dARNT, ARNT, HIF-1, jaywalker
Myc-type, helix loop helix and PAS family protein - Tango heterodimerizes with two transcription factors, Trachealess and Single minded, to regulate transcription in the trachea and central midline, respectively
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with ahr, trh or sim.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tgo using the Feature Mapper tool.
Comment: reference states transcript expressed up to 8-12 hr AEL
In addition to the midline and tracheal expression, tgo is expressed in the antennal segment, the gnathal segments, the leg anlage, and the PNS in embryos.
tgo is ubiquitously distributed in early embryos. Strong signals are transiently detected in tracheal pits at stage 11. Later, strong expression is observed in the CNS.
tgo is ubiquitously expressed during embryogenesis. Elevated levels were observed in tracheal placodes and tracheal pits.
In embryos, in addition to the midline and tracheal expression, tgo is expressed in the antennal segment, the gnathal segments, the leg anlage, the PNS, and the dorsal vessel.
tgo is uniformly distributed in preblastoderm embryos. During the extended germ band stage, tgo protein is found in all three germ layers. Enhanced levels of tgo protein are found around the forming tracheal pits. Enhanced levels of tgo protein continue to be observed in tracheal cells including the posterior spiracles from stage 11 to 17. Enhanced levels are also observed in the supraoesophageal ganglion and the ventral nerve cord.
GBrowse - Visual display of RNA-Seq signalsView Dmel\tgo in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: tgo jay
dsRNA has been made from templates generated with primers directed against this gene. RNAi of tgo results in reduced arborization of ddaD and ddaE neurons, defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis. However, RNAi causes no obvious defects in da dendrite development.
Two EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo.
tgo has been cloned and sequenced. Isolated form an embryonic cDNA library using a human hARNT cDNA as a probe.
sim and trh activate transcription by forming dimers with the tgo protein. Gene dosage studies reveal in vivo interactions between sim and tgo, and trh and tgo. The interacting proteins in vivo control CNS midline and tracheal transcription and development. tgo protein is found broadly distributed throughout embryogenesis, although certain cell types, including trachea and the CNS have enhanced levels.
Mutants cause CNS and tracheal defects.