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Gene Dmel\CG43689

General Information
Symbol	Dmel\CG43689	Species	D. melanogaster
Name		Annotation symbol	CG43689
Feature type	protein_coding_gene	FlyBase ID	FBgn0263772
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	CG43284, CG15376
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	4A5-4A5	Sequence location	X:3,970,107..3,986,186 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG43689 (FBgn0263772). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process: regulation of transcription, DNA-dependent. 5 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Armadillo-like helical; Zinc finger, C2HC-type. Gene sequence location is X:3970107..3986186.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	New/Merged/Split Record This record was either newly added to FlyBase for this release or is the result of merging or splitting existing records in this release
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 4A5-4A5   Limits computationally determined from genome sequence between P{EP}CG2930EP1352 and P{EP}EP425
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG43689 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene merge based on RNA-Seq data. Gene merge based on EST/cDNA and RNA-Seq data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG43689-RC FBtr0310493     4653   1332 CG43689-RD FBtr0310492     4584   1309 CG43689-RE FBtr0310495     6942   1706 CG43689-RF FBtr0310491     5685   1251 CG43689-RG FBtr0310494     6768   1648
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG43689-PC   FBpp0302631   141.6   1332   7.81       CG43689-PD   FBpp0302630   139.2   1309   7.82       CG43689-PE   FBpp0302633   178.6   1706   7.29       CG43689-PF   FBpp0302629   133.2   1251   7.28       CG43689-PG   FBpp0302632   172.6   1648   6.99
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo-like helical (IPR011989) Zinc finger, C2HC-type (IPR002515)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name CO329735   EC206630   EC216241   EW713041   EW713104   EY198842   FL502389   FL502726   GH291273   GH759316
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W4N4 Q8IRS8 Q9W4N3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG43689GD5208 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 CG43689GD5208 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 CG43689GD5208
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG43689 Class Mutagen Stocks Known lesion CG43689G17346 P-element activity 1 -- CG43689GG01071 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG43689 Class Mutagen Stocks Known lesion CG43689GD5208 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG43689JF02255 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG43689KK112118 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG43689G17346 NA P{Mae-UAS.6.11}CG43689GG01071 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with UniProtKB:P97500 (FlyBase Genome Annotators, 2002-2003) zinc ion binding inferred from electronic annotation with InterPro:IPR002515 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with UniProtKB:P97500 (FlyBase Genome Annotators, 2002-2003)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:P97500 (FlyBase Genome Annotators, 2002-2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG43689 allele Gene References
External Data
Linkouts
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20773 Dana\GF20774 Dere\GG18687 Dere\GG18688 Dgri\GH24140 Dgri\GH24141 Dmoj\GI16395 Dper\GL14768 Dper\GL14772 Dpse\GA13683 Dpse\GA24131 Dpse\GA25531 Dsec\GM12318 Dsec\GM12320 Dsec\GM12321 Dsim\GD16668 Dvir\GJ17013 Dvir\GJ17015 Dvir\GJ17016 Dwil\GK10260 Dwil\GK10261 Dyak\GE16324 Dyak\GE16325 Dyak\GE16326
Curated drosophilid orthologs	Dpse\GA13683   Dpse\GA17131   Dpse\GA17140
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	33304 w* P{EP}CG43689G17346 26715 y1 v1; P{TRiP.JF02255}attP2 11691 y1 w67c23 P{Mae-UAS.6.11}CG43689GG01071/FM7c
VDRC	v103499 P{KK112118}VIE-260B v15480 w1118; P{GD5208}v15480
Genomic Clones ( 2 )
	BACR21I10 BACR21M21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 8 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	191446 CK01.40D.E12 DMG1-chrX.4.075.a DMG2-chrX.4.058.a.1 DMG4-chrX.8.005.pred.a DMG5-chrX.7.009.pred.a EK293631 RP003323486
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG32790 CG32778 (FlyBase Genome Annotators, 2011) Source for merge of: CG43284 CG15376 (FlyBase Genome Annotators, 2012)
Additional comments	Annotations CG43284 and CG15376 merged as CG43689 in release 5.43 of the genome annotation. (FlyBase Genome Annotators, 2012) Annotations CG32790 and CG32778 merged as CG43284 in release 5.35 of the genome annotation. (FlyBase Genome Annotators, 2011) Annotation CG4985 split into CG32778 and CG32790 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AAF45913 AAF45914 AAN09115 Entrez Gene - A searchable database of RefSeq genes. • 31353 31354 318212 UniProtKB/TrEMBL • Q8IRS8 Q9W4N3 Q9W4N4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Armadillo-like helical (IPR011989) Zinc finger, C2HC-type (IPR002515)
Linkouts
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG4985 (Boutros et al., 2004, ) CG15376 (Cherbas et al., 2011, Keleman et al., 2009.8.5) CG32778 (Perkins et al., 2009.3.31, ) CG32790   CG43284 (Cherbas et al., 2011, FlyBase Genome Annotators, 2011, ) CG43689 (FlyBase Genome Annotators, 2012)
Name Synonym
Secondary FlyBase IDs
	FBgn0029691 FBgn0029692 FBgn0052778 FBgn0052790 FBgn0262973
References ( 14 )
Research paper	Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077]
Supplementary material	Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Boutros et al., 2004, Science 303(5659): Supporting Online Material: Figures S1 to S8; Tables S1 to S6. [FBrf0174218] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2010.12.22, GE836.xml GE836.xml [FBrf0212684] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 2009.3.31, TRiP stock collection set 2. TRiP stock collection set 2. [FBrf0207631] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Genome Annotators, 2012, Changes affecting gene model number or type in release 5.43 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.43 of the annotated D.melanogaster genome. [FBrf0216435] FlyBase Genome Annotators, 2011, Changes affecting gene model number or type in release 5.35 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.35 of the annotated D.melanogaster genome. [FBrf0212966] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]
Stock list	Bloomington Drosophila Stock Center, 19??-, Bloomington Stock List. Bloomington Stock List. [FBrf0141259]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]