FB2021_01, released Feb 18, 2021

Gene: Dmel\CG17684

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General Information
Symbol
Dmel\CG17684
Species
D. melanogaster
Name
Annotation Symbol
CG17684
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263780
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:1,866,080..2,262,115 [-]
Recombination map

2-55

RefSeq locus
NT_033778 REGION:1866080..2262115
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables dipeptidyl-peptidase activity
inferred from biological aspect of ancestor with PANTHER:PTN000198379
(assigned by GO_Central )
(Gaudet et al., 2011)
enables serine-type peptidase activity
inferred from electronic annotation with InterPro:IPR001375
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in proteolysis
inferred from electronic annotation with InterPro:IPR001375, InterPro:IPR002469
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
DIPEPTIDYL PEPTIDASES IV -
Dipeptidyl peptidase IV (DPPIV) belongs to the MEROPS S9 family, subfamily B, and is a highly specific dipeptidyl aminopeptidase. It is characterized by the release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is proline, provided Zaa is neither proline nor hydroxyproline. DPPIV is important in the processing of a variety of biologically active oligopeptides and also in the activation of signal transduction and cell matrix adherence processes. (Adapted from FBrf0194259.)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\CG17684 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG17684-RC
FBtr0300103
NM_001015352
3029
855
CG17684-RD
FBtr0334734
NM_001276228
2083
483
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG17684-PC
FBpp0289380
97.2
855
5.55
NP_001015352
EAA46098
CG17684-PD
FBpp0306782
55.6
483
6.41
NP_001263157
ELP57402
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG17684 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
adult stage
adult head
• membrane
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG17684 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG17684
Transgenic constructs containing regulatory region of CG17684
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation
Inferred from location
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    viable
    Sterility
    Allele
    fertile
    Phenotype manifest in
    Allele
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Download All OrthoDB Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (8)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    Isobase
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    RoundUp
    TreeFam
    ZFIN
    Alignment
    Complementation?
    Transgene?
    Hsap\DPP6
    9 of 15
    Yes
    Yes
    1  
    Hsap\DPP10
    9 of 15
    Yes
    Yes
    Hsap\FAP
    7 of 15
    No
    No
    Hsap\DPP4
    6 of 15
    No
    No
    Hsap\APEH
    1 of 15
    No
    Yes
    Hsap\DPP8
    1 of 15
    No
    No
    Hsap\DPP9
    1 of 15
    No
    No
    Hsap\PDGFRA
    1 of 15
    No
    No
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (7)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    Isobase
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    RoundUp
    TreeFam
    ZFIN
    Alignment
    Complementation?
    Transgene?
    Mmus\Dpp6
    9 of 15
    Yes
    Yes
    Mmus\Dpp10
    8 of 15
    No
    Yes
    Mmus\Dpp4
    7 of 15
    No
    No
    Mmus\Fap
    7 of 15
    No
    No
    Mmus\Apeh
    1 of 15
    No
    Yes
    Mmus\Dpp8
    1 of 15
    No
    No
    Mmus\Dpp9
    1 of 15
    No
    No
    Rattus norvegicus (Norway rat) (7)
    Rnor\Dpp6
    8 of 13
    Yes
    Yes
    Rnor\Dpp10
    8 of 13
    Yes
    Yes
    Rnor\Dpp4
    6 of 13
    No
    No
    Rnor\Fap
    5 of 13
    No
    No
    Rnor\Apeh
    1 of 13
    No
    Yes
    Rnor\Dpp8
    1 of 13
    No
    No
    Rnor\Dpp9
    1 of 13
    No
    No
    Xenopus tropicalis (Western clawed frog) (8)
    Xtro\dpp10
    7 of 12
    Yes
    Yes
    Xtro\dpp6
    6 of 12
    No
    Yes
    Xtro\dpp4
    5 of 12
    No
    No
    Xtro\fap
    2 of 12
    No
    No
    Xtro\apeh
    1 of 12
    No
    Yes
    Xtro\dpp8
    1 of 12
    No
    No
    Xtro\dpp9
    1 of 12
    No
    No
    Xtro\LOC100493708
    1 of 12
    No
    Yes
    Danio rerio (Zebrafish) (9)
    Drer\dpp6b
    7 of 15
    Yes
    Yes
    Drer\dpp4
    6 of 15
    No
    No
    Drer\dpp6a
    6 of 15
    No
    Yes
    Drer\fap
    5 of 15
    No
    No
    Drer\LOC101886435
    4 of 15
    No
    Yes
    Drer\apeh
    1 of 15
    No
    No
    Drer\dpp9
    1 of 15
    No
    No
    Drer\LOC101883320
    1 of 15
    No
    Yes
    Drer\zgc:136971
    1 of 15
    No
    No
    Caenorhabditis elegans (Nematode, roundworm) (5)
    Cele\dpf-1
    9 of 15
    Yes
    No
    Cele\dpf-2
    7 of 15
    No
    No
    Cele\dpf-3
    1 of 15
    No
    No
    Cele\dpf-6
    1 of 15
    No
    Yes
    Cele\dpf-7
    1 of 15
    No
    Yes
    Arabidopsis thaliana (thale-cress) (1)
    Atha\AT5G24260
    2 of 9
    Yes
    No
    Saccharomyces cerevisiae (Brewer's yeast) (2)
    Scer\DAP2
    7 of 15
    Yes
    No
    Scer\STE13
    5 of 15
    No
    No
    Schizosaccharomyces pombe (Fission yeast) (2)
    Spom\SPACUNK4.08
    5 of 12
    Yes
    No
    Spom\SPAC14C4.15c
    3 of 12
    No
    Yes
    Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902E9 )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila simulans
    Dsim\GD27273
    Drosophila erecta
    Dere\GG26273
    Drosophila yakuba
    Dyak\GE28099
    Drosophila ananassae
    Dana\GF27704
    Drosophila pseudoobscura pseudoobscura
    Dpse\GA25532
    Drosophila persimilis
    Dper\GL18983
    Drosophila willistoni
    Dwil\GK27663
    Drosophila virilis
    Dvir\GJ21972
    Drosophila mojavensis
    Dmoj\GI26667
    Drosophila grimshawi
    Dgri\GH13562
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501WX )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Mdoa\17019443
    Glossina morsitans
    Tsetse fly
    Gmor\GMOY007432
    Mayetiola destructor
    Hessian fly
    Mdes\Mdes016531
    Mayetiola destructor
    Hessian fly
    Mdes\Mdes015765
    Mayetiola destructor
    Hessian fly
    Mdes\Mdes011901
    Aedes aegypti
    Yellow fever mosquito
    Aaeg\AAEL007764
    Anopheles darlingi
    American malaria mosquito
    Adar\ADAC001564
    Anopheles gambiae
    Malaria mosquito
    Agam\AGAP005043
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01B2 )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Bombyx mori
    Silkmoth
    Bmor\BGIBMGA006181
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS214134-PA
    Heliconius melpomene
    Postman butterfly
    Hmel\HMEL002505
    Apis florea
    Little honeybee
    Aflo\2342673668
    Apis mellifera
    Western honey bee
    Amel\GB45029
    Bombus impatiens
    Common eastern bumble bee
    Bimp\BIMP15114
    Bombus terrestris
    Buff-tailed bumblebee
    Bter\15212362
    Linepithema humile
    Argentine ant
    Lhum\LH18636
    Megachile rotundata
    Alfalfa leafcutting bee
    Mrot\MROTU:00289e
    Nasonia vitripennis
    Parasitic wasp
    Nvit\Nasvi2EG023755
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_13071
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_00752
    Tribolium castaneum
    Red flour beetle
    Tcas\TC014728
    Pediculus humanus
    Human body louse
    Phum\PHUM153050
    Rhodnius prolixus
    Kissing bug
    Rpro\RPRC008949
    Cimex lectularius
    Bed bug
    Clec\CLEC007007
    Zootermopsis nevadensis
    Nevada dampwood termite
    Znev\Znev_02515
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0192 )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Tetranychus urticae
    Two-spotted spider mite
    Turt\tetur10g00880
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
    No non-Arthropod Metazoa orthologies identified
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (5)
    Gene Symbol
    Score
    Source
    Compara
    eggNOG
    Homologene
    Inparanoid
    Isobase
    OrthoDB
    OrthoFinder
    orthoMCL
    Panther
    RoundUp
    Alignment
    CG11034
    6 of 10
    ome
    5 of 10
    CG11319
    4 of 10
    CG45002
    4 of 10
    CG3744
    2 of 10
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      DPP6; dipeptidyl peptidase like 6
      9 of 15
      126141
       
      DPP10; dipeptidyl peptidase like 10
      9 of 15
      608209
          FAP; fibroblast activation protein alpha
          7 of 15
          600403
              DPP4; dipeptidyl peptidase 4
              6 of 15
              102720
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  esyN Network Diagram
                  Interactions Browser
                  Summary of Genetic Interactions
                  esyN Network Diagram
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  External Data
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  Pathways
                  Signaling Pathways (FlyBase)
                  Metabolic Pathways
                  External Data
                  Linkouts
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  2R
                  Recombination map

                  2-55

                  Cytogenetic map
                  Sequence location
                  2R:1,866,080..2,262,115 [-]
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  Heterochromatic, cytological location not yet determined.
                  (Drosophila Heterochromatin Genome Project, 2004, FlyBase Genome Annotators, 2002-2003)
                  Experimentally Determined Recombination Data
                  Location

                  2-55

                  (FlyBase, 2016)

                  2-55.3

                  (Comeron et al., 2012)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (5)
                  Genomic Clones (111)
                  cDNA Clones (193)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequenced
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of
                  Additional comments

                  The withdrawn annotation CG40260 corresponds to part of the CG17684 annotation.

                  (FlyBase, 1996-)
                  Other Comments

                  Annotation CG17684 renamed CG40072 in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)

                  New annotation (CG40260) in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)

                  Annotation eliminated prior to release 5.2 of the genome annotation.

                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 22 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  Synonyms and Secondary IDs (3)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (28)