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Gene Dmel\dysc

General Information
Symbol	Dmel\dysc	Species	D. melanogaster
Name	dyschronic	Annotation symbol	CG43749
Feature type	protein_coding_gene	FlyBase ID	FBgn0264006
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	CG34400, CG32132
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	70C5-70C5	Sequence location	3L:13,860,914..13,896,336 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dyschronic is referred to in FlyBase by the symbol Dmel\dysc (CG43749, FBgn0264006). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: positive regulation of ion transmembrane transporter activity; photoreceptor cell axon guidance; locomotor rhythm; muscle cell homeostasis; rhabdomere development. 21 alleles are reported. No phenotypic data is available. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: PDZ domain. Gene sequence location is 3L:13860914..13896336.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 70C5-70C5   Limits computationally determined from genome sequence between P{lacW}l(3)L5212L5212&P{PZ}l(3)0587105871 and P{EP}EP3561EP3561
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dysc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene merge based on EST/cDNA data Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Gene merge based on stop codon readthrough data. Stop-codon suppression (UAA) postulated; FBrf0216884. gene_with_stop_codon_read_through ; SO:0000697 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dysc-RC FBtr0330414  NM_140411   9453   990 dysc-RD FBtr0330415  NM_001104133   9075   864 dysc-RE FBtr0330417  NM_001144475   9081   866 dysc-RF FBtr0330416  NM_001144474   3942   689 dysc-RG FBtr0330418  NM_001274881   9453   1254 dysc-RH FBtr0330419  NM_001274882   9528   1015 dysc-RI FBtr0330420  NM_001274883   9441   986 dysc-RJ FBtr0333021  NM_001274884   9429   982
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dysc-PC   FBpp0303440   106.9   990   8.69     NP_648668   AAF49791 dysc-PD   FBpp0303441   93.1   864   8.29     NP_001097603   ABW08538 dysc-PE   FBpp0303443   93.4   866   8.13     NP_001137947   ACL83302 dysc-PF   FBpp0303442   74.0   689   8.89     NP_001137946   ACL83301 dysc-PG   FBpp0303444   138.1   1254   8.88     NP_001261810   AGB94503 dysc-PH   FBpp0303445   109.7   1015   9.10     NP_001261811   AGB94504 dysc-PI   FBpp0303446   106.4   986   9.01     NP_001261812   AGB94505 dysc-PJ   FBpp0305235   105.9   982   8.99     NP_001261813   AGB94506
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • PDZ domain (IPR001478)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49791   AE014296 ABW08538   AE014296 ACL83301   AE014296 ACL83302   AE014296 AGB94503   AE014296 AGB94504   AE014296 AGB94505   AE014296 AGB94506   BI375038   BI375051   BI564871   BI574490   BI574509   BI606079   BI613453   BI614747   BI614752   BI619094   BI626608   BP543963   BT001827   BT022942   BT025190   BT030199   BT083380   BT149844   CK135120   CO262524   CO264811   CO269408   CO273675   CO280753   CO281553   CO282788   CO314242   CO314295   CO318330   CO319755   CO320736   CO324418   CO327616   CO343788   CO343845   CZ468840   EC061244   EC073336   EC079745   EC084223   EC084893   EC086251   EC197298   EC204291   EC215129   EC222513   EC235252   EC242371   EC244308   EC250374   EC250601   EC252501   EC257654   EC258116   EC258509   EL873155   EL878748   EL878839   EL881001   EL886939   EL887003   EL887125
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	B7Z048 A8JNS6 Q8IQK7 Q9VU98 B7Z049
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   adult brain | restricted   • neuron projection (Jepson et al., 2012) adult mushroom body   • neuron projection (Jepson et al., 2012) ellipsoid body   • neuron projection (Jepson et al., 2012) adult antennal lobe   • neuron projection (Jepson et al., 2012) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Jepson et al., 2012)
Additional Descriptive Data
	dysc protein is detected in the neuronal tracts in the adult brain, including the mushroom body lobes, peduncle and calyx, and the ellipsoid body. There is strong colocalisation with slo. The protein levels and expression are not affected by circadian cycling. (Jepson et al., 2012)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    25 central nervous system, pupae P8    55 head, virgin 1-day female    47 head, virgin 4-day female    46 head, virgin 20-day female    21 head, mated 1-day female    48 head, mated 4-day female    34 head, mated 20-day female    22 head, mated 1-day male    67 head, mated 4-day male    63 head, mated 20-day male    39 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    25 central nervous system, pupae P8  (55) head, virgin 1-day female  (47) head, virgin 4-day female  (46) head, virgin 20-day female    21 head, mated 1-day female  (48) head, mated 4-day female  (34) head, mated 20-day female    22 head, mated 1-day male  (67) head, mated 4-day male  (63) head, mated 20-day male  (39) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    25 central nervous system, pupae P8    55 head, virgin 1-day female    47 head, virgin 4-day female    46 head, virgin 20-day female    21 head, mated 1-day female    48 head, mated 4-day female    34 head, mated 20-day female    22 head, mated 1-day male    67 head, mated 4-day male    63 head, mated 20-day male    39 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    25 central nervous system, pupae P8    55 head, virgin 1-day female    47 head, virgin 4-day female    46 head, virgin 20-day female    21 head, mated 1-day female    48 head, mated 4-day female    34 head, mated 20-day female    22 head, mated 1-day male    67 head, mated 4-day male    63 head, mated 20-day male    39 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    25 central nervous system, pupae P8    55 head, virgin 1-day female    47 head, virgin 4-day female    46 head, virgin 20-day female    21 head, mated 1-day female    48 head, mated 4-day female    34 head, mated 20-day female    22 head, mated 1-day male    67 head, mated 4-day male    63 head, mated 20-day male    39 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    25 central nervous system, pupae P8  (55) head, virgin 1-day female  (47) head, virgin 4-day female  (46) head, virgin 20-day female    21 head, mated 1-day female  (48) head, mated 4-day female  (34) head, mated 20-day female    22 head, mated 1-day male  (67) head, mated 4-day male  (63) head, mated 20-day male  (39) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    25 central nervous system, pupae P8    55 head, virgin 1-day female    47 head, virgin 4-day female    46 head, virgin 20-day female    21 head, mated 1-day female    48 head, mated 4-day female    34 head, mated 20-day female    22 head, mated 1-day male    67 head, mated 4-day male    63 head, mated 20-day male    39 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    25 central nervous system, pupae P8    55 head, virgin 1-day female    47 head, virgin 4-day female    46 head, virgin 20-day female    21 head, mated 1-day female    48 head, mated 4-day female    34 head, mated 20-day female    22 head, mated 1-day male    67 head, mated 4-day male    63 head, mated 20-day male    39 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    4 embryo 16-18hr    8 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    8 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    5 adult male 30day    7 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    4 embryo 16-18hr    8 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    8 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    5 adult male 30day    7 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    4 embryo 16-18hr    8 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    8 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    5 adult male 30day    7 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    4 embryo 16-18hr    8 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    8 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    5 adult male 30day    7 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    4 embryo 16-18hr    8 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    8 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    5 adult male 30day    7 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    4 embryo 16-18hr    8 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    8 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    5 adult male 30day    7 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    4 embryo 16-18hr    8 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    8 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    5 adult male 30day    7 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    4 embryo 16-18hr    8 embryo 18-20hr    9 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    8 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    5 adult male 30day    7 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    1 ovary fGS/OSS    49 ovary OSC    30 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    1 ovary fGS/OSS  (49) ovary OSC  (30) ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    1 ovary fGS/OSS    49 ovary OSC    30 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    1 ovary fGS/OSS    49 ovary OSC    30 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    1 ovary fGS/OSS    49 ovary OSC    30 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    1 ovary fGS/OSS  (49) ovary OSC  30 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    1 ovary fGS/OSS    49 ovary OSC    30 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    1 ovary fGS/OSS    49 ovary OSC    30 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    8 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    8 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    8 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    8 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    8 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    8 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    8 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    8 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 dyscGD14878 lethal | pupal stage, with Scer\GAL4pnr-MD237 dyscGD14878 viable dyscc03838 viable, with Scer\GAL4pnr-MD237 dyscGD6094 dyscGD13362 dyscGD14018 Sterility Allele fertile dyscc03838 Other Phenotypes Allele locomotor rhythm defective (with Df(3L)BSC614) dyscc03838 dyscs168 locomotor rhythm defective (with dyscc03838) dyscc05107 dyscs168 locomotor rhythm defective (with dyscc05107) dyscc03838 dyscs168 locomotor rhythm defective (with dyscs168) dyscc03838 dyscc05107 locomotor rhythm defective | recessive dyscc03838 dyscc05107 dyscs168 neurophysiology defective | adult stage dyscs168 Phenotype manifest in Allele
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of dysc Class Mutagen Stocks Known lesion dyscc03838 amorphic allele - molecular evidence piggyBac transposase 2 Yes dyscc03284 1 -- dyscc03314 1 -- dyscc05107 hypomorphic allele - molecular evidence 1 Yes dyscMI01684 1 -- dyscMI02729 1 -- dyscc04311 0 -- dyscc04314 0 -- dyscc07121 0 -- dyscpr9e P-element activity 0 Yes dyscs168 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dysc Class Mutagen Stocks Known lesion dyscGD13362 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dyscGD14018 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dyscGD14878 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dyscGD6094 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dyscKK108060 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes dyscKK112280 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes dyscKK112696 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes dyscNIG.32131R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes dyscScer\UAS.f in vitro construct - regulatory fusion 0 Yes dyscScer\UAS.g in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC614 (Jepson et al., 2012)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.32131R} NA P{UAS-dysc.f} NA P{UAS-dysc.g} NA GAL4 construct P{dysc-GAL4.J} No
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}dyscMI01684 NA Mi{MIC}dyscMI02729 NA PBac{PB}dyscc03284 NA PBac{PB}dyscc03314 NA PBac{PB}dyscc03838 NA PBac{PB}dyscc04311 NA PBac{PB}dyscc04314 NA PBac{PB}dyscc05107 NA PBac{PB}dyscc07121 NA insertion of mobile activating element P{XP}dyscs168 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
	There is no information supporting a cellular component or molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
locomotor rhythm inferred from mutant phenotype (Jepson et al., 2012) muscle cell homeostasis inferred from genetic interaction with Dg (Kucherenko et al., 2011) inferred from genetic interaction with Dys (Kucherenko et al., 2011) inferred from mutant phenotype (Kucherenko et al., 2011) photoreceptor cell axon guidance inferred from mutant phenotype (Marrone et al., 2011) positive regulation of ion transmembrane transporter activity inferred from mutant phenotype (Jepson et al., 2012) rhabdomere development inferred from mutant phenotype (Marrone et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
dysc - slo anti tag coimmunoprecipitation, western blot (Jepson et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dysc allele Gene References
External Data
Linkouts	SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • A8JNS6
Orthologs
OrthoDB Orthologs (34) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6M92B9 Dipteran inclusive ortholog search EOG6SN1X8 Insect inclusive ortholog search EOG60K6V9 Arthropod inclusive ortholog search EOG6S1RPM Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6M92B9)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dysc     Drosophila simulans   Dsim\GD12647     Drosophila sechellia   Dsec\GM24575     Drosophila erecta   Dere\GG13750     Drosophila yakuba   Dyak\GE20047     Drosophila ananassae   Dana\GF10407     Drosophila pseudoobscura pseudoobscura   Dpse\GA23508     Drosophila willistoni   Dwil\GK12438     Drosophila virilis   Dvir\GJ11819     Drosophila mojavensis   Dmoj\GI13457     Drosophila grimshawi   Dgri\GH16730
Orthologs in non-Drosophila Dipterans (EOG6SN1X8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000908   Anopheles gambiae Malaria mosquito  Agam\AGAP010778   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012549
Orthologs in non-Dipteran Insects (EOG60K6V9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45054   Apis mellifera Western honey bee  Amel\GB45053   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003269   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21382   Atta cephalotes Leafcutter ant  Acep\ACEP10917   Atta cephalotes Leafcutter ant  Acep\ACEP10920   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23092   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16000   Linepithema humile Argentine ant  Lhum\LH22577   Linepithema humile Argentine ant  Lhum\LH22581   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15470   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15469   Solenopsis invicta Red fire ant  Sinv\SINV14267   Solenopsis invicta Red fire ant  Sinv\SINV14279   Acyrthosiphon pisum Pea aphid  Apim\ACYPI068685   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009285   Bombyx mori Silkmoth  Bmor\BGIBMGA003012   Pediculus humanus Human body louse  Phum\PHUM626250   Tribolium castaneum Red flour beetle  Tcas\TC003756
Orthologs in non-Insect Arthropods (EOG6S1RPM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW013614
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (5) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila ananassae Dana\GF10409 Drosophila pseudoobscura pseudoobscura Dpse\GA23509 Drosophila virilis Dvir\GJ11821 Drosophila mojavensis Dmoj\GI16953 Drosophila grimshawi Dgri\GH16732
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	11313 w1118; PBac{PB}dyscc03838
Harvard	- PBac{PB}dyscc03284 - PBac{PB}dyscc03314 - PBac{PB}dyscc03838 - PBac{PB}dyscc05107
VDRC	v14082 w1118; P{GD6094}v14082 v23279 w1118; P{GD13362}v23279 v28945 w1118; P{GD14018}v28945 v28946 w1118; P{GD14018}v28946 v23278 w1118; P{GD13362}v23278/TM3 v30008 w1118; P{GD14878}v30008/TM3 v30009 w1118; P{GD14878}v30009/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR02M20 BACR29O22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 59 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP05104 IP08406 RH44168
Other clones	IP18016 IP18316 MIP36001
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE62752 RE62769 RH24419 RH42612 RH44209 RH44215 RH50064 RH62407 RH67605 RH72169
Other clones	19473 20233 30694 41447 42758 45328 65808 66030 156997 166216 175533 182981 214283.52 214443.44 214507.47 214541.20 CK01.1C.B2 CK01.101C.G6 CK01.124B.A10 EK085645 EK094435 EK111902 EK140361 EK154761 EK157432 EK161218 EK193622 EK235512 EK235646 EK271553 EK280358 EK287845 EP07712 EP18034 EP18219 FGC023D01 IP05004 IP08606 IP08706 IP10833 IP18116 IP18216 RH24241
RNAi & Array Information
Linkouts
Antibody Information
	polyclonal (Jepson et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dysc CG43749 (Jepson et al., 2012)
Source for database merge of	Source for merge of: CG17368 CG8760 CG32131 (FlyBase Genome Annotators, 2007) Source for merge of: CG32131 anon-AE003536.1 (FlyBase, 1996-) Source for merge of: CG32132 CG34400 (FlyBase Genome Annotators, 2012)
Additional comments	Annotations CG32132 and CG34400 merged as CG43749 in release 5.44 of the genome annotation. (FlyBase Genome Annotators, 2012) Annotations CG17368, CG8760 and CG32131 merged as CG34400 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007) Source for merge of CG32131 anon-AE003536.1 was sequence comparison (date:030925). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) New annotation (CG32132) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) New annotation (CG32131) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140411 NM_001104133 NM_001144474 NM_001144475 NM_001274881 NM_001274882 NM_001274883 NM_001274884 RefSeq (Proteins) • NP_648668 NP_001097603 NP_001137946 NP_001137947 NP_001261810 NP_001261811 NP_001261812 NP_001261813 DDBJ / EMBL / GenBank • AAF49791 AAN11813 ABW08538 ACL83301 ACL83302 AGB94503 AGB94504 AGB94505 AGB94506 BI574490 CZ468840 Entrez Gene - A searchable database of RefSeq genes. • 39533 317877 UniProtKB/TrEMBL • A8JNS6 B7Z048 B7Z049 Q8IQK7 Q9VU98
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • PDZ domain (IPR001478)
Linkouts
	SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • A8JNS6
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-AE003536.1   CG8760   CG17368 (Staudt et al., 2005) CG32131   CG32132 (Keleman et al., 2009.8.5, Smibert et al., 2012) CG34400 (Jungreis et al., 2011, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2007, Jepson et al., 2012, Kucherenko et al., 2011, Marrone et al., 2011, Japanese National Institute of Genetics, 2012.5.21) CG43749 (FlyBase Genome Annotators, 2012, ) Dm_3L:69335 (Ladoukakis et al., 2011) dysc (Jepson et al., 2012) unnamed (Robertson, 2001.1.8)
Name Synonym	CG8760   CG17368   CG32131   dyschronic (Jepson et al., 2012, )
Secondary FlyBase IDs
	FBgn0036383 FBgn0036384 FBgn0043542 FBgn0052131 FBgn0052132 FBgn0085429
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 4 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 8 ) Stock list  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Jepson et al., 2012, PLoS Genet. 8(4): e1002671 dyschronic, a Drosophila Homolog of a Deaf-Blindness Gene, Regulates Circadian Output and Slowpoke Channels. [FBrf0218124] Kucherenko et al., 2011, Dev. Biol. 352(2): 228--242 Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. [FBrf0214383] Marrone et al., 2011, BMC Neurosci. 12: 93 New Dystrophin/Dystroglycan interactors control neuron behavior in Drosophila eye. [FBrf0216731] Show all research papers ...