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General Information
Symbol
Dmel\Su(var)3-9
Species
D. melanogaster
Name
Suppressor of variegation 3-9
Annotation Symbol
CG43664
Feature Type
FlyBase ID
FBgn0263755
Gene Model Status
Stock Availability
Enzyme Name (EC)
Histone-lysine N-methyltransferase (2.1.1.43)
Gene Snapshot
In progress.Contributions welcome.
Also Known As
Su-var(3)9, SuVar3-9, SUV39, ptn
Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:15,259,864..15,263,458 [-]
Recombination map
3-56
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (P45975)
Catalytic Activity (EC)
Experimental Evidence
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone] (2.1.1.43)
Predictions / Assertions
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone] (2.1.1.43)
Summaries
Gene Group (FlyBase)
SET DOMAIN LYSINE METHYLTRANSFERASES -
SET domain lysine methyltransferases (KMTs) catalyze the addition of methyl groups to lysine residues. SET domain KMTs possess a domain that was original characterized in the D.mel KMTs Su(var)3-9, E(z) and trx. (Adapted from FBrf0216343).
Protein Function (UniProtKB)
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation.
(UniProt, P45975)
Summary (Interactive Fly)
involved in gene silencing - a modifier of position effect variegation - methylates histone H3 thus providing a mark for the association of HP1 to heterochromatin
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Su(var)3-9 or the JBrowse view of Dmel\Su(var)3-9 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.42
Genes with CDS overlap: eIF-2gamma and Su(var)3-9 share promoter, first exon and N-terminal coding sequences (80 residues); overlapping structure not conserved outside of insects (see FBrf0189765).
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0310385
2386
635
Additional Transcript Data and Comments
Reported size (kB)
2.4, 2.0 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0302536
71.8
635
8.35
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
635, 475 (aa); 51 (kD predicted)
Comments
Has 80 N-terminal amino acids in common with the 475aa Su(var)3-9 protein. Genetic evidence suggests that this protein carries out the genetically defined functions of the gene.
External Data
Subunit Structure (UniProtKB)
Interacts with Su(var)205 and Su(var)3-7. Probably associates with Rpd3.
(UniProt, P45975)
Domain
Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity). In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
(UniProt, P45975)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(var)3-9 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (25 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000526939
(assigned by GO_Central )
traceable author statement
inferred from electronic annotation with InterPro:IPR003606, InterPro:IPR007728
(assigned by InterPro )
Biological Process (17 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from high throughput mutant phenotype
inferred from high throughput mutant phenotype
inferred from high throughput mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
non-traceable author statement
traceable author statement
(assigned by UniProt )
inferred from biological aspect of ancestor with PANTHER:PTN000526939
(assigned by GO_Central )
traceable author statement
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000526939
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
The 2.4 kb transcript is detected in all developmental stages by Northern blot, but it is enriched at 0-9 hr of embryogenesis.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter or direct label
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
A fusion of eGFP and the Su(var)3-9 protein concentrates primarily at the chromocenters and telomeric heterochromatin with a few foci in the euchromatin of larval salivary gland chromosomes.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Su(var)3-9 in GBrowse 2
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 67 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Su(var)3-9
Transgenic constructs containing regulatory region of Su(var)3-9
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
nurse cell & nucleus
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
4 of 15
No
Yes
 
 
4 of 15
Yes
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
4 of 15
No
Yes
4 of 15
Yes
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (5)
4 of 13
Yes
Yes
3 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
3 of 12
Yes
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (10)
5 of 15
Yes
No
4 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (14)
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (2)
1 of 15
Yes
No
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
2 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902DX )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915016J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00ZI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03TA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0624 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (14)
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Dmel gene
    Ortholog showing functional complementation
    Supporting References
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts with Su(var)205 and Su(var)3-7. Probably associates with Rpd3.
    (UniProt, P45975 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-56
    Cytogenetic map
    Sequence location
    3R:15,259,864..15,263,458 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    88E7-88E8
    Limits computationally determined from genome sequence between P{lacW}Hsc70-4L3929 and P{lacW}MRG15j6A3
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Genetic map position of Su(var)3-9306 mutation on Gl Sb H chromosome is at 57.9 and on the cv-c Sb chromosome locus is at 56.4. Genetic map position of Su(var)3-9310 mutation on Gl Sb H chromosome is at 56.7 and on the cv-c Sb chromosome locus is at 56.5. Genetic map position of Su(var)3-9328 mutation on Gl Sb H chromosome is at 57.3 and on the cv-c Sb chromosome locus is at 56.4. Genetic map position of Su(var)3-9340 mutation on Gl Sb H chromosome is at 55.6 and on the cv-c Sb chromosome locus is at 56.9. Genetic map position of Su(var)3-9322 mutation on Gl Sb H chromosome is at 57.8 and on the cv-c Sb chromosome locus is at 56.4. Genetic map position of Su(var)3-9336 mutation on Gl Sb H chromosome is at 54.9 and on the cv-c Sb chromosome locus is at 56.2.
    Stocks and Reagents
    Stocks (12)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (47)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    The CG6476 annotation has been split into two CG43664 (which corresponds to Su(var)3-9) and CG43665 (which corresponds to eIF-2γ) in release 5.43 of the genome annotation.
    The "pitkinD" mutation maps within Su(var)3-9 at 88E, not at 67C as previously reported (FBrf0134644). The locus at 67C described in FBrf0134644 is a separate "modifier of dominant female sterility".
    FlyBase curator comment: Su(var)3-9ptn was reported to be allelic to two P-element insertion alleles at 67C (l(3)S089004S089004 and l(3)S089004S089302) in FBrf0134644. However, FBrf0180260 demonstrates that Su(var)3-9ptn is an allele of Su(var)3-9 (at 88E) and that the l(3)S089004S089004 and l(3)S089004S089302 alleles at 67C represent a separate "modifier of dominant female sterility" locus.
    The genomic region around Su(var)3-9 encodes two classes of transcript (2.4kb and 2.0kb), which show a 330bp overlap at their 5' ends, producing an overlap of 80 amino acids at the N-terminal ends of the encoded proteins. The encoded proteins are otherwise different in sequence. The 2.4kb transcript encodes Su(var)3-9 and the 2.0kb transcript encodes eIF-2γ.
    Other Comments
    Haploinsufficient locus.
    DNA-protein interactions: genome-wide binding profile assayed for Su(var)3-9 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
    The organisation of nucleosomes over the entire histone complex region is altered in Su(var)3-9 mutants and there is a concomitant increase in expression of the histone genes.
    Su(var)3-9 has a central role in heterochromatin-induced gene silencing.
    Su(var)3-9 is required for normal development of the female germ line.
    Variegation of bwD suppressed.
    Phenotype of wbl is unchanged by Su(var)3-9.
    Su(var)3-9 is a haplo suppressor and a triplo enhancer and a non-essential gene. The suppressor effect of mutations dominate over enhancer mutations of over 40 different haplo-dependent enhancer genes. Results indicate that Su(var)3-9 plays an important role in the regulation of gene inactivation through heterochromatinization in position effect variegation (PEV). Su(var)3-9 mutations are epistatic to E(var)2-88.
    Su(var) mutants have dramatic effects on chromosome morphology and gene expression but negligible effects on nuclease sensitivity of the w gene chromatin: changes due to alterations in chromosomal packaging.
    Origin and Etymology
    Discoverer
    Etymology
    The gene is named after "Pitkin", the principal figure in Robert Ascher's movie "A Stitch in Time", who caused perplexing confusions by overdoing almost everything.
    Identification
    External Crossreferences and Linkouts ( 31 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (34)
    Reported As
    Symbol Synonym
    E(var)3-2
    Su(var) 3-9
    Su(var)3-9
    (Berlandi et al., 2019, Chang et al., 2019, Glenn and Geyer, 2019, Lee et al., 2019, Martins et al., 2019, Seller et al., 2019, Shimaji et al., 2019, Sidorenko et al., 2019, Deshpande and Meller, 2018, Hughes et al., 2018, Lee et al., 2018, Masuko et al., 2018, Amaral et al., 2017, Caridi et al., 2017, Colmenares et al., 2017, Teixeira et al., 2017, Tsurumi et al., 2017, Bayona-Feliu et al., 2016, Boltengagen et al., 2016, Guida et al., 2016, Kavi et al., 2016, Timms et al., 2016, Aradska et al., 2015, Boija and Mannervik, 2015, Dent et al., 2015, Dietz et al., 2015, Meller et al., 2015, Sienski et al., 2015, Alekseyenko et al., 2014, Boyle et al., 2014, Comoglio and Paro, 2014, Eissenberg and Elgin, 2014, Frost et al., 2014, Gonzalez et al., 2014, Ost et al., 2014, Ross et al., 2014, Wang et al., 2014, Wang et al., 2014, Xu et al., 2014, Zhang et al., 2014, Debruhl et al., 2013, Elgin and Reuter, 2013, Huang et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Lu et al., 2013, Sentmanat et al., 2013, Silva-Sousa and Casacuberta, 2013, Vasanthi et al., 2013, Antao et al., 2012, Cook et al., 2012, Ferree and Prasad, 2012, Figueiredo et al., 2012, Hazelett et al., 2012, Ito et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Nowak et al., 2012, Sakoparnig et al., 2012, Sawamura, 2012, Sentmanat and Elgin, 2012, Sim et al., 2012, Stern et al., 2012, Szabad et al., 2012, Abramov et al., 2011, Boeke et al., 2011, Cryderman et al., 2011, Di Stefano et al., 2011, Friedman et al., 2011, Gibert et al., 2011, Kappes et al., 2011, Koryakov et al., 2011, Wang et al., 2011, Yan et al., 2011, Deng et al., 2010, Gan et al., 2010, Lee et al., 2010, Lemos et al., 2010, Moshkovich and Lei, 2010, Skora and Spradling, 2010, Abel et al., 2009, Brower-Toland et al., 2009, Fagegaltier et al., 2009, Gracheva et al., 2009, Hofmann et al., 2009, Lu et al., 2009, Paredes and Maggert, 2009, Peng and Karpen, 2009, Phalke et al., 2009, Vogel et al., 2009, Andreyeva et al., 2008, Cai et al., 2008, Chiolo et al., 2008, Ciurciu et al., 2008, de Wit et al., 2008, Doheny et al., 2008, Kent, 2008, Lin et al., 2008, Nisha et al., 2008, Pindyurin et al., 2008, Sakaguchi et al., 2008, Scaria et al., 2008, Yasuhara and Wakimoto, 2008, Yoon et al., 2008, Zhang et al., 2008, Zhou et al., 2008, Andreyeva et al., 2007, Bai et al., 2007, Budde, 2007, Demakova et al., 2007, Deng et al., 2007, Goldberg et al., 2007, Greil et al., 2007, Haigh and Lloyd, 2007, Haynes et al., 2007, Johansson et al., 2007, Lecuyer et al., 2007, Li et al., 2007, Maines et al., 2007, Marygold et al., 2007, Mohan et al., 2007, Nurminsky, 2007, Peng and Karpen, 2007, Seum et al., 2007, Seum et al., 2007, Stuart et al., 2007, Xing et al., 2007, Zaratiegui, 2007, Haynes et al., 2006, Koryakov et al., 2006, Krauss et al., 2006, Mis et al., 2006, Moorman et al., 2006, Moorman et al., 2006, Pickersgill et al., 2006, Qi et al., 2006, Shi et al., 2006, Talbert and Henikoff, 2006, de Wit et al., 2005, Dillon et al., 2005, Kalmykova et al., 2005, Krauss et al., 2005, Lam et al., 2005, Bazin et al., 2004, Delattre et al., 2004, Taylor-Harding et al., 2004, Fahrner and Baylin, 2003, Shareef et al., 2003, Weissmann et al., 2003, Balasov, 2002, Czermin et al., 2002, Joanis and Lloyd, 2002, Krauss and Reuter, 2000, Tschiersch et al., 1994)
    Su(var)3-902
    Su(var)306
    Su(var)310
    Su(var)328
    Suvar(3)9
    Name Synonyms
    Enhancer of variegation 3-2
    Suppressor of variegation 306
    Suppressor of variegation 310
    Suppressor of variegation 328
    histone methyltransferase
    Secondary FlyBase IDs
    • FBgn0003600
    • FBgn0003624
    • FBgn0004560
    • FBgn0014846
    • FBgn0263739
    Datasets (4)
    Study focus (4)
    Experimental Role
    Project
    Project Type
    Title
    • transgene_used
    Protein profiling reveals five principal chromatin types in Drosophila cells.
    • bait_protein
    Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
    • allele_used
    Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.
    • allele_used
    Genome-wide localization of histones and their modifications in fly tissues by ChIP-chip and ChIP-Seq.
    References (358)