FB2025_01 , released February 20, 2025
Gene: Hsap\ALK
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General Information
Symbol
Hsap\ALK
Species
H. sapiens
Name
anaplastic lymphoma receptor tyrosine kinase
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0264073
Gene Model Status
Not Applicable
Stock Availability
None publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

ALK, hALK

Key Links
Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == ALK; HGNC:427.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hsap\ALK
Transgenic constructs containing regulatory region of Hsap\ALK
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (44)
Alk
12 of 14
Yes
Yes
0  
sev
3 of 14
No
No
0  
Abl
1 of 14
No
No
0  
Ack
1 of 14
No
No
0  
Ack-like
1 of 14
No
No
0  
Btk
1 of 14
No
No
0  
btl
1 of 14
No
No
0  
Cad96Ca
1 of 14
No
No
0  
CG3277
1 of 14
No
No
0  
CG17528
1 of 14
No
No
0  
Csk
1 of 14
No
No
0  
Ddr
1 of 14
No
No
0  
dnt
1 of 14
No
No
0  
Drl-2
1 of 14
No
No
0  
drl
1 of 14
No
No
0  
Egfr
1 of 14
No
No
0  
Eph
1 of 14
No
No
0  
Fak
1 of 14
No
No
0  
FER
1 of 14
No
No
0  
htl
1 of 14
No
No
0  
InR
1 of 14
No
No
0  
ksr
1 of 14
No
No
0  
LIMK1
1 of 14
No
No
0  
lok
1 of 14
No
No
0  
Lrrk
1 of 14
No
No
0  
Myt1
1 of 14
No
No
0  
Nrk
1 of 14
No
No
0  
otk2
1 of 14
No
No
0  
otk
1 of 14
No
No
0  
Pkc53E
1 of 14
No
No
0  
Pvr
1 of 14
No
No
0  
Ret
1 of 14
No
No
0  
robo3
1 of 14
No
No
0  
Ror
1 of 14
No
No
0  
Shark
1 of 14
No
No
0  
slpr
1 of 14
No
No
0  
smal
1 of 14
No
No
0  
Src42A
1 of 14
No
No
0  
Src64B
1 of 14
No
No
0  
Tak1
1 of 14
No
No
0  
Tie
1 of 14
No
No
0  
tutl
1 of 14
No
No
0  
wnd
1 of 14
No
No
0  
Wsck
1 of 14
No
No
0  
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Hsap\ALKF1174L.UAS
model of  cancer
is ameliorated by Sos34Ea-7
(Wolfstetter et al., 2020)
is ameliorated by 14-3-3εS-696
(Wolfstetter et al., 2020)
is ameliorated by ksrS-627
(Wolfstetter et al., 2020)
is ameliorated by pntΔ88
(Wolfstetter et al., 2020)
is ameliorated by wndd00622
(Wolfstetter et al., 2020)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Other Interaction Browsers
Summary of Genetic Interactions
esyN Network Diagram
Other Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
Class of Gene
Stocks and Reagents
Stocks (0)
Other Comments
Relationship to Other Genes
Source for database merge of
Additional comments

FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

(FlyBase Curators, 1992-)
Nomenclature History
Source for database identify of
Nomenclature comments
Etymology
Synonyms and Secondary IDs (10)
Reported As
Symbol Synonym
ALK
(Guan et al., 2017, Chand et al., 2013, HGNC Curators and FlyBase Curators, 2013-, Schönherr et al., 2011)
ALK1
(HGNC Curators and FlyBase Curators, 2013-)
CD246
(HGNC Curators and FlyBase Curators, 2013-)
HsALK
(Fadeev et al., 2018)
Hsap\ALK
hALK
(Kim et al., 2019, Hugosson et al., 2014, Schönherr et al., 2011)
Name Synonyms
ALK receptor tyrosine kinase
(HGNC Curators and FlyBase Curators, 2013-)
Anaplastic lymphoma receptor tyrosine kinase
anaplastic lymphoma kinase (Ki-1)
(HGNC Curators and FlyBase Curators, 2013-)
anaplastic lymphoma receptor tyrosine kinase
(HGNC Curators and FlyBase Curators, 2013-)
Secondary FlyBase IDs
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (0)
    Result
    Result Type
    Title
    External Crossreferences and Linkouts ( 6 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    Other crossreferences
    Ensembl_Homo_sapiens -
    HUGO Gene Nomenclature Committee -
    MARRVEL - MARRVEL (human gene)
    OMIM_GENE - Online Mendelian Inheritance in Man (Genes)
    OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)
    References (17)