
No
No
Xtro\brdt
1 of 12
No
No
Xtro\cecr2
1 of 12
No
No
Xtro\crebbp
1 of 12
No
No
Xtro\kat2a
1 of 12
No
No
Xtro\kat2b
1 of 12
No
No
Xtro\pbrm1
1 of 12
No
No
Xtro\setd1b
1 of 12
No
No
Xtro\tbrg1
1 of 12
No
No
Danio rerio (Zebrafish) (33)
Drer\kmt2cb
5 of 15
Yes
No
Drer\kmt2ca
4 of 15
No
No
Drer\kmt2d
4 of 15
No
No
Drer\ash1l
1 of 15
No
No
Drer\baz1a
1 of 15
No
No
Drer\baz2ba
1 of 15
No
No
Drer\bptf
1 of 15
No
No
Drer\brd2a
1 of 15
No
No
Drer\brd3a
1 of 15
No
No
Drer\brd4
1 of 15
No
No
Drer\brd8
1 of 15
No
No
Drer\brdt
1 of 15
No
No
Drer\cecr2
1 of 15
No
No
Drer\crebbpa
1 of 15
No
No
Drer\crebbpb
1 of 15
No
No
Drer\crebbp
1 of 15
No
No
Drer\ep300a
1 of 15
No
No
Drer\ep300b
1 of 15
No
No
Drer\kat2a
1 of 15
No
No
Drer\kat2b
1 of 15
No
No
Drer\kmt2e
1 of 15
No
No
Drer\LOC100536981
1 of 15
No
No
Drer\nsd1b
1 of 15
No
No
Drer\nsd2
1 of 15
No
No
Drer\nsd3
1 of 15
No
No
Drer\pbrm1
1 of 15
No
No
Drer\pbrm1l
1 of 15
No
No
Drer\phf3
1 of 15
No
No
Drer\phf20b
1 of 15
No
No
Drer\phf20l1
1 of 15
No
No
Drer\setd1ba
1 of 15
No
No
Drer\si:ch211-59d17.3
1 of 15
No
No
Drer\tbrg1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (23)
Cele\set-16
5 of 15
Yes
No
Cele\athp-2
1 of 15
No
No
Cele\baz-2
1 of 15
No
No
Cele\bet-1
1 of 15
No
No
Cele\C16A11.4
1 of 15
No
No
Cele\C29F9.5
1 of 15
No
No
Cele\C49F5.5
1 of 15
No
No
Cele\cbp-1
1 of 15
No
No
Cele\CE7X_3.2
1 of 15
No
Yes
Cele\F13C5.2
1 of 15
No
No
Cele\F22F1.3
1 of 15
No
Yes
Cele\F53H1.4
1 of 15
No
No
Cele\lin-59
1 of 15
No
No
Cele\mes-4
1 of 15
No
No
Cele\met-1
1 of 15
No
No
Cele\pbrm-1
1 of 15
No
No
Cele\pcaf-1
1 of 15
No
No
Cele\sepa-1
1 of 15
No
Yes
Cele\set-5
1 of 15
No
No
Cele\set-9
1 of 15
No
No
Cele\set-12
1 of 15
No
No
Cele\set-26
1 of 15
No
No
Cele\ZK1010.10
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\AT3G08020
1 of 9
Yes
Yes
Atha\AT3G52100
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (15)
Scer\BDF1
1 of 15
Yes
No
Scer\BDF2
1 of 15
Yes
No
Scer\BYE1
1 of 15
Yes
No
Scer\CTI6
1 of 15
Yes
No
Scer\GCN5
1 of 15
Yes
No
1  
Scer\ITC1
1 of 15
Yes
No
Scer\RSC1
1 of 15
Yes
No
Scer\RSC2
1 of 15
Yes
No
Scer\RSC4
1 of 15
Yes
No
Scer\SET1
1 of 15
Yes
No
Scer\SET2
1 of 15
Yes
No
Scer\SET3
1 of 15
Yes
No
Scer\SET4
1 of 15
Yes
No
Scer\SPT7
1 of 15
Yes
No
Scer\YPL216W
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\cti6
1 of 12
Yes
No
Spom\set1
1 of 12
Yes
No
Spom\set2
1 of 12
Yes
No
Spom\set3
1 of 12
Yes
No
Spom\SPCC645.13
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919012X )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005489
Drosophila simulans
Dsim\GD11808
Drosophila sechellia
Dsec\GM16061
Drosophila erecta
Dere\GG22900
Drosophila yakuba
Dyak\GE14338
Drosophila ananassae
Dana\GF12873
Drosophila pseudoobscura pseudoobscura
Dpse\GA18992
Drosophila persimilis
Dper\GL11176
Drosophila willistoni
Dwil\GK15714
Drosophila virilis
Dvir\GJ21880
Drosophila mojavensis
Dmoj\GI18846
Drosophila grimshawi
Dgri\GH21693
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500MH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013353
Glossina morsitans
Tsetse fly
Gmor\GMOY004103
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08453
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005378
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011193
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (21)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
trr
5 of 10
Acf
1 of 10
ash1
1 of 10
Brd8
1 of 10
CG31109
1 of 10
CG31111
1 of 10
dikar
1 of 10
fs(1)h
1 of 10
Gcn5
1 of 10
MBD-R2
1 of 10
nej
1 of 10
NSD
1 of 10
polybromo
1 of 10
pps
1 of 10
Set1
1 of 10
Set2
1 of 10
tbrd-1
1 of 10
tbrd-2
1 of 10
tbrd-3
1 of 10
tou
1 of 10
upSET
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    KMT2C; lysine methyltransferase 2C
    7 of 15
    606833
    KMT2D; lysine methyltransferase 2D
    7 of 15
    602113
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Lpt
    suppressible
    ash2
    (Chauhan et al., 2012)
    Lpt
    enhanceable
    Dcr-2
    (Chauhan et al., 2013)
    Lpt
    suppressible
    dpp
    (Chauhan et al., 2013)
    Lpt
    suppressible
    trr
    (Chauhan et al., 2012)
    Lpt
    enhanceable
    trr
    (Chauhan et al., 2012)
    Lpt
    suppressible
    usp
    (Chauhan et al., 2012)
    Lpt
    suppressible
    Utx
    (Chauhan et al., 2012)
    Lpt
    enhanceable
    Utx
    (Chauhan et al., 2012)
    Lpt
    suppressible
    wds
    (Chauhan et al., 2012)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    B
    enhanceable
    Lpt
    (Chauhan et al., 2012)
    dpp
    enhanceable
    Lpt
    (Chauhan et al., 2013)
    tkv
    enhanceable
    Lpt
    (Chauhan et al., 2013)
    tkv
    suppressible
    Lpt
    (Chauhan et al., 2013)
    trr
    enhanceable
    Lpt
    (Chauhan et al., 2012)
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-105
    Cytogenetic map
    60A9-60A9
    Sequence location
    2R:23,898,561..23,903,661 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    60A9-60A9
    Limits computationally determined from genome sequence between P{lacW}kenk11035&P{EP}CG17658EP730 and P{EP}TalEP489&P{EP}CG3065EP316
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-105

    (FlyBase, 2016)

    2-109.6

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (16)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (25)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Zraly et al., 2020, Chauhan et al., 2012, Mohan et al., 2011)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Lpt CG5591

      (Mohan et al., 2011)
      Source for database merge of

      Source for merge of: CG5591 cmi

      (Dingwall, 2011.9.19)
      Additional comments
      Other Comments

      S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

      (Stroschein-Stevenson et al., 2006)
      Origin and Etymology
      Discoverer
      Etymology

      Named 'cara mitad', which translates as 'dear half', as it's the ortholog of the N-terminal region of mammalian MLL2 and MLL3. (The ortholog of the C-terminal portion is 'trr'.)

      (Chauhan et al., 2012)
      Identification
      External Crossreferences and Linkouts ( 32 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (13)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (59)