FlyBase Gene Report: Dmel\CG43759

General Information

Symbol

Dmel\CG43759

Species

D. melanogaster

Name

Annotation Symbol

CG43759

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264090

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

EP(X)1644

Key Links

Genomic Location

Cytogenetic map

17F3-18A2

Sequence location

X:18,930,335..19,028,629 [+]

Recombination map

1-62

RefSeq locus

NC_004354 REGION:18930335..19028629

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG43759 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PF59)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884. (supp. material, original list of 283 candidates)

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG43759-RA

FBtr0331156

NM_133114

4583

735

CG43759-RB

FBtr0331157

NM_001272768

4583

900

CG43759-RC

FBtr0332994

NM_001272769

6340

735

CG43759-RD

FBtr0343982

NM_001298493

4396

735

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG43759-PA

FBpp0303583

74.9

735

9.12

FBpp0303584

94.4

900

7.64

FBpp0305209

74.9

735

9.12

FBpp0310434

74.9

735

9.12

Q9VWN1

NP_001285422

AHN59892

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

735 aa isoforms: CG43759-PA, CG43759-PC, CG43759-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG43759 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.96

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG43759 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG43759

View exonic expression by tissue for Dmel\CG43759

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32889/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264090

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052541

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264090

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32541

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 27 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG43759

Transgenic constructs containing regulatory region of CG43759

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 29 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

CG43759^GD8251

Other Phenotypes

Allele

abnormal behavior | recessive

CG43759^BG00670

some die during pupal stage, with Scer\GAL4^pnr-MD237

CG43759^GD8251

visible, with Scer\GAL4^pnr-MD237

CG43759^GD8251

Phenotype manifest in

Allele

macrochaeta

mesonotum, with Scer\GAL4^pnr-MD237

CG43759^GD8251

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\ARHGEF10

1 of 14

Yes

Hsap\ARHGEF10L

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

Rnor\Arhgef10l

1 of 14

Yes

Rnor\Arhgef10

1 of 14

Yes

Mus musculus (laboratory mouse) (2)

Mmus\Arhgef10l

1 of 14

Yes

Mmus\Arhgef10

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\arhgef10l

1 of 13

Yes

Xtro\arhgef10

1 of 13

Yes

Danio rerio (Zebrafish) (3)

Drer\arhgef10

1 of 14

Yes

Drer\arhgef10la

1 of 14

Yes

Drer\arhgef10lb

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP013265

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG43759. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

CG43658

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

pnr

enhanceable

CG43759

(Pena-Rangel et al., 2002)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264090

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-62

Cytogenetic map

17F3-18A2

Sequence location

X:18,930,335..19,028,629 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

17F3-18A2

Limits computationally determined from genome sequence between P{EP}CG7326^EP1133 and P{EP}CG7502^EP1326

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-62

(FlyBase, 2016)

1-60.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

37612

y¹ w^* Mi{MIC}CG43759^MI03719

50495

y¹ w^* Mi{MIC}CG43759^MI08964

58590

y¹ w^* Mi{MIC}CG43759^MI13238

61117

y¹ w^* Mi{MIC}CG43759^MI15650

11454

w¹¹¹⁸ P{EP}EP1644a P{EP}EP1644b CG43759^EP1644

11654

12527R-1

v104617

v32098

w¹¹¹⁸; P{GD8251}v32098

Genomic Clones (32)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (34)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD15404

Other clones

DPiM_LD15404

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264090

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identified as a candidate gene for hypoxia-specific selection (via an experimental evolution paradigm) that is also differentially expressed between control and hypoxia-adapted larvae.

(Jha et al., 2016)

New annotation (CG42506) in release 5.13 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG12527 CG14188

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: CG32541 CG42506

(FlyBase Genome Annotators, 2012)

Additional comments

Annotations CG32541 and CG42506 merged as CG43759 in release 5.44 of the genome annotation. Merge supported by stop codon read-through analysis (FBrf0216884).

(FlyBase Genome Annotators, 2012)

Annotations CG12527 and CG14188 merged as CG32541 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG12527

(Mount, 2001.8.14)

CG14188

(Bidet et al., 2003)

CG32541

(Jha et al., 2016, Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Smibert et al., 2012, Jungreis et al., 2011, Reis et al., 2010, Edwards et al., 2009, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2008, Quinones-Coello, 2007)

CG42506

(FlyBase Genome Annotators, 2008)

CG43759

(Jha et al., 2016, Duff et al., 2015, FlyBase Genome Annotators, 2012)

EP(X)1644

(Norga et al., 2003, Pena-Rangel et al., 2002)

LD15404

(Pena-Rangel et al., 2002)

Name Synonyms

Secondary FlyBase IDs

FBgn0052541
FBgn0030977
FBgn0030978
FBgn0260232

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32889

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PF59

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PF59

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32889/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264090

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264090

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43759

MARRVEL_MODEL - MARRVEL (model organism gene)

32889

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264090

DroID - A comprehensive database of gene and protein interactions.

FBgn0264090

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052541

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0264090

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32541

References (40)

The following external sites may use different assemblies or annotations than FlyBase.

-0.96

Report Sections