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Gene Dmel\BubR1

General Information
Symbol	Dmel\BubR1	Species	D. melanogaster
Name	Bub1-related kinase	Annotation symbol	CG7838
Feature type	protein_coding_gene	FlyBase ID	FBgn0263855
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	bub1, Dmbub1
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	42A5-42A6	Sequence location	2R:1,856,600..1,862,122 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Bub1-related kinase is referred to in FlyBase by the symbol Dmel\BubR1 (CG7838, FBgn0263855). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity. There is experimental evidence for 16 unique biological process terms, many of which group under: cell cycle; cellular component organization or biogenesis; biological regulation; cell cycle process; regulation of cellular component organization; M phase of meiotic cell cycle; regulation of cell cycle arrest; regulation of organelle organization; system development; multicellular organismal development. 19 alleles are reported. The phenotypes of these alleles are annotated with: organelle; anatomical structure; multicellular structure; spindle; cell cycle; spindle microtubule; intracellular non-membrane-bounded organelle; intracellular organelle part; eo support cell; cellular component organization or biogenesis; nucleus; imaginal precursor; organ system. It has one annotated transcript and one annotated polypeptide. Protein features are: Mad3/BUB1 homology region 1; Mitotic checkpoint serine/threonine protein kinase, Bub1; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain. Gene sequence location is 2R:1856600..1862122.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	New/Merged/Split Record This record was either newly added to FlyBase for this release or is the result of merging or splitting existing records in this release
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42A5-42A6   Limits computationally determined from genome sequence between P{PZ}l(2)0985109851&P{lacW}Src42Ak10108 and P{lacW}l(2)k09848k09848&P{EP}EP407
Experimentally Determined Cytological Location
Cytogenetic map Notes References 42A1-42A2   (determined by in situ hybridisation)   (Spradling et al., 1999) 42A1-42A3   (determined by in situ hybridisation)   (Basu et al., 1999) 42A1-42A2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Wakimoto et al., 2004)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\BubR1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) BubR1-RA FBtr0086032  NM_058034   4862   1460
Additional Transcript Data & Comments
Reported size (kB)	4.601 (longest cDNA) (Basu et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein BubR1-PA   FBpp0085368   165.1   1460   6.27     NP_477382   AAF57298
Additional Polypeptide Data & Comments
Reported size (kDa)	1461 (aa); 165 (kD observed); 165 (kD predicted) (Basu et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Mad3/BUB1 homology region 1 (IPR013212) Mitotic checkpoint serine/threonine protein kinase, Bub1 (IPR015661) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263689   AA438552   AA441296   AA538805   AA539566   AA820292   AA820408   AA941084   AA942348   AA952281   AA979700   AE013599 AAF57298   AC009847   AF080399 AAC32190   AF132565 AAD27864   AI455383   AI456003   AI514378   AI519744   AI520083   AQ025781   BE977679   BG638142   BG638777   BI373082   BP551408   BP551409   CO267975   CO290007   CO307858   CO316090   CO321484   CO322184   CO327123   CO328433   CZ466426   DN154273   EC052327   EC054841   EC055041   EC056081   EC056537   EC062937   EC064158   EC212587   EC219141   EC226512   EC226810   EC231558   EC240560   EC243802
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O76755 Q7KN56 A1Z6I7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
	Bub1 protein is detected at the kinetochore in chromosomes from colchicine treated S2 cells and larval neuroblasts. Bub1 protein shows cell-cycle dependent localization. Diffuse nucleoplasmic staining is detected at interphase. Strong kinetochore localization is found in prophase. This staining is weaker at prometaphase. At metaphase, no Bub1 protein is detected at chromosomes at the metaphase plate. Weak kintetochore staining may be seen in early anaphase, but not in late anaphase or telophase. Localization of Bub1 protein shows a similar dynamic distribution pattern in the first and second meiotic divisions during spermatogenesis. (Basu et al., 1999)
Marker for
Subcellular Localization
CV Term	kinetochore (Basu et al., 1999)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 BubR1GD10778 lethal | recessive BubR1k03113 BubR1k06109 semi-viable BubR1Rev1 viable BubR1A1204K.T:Avic\GFP-S65T BubR1D1326N BubR1KEN.T:Disc\RFP-mRFP viable, with Scer\GAL4pnr-MD237 BubR1GD10778 viable (with BubR1D1326N) BubR1k06109 BubR1Rev1 viable (with BubR1k06109) BubR1D1326N viable (with BubR1Rev1) BubR1D1326N viable (with Df(2R)nap9) BubR1D1326N Sterility Allele female sterile BubR1Rev1 fertile BubR1A1204K.T:Avic\GFP-S65T BubR1KEN.T:Disc\RFP-mRFP male fertile BubR1D1326N Other Phenotypes Allele cell cycle defective BubR1A1204K.PR meiotic cell cycle defective (with BubR1D1326N) BubR1k06109 BubR1Rev1 meiotic cell cycle defective (with BubR1k06109) BubR1D1326N meiotic cell cycle defective (with BubR1Rev1) BubR1D1326N meiotic cell cycle defective (with Df(2R)nap9) BubR1D1326N meiotic cell cycle defective | recessive BubR1unspecified mitotic cell cycle defective BubR1A1204K.T:Avic\GFP-S65T BubR1dsRNA.cGa BubR1k03113 BubR1k06109 BubR1KEN.T:Disc\RFP-mRFP BubR1Rev1 BubR1unspecified mitotic cell cycle defective (with BubR1k06109) BubR1Rev1 mitotic cell cycle defective (with BubR1Rev1) BubR1k06109 mitotic cell cycle defective | embryonic stage 2 BubR1Rev1 mitotic cell cycle defective | embryonic stage 3 BubR1Rev1 mitotic cell cycle defective | embryonic stage 4 BubR1Rev1 mitotic cell cycle defective | recessive BubR1k03113 BubR1k06109 neuroanatomy defective | larval stage, with Scer\GAL41407 BubR1GD10778 visible, with Scer\GAL4pnr-MD237 BubR1GD10778 Phenotype manifest in Allele chromosome BubR1A1204K.T:Avic\GFP-S65T condensed chromosome BubR1k06109 BubR1Rev1 condensed chromosome (with BubR1k06109) BubR1Rev1 condensed chromosome (with BubR1Rev1) BubR1k06109 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 BubR1GD10778 ganglion mother cell | larval stage, with Scer\GAL41407 BubR1GD10778 imaginal disc BubR1k03113 kinetochore microtubule BubR1dsRNA.cGa meiotic cell cycle | male BubR1unspecified mitosis & nuclear chromosome BubR1unspecified mitotic anaphase BubR1unspecified BubR1k06109 BubR1k03113 mitotic anaphase & nuclear chromosome BubR1k06109 BubR1k03113 mitotic cell cycle BubR1unspecified BubR1k06109 BubR1k03113 neuroblast BubR1k06109 BubR1Rev1 neuroblast (with BubR1k06109) BubR1Rev1 neuroblast (with BubR1Rev1) BubR1k06109 nucleus BubR1Rev1 onion stage spermatid BubR1unspecified onion stage spermatid & nucleus BubR1unspecified BubR1D1326N S2 cell-line BubR1dsRNA.cGa spindle BubR1A1204K.T:Avic\GFP-S65T BubR1Rev1 spindle microtubule BubR1k06109 trichogen cell, with Scer\GAL4pnr-MD237 BubR1GD10778
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of BubR1 Class Mutagen Stocks Known lesion BubR1k03113 hypomorphic allele - genetic evidence P-element activity 2 Yes BubR1c00394 piggyBac transposase 1 -- BubR1k06109 hypomorphic allele - genetic evidence P-element activity 1 Yes BubR1MI01546 1 -- BubR1NP4609 1 -- BubR1D1326N hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes BubR1Rev1 hypomorphic allele - genetic evidence 0 Yes BubR1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of BubR1 Class Mutagen Stocks Known lesion BubR1DN.Scer\UAS antimorphic allele - genetic evidence in vitro construct - regulatory fusion in vitro construct - deletion 3 Yes BubR1Scer\UAS.Exel in vitro construct - regulatory fusion 3 Yes BubR1GD10778 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BubR1GL00236 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BubR1GLV21065 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BubR1A1204K.PR in vitro construct - amino acid replacement 0 Yes BubR1A1204K.T:Avic\GFP-S65T in vitro construct - amino acid replacement 0 Yes BubR1dsRNA.cGa in vitro construct - RNAi 0 -- BubR1KEN.T:Disc\RFP-mRFP in vitro construct - amino acid replacement 0 Yes BubR1T:Avic\GFP-S65T in vitro construct - coding region fusion 0 Yes BubR1T:Disc\RFP-mRFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7085 (Ryder, 2004.4.26) Df(2R)nap1 (Myster et al., 2004, Basu et al., 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)nap2 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Basu et al., 1999) Df(2R)nap9 (Malmanche et al., 2007) Df(2R)NC13 (Myster et al., 2004, Myster and Peifer, 2003.9.11) Df(2R)NC228 (Myster et al., 2004, Myster and Peifer, 2003.9.11) In(2R)bwVDe2LCyR (Malmanche et al., 2007)
Not disrupted in	Df(2R)244 (Myster et al., 2004) Df(2R)247 (Myster et al., 2004) Df(2R)Dark2 (Myster et al., 2004) Df(2R)M41A2 (Myster et al., 2004, Myster et al., 2004) Df(2R)M41A4 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)M41A8 (Myster et al., 2004, Myster et al., 2004) Df(2R)M41A10 (Myster et al., 2004, Myster et al., 2004) Df(2R)NC32 (Myster et al., 2004) Df(2R)NC50 (Myster et al., 2004) Df(2R)NC68 (Myster et al., 2004) Df(2R)NC73 (Myster et al., 2004) Df(2R)NC98 (Myster et al., 2004) Df(2R)NC125 (Myster et al., 2004) Df(2R)NC167 (Myster et al., 2004) Df(2R)NC168 (Myster et al., 2004) Df(2R)NC191 (Myster et al., 2004) Df(2R)NC195 (Myster et al., 2004) Df(2R)NC202 (Myster et al., 2004) Df(2R)NC207 (Myster et al., 2004) Df(2R)NC218 (Myster et al., 2004) Df(2R)NC219 (Myster et al., 2004) Df(2R)NC1198 (Myster et al., 2004) Df(2R)Nipped-D (Myster et al., 2004, Myster et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.GL00236} NA P{TRiP.GLV21065} NA P{UAS-BubR1.DN} NA P{UAS-BubR1.Exel} NA characterization construct P{BubR1-KD.A1204K.GFP} NA P{BubR1-KD.A1204K} NA P{BubR1-KEN.mRFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}BubR1k03113 No P{lacW}BubR1k06109 No insertion of enhancer trap binary system P{GawB}BubR1NP4609 No miscellaneous insertions Mi{MIC}BubR1MI01546 NA PBac{PB}BubR1c00394 NA
Gene Ontology: Function, Process & Cellular Component ( 23 unique terms )
Terms Based on Experimental Evidence ( 18 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell cycle process inferred from mutant phenotype (Rahmani et al., 2009) female meiosis sister chromatid cohesion inferred from mutant phenotype (Malmanche et al., 2007) male meiosis inferred from mutant phenotype (Wakimoto et al., 2004) male meiosis sister chromatid cohesion inferred from mutant phenotype (Malmanche et al., 2007) meiotic sister chromatid cohesion, centromeric inferred from mutant phenotype (Malmanche et al., 2007) mitotic cell cycle spindle assembly checkpoint inferred from direct assay (Logarinho et al., 2004) inferred from mutant phenotype (Basu et al., 1999) mitotic cell cycle spindle checkpoint inferred from mutant phenotype (Rahmani et al., 2009) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) regulation of exit from mitosis inferred from genetic interaction with dup AND inferred from mutant phenotype (Garner et al., 2001) regulation of mitotic prometaphase inferred from mutant phenotype (Rahmani et al., 2009) regulation of mitotic sister chromatid separation inferred from mutant phenotype (Rahmani et al., 2009) sister chromatid segregation inferred from mutant phenotype (Rahmani et al., 2009) spindle checkpoint inferred from mutant phenotype (Perez-Mongiovi et al., 2005) synaptonemal complex organization inferred from mutant phenotype (Malmanche et al., 2007) syncytial blastoderm mitotic cell cycle inferred from mutant phenotype (Perez-Mongiovi et al., 2005)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Buffin et al., 2005) kinetochore inferred from direct assay (Buffin et al., 2005)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Spradling et al., 1999) non-traceable author statement (Basu, 1998.7.24)
Biological Process
CV term Evidence References
mitotic cell cycle spindle assembly checkpoint inferred from sequence or structural similarity (Spradling et al., 1999) traceable author statement (Lee and Orr-Weaver, 2003) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
condensed chromosome outer kinetochore non-traceable author statement (Blower and Karpen, 2001) kinetochore traceable author statement (Basu et al., 1998)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions BubR1 allele Gene References Bub1k03113 asp (Basto et al., 2000) dup (Garner et al., 2001) Bub1k06109 polo (Donaldson et al., 2001) unspecified Cdc27 (Deak, 1999.9.15)
External Data
Linkouts
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13829 Dere\GG10842 Dgri\GH20410 Dmoj\GI19597 Dper\GL17789 Dpse\GA20621 Dsec\GM16494 Dsim\GD10345 Dvir\GJ18402 Dwil\GK21755 Dyak\GE19436
Curated drosophilid orthologs	Dpse\GA20621
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	8380 y1 w1118; P{UAS-BubR1.DN}2 8381 P{UAS-BubR1.DN}1, y1 w1118 8382 y1 w1118; P{UAS-BubR1.DN}3 8385 P{UAS-BubR1.Exel}1, y1 w1118 8384 y1 w1118; P{UAS-BubR1.Exel}2/CyO 34208 y1 w*; Mi{MIC}BubR1MI01546 35329 y1 sc* v1; P{TRiP.GL00236}attP2 35700 y1 sc* v1; P{TRiP.GLV21065}attP2 10526 y1 w67c23; P{lacW}BubR1k03113/CyO
Harvard	- PBac{PB}BubR1c00394
Kyoto	104712 w*; P{GawB}BubR1NP4609 / CyO
VDRC	v26109 w1118; P{GD10778}v26109/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR03L10 BACR39E09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 43 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23835
Other clones	DPiM_LD23835
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD06986 LD12353 LD16179 LD17380 LD17759 LD18419 LD24007 LD25038 LD25638 LD26503 LD29402 LD39483 LD40040 LD40862 RE60294
Other clones	10135 60643 73887 79017 149943 160334 bs67f08 CK01.10D.H9 CK01.93B.A8 CK01.118C.B2 EC052327 EC054841 EC055041 EC056081 EC056537 EK072836 EK089837 EK185754 EK187509 EK208545 EK255851 EK263634 EP05907 EP09209 FGM212F12 LD35813
RNAi & Array Information
Linkouts
Antibody Information
	polyclonal (Basu et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: BubR1 CG7838 (Logarinho et al., 2004)
Source for database merge of	Source for merge of: BubR1 mcl(2)Z1525 (Malmanche et al., 2007)
Additional comments	Previous molecular and genetic analysis (FBrf0109303) identified the CG7838 annotation as having significant homology to "Bub1" proteins from other organisms (FlyBase curator comment: this resulted in the "CG7838" gene being renamed to "Bub1" in FlyBase). However, the completion of the Drosophila genome revealed the existence of a second annotation, CG14030, that is also closely related to "Bub1" proteins. Higher eukaryotes also have two genes encoding proteins closely related to "Bub1", one of which retains the symbol "Bub1", while the other is called "BubR1". From phylogenetic analysis including both CG7838 and CG14030 it is difficult to determine unequivocally which gene codes for "Bub1" and which gene codes for "BubR1". However, functional analysis of these proteins in FBrf0174806 suggests that CG14030 encodes the homolog of Bub1 (FlyBase curator comment: as a consequence of this, the gene corresponding to the CG7838 annotation has been renamed "BubR1" and the gene corresponding to the CG14030 annotation has been renamed "Bub1" in FlyBase). (Logarinho et al., 2004)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) dsRNA against this gene has been used to treat SL2 cells to study the effect of depletion of BubR1 on the spindle checkpoint. (Muller et al., 2006) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, aneuploidy, an increase in mitotic index, a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells, a whole range of mitotic abnormalities, central spindle defects, chromosome abnormalities, and lagging chromatids are seen. (Bettencourt-Dias et al., 2004) BubR1 has a role in blocking exit from mitosis. (Garner et al., 2001) Loss of function mutations in BubR1 cause severe mitotic abnormalities consistent with accelerated transit through metaphase. (Basu et al., 1999) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058034 RefSeq (Proteins) • NP_477382 DDBJ / EMBL / GenBank • AA263689 AA538805 AA820292 AA820408 AAC32190 AAD27864 AAF57298 AC009847 AF080399 AF132565 AI455383 AQ025781 CZ466426 Entrez Gene - A searchable database of RefSeq genes. • 35522 UniProtKB/TrEMBL • A1Z6I7 O76755 Q7KN56
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Mad3/BUB1 homology region 1 (IPR013212) Mitotic checkpoint serine/threonine protein kinase, Bub1 (IPR015661) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	31/13 (Roch et al., 1998) BcDNA:LD23835   bub1 (Fisk and Winey, 2004, Deak et al., 2003, Myster et al., 2004, Lee and Orr-Weaver, 2003, Basto et al., 2000, Champion et al., 2002, Donaldson et al., 2001, Basu et al., 1999, Basu et al., 1998) BUB1 (Williams et al., 2003) Bub1 (De Lucia et al., 2005, Goshima et al., 2007) BubR1 (Neumüller et al., 2011, Przewloka et al., 2011, Venkei et al., 2011, Di Stefano et al., 2011, Nishiyama et al., 2010, Muller et al., 2006, Gilliland et al., 2007, Buffin, 2005, Heeger et al., 2005, Perez-Mongiovi et al., 2005, Buffin et al., 2005, Bettencourt-Dias et al., 2004, Royou et al., 2005, Fischer et al., 2004, Royou et al., 2005, Maiato et al., 2002, Parry et al., 2003, Buffin et al., 2005, Malmanche and Sunkel, 2005, Maia and Sunkel, 2005, Karess, 2005, Li et al., 2007, Abad et al., 2004, Lehner et al., 2007, Garcia et al., 2007, Goshima and Vale, 2005, Logarinho et al., 2004, Parks, 2004.5.12, Page et al., 2005, Pauli et al., 2008, Orr et al., 2007, Dzhindzhev et al., 2005, Buffin et al., 2007, Wen et al., 2008, Kwon et al., 2008, Pandey et al., 2007, Delcros et al., 2006, Laycock et al., 2006, Cesario et al., 2006, Martins et al., 2009, Lince-Faria et al., 2009, Bucciarelli et al., 2009, Blower et al., 2006, Schittenhelm et al., 2009, Royou et al., 2010, Li et al., 2010, Schittenhelm et al., 2010, Rahmani et al., 2009) bubr1 (Blower et al., 2006) bubR1 (Cullen et al., 2005, Cenci et al., 2008, Castellanos et al., 2008, Williams et al., 2007, Wainman et al., 2009, Musarò et al., 2008, Rahmani et al., 2009, Royou et al., 2010, Malmanche et al., 2007) BUBR1 (Heun et al., 2006) CG7838 (Ni et al., 2011.7.19, Buffin et al., 2005, Logarinho et al., 2004, Jin et al., 2001, Morrison et al., 2000, Goshima et al., 2007) CG 7838 (Buffin, 2005) dBUB1 (Dobie et al., 1999) Dmbub1 (Lopes et al., 2000) DmBUB1 (Tyler-Smith and Floridia, 2000) l(2)k03113 (BDGP Project Members, 1994-1999, ) l(2)k06109 (Beaton, 2000.1.31) mcl(2)Z1525
Name Synonym	Bub1   Bub1-related kinase   bub related one (Castellanos et al., 2008) mcl(2)Z1525
Secondary FlyBase IDs
	FBgn0022226 FBgn0025458 FBgn0069180
References ( 125 )
Generate a list of	All references relating to this gene ( 125 )
List References by type	Research paper  ( 69 ) Supplementary material  ( 7 ) Review  ( 7 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 17 ) FlyBase analysis  ( 4 ) Computer file  ( 4 ) Conference report  ( 1 ) DNA/RNA sequence record  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 3 )
Recent research papers ( 8 )
	Di Stefano et al., 2011, Genes Dev. 25(1): 17--28 Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Przewloka et al., 2011, Curr. Biol. 21(5): 399--405 CENP-C Is a Structural Platform for Kinetochore Assembly. [FBrf0213151] Venkei et al., 2011, Genetics 187(1): 131--140 Drosophila mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint. [FBrf0212773] Li et al., 2010, Mol. Cell. Biol. 30(13): 3384--3395 Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster. [FBrf0210988] Nishiyama et al., 2010, Cell 143(5): 737--749 Sororin mediates sister chromatid cohesion by antagonizing wapl. [FBrf0212332] Royou et al., 2010, Cell 140(2): 235--245 BubR1- and Polo-Coated DNA Tethers Facilitate Poleward Segregation of Acentric Chromatids. [FBrf0209924] Schittenhelm et al., 2010, J. Cell Sci. 123(21): 3768--3779 Detrimental incorporation of excess Cenp-A/Cid and Cenp-C into Drosophila centromeres is prevented by limiting amounts of the bridging factor Cal1. [FBrf0212150] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...