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Gene Dmel\l(2)k12914

General Information
Symbol	Dmel\l(2)k12914	Species	D. melanogaster
Name	lethal (2) k12914	Annotation symbol	CG13393
Feature type	protein_coding_gene	FlyBase ID	FBgn0263852
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	29C1-29B4	Sequence location	2L:8,383,612..8,384,137 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lethal (2) k12914 is referred to in FlyBase by the symbol Dmel\l(2)k12914 (CG13393, FBgn0263852). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: oligosaccharyl transferase activity. It is reported to be involved in the biological process: negative regulation of apoptotic process. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: DAD/Ost2. Gene sequence location is 2L:8383612..8384137.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 29C1-29B4   Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338); Limits computationally determined from genome sequence between P{EP}EP646EP646&P{lacW}RpS13k09614 and P{lacW}l(2)k12914k12914&P{lacW}Akap200k07118a
Experimentally Determined Cytological Location
Cytogenetic map Notes References 29C1-29C2   (determined by in situ hybridisation)   (Spradling et al., 1999) 29C1-29C2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\l(2)k12914 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) l(2)k12914-RA FBtr0079719  NM_135378   526   112
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein l(2)k12914-PA   FBpp0079324   12.5   112   8.32     NP_609222   AAF52660
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DAD/Ost2 (IPR003038)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52660   AQ026046   AY113429 AAM29434   BE978784   BG640205   BI216657   CO156801   CO178588   CO192398   CO304190   CO313235   CO336774   EC069799   EC229683   EC237071   EC248484   EC261479   EC262183   EV578199   EV598035   GH744374   GH745139   GH761595
UniProtKB/Swiss-Prot	Q9VLM5
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    48 central nervous system, pupae P8    27 head, virgin 1-day female    23 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    10 head, mated 4-day male    19 head, mated 20-day male    26 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    24 digestive system, 4-day adult    20 digestive system, 20-day adult    22 fat body, larvae L3 wandering    18 fat body, white prepupae    22 fat body, pupae P8    21 carcass, larvae L3 wandering    46 carcass, 1-day adult    11 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    55 ovary, mated 4-day female    38 testis, mated 4-day male    30 accessory gland, mated 4-day male    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (52) central nervous system, larvae L3  (48) central nervous system, pupae P8  (27) head, virgin 1-day female    23 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    10 head, mated 4-day male    19 head, mated 20-day male  26 salivary gland, larvae L3 wandering  (42) salivary gland, white prepupae    19 digestive system, larvae L3 wandering  (32) digestive system, 1-day adult    24 digestive system, 4-day adult    20 digestive system, 20-day adult    22 fat body, larvae L3 wandering    18 fat body, white prepupae    22 fat body, pupae P8    21 carcass, larvae L3 wandering  (46) carcass, 1-day adult    11 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female  (55) ovary, mated 4-day female  (38) testis, mated 4-day male  (30) accessory gland, mated 4-day male  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    48 central nervous system, pupae P8    27 head, virgin 1-day female    23 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    10 head, mated 4-day male    19 head, mated 20-day male    26 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    24 digestive system, 4-day adult    20 digestive system, 20-day adult    22 fat body, larvae L3 wandering    18 fat body, white prepupae    22 fat body, pupae P8    21 carcass, larvae L3 wandering    46 carcass, 1-day adult    11 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    55 ovary, mated 4-day female    38 testis, mated 4-day male    30 accessory gland, mated 4-day male    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    48 central nervous system, pupae P8    27 head, virgin 1-day female    23 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    10 head, mated 4-day male    19 head, mated 20-day male    26 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    24 digestive system, 4-day adult    20 digestive system, 20-day adult    22 fat body, larvae L3 wandering    18 fat body, white prepupae    22 fat body, pupae P8    21 carcass, larvae L3 wandering    46 carcass, 1-day adult    11 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    55 ovary, mated 4-day female    38 testis, mated 4-day male    30 accessory gland, mated 4-day male    80 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    48 central nervous system, pupae P8    27 head, virgin 1-day female    23 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    10 head, mated 4-day male    19 head, mated 20-day male    26 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    24 digestive system, 4-day adult    20 digestive system, 20-day adult    22 fat body, larvae L3 wandering    18 fat body, white prepupae    22 fat body, pupae P8    21 carcass, larvae L3 wandering    46 carcass, 1-day adult    11 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    55 ovary, mated 4-day female    38 testis, mated 4-day male    30 accessory gland, mated 4-day male    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (52) central nervous system, larvae L3  (48) central nervous system, pupae P8  27 head, virgin 1-day female    23 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    10 head, mated 4-day male    19 head, mated 20-day male  26 salivary gland, larvae L3 wandering  (42) salivary gland, white prepupae    19 digestive system, larvae L3 wandering  32 digestive system, 1-day adult    24 digestive system, 4-day adult    20 digestive system, 20-day adult    22 fat body, larvae L3 wandering    18 fat body, white prepupae    22 fat body, pupae P8    21 carcass, larvae L3 wandering  (46) carcass, 1-day adult    11 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female  (55) ovary, mated 4-day female  (38) testis, mated 4-day male  30 accessory gland, mated 4-day male  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    48 central nervous system, pupae P8    27 head, virgin 1-day female    23 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    10 head, mated 4-day male    19 head, mated 20-day male    26 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    24 digestive system, 4-day adult    20 digestive system, 20-day adult    22 fat body, larvae L3 wandering    18 fat body, white prepupae    22 fat body, pupae P8    21 carcass, larvae L3 wandering    46 carcass, 1-day adult    11 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    55 ovary, mated 4-day female    38 testis, mated 4-day male    30 accessory gland, mated 4-day male    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    48 central nervous system, pupae P8    27 head, virgin 1-day female    23 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    10 head, mated 4-day male    19 head, mated 20-day male    26 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    24 digestive system, 4-day adult    20 digestive system, 20-day adult    22 fat body, larvae L3 wandering    18 fat body, white prepupae    22 fat body, pupae P8    21 carcass, larvae L3 wandering    46 carcass, 1-day adult    11 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    55 ovary, mated 4-day female    38 testis, mated 4-day male    30 accessory gland, mated 4-day male    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    159 embryo 04-06hr    170 embryo 06-08hr    136 embryo 08-10hr    142 embryo 10-12hr    150 embryo 12-14hr    124 embryo 14-16hr    103 embryo 16-18hr    78 embryo 18-20hr    40 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    76 larva L2    146 larva L3 12hr old    84 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    77 larva L3 puffstage 7-9    102 white prepupae new    102 white prepupae 12hr    76 white prepupae 24hr    99 pupae 2d postWPP    90 pupae 3d postWPP    43 pupae 4d postWPP    35 adult male 01day    59 adult male 05day    64 adult male 30day    71 adult female 01day    60 adult female 05day    86 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (105) embryo 02-04hr  (159) embryo 04-06hr  (170) embryo 06-08hr  (136) embryo 08-10hr  (142) embryo 10-12hr  (150) embryo 12-14hr  (124) embryo 14-16hr  (103) embryo 16-18hr  (78) embryo 18-20hr  (40) embryo 20-22hr  (34) embryo 22-24hr  (39) larva L1  (76) larva L2  (146) larva L3 12hr old  (84) larva L3 puffstage 1-2  (79) larva L3 puffstage 3-6  (77) larva L3 puffstage 7-9  (102) white prepupae new  (102) white prepupae 12hr  (76) white prepupae 24hr  (99) pupae 2d postWPP  (90) pupae 3d postWPP  (43) pupae 4d postWPP  (35) adult male 01day  (59) adult male 05day  (64) adult male 30day  (71) adult female 01day  (60) adult female 05day  (86) adult female 30day  (87) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  105 embryo 02-04hr  (159) embryo 04-06hr  (170) embryo 06-08hr  (136) embryo 08-10hr  (142) embryo 10-12hr  (150) embryo 12-14hr  (124) embryo 14-16hr  103 embryo 16-18hr    78 embryo 18-20hr    40 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    76 larva L2  (146) larva L3 12hr old    84 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    77 larva L3 puffstage 7-9  102 white prepupae new  102 white prepupae 12hr    76 white prepupae 24hr    99 pupae 2d postWPP    90 pupae 3d postWPP    43 pupae 4d postWPP    35 adult male 01day    59 adult male 05day    64 adult male 30day    71 adult female 01day    60 adult female 05day    86 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    159 embryo 04-06hr    170 embryo 06-08hr    136 embryo 08-10hr    142 embryo 10-12hr    150 embryo 12-14hr    124 embryo 14-16hr    103 embryo 16-18hr    78 embryo 18-20hr    40 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    76 larva L2    146 larva L3 12hr old    84 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    77 larva L3 puffstage 7-9    102 white prepupae new    102 white prepupae 12hr    76 white prepupae 24hr    99 pupae 2d postWPP    90 pupae 3d postWPP    43 pupae 4d postWPP    35 adult male 01day    59 adult male 05day    64 adult male 30day    71 adult female 01day    60 adult female 05day    86 adult female 30day    87 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    159 embryo 04-06hr    170 embryo 06-08hr    136 embryo 08-10hr    142 embryo 10-12hr    150 embryo 12-14hr    124 embryo 14-16hr    103 embryo 16-18hr    78 embryo 18-20hr    40 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    76 larva L2    146 larva L3 12hr old    84 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    77 larva L3 puffstage 7-9    102 white prepupae new    102 white prepupae 12hr    76 white prepupae 24hr    99 pupae 2d postWPP    90 pupae 3d postWPP    43 pupae 4d postWPP    35 adult male 01day    59 adult male 05day    64 adult male 30day    71 adult female 01day    60 adult female 05day    86 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (105) embryo 02-04hr  (159) embryo 04-06hr  (170) embryo 06-08hr  (136) embryo 08-10hr  (142) embryo 10-12hr  (150) embryo 12-14hr  (124) embryo 14-16hr  (103) embryo 16-18hr  (78) embryo 18-20hr  (40) embryo 20-22hr  (34) embryo 22-24hr  (39) larva L1  (76) larva L2  (146) larva L3 12hr old  (84) larva L3 puffstage 1-2  (79) larva L3 puffstage 3-6  (77) larva L3 puffstage 7-9  (102) white prepupae new  (102) white prepupae 12hr  (76) white prepupae 24hr  (99) pupae 2d postWPP  (90) pupae 3d postWPP  (43) pupae 4d postWPP  (35) adult male 01day  (59) adult male 05day  (64) adult male 30day  (71) adult female 01day  (60) adult female 05day  (86) adult female 30day  (87) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  105 embryo 02-04hr  (159) embryo 04-06hr  (170) embryo 06-08hr  136 embryo 08-10hr  142 embryo 10-12hr  (150) embryo 12-14hr  124 embryo 14-16hr  103 embryo 16-18hr    78 embryo 18-20hr    40 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    76 larva L2  (146) larva L3 12hr old    84 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    77 larva L3 puffstage 7-9  102 white prepupae new  102 white prepupae 12hr    76 white prepupae 24hr    99 pupae 2d postWPP    90 pupae 3d postWPP    43 pupae 4d postWPP    35 adult male 01day    59 adult male 05day    64 adult male 30day    71 adult female 01day    60 adult female 05day    86 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    159 embryo 04-06hr    170 embryo 06-08hr    136 embryo 08-10hr    142 embryo 10-12hr    150 embryo 12-14hr    124 embryo 14-16hr    103 embryo 16-18hr    78 embryo 18-20hr    40 embryo 20-22hr    34 embryo 22-24hr    39 larva L1    76 larva L2    146 larva L3 12hr old    84 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    77 larva L3 puffstage 7-9    102 white prepupae new    102 white prepupae 12hr    76 white prepupae 24hr    99 pupae 2d postWPP    90 pupae 3d postWPP    43 pupae 4d postWPP    35 adult male 01day    59 adult male 05day    64 adult male 30day    71 adult female 01day    60 adult female 05day    86 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    262 Schneider line 2 Sg4    162 embryonic 1182-4H    78 embryonic GM2    106 embryonic Kc167    84 embryonic S1    99 embryonic S3    180 leg disc CME L1    123 wing disc CME-W2    120 wing disc ML-DmD8    65 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    86 wing disc ML-DmD21    137 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    185 eye-antennal disc ML-DmD11    69 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    109 CNS ML-DmBG1-c1    101 CNS ML-DmBG2-c2    129 tumorous blood cells mbn2    147 ovary fGS/OSS    26 ovary OSC    42 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (262) Schneider line 2 Sg4  (162) embryonic 1182-4H  (78) embryonic GM2  (106) embryonic Kc167  (84) embryonic S1  (99) embryonic S3  (180) leg disc CME L1  (123) wing disc CME-W2  (120) wing disc ML-DmD8  (65) wing disc ML-DmD9  (78) wing disc ML-DmD16-c3  (86) wing disc ML-DmD21  (137) wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3  (185) eye-antennal disc ML-DmD11  (69) antennal disc ML-DmD20-c5  (127) mixed discs ML-DmD4-c1  (109) CNS ML-DmBG1-c1  (101) CNS ML-DmBG2-c2  (129) tumorous blood cells mbn2  (147) ovary fGS/OSS  26 ovary OSC  (42) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (262) Schneider line 2 Sg4  (162) embryonic 1182-4H    78 embryonic GM2  106 embryonic Kc167    84 embryonic S1    99 embryonic S3  (180) leg disc CME L1  (123) wing disc CME-W2  (120) wing disc ML-DmD8    65 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    86 wing disc ML-DmD21  (137) wing disc ML-DmD32    56 haltere disc ML-DmD17-c3  (185) eye-antennal disc ML-DmD11    69 antennal disc ML-DmD20-c5  (127) mixed discs ML-DmD4-c1  (109) CNS ML-DmBG1-c1  101 CNS ML-DmBG2-c2  (129) tumorous blood cells mbn2  (147) ovary fGS/OSS    26 ovary OSC    42 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    262 Schneider line 2 Sg4    162 embryonic 1182-4H    78 embryonic GM2    106 embryonic Kc167    84 embryonic S1    99 embryonic S3    180 leg disc CME L1    123 wing disc CME-W2    120 wing disc ML-DmD8    65 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    86 wing disc ML-DmD21    137 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    185 eye-antennal disc ML-DmD11    69 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    109 CNS ML-DmBG1-c1    101 CNS ML-DmBG2-c2    129 tumorous blood cells mbn2    147 ovary fGS/OSS    26 ovary OSC    42 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    262 Schneider line 2 Sg4    162 embryonic 1182-4H    78 embryonic GM2    106 embryonic Kc167    84 embryonic S1    99 embryonic S3    180 leg disc CME L1    123 wing disc CME-W2    120 wing disc ML-DmD8    65 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    86 wing disc ML-DmD21    137 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    185 eye-antennal disc ML-DmD11    69 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    109 CNS ML-DmBG1-c1    101 CNS ML-DmBG2-c2    129 tumorous blood cells mbn2    147 ovary fGS/OSS    26 ovary OSC    42 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (262) Schneider line 2 Sg4  (162) embryonic 1182-4H  (78) embryonic GM2  (106) embryonic Kc167  (84) embryonic S1  (99) embryonic S3  (180) leg disc CME L1  (123) wing disc CME-W2  (120) wing disc ML-DmD8  (65) wing disc ML-DmD9  (78) wing disc ML-DmD16-c3  (86) wing disc ML-DmD21  (137) wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3  (185) eye-antennal disc ML-DmD11  (69) antennal disc ML-DmD20-c5  (127) mixed discs ML-DmD4-c1  (109) CNS ML-DmBG1-c1  (101) CNS ML-DmBG2-c2  (129) tumorous blood cells mbn2  (147) ovary fGS/OSS  26 ovary OSC  (42) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (262) Schneider line 2 Sg4  (162) embryonic 1182-4H    78 embryonic GM2  106 embryonic Kc167    84 embryonic S1    99 embryonic S3  (180) leg disc CME L1  123 wing disc CME-W2  120 wing disc ML-DmD8    65 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    86 wing disc ML-DmD21  137 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3  (185) eye-antennal disc ML-DmD11    69 antennal disc ML-DmD20-c5  127 mixed discs ML-DmD4-c1  109 CNS ML-DmBG1-c1  101 CNS ML-DmBG2-c2  129 tumorous blood cells mbn2  (147) ovary fGS/OSS    26 ovary OSC    42 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    262 Schneider line 2 Sg4    162 embryonic 1182-4H    78 embryonic GM2    106 embryonic Kc167    84 embryonic S1    99 embryonic S3    180 leg disc CME L1    123 wing disc CME-W2    120 wing disc ML-DmD8    65 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    86 wing disc ML-DmD21    137 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    185 eye-antennal disc ML-DmD11    69 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    109 CNS ML-DmBG1-c1    101 CNS ML-DmBG2-c2    129 tumorous blood cells mbn2    147 ovary fGS/OSS    26 ovary OSC    42 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    66 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    70 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    48 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    58 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult  (33) Cadmium 50 mM 6 hrs, larvae L3  (54) Cadmium 50 mM 12 hrs, larvae L3  (66) Cadmium 50 mM 48 hrs, 4-day adult  (31) Cadmium 100 mM 48 hrs, 4-day adult  (40) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult  (40) Zinc 5 mM 12 hrs, larvae L3  (28) Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3  (32) Ethanol 5% 3 hrs, larvae L3  (70) Ethanol 10% 3 hrs, larvae L3  (45) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (48) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (31) Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult  (30) Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3  (58) Rotenone 8 μg 12 hrs, larvae L3  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    66 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    70 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    48 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    58 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    66 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    70 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    48 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    58 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    66 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    70 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    48 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    58 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult  (33) Cadmium 50 mM 6 hrs, larvae L3  (54) Cadmium 50 mM 12 hrs, larvae L3  (66) Cadmium 50 mM 48 hrs, 4-day adult  31 Cadmium 100 mM 48 hrs, 4-day adult  (40) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult  (40) Zinc 5 mM 12 hrs, larvae L3  28 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3  32 Ethanol 5% 3 hrs, larvae L3  (70) Ethanol 10% 3 hrs, larvae L3  (45) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (48) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  31 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult  30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3  (58) Rotenone 8 μg 12 hrs, larvae L3  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    66 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    70 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    48 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    58 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    14 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    66 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    70 Ethanol 10% 3 hrs, larvae L3    45 Caffeine 1.5 mg/ml 4 hrs, larvae L3    48 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    58 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 l(2)k12914GD1006 lethal | recessive l(2)k12914k12914 l(2)k12914k14509 Phenotype manifest in Allele lysosome & larval fat body | somatic clone | cell autonomous l(2)k12914k12914
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of l(2)k12914 Class Mutagen Stocks Known lesion l(2)k12914k12914 P-element activity 2 -- l(2)k12914k14509 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of l(2)k12914 Class Mutagen Stocks Known lesion l(2)k12914GD1006 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)N22-5 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)N22-14 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)k12914k12914 No P{lacW}l(2)k12914k14509 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
dolichyl-diphosphooligosaccharide-protein glycotransferase activity inferred from electronic annotation with InterPro:IPR003038 (FlyBase Curators et al., 2004-) oligosaccharyl transferase activity inferred from sequence or structural similarity with EMBL:U81052 (FlyBase, 1992-)
Biological Process
CV term Evidence References
negative regulation of apoptotic process non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR003038 (FlyBase Curators et al., 2004-) oligosaccharyltransferase complex inferred from sequence or structural similarity with EMBL:U81052 (FlyBase, 1992-) plasma membrane non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
l(2)k12914 - CG11190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - CG11723 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - CG15643 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - CG2263 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - CG2789 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - CG33145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - CG4563 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - CG6712 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - CG8311 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - Cdc23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - Cyp4ad1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - Gyk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - Pis anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - Pka-R1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - Snap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - Tango4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - Vha55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)k12914 - mael anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions l(2)k12914 allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6VHKT5 Dipteran inclusive ortholog search EOG673Q1V Insect inclusive ortholog search EOG605QXX Arthropod inclusive ortholog search EOG6XSJ6N Metazoa inclusive ortholog search EOG6X6R50
Orthologs in Drosophila Species (EOG6VHKT5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\l(2)k12914     Drosophila simulans   Dsim\GD22410 Y   Drosophila sechellia   Dsec\GM12988 Y   Drosophila erecta   Dere\GG23447 Y   Drosophila yakuba   Dyak\GE11027 Y   Drosophila ananassae   Dana\GF14682 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12252 Y   Drosophila persimilis   Dper\GL25808 Y   Drosophila willistoni   Dwil\GK24842 Y   Drosophila virilis   Dvir\GJ18193 Y   Drosophila mojavensis   Dmoj\GI12966 Y   Drosophila grimshawi   Dgri\GH23638 Y   Drosophila grimshawi   Dgri\GH11354
Orthologs in non-Drosophila Dipterans (EOG673Q1V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002183   Anopheles gambiae Malaria mosquito  Agam\AGAP008491   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003512
Orthologs in non-Dipteran Insects (EOG605QXX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC727568   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG023627   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18454   Atta cephalotes Leafcutter ant  Acep\ACEP10572   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21308   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13993   Linepithema humile Argentine ant  Lhum\LH22259   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22789   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000222   Bombyx mori Silkmoth  Bmor\BGIBMGA000188   Pediculus humanus Human body louse  Phum\PHUM477820   Tribolium castaneum Red flour beetle  Tcas\TC016366
Orthologs in non-Insect Arthropods (EOG6XSJ6N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_300829   Ixodes scapularis Deer tick  Isca\ISCW024010
Orthologs in non-Arthropod Metazoa (EOG6X6R50)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\dad-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001933gn   Danio rerio Zebrafish  Drer\dad1   Xenopus tropicalis Western clawed frog  Xtro\dad1   Gallus gallus Domestic chicken  Ggal\DAD1   Mus musculus House mouse  Mmus\Dad1   Rattus norvegicus Norway rat  Rnor\Dad1   Homo sapiens Human  Hsap\DAD1
Human Orthologs (1)
Gene OMIM HGNC Hsap\DAD1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22410 Drosophila sechellia Dsec\GM12988 Drosophila erecta Dere\GG23447 Drosophila yakuba Dyak\GE11027 Drosophila ananassae Dana\GF14682 Drosophila pseudoobscura pseudoobscura Dpse\GA12252 Drosophila persimilis Dper\GL25808 Drosophila willistoni Dwil\GK24842 Drosophila virilis Dvir\GJ18193 Drosophila mojavensis Dmoj\GI12966 Drosophila grimshawi Dgri\GH23638
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	11070 y1 w67c23; P{lacW}l(2)k12914k12914/CyO
Kyoto	102935 y1 w67c23 ; P{lacW}l(2)k12914k14509 / CyO 111317 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}l(2)k12914k12914 P{neoFRT}40A/CyO y+
VDRC	v33164 w1118; P{GD1006}v33164 v33166 w1118; P{GD1006}v33166
Genomic Clones ( 2 )
	BACR02I15 BACR15P08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE23864
Other clones	DPiM_RE23864
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	SD11173
Other clones	105683 106418 528256 561826 bs82h01 CK01.48D.C12 CK01.72A.H7 Dmel_dig_013089_0609_1592 Dmel_neb_014148_0887_2756 EC33631 EK057132 EK231949 EK244058 EN09333 EN13219 RP001004587 RP001008572 RP001050339
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG13393 BcDNA:RE23864 (FlyBase, 1996-) Source for merge of: l(2)k12914 CG13393 (Arsham and Neufeld, 2009)
Additional comments	Source for merge of CG13393 BcDNA:RE23864 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135378 RefSeq (Proteins) • NP_609222 DDBJ / EMBL / GenBank • AAF52660 AAM29434 AQ026046 AY113429 BI216657 Entrez Gene - A searchable database of RefSeq genes. • 34159 UniProtKB/Swiss-Prot • Q9VLM5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DAD/Ost2 (IPR003038)
Linkouts
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	BcDNA:RE23864   CG13393 (Cammarato et al., 2011, Arsham and Neufeld, 2009) l(2)k12914
Name Synonym	lethal (2) k12914
Secondary FlyBase IDs
	FBgn0021896 FBgn0032035 FBgn0063049
References ( 16 )
Research paper	Arsham and Neufeld, 2009, PLoS ONE 4(6): e6068 A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. [FBrf0208155] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078] Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Protein sequence record	Swiss-Prot Project Members, 2002.3.1, UniProtKB: Q9VLM5 Defender against cell death 1 (DAD-1). [FBrf0151091]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705] Kodira, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126678]