FB2020_06, released Dec 22, 2020

Gene: Dmel\MsR2

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General Information
Symbol
Dmel\MsR2
Species
D. melanogaster
Name
Myosuppressin receptor 2
Annotation Symbol
CG43745
Feature Type
protein_coding_gene
FlyBase ID
FBgn0264002
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Snapshot
Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

DmsR-2, Dromyosuppressin receptor 2

Key Links
Genomic Location
Cytogenetic map
62D5-62D5
Sequence location
3L:2,282,883..2,300,944 [+]
Recombination map

3-2

RefSeq locus
NT_037436 REGION:2282883..2300944
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables myosuppressin receptor activity
inferred from direct assay
(Johnson et al., 2003)
inferred from physical interaction with FLYBASE:Ms; FB:FBgn0011581
(Egerod et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables G protein-coupled receptor activity
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
enables neuropeptide receptor activity
inferred from sequence model
(Hewes and Taghert, 2001)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
inferred from direct assay
(Johnson et al., 2003)
involved_in adult locomotory behavior
inferred from mutant phenotype
(Kiss et al., 2013)
involved_in behavioral defense response
inferred from mutant phenotype
(Klose et al., 2010)
involved_in larval locomotory behavior
inferred from mutant phenotype
(Klose et al., 2010)
involved_in neuropeptide signaling pathway
inferred from direct assay
(Egerod et al., 2003, Johnson et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in G protein-coupled receptor signaling pathway
inferred from sequence model
(Hewes and Taghert, 2001)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(Johnson et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence model
(Hewes and Taghert, 2001)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -
The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\MsR2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Stop-codon suppression (UAG) postulated; FBrf0216884.

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.45

Gene model reviewed during 5.44

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
MsR2-RA
FBtr0330358
NM_139454
2592
488
MsR2-RB
FBtr0330359
NM_167945
2918
488
MsR2-RC
FBtr0330360
NM_001274394
2918
647
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
MsR2-PA
FBpp0303390
54.6
488
9.21
NP_647711
AAF47633
MsR2-PB
FBpp0303391
54.6
488
9.21
NP_728735
AAN12219
MsR2-PC
FBpp0303392
71.3
647
8.72
NP_001261323
AGB94018
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

488 aa isoforms: MsR2-PA, MsR2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MsR2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16 -- 17
VUM4 interneuron
(Fontana and Crews, 2012)
VUM6 interneuron
(Fontana and Crews, 2012)
RNA-seq
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
ventral midline of embryo
(Fontana and Crews, 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
crop
(Veenstra et al., 2008)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(Johnson et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\MsR2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of MsR2
Transgenic constructs containing regulatory region of MsR2
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act5C.PU
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Act5C.PU
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GPR139
2 of 15
Yes
No
Hsap\GPR142
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gpr139
1 of 15
Yes
No
Mmus\Gpr142
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (1)
Rnor\Gpr139
2 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (1)
Xtro\gpr139
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (3)
Drer\gper1
1 of 15
Yes
Yes
Drer\gpr139
1 of 15
Yes
Yes
Drer\gpr142
1 of 15
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (39)
Cele\dmsr-1
11 of 15
Yes
Yes
Cele\dmsr-7
8 of 15
No
No
Cele\dmsr-8
8 of 15
No
Yes
Cele\dmsr-4
7 of 15
No
Yes
Cele\dmsr-5
6 of 15
No
Yes
Cele\dmsr-6
6 of 15
No
Yes
Cele\dmsr-2
4 of 15
No
Yes
Cele\dmsr-3
3 of 15
No
Yes
Cele\dmsr-9
3 of 15
No
No
Cele\dmsr-11
3 of 15
No
No
Cele\dmsr-13
3 of 15
No
No
Cele\dmsr-14
3 of 15
No
Yes
Cele\dmsr-15
3 of 15
No
Yes
Cele\dmsr-16
3 of 15
No
Yes
Cele\dmsr-10
2 of 15
No
No
Cele\dmsr-12
2 of 15
No
No
Cele\egl-6
2 of 15
No
Yes
Cele\M03F8.7
1 of 15
No
Yes
Cele\srw-13
1 of 15
No
Yes
Cele\srw-15
1 of 15
No
Yes
Cele\srw-23
1 of 15
No
Yes
Cele\srw-30
1 of 15
No
Yes
Cele\srw-34
1 of 15
No
Yes
Cele\srw-36
1 of 15
No
Yes
Cele\srw-39
1 of 15
No
Yes
Cele\srw-40
1 of 15
No
Yes
Cele\srw-72
1 of 15
No
Yes
Cele\srw-76
1 of 15
No
Yes
Cele\srw-79
1 of 15
No
Yes
Cele\srw-84
1 of 15
No
Yes
Cele\srw-107
1 of 15
No
Yes
Cele\srw-111
1 of 15
No
Yes
Cele\srw-118
1 of 15
No
Yes
Cele\srw-119
1 of 15
No
Yes
Cele\srw-120
1 of 15
No
Yes
Cele\srw-123
1 of 15
No
Yes
Cele\srw-124
1 of 15
No
Yes
Cele\srw-143
1 of 15
No
Yes
Cele\srw-144
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919087C )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004401
Drosophila simulans
Dsim\GD13679
Drosophila sechellia
Dsec\GM14482
Drosophila erecta
Dere\GG14856
Drosophila yakuba
Dyak\GE20313
Drosophila ananassae
Dana\GF24912
Drosophila pseudoobscura pseudoobscura
Dpse\GA12540
Drosophila persimilis
Dper\GL24647
Drosophila willistoni
Dwil\GK12635
Drosophila virilis
Dvir\GJ13425
Drosophila mojavensis
Dmoj\GI12147
Drosophila grimshawi
Dgri\GH16474
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504M1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018359
Musca domestica
House fly
Mdoa\17018357
Glossina morsitans
Tsetse fly
Gmor\GMOY009670
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08864
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08866
Mayetiola destructor
Hessian fly
Mdes\Mdes004325
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRDMS
Anopheles gambiae
Malaria mosquito
Agam\AGAP005229
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000143
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W062N )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004085
Bombyx mori
Silkmoth
Bmor\BGIBMGA004034
Bombyx mori
Silkmoth
Bmor\Bmo.12511
Bombyx mori
Silkmoth
Bmor\BGIBMGA006544
Danaus plexippus
Monarch butterfly
Dple\DPOGS203055-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203056-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211778-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210158-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210161-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015599
Heliconius melpomene
Postman butterfly
Hmel\HMEL016140
Heliconius melpomene
Postman butterfly
Hmel\HMEL007085
Heliconius melpomene
Postman butterfly
Hmel\HMEL013428
Heliconius melpomene
Postman butterfly
Hmel\HMEL007089
Heliconius melpomene
Postman butterfly
Hmel\HMEL004904
Apis florea
Little honeybee
Aflo\3225465252
Apis florea
Little honeybee
Aflo\2368864388
Apis mellifera
Western honey bee
Amel\GB51670
Apis mellifera
Western honey bee
Amel\GB46789
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18814
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23268
Bombus terrestris
Buff-tailed bumblebee
Bter\15208783
Bombus terrestris
Buff-tailed bumblebee
Bter\15216624
Linepithema humile
Argentine ant
Lhum\LH19910
Linepithema humile
Argentine ant
Lhum\LH22031
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00089c
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002713
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013146
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018571
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05276
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05889
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04370
Tribolium castaneum
Red flour beetle
Tcas\TC031448
Tribolium castaneum
Red flour beetle
Tcas\TC033607
Tribolium castaneum
Red flour beetle
Tcas\TC031190
Pediculus humanus
Human body louse
Phum\PHUM054050
Pediculus humanus
Human body louse
Phum\PHUM309270
Cimex lectularius
Bed bug
Clec\CLEC003854
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002393
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI41803
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02163
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18458
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X072X )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008736
Strigamia maritima
European centipede
Smar\SMAR001494
Ixodes scapularis
Black-legged tick
Isca\ISCW004636
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68983.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80370.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66938.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66935.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur35g01370
Tetranychus urticae
Two-spotted spider mite
Turt\tetur38g00540
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44675
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
MsR1
7 of 10
CG13229
4 of 10
CG15614
1 of 10
CG33639
1 of 10
CNMaR
1 of 10
FMRFaR
1 of 10
Proc-R
1 of 10
SPR
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map

    3-2

    Cytogenetic map
    62D5-62D5
    Sequence location
    3L:2,282,883..2,300,944 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    62D5-62D5
    Limits computationally determined from genome sequence between P{PZ}slsrL182 and P{PZ}Spn06911
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-2

    (FlyBase, 2016)

    3-4.3

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (10)
    Genomic Clones (27)
    cDNA Clones (8)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: DmsR-2 CG13803

      (Egerod et al., 2003)

      Source for identity of: MsR2 DmsR-2

      (FlyBase, 2009-)
      Source for database merge of

      Source for merge of: DmsR-2 anon-WO0170980.160 anon-WO0170980.161

      (FlyBase, 1996-)
      Additional comments

      FlyBase curator comment: Renamed from 'DmsR-2/Dromyosuppressin receptor 2' to 'MsR2/Myosuppressin receptor 2' to remove the unnecessary reference to 'Drosophila' and comply with FlyBase nomenclature rules.

      (FlyBase, 2009-)

      Source for merge of DmsR-2 anon-WO0170980.160 anon-WO0170980.161 was sequence comparison ( date:051113 ).

      (FlyBase, 1996-)
      Other Comments
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 30 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Synonyms and Secondary IDs (15)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (57)