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Gene Dmel\CG43755

General Information
Symbol	Dmel\CG43755	Species	D. melanogaster
Name		Annotation symbol	CG43755
Feature type	protein_coding_gene	FlyBase ID	FBgn0264086
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	CG31920
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	21C1-21C1	Sequence location	2L:325,522..329,761 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG43755 (FBgn0264086). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Gene sequence location is 2L:325522..329761.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21C1-21C1   Limits computationally determined from genome sequence between P{lacW}U2af38k14504 and P{lacW}RpI135k16513&P{lacW}ebik16213
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG43755 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.46 Gene merge based on RNA-Seq and protein similarity data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG43755-RB FBtr0330696  NM_001272890   2333   682 CG43755-RD FBtr0330695  NM_164379   1709   407
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG43755-PB   FBpp0303539   77.5   682   8.90     NP_001259819   AGB92356 CG43755-PD   FBpp0303538   46.0   407   8.33     NP_722626   AAN10494
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAN10494   AE014134 AGB92356   AI114098   AI946166   AI946325   AW940382   AX154713   AY070508 AAL47979   BE976082   BE977609   BE977657   BE978153   BF486190   BF489705   BF489718   BF489744   BF497250   BF502938   BT021467   CO181537   CO182555
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q2PDW0 Q8SZU1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010, Dorus et al., 2006)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    107 central nervous system, larvae L3    0 central nervous system, pupae P8    5 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    55 fat body, pupae P8    121 carcass, larvae L3 wandering    1 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    676 accessory gland, mated 4-day male    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (107) central nervous system, larvae L3    0 central nervous system, pupae P8    5 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae  (55) fat body, pupae P8  (121) carcass, larvae L3 wandering    1 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male  (676) accessory gland, mated 4-day male  (81) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  107 central nervous system, larvae L3    0 central nervous system, pupae P8    5 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    55 fat body, pupae P8  (121) carcass, larvae L3 wandering    1 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male  (676) accessory gland, mated 4-day male    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    107 central nervous system, larvae L3    0 central nervous system, pupae P8    5 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    55 fat body, pupae P8    121 carcass, larvae L3 wandering    1 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    676 accessory gland, mated 4-day male    81 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    107 central nervous system, larvae L3    0 central nervous system, pupae P8    5 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    55 fat body, pupae P8    121 carcass, larvae L3 wandering    1 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    676 accessory gland, mated 4-day male    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (107) central nervous system, larvae L3    0 central nervous system, pupae P8    5 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae  (55) fat body, pupae P8  (121) carcass, larvae L3 wandering    1 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male  (676) accessory gland, mated 4-day male  (81) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  107 central nervous system, larvae L3    0 central nervous system, pupae P8    5 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    55 fat body, pupae P8  121 carcass, larvae L3 wandering    1 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male  (676) accessory gland, mated 4-day male    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    107 central nervous system, larvae L3    0 central nervous system, pupae P8    5 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    55 fat body, pupae P8    121 carcass, larvae L3 wandering    1 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    676 accessory gland, mated 4-day male    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    25 white prepupae 24hr    38 pupae 2d postWPP    54 pupae 3d postWPP    63 pupae 4d postWPP    50 adult male 01day    101 adult male 05day    116 adult male 30day    108 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    25 white prepupae 24hr  (38) pupae 2d postWPP  (54) pupae 3d postWPP  (63) pupae 4d postWPP  (50) adult male 01day  (101) adult male 05day  (116) adult male 30day  (108) adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    25 white prepupae 24hr    38 pupae 2d postWPP    54 pupae 3d postWPP    63 pupae 4d postWPP    50 adult male 01day  101 adult male 05day  (116) adult male 30day  (108) adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    25 white prepupae 24hr    38 pupae 2d postWPP    54 pupae 3d postWPP    63 pupae 4d postWPP    50 adult male 01day    101 adult male 05day    116 adult male 30day    108 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    25 white prepupae 24hr    38 pupae 2d postWPP    54 pupae 3d postWPP    63 pupae 4d postWPP    50 adult male 01day    101 adult male 05day    116 adult male 30day    108 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    25 white prepupae 24hr  (38) pupae 2d postWPP  (54) pupae 3d postWPP  (63) pupae 4d postWPP  (50) adult male 01day  (101) adult male 05day  (116) adult male 30day  (108) adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    25 white prepupae 24hr    38 pupae 2d postWPP    54 pupae 3d postWPP    63 pupae 4d postWPP    50 adult male 01day  101 adult male 05day  116 adult male 30day  108 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    25 white prepupae 24hr    38 pupae 2d postWPP    54 pupae 3d postWPP    63 pupae 4d postWPP    50 adult male 01day    101 adult male 05day    116 adult male 30day    108 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    40 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    69 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    158 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    188 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    48 Paraquat 5 mM 48 hrs, 4-day adult    82 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (50) cold shock, 4-day adult  (40) heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult  26 Cadmium 100 mM 48 hrs, 4-day adult  (69) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  (158) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  (188) Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult  (48) Paraquat 5 mM 48 hrs, 4-day adult  (82) Paraquat 10 mM 48 hrs, 4-day adult  (80) Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    40 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    69 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  (158) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  (188) Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    48 Paraquat 5 mM 48 hrs, 4-day adult    82 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    40 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    69 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    158 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    188 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    48 Paraquat 5 mM 48 hrs, 4-day adult    82 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    40 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    69 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    158 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    188 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    48 Paraquat 5 mM 48 hrs, 4-day adult    82 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (50) cold shock, 4-day adult  (40) heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult  26 Cadmium 100 mM 48 hrs, 4-day adult  (69) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  (158) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  (188) Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult  (48) Paraquat 5 mM 48 hrs, 4-day adult  (82) Paraquat 10 mM 48 hrs, 4-day adult  (80) Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    40 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    69 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  (158) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  (188) Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    48 Paraquat 5 mM 48 hrs, 4-day adult    82 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    40 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    69 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    158 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    188 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    48 Paraquat 5 mM 48 hrs, 4-day adult    82 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_33 mE1_20_mRNA_expression_cluster_18
External Data & Images
Linkouts	BDGP expression data • AT12221 GH10778
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG43755GD10409 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG43755 Class Mutagen Stocks Known lesion CG43755MI01911 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG43755 Class Mutagen Stocks Known lesion CG43755GD10409 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG43755KK105584 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG43755NIG.31920R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.31920R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Plc21CMI01911 NA PBac{PB}Plc21Cc00245 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
	There is no information supporting a biological process, cellular component or molecular function term for this gene. (Based on a review of available data on: 2006-05-23)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG43755 - CG6543 experimental knowledge based (Guruharsha et al., 2011) CG43755 - Hsp23 experimental knowledge based (Guruharsha et al., 2011) CG43755 - Hsp26 experimental knowledge based (Guruharsha et al., 2011) CG43755 - TER94 experimental knowledge based (Guruharsha et al., 2011) CG43755 - eEF1δ experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG43755 allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (17) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG68PN4Z Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG68PN4Z)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG31921     Drosophila melanogaster fruit fly  Dmel\CG43755     Drosophila simulans   Dsim\GD22964   Y Drosophila simulans   Dsim\GD22963   Y Drosophila sechellia   Dsec\GM16674   Y Drosophila sechellia   Dsec\GM16675   Y Drosophila erecta   Dere\GG24656   Y Drosophila erecta   Dere\GG24655   Y Drosophila yakuba   Dyak\GE16195   Y Drosophila yakuba   Dyak\GE16184   Y Drosophila ananassae   Dana\GF24838   Y Drosophila ananassae   Dana\GF24860   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA16567   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA16566   Y Drosophila persimilis   Dper\GL19273   Y Drosophila persimilis   Dper\GL19274   Y Drosophila willistoni   Dwil\GK23886   Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	32799 y1 w*; Mi{MIC}Plc21CMI01911 CG43755MI01911/SM6a
VDRC	v101265 P{KK105584}VIE-260B v25912 w1118; P{GD10409}v25912 v25914 w1118; P{GD10409}v25914
Genomic Clones ( 1 )
	BACR22C14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 17 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT12221 GH10778
Other clones	DPiM_GH10778
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11385 AT18803 AT20409 AT25834 AT25848 AT25881
Other clones	bs21f09 bs23f04 bs46h03 bs66g05 bs67d08 bs74f02 EC14493 EC22962
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CG33992 NEST:bs23f04 (FlyBase Genome Annotators, 2005)
Source for database merge of	Source for merge of: CG31920 anon-WO0140519.62 (FlyBase, 1996-) Source for merge of: CG31920 BcDNA:GH10778 (FlyBase, 1996-) Source for merge of: CG31920 CG33992 (FlyBase Genome Annotators, 2012) Source for merge of: CG31920 NEST:bs21f09 (Rana, 2004.7.8)
Additional comments	Annotations CG31920 and CG33992 merged as CG43755 in release 5.44 of the genome annotation. Merge supported by RNA-Seq coverage data. (FlyBase Genome Annotators, 2012) Source for merge of CG31920 anon-WO0140519.62 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of CG31920 BcDNA:GH10778 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	New annotation (CG33992) in release 4.3 of the genome annotation. (FlyBase Genome Annotators, 2005) New annotation (CG31920) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_164379 NM_001272890 RefSeq (Proteins) • NP_722626 NP_001259819 DDBJ / EMBL / GenBank • AAL47979 AAN10494 ABC65866 AGB92356 AI114098 AI946166 AI946325 AW940382 AX154713 AY070508 Entrez Gene - A searchable database of RefSeq genes. • 319026 3885609 UniProtKB/TrEMBL • Q2PDW0 Q8SZU1
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • AT12221 GH10778
Linkouts
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	anon-WO0140519.62   BcDNA:GH10778   CG31920 (Wasbrough et al., 2010, Dorus et al., 2006, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21) CG33992 (Wasbrough et al., 2010, ) CG43755 (FlyBase Genome Annotators, 2012) NEST:bs21f09   NEST:bs23f04
Name Synonym
Secondary FlyBase IDs
	FBgn0044566 FBgn0045202 FBgn0045216 FBgn0047313 FBgn0051920 FBgn0053992
References ( 20 )
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Dorus et al., 2006, Nat. Genet. 38(12): Supplementary Table 1. Genes encoding the Drosophila melanogaster sperm proteome. [FBrf0206129]
Personal communication to FlyBase	Bellen, 2010.11.12, Set908.xml Set908.xml [FBrf0212197] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Rana, 2004.7.8, BLAST analysis. BLAST analysis. [FBrf0178762] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] Oliver, 2001.8.16, Genome Res.: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Genome Annotators, 2012, Changes affecting gene model number or type in release 5.44 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.44 of the annotated D.melanogaster genome. [FBrf0216941] FlyBase Genome Annotators, 2005, Changes affecting gene model number or type in release 4.3 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 4.3 of the annotated D.melanogaster genome. [FBrf0188580] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Patent	Greenspan, 2001.6.7, World Patent 0140519-A: Methods for identifying modulators for balance related disorders. [FBrf0141245]