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Gene Dmel\sick

General Information
Symbol	Dmel\sick	Species	D. melanogaster
Name	sickie	Annotation symbol	CG43720
Feature type	protein_coding_gene	FlyBase ID	FBgn0263873
Gene Model Status	Current	Stock availability	34 publicly available
Also Known As	CG34343
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	38A8-38A8	Sequence location	2L:19,796,365..19,957,767 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene sickie is referred to in FlyBase by the symbol Dmel\sick (CG43720, FBgn0263873). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: nucleoside-triphosphatase activity; ATP binding. There is experimental evidence that it is involved in the biological process: defense response to Gram-negative bacterium. 33 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: ATPase, AAA+ type, core; ATPase, AAA-type, core; Calponin homology domain. Gene sequence location is 2L:19796365..19957767.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	New/Merged/Split Record This record was either newly added to FlyBase for this release or is the result of merging or splitting existing records in this release
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 38A8-38A8   Limits computationally determined from genome sequence between P{lacW}l(2)k10239k10239 and P{lacW}barrk14014
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sick for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data. Gene merge based on EST data Gene model includes transcripts encoding non-overlapping portions of the full CDS. Gene merge based on protein similarity data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sick-RB FBtr0329842     6992   2197 sick-RC FBtr0329841     4168   1124 sick-RD FBtr0329843     6808   2018 sick-RE FBtr0329844     4703   1346 sick-RF FBtr0329840     6775   2018 sick-RG FBtr0329839     4804   1346 sick-RH FBtr0329838     7534   2192 sick-RI FBtr0329845     8553   2707 sick-RJ FBtr0329846     9239   2707
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sick-PB   FBpp0302883   234.5   2197   9.67       sick-PC   FBpp0302882   117.6   1124   10.72       sick-PD   FBpp0302884   214.9   2018   9.86       sick-PE   FBpp0302885   147.1   1346   7.60       sick-PF   FBpp0302881   214.9   2018   9.86       sick-PG   FBpp0302880   147.1   1346   7.60       sick-PH   FBpp0302879   234.1   2192   9.74       sick-PI   FBpp0302886   291.3   2707   9.03       sick-PJ   FBpp0302887   291.3   2707   9.03
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ATPase, AAA+ type, core (IPR003593) Calponin homology domain (IPR001715) ATPase, AAA-type, core (IPR003959)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141070   AA697705   AY094965   AY122065 AAM52577   BE975173   BE978295   BF505656   BI353512   BI358426   BI573341   BI573342   BI613600   BI625266   BI640274   BT021363   BT029089   BT029259   BT030451   BT122143   CO264570   CO274337   CO297265   CO301641   CO302459   CO313683   CO326900   CZ485815   EC072063   EC210177   EC211716   EC221684   EC222961   EC225469   EC234483   EC234541   EC235757   EC236398   EC244290   EC248591   EC253153   EC256599   EC259609   EL881852   EL881853   EL881855   EL881967   EL881968   EL882083   EL882199   EL882200   EL882202   EL885764   EL885765   EL886560   EL886663   FE527528   GH291268   GH963897
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MR85 Q9VIQ9 Q9VIR0 Q9VIR6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11 mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 sickGD5416 sickGD8183 viable, with Scer\GAL4pnr-MD237 sickGD7056 sickGD8184 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 sickGD5416 sickGD8183 visible, with Scer\GAL4pnr-MD237 sickGD5416 sickGD8183 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 sickGD5416 sickGD8183 trichogen cell, with Scer\GAL4pnr-MD237 sickGD8183
Classical Alleles ( 25 )
For All Classical Alleles Show
Allele of sick Class Mutagen Stocks Known lesion sickA384 2 -- sickc00384a 1 -- sickd00749 1 -- sickd03101 1 -- sickd07725 1 -- sickd09251 1 -- sickDG19701 P-element activity 1 -- sicke02238 1 -- sicke03752 1 -- sickEY00205 1 -- sickEY01145 1 -- sickEY08088 1 -- sickf03273 piggyBac transposase 1 -- sickf04197 1 -- sickf04384 1 -- sickf04819 1 -- sickf06833 1 -- sickMB04228 1 -- sickMB04779 1 -- sickMB06621 1 -- sickMI02587 1 -- sickNP0608 1 -- sickNP7334 1 -- sickd04583 0 -- sickEP2328 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sick Class Mutagen Stocks Known lesion sickGD5416 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes sickGD8183 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes sickGD8184 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes sickGD7056 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sickKK103677 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sickKK107770 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sickKK110037 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sickGD8182 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6045 (Ryder, 2004.4.26) Df(2L)Exel7077 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5415} NA P{GD5416} NA P{GD7056} NA P{GD8183} NA P{KK103677} NA P{KK107770} NA P{KK110037} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}sickEP2328 NA P{EPgy2}sickEY00205 NA P{EPgy2}sickEY01145 NA P{EPgy2}sickEY08088 NA P{XP}sickd00749 NA P{XP}sickd03101 NA P{XP}sickd04583 NA P{XP}sickd07725 NA P{XP}sickd09251 NA miscellaneous insertions Mi{MIC}sickMI02587 NA P{SUPor-P}KG01388 NA P{wHy}sickDG19701 NA PBac{5HPw+}sickA384 NA PBac{PB}sickc00384a NA PBac{RB}sicke02238 NA PBac{RB}sicke03752 NA PBac{WH}sickf03273 NA PBac{WH}sickf04197 NA PBac{WH}sickf04384 NA PBac{WH}sickf04819 NA PBac{WH}sickf06833 NA insertion of enhancer trap binary system Mi{ET1}sickMB04228 No Mi{ET1}sickMB04779 No Mi{ET1}sickMB06621 No P{GawB}sickNP0608 No P{GawB}sickNP7334 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
defense response to Gram-negative bacterium inferred from mutant phenotype (assigned by UniProtKB) (Foley and O'Farrell, 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR003959 (FlyBase Curators et al., 2004-) nucleoside-triphosphatase activity inferred from electronic annotation with InterPro:IPR003593 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene (Anonymous, 2005) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sick allele Gene References
External Data
Linkouts
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14436 Dana\GF14438 Dere\GG21209 Dere\GG21211 Dgri\GH13831 Dgri\GH13833 Dmoj\GI20247 Dmoj\GI20280 Dper\GL26325 Dper\GL26329 Dpse\GA12657 Dpse\GA12662 Dsec\GM17379 Dsim\GD24234 Dvir\GJ13611 Dvir\GJ13634 Dwil\GK14927 Dwil\GK14930 Dyak\GE13285
Curated drosophilid orthologs	Dpse\GA10476   Dpse\GA12657   Dpse\GA12662
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 34 )
Harvard	- P{XP}sickd00749 - P{XP}sickd03101 - P{XP}sickd07725 - P{XP}sickd09251 - PBac{RB}sicke02238 - PBac{RB}sicke03752 - PBac{WH}sickf03273 - PBac{WH}sickf04197 - PBac{WH}sickf04384
VDRC	v103986 P{KK107770}VIE-260B v104551 P{KK110037}VIE-260B v107037 P{KK103677}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR22E16 BACR48M05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 49 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT07927 IP11768 LP11437 SD07008
Other clones	FI01119 IP17012 MIP20102
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM23988 HL03015 RE45192 RH42792 RH65578 SD23088
Other clones	30407 31678 31742 55008 55078 55865 59999 74192 83172 104645 107920 214315.30 214571.32 bs39d11 bs76g03 CK01143 DMG3-chr2L.2236.pred.a DMG5-chr2L.34.003.pred.a EK113836 EK139631 EK181760 EK184210 EK216519 EK233728 EP04932 IP11667 IP11668 IP11767 IP11868 IP11967 IP11968 IP17112 IP17820 IP17920 RH09012 RP004509704
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CG10662 sick (Foley and O'Farrell, 2004)
Source for database merge of	Source for merge of: CG13959 CG13960 CG13961 (FlyBase Genome Annotators, 2004) Source for merge of: sick CG13958 (FlyBase Genome Annotators, 2012) Source for merge of: sick CG13964 (FlyBase Genome Annotators, 2009) Source for merge of: sick CG33316 (FlyBase Genome Annotators, 2007)
Additional comments	Annotations CG42589 and CG13958 merged as CG43720 in release 5.43 of the genome annotation. (FlyBase Genome Annotators, 2012) Annotations CG34343 and CG13964 merged as CG42589 in release 5.18 of the genome annotation. (FlyBase Genome Annotators, 2009) Annotations CG10662 and CG33316 merged as CG34343 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007) Annotations CG13959, CG13960 and CG13961 merged as CG33316 in release 3.2 of the genome annotation. (FlyBase Genome Annotators, 2004)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AAF53849 AAF53855 AAF53856 AAM52577 AAS64722 AAS64723 AY122065 BF505656 BI353512 BI573341 BI573342 CZ485815 Entrez Gene - A searchable database of RefSeq genes. • 35271 35277 UniProtKB/TrEMBL • Q8MR85 Q9VIQ9 Q9VIR0 Q9VIR6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ATPase, AAA+ type, core (IPR003593) Calponin homology domain (IPR001715) ATPase, AAA-type, core (IPR003959)
Linkouts
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG10662   CG13958   CG13959   CG13960 (Giot et al., 2003, ) CG13961   CG13964 (Keleman et al., 2009.8.5) CG33316   CG34343 (Cammarato et al., 2011, FlyBase Genome Annotators, 2007, Keleman et al., 2009.8.5) CG42589 (FlyBase Genome Annotators, 2009) CG43720 (FlyBase Genome Annotators, 2012) sick (Luo et al., 2011, ) sickie (Anonymous, 2005)
Name Synonym	CG13964   CG33316   sick (Cammarato et al., 2011) sickie (Foley and O'Farrell, 2004, )
Secondary FlyBase IDs
	FBgn0032825 FBgn0032826 FBgn0032828 FBgn0032830 FBgn0032831 FBgn0032832 FBgn0053316 FBgn0085372 FBgn0260966
References ( 28 )
Generate a list of	All references relating to this gene ( 28 )
List References by type	Research paper  ( 2 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 7 ) Computer file  ( 3 )
Recent research papers ( 1 )
	Luo et al., 2011, Development 138(13): 2761--2771 Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. [FBrf0213878] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...