FB2025_04 , released October 2, 2025
Gene: Dmel\esn
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General Information
Symbol
Dmel\esn
Species
D. melanogaster
Name
espinas
Annotation Symbol
CG43722
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263934
Gene Model Status
Current
Stock Availability
46 publicly available
Gene Summary
espinas (esn) encodes a LIM domain protein that binds to the seven-pass transmembrane cadherin encoded by stan. This stan-esn interplay elicits repulsion between dendritic branches of sensory neurons. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Dm_2R:11728

Key Links
Genomic Location
Cytogenetic map
42F1-42F2
Sequence location
Recombination map
2-55
RefSeq locus
NT_033778 REGION:7086316..7127868
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR010442
(InterPro Project Members, 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in dendrite self-avoidance
inferred from mutant phenotype
(Matsubara et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the prickle / espinas / testin family. (Q9U1I1)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
espinas (esn) encodes a LIM domain protein that binds to the seven-pass transmembrane cadherin encoded by stan. This stan-esn interplay elicits repulsion between dendritic branches of sensory neurons. [Date last reviewed: 2019-03-07]
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\esn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9U1I1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.48

Low-frequency RNA-Seq exon junction(s) not annotated.

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
esn-RA
FBtr0329857
NM_165507
3982
785
esn-RB
FBtr0329856
NM_080251
4292
785
esn-RC
FBtr0329858
NM_001273831
4708
1134
esn-RD
FBtr0329859
NM_001273832
3982
851
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
esn-PA
FBpp0302895
86.6
785
6.69
Q9U1I1
NP_724533
AAF59292
esn-PB
FBpp0302894
86.6
785
6.69
Q9U1I1
NP_524990
AAM68907
esn-PC
FBpp0302896
125.2
1134
8.02
A0A0B4KED7
NP_001260760
AGB93293
esn-PD
FBpp0302897
94.1
851
6.88
A0A0B4KEK5
NP_001260761
AGB93294
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

785 aa isoforms: esn-PA, esn-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\esn using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.47

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 11
external sensory organ precursor cell
(Matsubara et al., 2011)
embryonic stage 11 -- 12
clypeo-labral primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | segmentally repeated
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
labral segment
(Fisher et al., 2012)
organism | segmentally repeated
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 14
sensory neuron | subset
(Matsubara et al., 2011)
embryonic stage 17
larval ventral nerve cord | subset
(Matsubara et al., 2011)
Additional Descriptive Data

esn transcripts are detected in SOPs and in a subset of sensory neurons and neurons in the ventral nerve cord.

(Matsubara et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
external sensory organ precursor cell
(Matsubara et al., 2011)
embryonic stage 16
larval dorsal multidendritic neuron ddaE
(Matsubara et al., 2011)
larval posterior commissure | subset
(Matsubara et al., 2011)
larval longitudinal connective | lateral
(Matsubara et al., 2011)
Additional Descriptive Data

esn protein is detected in SOPs. It is detected in sensory neurons in the embryonic dorsal cluster identified as ddaE. In the ventral nerve cord, it is detected in the posterior commissure and at the lateral edge of the longitudinal connectives.

(Matsubara et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\esn in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of esn
Transgenic constructs containing regulatory region of esn
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel6283
(Ryder, 2004.4.26)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (68)
Hsap\PRICKLE2
11 of 14
Yes
Yes
Hsap\PRICKLE1
10 of 14
No
Yes
Hsap\PRICKLE3
9 of 14
No
Yes
1  
Hsap\LMCD1
4 of 14
No
No
1  
Hsap\TES
4 of 14
No
No
Hsap\FBLIM1
3 of 14
No
Yes
Hsap\FHL1
3 of 14
No
No
2  
Hsap\FHL2
3 of 14
No
No
1  
Hsap\FHL3
3 of 14
No
No
Hsap\FHL5
3 of 14
No
No
Hsap\LIMS2
3 of 14
No
No
Hsap\AJUBA
2 of 14
No
No
Hsap\LIMD1
2 of 14
No
No
7  
Hsap\LIMS1
2 of 14
No
No
Hsap\LPXN
2 of 14
No
No
1  
Hsap\PDLIM5
2 of 14
No
No
Hsap\PDLIM7
2 of 14
No
No
Hsap\PRICKLE4
2 of 14
No
No
Hsap\PXN
2 of 14
No
No
Hsap\TGFB1I1
2 of 14
No
No
Hsap\TRIP6
2 of 14
No
No
1  
Hsap\WTIP
2 of 14
No
No
1  
Hsap\ZYX
2 of 14
No
No
1  
Hsap\ABLIM1
1 of 14
No
No
Hsap\ABLIM2
1 of 14
No
No
1  
Hsap\ABLIM3
1 of 14
No
No
Hsap\CRIP1
1 of 14
No
No
Hsap\CRIP2
1 of 14
No
No
Hsap\CRIP3
1 of 14
No
No
Hsap\CSRP1
1 of 14
No
No
Hsap\CSRP2
1 of 14
No
No
Hsap\CSRP3
1 of 14
No
No
2  
Hsap\DMBX1
1 of 14
No
No
Hsap\ISL1
1 of 14
No
No
Hsap\ISL2
1 of 14
No
No
1  
Hsap\LASP1
1 of 14
No
No
Hsap\LDB3
1 of 14
No
No
1  
Hsap\LHX1
1 of 14
No
No
1  
Hsap\LHX2
1 of 14
No
No
1  
Hsap\LHX3
1 of 14
No
No
Hsap\LHX4
1 of 14
No
No
Hsap\LHX5
1 of 14
No
No
Hsap\LHX6
1 of 14
No
No
1  
Hsap\LHX8
1 of 14
No
No
Hsap\LHX9
1 of 14
No
No
1  
Hsap\LIMA1
1 of 14
No
No
1  
Hsap\LIMCH1
1 of 14
No
No
Hsap\LIMD2
1 of 14
No
No
1  
Hsap\LIMS3
1 of 14
No
No
Hsap\LIMS4
1 of 14
No
No
Hsap\LMO7
1 of 14
No
Yes
Hsap\LMX1A
1 of 14
No
No
Hsap\LMX1B
1 of 14
No
No
Hsap\LPP
1 of 14
No
No
1  
Hsap\MICAL1
1 of 14
No
No
1  
Hsap\MICALL2
1 of 14
No
No
Hsap\PDLIM1
1 of 14
No
No
Hsap\PDLIM4
1 of 14
No
No
Hsap\SCEL
1 of 14
No
Yes
Hsap\ZFHX2
1 of 14
No
No
1  
Hsap\ZFHX3
1 of 14
No
No
1  
Hsap\ZFHX4
1 of 14
No
No
Hsap\ZNF93
1 of 14
No
No
Hsap\ZNF185
1 of 14
No
Yes
Hsap\ZNF347
1 of 14
No
No
Hsap\ZNF432
1 of 14
No
No
Hsap\ZNF534
1 of 14
No
No
Hsap\ZNF888
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (40)
Rnor\Prickle2
11 of 14
Yes
Yes
Rnor\Prickle1
10 of 14
No
Yes
Rnor\Prickle3
8 of 14
No
Yes
Rnor\Lmcd1
4 of 14
No
No
Rnor\Tesl
4 of 14
No
No
Rnor\Fblim1
3 of 14
No
No
Rnor\Fhl1
3 of 14
No
No
Rnor\Fhl2
3 of 14
No
No
Rnor\Fhl3
3 of 14
No
No
Rnor\Fhl5
3 of 14
No
No
Rnor\Lims1
3 of 14
No
No
Rnor\RGD1566184
3 of 14
No
No
Rnor\Tes
3 of 14
No
No
Rnor\Fhl4
2 of 14
No
No
Rnor\Limd1
2 of 14
No
No
Rnor\Lims2
2 of 14
No
No
Rnor\Lpp
2 of 14
No
No
Rnor\Lpxn
2 of 14
No
No
Rnor\Pdlim5
2 of 14
No
No
Rnor\Pdlim7
2 of 14
No
No
Rnor\Pxn
2 of 14
No
No
Rnor\RGD1566387
2 of 14
No
No
Rnor\Tgfb1i1
2 of 14
No
No
Rnor\Trip6
2 of 14
No
No
Rnor\Zyx
2 of 14
No
No
Rnor\Ablim2
1 of 14
No
No
Rnor\Ablim3
1 of 14
No
No
Rnor\Ajuba
1 of 14
No
No
Rnor\Csrp1
1 of 14
No
No
Rnor\Csrp2
1 of 14
No
No
Rnor\Csrp3
1 of 14
No
No
Rnor\Ldb3
1 of 14
No
No
Rnor\Limch1
1 of 14
No
No
Rnor\Lmx1a
1 of 14
No
No
Rnor\Lmx1b
1 of 14
No
No
Rnor\Pdlim1
1 of 14
No
No
Rnor\Pdlim4
1 of 14
No
No
Rnor\Prickle4
1 of 14
No
No
Rnor\Scel
1 of 14
No
Yes
Rnor\Wtip
1 of 14
No
No
Mus musculus (laboratory mouse) (42)
Mmus\Prickle1
10 of 14
Yes
Yes
Mmus\Prickle2
10 of 14
Yes
Yes
Mmus\Prickle3
8 of 14
No
Yes
Mmus\Lmcd1
4 of 14
No
No
Mmus\Tesl1
4 of 14
No
No
Mmus\Tes
4 of 14
No
No
Mmus\Fblim1
3 of 14
No
Yes
Mmus\Fhl1
3 of 14
No
No
Mmus\Fhl2
3 of 14
No
No
Mmus\Fhl3
3 of 14
No
No
Mmus\Fhl4
3 of 14
No
No
Mmus\Fhl5
3 of 14
No
No
Mmus\Lims1
3 of 14
No
No
Mmus\Limd1
2 of 14
No
No
Mmus\Lims2
2 of 14
No
No
Mmus\Lpp
2 of 14
No
No
Mmus\Lpxn
2 of 14
No
No
Mmus\Pdlim5
2 of 14
No
No
Mmus\Pdlim7
2 of 14
No
No
Mmus\Prickle4
2 of 14
No
No
Mmus\Pxn
2 of 14
No
No
Mmus\Tesl2
2 of 14
No
No
Mmus\Tgfb1i1
2 of 14
No
No
Mmus\Trip6
2 of 14
No
No
Mmus\Wtip
2 of 14
No
No
Mmus\Zyx
2 of 14
No
No
Mmus\Ablim1
1 of 14
No
No
Mmus\Ablim2
1 of 14
No
No
Mmus\Ablim3
1 of 14
No
No
Mmus\Ajuba
1 of 14
No
No
Mmus\Csrp1
1 of 14
No
No
Mmus\Csrp2
1 of 14
No
No
Mmus\Csrp3
1 of 14
No
No
Mmus\Ldb3
1 of 14
No
No
Mmus\Limch1
1 of 14
No
No
Mmus\Lmo7
1 of 14
No
Yes
Mmus\Lmx1a
1 of 14
No
No
Mmus\Pdlim1
1 of 14
No
No
Mmus\Pdlim3
1 of 14
No
No
Mmus\Pdlim4
1 of 14
No
No
Mmus\Scel
1 of 14
No
Yes
Mmus\Zfp185
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (45)
Xtro\prickle1
8 of 13
Yes
Yes
Xtro\prickle2
7 of 13
No
Yes
Xtro\prickle3
5 of 13
No
Yes
Xtro\prickle4
4 of 13
No
Yes
Xtro\tes
3 of 13
No
No
Xtro\fhl2
2 of 13
No
No
Xtro\fhl3
2 of 13
No
No
Xtro\fhl5
2 of 13
No
No
Xtro\lmcd1
2 of 13
No
No
Xtro\pdlim5
2 of 13
No
No
Xtro\pxn
2 of 13
No
No
Xtro\ablim2
1 of 13
No
No
Xtro\atxn7l1
1 of 13
No
No
Xtro\crybb2
1 of 13
No
No
Xtro\csrp3
1 of 13
No
No
Xtro\fblim1
1 of 13
No
Yes
Xtro\fhl1
1 of 13
No
No
Xtro\isl2
1 of 13
No
No
Xtro\lasp1
1 of 13
No
No
Xtro\ldb3
1 of 13
No
No
Xtro\lhx1
1 of 13
No
No
Xtro\lhx5
1 of 13
No
No
Xtro\lhx6
1 of 13
No
No
Xtro\lhx8
1 of 13
No
No
Xtro\lhx9
1 of 13
No
No
Xtro\lima1
1 of 13
No
Yes
Xtro\limd1
1 of 13
No
No
Xtro\lims1
1 of 13
No
No
Xtro\lmo4.2
1 of 13
No
No
Xtro\lmx1a
1 of 13
No
No
Xtro\lmx1b.1
1 of 13
No
No
Xtro\lmx1b.2
1 of 13
No
No
Xtro\lpp
1 of 13
No
No
Xtro\marf1
1 of 13
No
No
Xtro\mical3
1 of 13
No
No
Xtro\micall1
1 of 13
No
No
Xtro\nobox
1 of 13
No
No
Xtro\pdlim1
1 of 13
No
No
Xtro\pdlim7
1 of 13
No
No
Xtro\sap130
1 of 13
No
No
Xtro\tgfb1i1
1 of 13
No
No
Xtro\tmem204
1 of 13
No
Yes
Xtro\zfhx3
1 of 13
No
No
Xtro\zfhx4
1 of 13
No
No
Xtro\zyx
1 of 13
No
No
Danio rerio (Zebrafish) (39)
Drer\prickle2a
11 of 14
Yes
Yes
Drer\prickle1a
10 of 14
No
Yes
Drer\prickle1b
10 of 14
No
Yes
Drer\prickle2b
10 of 14
No
Yes
Drer\prickle3
8 of 14
No
Yes
Drer\lmcd1
4 of 14
No
No
Drer\tes
4 of 14
No
No
Drer\fblim1
3 of 14
No
Yes
Drer\fhl1a
3 of 14
No
No
Drer\fhl1b
3 of 14
No
No
Drer\fhl2a
3 of 14
No
No
Drer\fhl3a
3 of 14
No
No
Drer\fhl5
3 of 14
No
No
Drer\lims1
3 of 14
No
No
Drer\lims2
3 of 14
No
No
Drer\ajuba
2 of 14
No
No
Drer\fhl2b
2 of 14
No
No
Drer\fhl3b
2 of 14
No
No
Drer\lpp
2 of 14
No
No
Drer\lpxn
2 of 14
No
No
Drer\pdlim5a
2 of 14
No
No
Drer\pdlim5b
2 of 14
No
No
Drer\pdlim7
2 of 14
No
No
Drer\pxna
2 of 14
No
No
Drer\pxnb
2 of 14
No
No
Drer\zyx
2 of 14
No
No
Drer\ablim2
1 of 14
No
No
Drer\ldb3a
1 of 14
No
No
Drer\lmo7a
1 of 14
No
Yes
Drer\lmo7b
1 of 14
No
Yes
Drer\lmx1ba
1 of 14
No
No
Drer\lmx1bb
1 of 14
No
No
Drer\LOC110438489
1 of 14
No
Yes
Drer\pdlim1
1 of 14
No
No
Drer\pdlim2
1 of 14
No
No
Drer\pdlim3a
1 of 14
No
No
Drer\pdlim3b
1 of 14
No
No
Drer\scel
1 of 14
No
Yes
Drer\wtip
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (26)
Cele\prkl-1
9 of 14
Yes
Yes
Cele\tes-1
5 of 14
No
No
Cele\lim-9
3 of 14
No
No
Cele\unc-97
3 of 14
No
No
Cele\pxl-1
2 of 14
No
No
Cele\alp-1
1 of 14
No
No
Cele\C26C6.6
1 of 14
No
No
Cele\C34B2.4
1 of 14
No
No
Cele\ceh-14
1 of 14
No
No
Cele\exc-9
1 of 14
No
No
Cele\F33D11.1
1 of 14
No
No
Cele\lim-4
1 of 14
No
No
Cele\lim-6
1 of 14
No
No
Cele\lim-7
1 of 14
No
No
Cele\lin-11
1 of 14
No
No
Cele\mec-3
1 of 14
No
No
Cele\mlp-1
1 of 14
No
No
Cele\pin-2
1 of 14
No
No
Cele\pqn-22
1 of 14
No
Yes
Cele\tag-273
1 of 14
No
No
Cele\ttx-3
1 of 14
No
No
Cele\unc-62
1 of 14
No
No
Cele\valv-1
1 of 14
No
No
Cele\Y1A5A.1
1 of 14
No
No
Cele\Y65B4A.7
1 of 14
No
No
Cele\zyx-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (25)
Agam\PRIC1_ANOGA
10 of 12
Yes
Yes
Agam\AgaP_AGAP011136
4 of 12
No
No
Agam\AgaP_AGAP012744
3 of 12
No
No
Agam\AgaP_AGAP000755
2 of 12
No
No
Agam\AgaP_AGAP003429
2 of 12
No
No
Agam\AgaP_AGAP004548
2 of 12
No
No
Agam\AgaP_AGAP005398
2 of 12
No
No
Agam\AgaP_AGAP005400
2 of 12
No
No
Agam\AgaP_AGAP008532
2 of 12
No
No
Agam\AgaP_AGAP009503
2 of 12
No
No
Agam\AgaP_AGAP000149
1 of 12
No
No
Agam\AgaP_AGAP000222
1 of 12
No
No
Agam\AgaP_AGAP005138
1 of 12
No
No
Agam\AgaP_AGAP005425
1 of 12
No
No
Agam\AgaP_AGAP006536
1 of 12
No
No
Agam\AgaP_AGAP006537
1 of 12
No
No
Agam\AgaP_AGAP006540
1 of 12
No
No
Agam\AgaP_AGAP006901
1 of 12
No
No
Agam\AgaP_AGAP008979
1 of 12
No
No
Agam\AgaP_AGAP008980
1 of 12
No
No
Agam\AgaP_AGAP009088
1 of 12
No
No
Agam\AgaP_AGAP010209
1 of 12
No
No
Agam\AgaP_AGAP010391
1 of 12
No
No
Agam\AgaP_AGAP011134
1 of 12
No
No
Agam\AgaP_AGAP012305
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (15)
Atha\AT4G36860
1 of 13
Yes
No
Atha\ATHB13
1 of 13
Yes
No
Atha\DA1
1 of 13
Yes
No
Atha\DAR2
1 of 13
Yes
No
Atha\DAR3
1 of 13
Yes
No
Atha\DAR5
1 of 13
Yes
No
Atha\DAR6
1 of 13
Yes
No
Atha\DAR7
1 of 13
Yes
No
Atha\HB21
1 of 13
Yes
No
Atha\PLIM2a
1 of 13
Yes
No
Atha\PLIM2b
1 of 13
Yes
No
Atha\PLIM2c
1 of 13
Yes
No
Atha\WLIM1
1 of 13
Yes
No
Atha\WLIM2a
1 of 13
Yes
No
Atha\WLIM2b
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\LRG1
1 of 13
Yes
No
Scer\RGA1
1 of 13
Yes
No
Scer\RGA2
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\pxl1
3 of 12
Yes
No
Spom\rga1
1 of 12
No
No
Spom\rga3
1 of 12
No
No
Spom\rga4
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:esn. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (29)
pk
11 of 13
Tes
5 of 13
Pax
3 of 13
stck
3 of 13
CG30178
2 of 13
CG31624
2 of 13
CG34325
2 of 13
jub
2 of 13
Zyx
2 of 13
ap
1 of 13
Awh
1 of 13
CG4328
1 of 13
CG5708
1 of 13
CG31988
1 of 13
CG33521
1 of 13
Lim1
1 of 13
Lim3
1 of 13
LIMK1
1 of 13
Lmx1a
1 of 13
MICAL-like
1 of 13
Mical
1 of 13
Mlp60A
1 of 13
Mlp84B
1 of 13
Rassf
1 of 13
smash
1 of 13
tup
1 of 13
Unc-115a
1 of 13
Unc-115b
1 of 13
Zasp52
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PRICKLE2; prickle planar cell polarity protein 2
    11 of 14
    608501
        PRICKLE1; prickle planar cell polarity protein 1
        10 of 14
        608500
        PRICKLE3; prickle planar cell polarity protein 3
        9 of 14
        PRICKLE PLANAR CELL POLARITY PROTEIN 3; PRICKLE3
           
          LMCD1; LIM and cysteine rich domains 1
          4 of 14
          604859
               
              TES; testin LIM domain protein
              4 of 14
              606085
                  FBLIM1; filamin binding LIM protein 1
                  3 of 14
                  607747
                      FHL1; four and a half LIM domains 1
                      3 of 14
                      FOUR-AND-A-HALF LIM DOMAINS 1; FHL1
                       
                      FHL2; four and a half LIM domains 2
                      3 of 14
                      602633
                           
                          FHL3; four and a half LIM domains 3
                          3 of 14
                          602790
                              FHL5; four and a half LIM domains 5
                              3 of 14
                              605126
                                  LIMS2; LIM zinc finger domain containing 2
                                  3 of 14
                                  607908
                                  Functional Complementation Data
                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                  Interactions
                                  Summary of Physical Interactions
                                  Interaction Browsers
                                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                                  Please see the Physical Interaction reports below for full details
                                  protein-protein
                                  Physical Interaction
                                  Assay
                                  References
                                  esn - stan
                                  two hybrid, anti tag coimmunoprecipitation, anti tag western blot
                                  (Matsubara et al., 2011)
                                  Summary of Genetic Interactions
                                  Interaction Browsers
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  External Data
                                  Linkouts
                                  DroID - A comprehensive database of gene and protein interactions.
                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                  Pathways
                                  Signaling Pathways (FlyBase)
                                  Metabolic Pathways
                                  FlyBase
                                  External Links
                                  External Data
                                  Linkouts
                                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                  Class of Gene
                                  Genomic Location and Detailed Mapping Data
                                  Chromosome (arm)
                                  2R
                                  Recombination map
                                  2-55
                                  Cytogenetic map
                                  42F1-42F2
                                  Sequence location
                                  FlyBase Computed Cytological Location
                                  Cytogenetic map
                                  Evidence for location
                                  42F1-42F2
                                  Limits computationally determined from genome sequence between P{lacW}vimark16722 and P{lacW}cosk16101
                                  Experimentally Determined Cytological Location
                                  Cytogenetic map
                                  Notes
                                  References
                                  esn maps just proximal to the 43A1.2 Serpin cluster.
                                  (Gubb et al., 1999)
                                  43A1-43A2
                                  (Green, 1999.12.22)
                                  Experimentally Determined Recombination Data
                                  Location

                                  2-55

                                  (FlyBase, 2016)

                                  2-56.3

                                  (Comeron et al., 2012)

                                  2-

                                  (Gubb et al., 1999)
                                  Left of (cM)
                                  Right of (cM)
                                  Notes
                                  Stocks and Reagents
                                  Stocks (46)
                                  Genomic Clones (31)
                                  cDNA Clones (9)
                                   

                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                  cDNA clones, fully sequenced
                                  BDGP DGC clones
                                  Other clones
                                  Drosophila Genomics Resource Center cDNA clones

                                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                  cDNA Clones, End Sequenced (ESTs)
                                  BDGP DGC clones
                                    Other clones
                                    RNAi and Array Information
                                    Linkouts
                                    Antibody Information
                                    Laboratory Generated Antibodies
                                     

                                    polyclonal

                                    (Matsubara et al., 2011)
                                    Commercially Available Antibodies
                                     
                                    Cell Line Information
                                    Publicly Available Cell Lines
                                     
                                      Other Stable Cell Lines
                                       
                                        Other Comments
                                        Relationship to Other Genes
                                        Source for database merge of

                                        Source for merge of: esn CG12835

                                        (FlyBase Genome Annotators, 2012)

                                        Source for merge of: espinas CG12833

                                        (Bayraktaroglu, 2000.8.7)
                                        Additional comments

                                        Annotations CG12833 and CG12835 merged as CG43722 in release 5.44 of the genome annotation. Merge supported by RNA-Seq, exon junction and cDNA data.

                                        (FlyBase Genome Annotators, 2012)
                                        Nomenclature History
                                        Source for database identify of
                                        Nomenclature comments
                                        Etymology
                                        Synonyms and Secondary IDs (8)
                                        Datasets (0)
                                        Study focus (0)
                                        Experimental Role
                                        Project
                                        Project Type
                                        Title
                                        Study result (0)
                                        Result
                                        Result Type
                                        Title
                                        External Crossreferences and Linkouts ( 63 )
                                        Sequence Crossreferences
                                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                        Other crossreferences
                                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                        InterPro - A database of protein families, domains and functional sites
                                        KEGG Genes - Molecular building blocks of life in the genomic space.
                                        MARRVEL_MODEL - MARRVEL (model organism gene)
                                        Linkouts
                                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                        DroID - A comprehensive database of gene and protein interactions.
                                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                        MIST (protein-protein) - An integrated Molecular Interaction Database
                                        References (59)