cytoskeletal motor protein required during dorsal closure for the correct alignment of cells on opposing sides of the fusing epithelial sheets and for adhesion of the cells during the final zippering/fusion phase
Gene model reviewed during 5.52
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.42
merge of CG16922 and Myo10A
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Myo10A using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Myo10A in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Myo10A CG2174
Annotations CG2174 and CG16922 merged as CG43657 in release 5.42 of the genome annotation.
Merge supported by RNA-seq junction and RNA-seq expression data.
Annotations CG2174 and CG2136 merged as CG2174 in release 3 of the genome annotation.
Source for identity of Myo10A CG2174 was sequence comparison ( date:020316 ).
Embryos injected with dsRNA made from templates generated with primers directed against this gene exhibit misaligned stripes and delayed or incomplete dorsal hole closure. 68% of embryos show abnormal constriction of the leading edge cells in opposing segments; these embryos progress slowly and fail to close. The leading edge cells are missing filopodia in embryos of this phenotype. Embryos injected with Myo10A dsRNA that show proper epithelial matching exhibit an intermediate phenotype and have lamellipodia-like extensions instead of filopodia at their leading edge. Additionally, embryos injected with Myo10A dsRNA show disruptions to both actin and microtubule cytoskeletal organization, with disruptions being particularly severe near the leading edge.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.