FB2022_02, released March 29, 2022

Gene: Dmel\jv

Open Close
General Information
Symbol
Dmel\jv
Species
D. melanogaster
Name
javelin
Annotation Symbol
CG32397
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263973
Gene Model Status
Current
Stock Availability
82 publicly available
Gene Summary
javelin (jv) encodes an actin associated protein with roles in actin organization during bristle growth. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
65A5-65E1
Sequence location
Recombination map
3-17
RefSeq locus
NT_037436 REGION:6563197..6589479
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in chaeta morphogenesis
inferred from mutant phenotype
(Shapira et al., 2011)
involved_in parallel actin filament bundle assembly
inferred from mutant phenotype
(Shapira et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
colocalizes_with actin filament bundle
inferred from direct assay
(Shapira et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Snapshot
    javelin (jv) encodes an actin associated protein with roles in actin organization during bristle growth. [Date last reviewed: 2019-03-07]
    Protein Function (UniProtKB)
    Important for normal assembly of actin bundles during bristle formation.
    (UniProt, M9NE38)
    Phenotypic Description (Red Book; Lindsley and Zimm 1992)
    jv: javelin
    All bristles and hairs cylindrical, instead of tapered, with small enlargement before tip. Cell autonomous and useful as a marker for epidermal clones (Morata and Ripoll, 1975, Dev. Biol. 42: 211-21). RK2.
    Gene Model and Products
    Number of Transcripts
    3
    Number of Unique Polypeptides
    2

    Please see the JBrowse view of Dmel\jv for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure New Section
    Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9NE38)

    If you don't see the viewer to the right, refresh your browser.
    Model Confidence:
    • Very high (pLDDT > 90)
    • Confident (90 > pLDDT > 70)
    • Low (70 > pLDDT > 50)
    • Very low (pLDDT < 50)

    AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

    Comments on Gene Model

    Gene model reviewed during 5.46

    Sequence Ontology: Class of Gene
    gene
    nuclear_gene
    protein_coding_gene
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    jv-RB
    FBtr0307512
    NM_168171
    6142
    1892
    jv-RC
    FBtr0307513
    NM_001259719
    6376
    1892
    jv-RD
    FBtr0307514
    NM_001259720
    6202
    1912
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    RefSeq ID
    GenBank
    jv-PB
    FBpp0300167
    212.5
    1892
    6.14
    NP_729175
    AAN12084
    jv-PC
    FBpp0300168
    212.5
    1892
    6.14
    NP_001246648
    AFH04319
    jv-PD
    FBpp0300169
    215.0
    1912
    6.36
    NP_001246649
    AFH04320
    Polypeptides with Identical Sequences

    The group(s) of polypeptides indicated below share identical sequence to each other.

    1892 aa isoforms: jv-PB, jv-PC
    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jv using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    mass spectroscopy
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    day 5 of adulthood & male -- day 7 of adulthood & male
    spermatozoon
    (Wasbrough et al., 2010)
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    colocalizes_with actin filament bundle
    inferred from direct assay
    (Shapira et al., 2011)
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\jv in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Images
    FlyBase Wiki
    Image Based Resources
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 9 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 8 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of jv
    Transgenic constructs containing regulatory region of jv
    Aberrations (Deficiencies and Duplications) ( 3 )
    Inferred from experimentation ( 3 )
    Gene not disrupted in
    Df(3L)h-i22
    (Ingham et al., 1985)
    Tp(3;3)hM3
    (Ingham et al., 1985)
    Gene duplicated in
    Dp(3;4)h+44
    (Ingham et al., 1985)
    Inferred from location ( 0 )
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (0)
    No records found.
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (0)
    No records found.
    Rattus norvegicus (Norway rat) (0)
    No records found.
    Xenopus tropicalis (Western clawed frog) (0)
    No records found.
    Danio rerio (Zebrafish) (0)
    No records found.
    Caenorhabditis elegans (Nematode, roundworm) (0)
    No records found.
    Arabidopsis thaliana (thale-cress) (0)
    No records found.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No records found.
    Other Organism Orthologs (via OrthoDB)
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (0)
    No records found.
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      f|jv
      enhanceable
      sn
      (Krishnan et al., 2021)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      f
      enhanceable
      jv
      (Krishnan et al., 2021)
      f
      suppressible
      jv
      (Krishnan et al., 2021)
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map
      3-17
      Cytogenetic map
      65A5-65E1
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      65A5-65E1
      Left limit from recombination mapping relative to Lcp65Ab2 (FBrf0044447) Right limit from inclusion within Df(3L)Vn (citation unavailable)
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-17

      (FlyBase, 2016)

      3-15.1

      (Comeron et al., 2012)

      3-19.2

      (Buzzati-Traverso, 1947)
      Left of (cM)
      (Ohnishi and Voelker, 1982)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (82)
      Genomic Clones (32)
      cDNA Clones (3)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for database merge of

                Source for merge of: CG32397 anon-WO0138581.6

                (FlyBase, 1996-)

                Source for merge of: jv CG32397

                (Shapira et al., 2011)
                Additional comments

                Source for merge of CG32397 anon-WO0138581.6 was sequence comparison ( date:051113 ).

                (FlyBase, 1996-)
                Other Comments

                New annotation (CG32397) in release 3 of the genome annotation.

                (FlyBase Genome Annotators, 2002-2003)

                Definitive denticle belt phenotypes (abnormal hairs and/or bristles) are foreshadowed by abnormal organisation of the actin cytoskeleton in embryonic epidermal cells.

                (Dickinson and Thatcher, 1997)

                Mutant alleles are useful as markers in clonal analysis.

                (Lawrence et al., 1986)
                Origin and Etymology
                Discoverer

                Mohr, 29th Oct. 1931.

                Etymology
                Identification
                External Crossreferences and Linkouts ( 25 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Synonyms and Secondary IDs (4)
                Datasets (7)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (7)
                Result
                Result Type
                Title
                scRNAseq_2020_Cattenoz_NI_seq_clustering
                Clustering analysis of hemocytes from non-infested third instar larvae
                scRNAseq_2020_Cattenoz_WI_seq_clustering
                Clustering analysis of hemocytes from wasp-infested third instar larvae
                scRNAseq_2020_Cho_NI72LG_seq_clustering
                Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
                scRNAseq_2020_Cho_NI96LG_seq_clustering
                Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
                scRNAseq_2020_Cho_NI120LG_seq_clustering
                Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
                scRNAseq_2020_Cho_WI96LG_seq_clustering
                Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
                scRNAseq_2020_Cho_NI120HL_seq_clustering
                Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
                References (47)