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Gene Dmel\Det

General Information
Symbol	Dmel\Det	Species	D. melanogaster
Name	Deterin	Annotation symbol	CG12265
Feature type	protein_coding_gene	FlyBase ID	FBgn0264291
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map	3-59.1
Cytogenetic map	90A1-90A2	Sequence location	3R:12,975,389..12,976,177 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Deterin is referred to in FlyBase by the symbol Dmel\Det (CG12265, FBgn0264291). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: lateral inhibition; negative regulation of apoptotic process; cytokinesis; cytokinesis after meiosis II; spindle organization; spindle assembly; cytokinesis, actomyosin contractile ring assembly; neurogenesis; cytokinesis after meiosis I. 12 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; Nebenkern; contractile ring; chaeta. It has one annotated transcript and one annotated polypeptide. Protein features are: Baculoviral inhibition of apoptosis protein repeat. Gene sequence location is 3R:12975389..12976177.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 90A1-90A2   Left limit from in situ hybridisation (FBrf0128513) Right limit from in situ hybridisation (FBrf0128513)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 90A1-90A2   (determined by in situ hybridisation)   (Jones et al., 2000)
Experimentally Determined Recombination Data
Location	3-59.1 (Giansanti et al., 2004)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Det for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Det-RA FBtr0083408  NM_142351   651   153
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Det-PA   FBpp0082849   17.5   153   6.27     NP_650608   AAF55399
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Baculoviral inhibition of apoptosis protein repeat (IPR001370)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55399   AI260030   AY071487 AAL49109   BG640444   BG640983   BI162902   BI352250   BI369328   BI633072   BI636213   BP544750   BP544751   CO182522   CO284715   CO308409   CO312375   CO317046   CO323574   CO339523   CO340974   CZ479340   EC066243   EC204300   EC210812   EC223631   EC226966   EC255321   EC255907   EV578217   GH739700   GH739853   GH746648   GH762650   GH763700   GH766179   GH768163   GH768715   GH779855   GO254484
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VEM2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 1 -- 4   organism | ubiquitous & uniform   (Jones et al., 2000) embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 5   somatic cell   (Jones et al., 2000) embryonic stage 6 -- 9   organism | restricted   (Jones et al., 2000) Comment:reference states only "becomes more restricted as development proceeds" embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 10   embryonic brain   (Jones et al., 2000) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic stage 15 -- 16   gonad   (Jones et al., 2000) adult stage | female   ovary   (Jones et al., 2000) adult stage | femaleoogenesis stage S10 -- S13   nurse cell   • cytoplasm (Jones et al., 2000) Comment:strongest expression at stages S10-11 adult stage | femaleoogenesis stage S13 -- S14   oocyte   (Jones et al., 2000) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 12   organism   (Jones et al., 2000) Comment:reference states 0-8 hr AEL third instar larval stage   organism   (Jones et al., 2000) RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Jones et al., 2000) late third instar larval stage   organism   (Jones et al., 2000) adult stage | female   organism   (Jones et al., 2000) Comment:mated female
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter or direct label Stage Tissue/Position (including subcellular localization) Reference   S2 cell-line   • cytoplasm (Jones et al., 2000) immunolocalization Stage Tissue/Position (including subcellular localization) Reference   S2 cell-line   • cytoplasm (Jones et al., 2000)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Jones et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    13 ovary, mated 4-day female    10 testis, mated 4-day male    8 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    13 ovary, mated 4-day female    10 testis, mated 4-day male    8 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    13 ovary, mated 4-day female    10 testis, mated 4-day male    8 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    13 ovary, mated 4-day female    10 testis, mated 4-day male    8 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    13 ovary, mated 4-day female    10 testis, mated 4-day male    8 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    13 ovary, mated 4-day female    10 testis, mated 4-day male    8 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    13 ovary, mated 4-day female    10 testis, mated 4-day male    8 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    13 ovary, mated 4-day female    10 testis, mated 4-day male    8 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    44 embryo 04-06hr    67 embryo 06-08hr    60 embryo 08-10hr    52 embryo 10-12hr    21 embryo 12-14hr    15 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    6 larva L1    2 larva L2    2 larva L3 12hr old    3 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    14 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    6 adult male 30day    4 adult female 01day    7 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (37) embryo 02-04hr  (44) embryo 04-06hr  (67) embryo 06-08hr  (60) embryo 08-10hr  (52) embryo 10-12hr    21 embryo 12-14hr    15 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    6 larva L1    2 larva L2    2 larva L3 12hr old    3 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    14 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    6 adult male 30day    4 adult female 01day    7 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    44 embryo 04-06hr    67 embryo 06-08hr    60 embryo 08-10hr    52 embryo 10-12hr    21 embryo 12-14hr    15 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    6 larva L1    2 larva L2    2 larva L3 12hr old    3 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    14 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    6 adult male 30day    4 adult female 01day    7 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    44 embryo 04-06hr    67 embryo 06-08hr    60 embryo 08-10hr    52 embryo 10-12hr    21 embryo 12-14hr    15 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    6 larva L1    2 larva L2    2 larva L3 12hr old    3 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    14 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    6 adult male 30day    4 adult female 01day    7 adult female 05day    24 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    44 embryo 04-06hr    67 embryo 06-08hr    60 embryo 08-10hr    52 embryo 10-12hr    21 embryo 12-14hr    15 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    6 larva L1    2 larva L2    2 larva L3 12hr old    3 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    14 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    6 adult male 30day    4 adult female 01day    7 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (37) embryo 02-04hr  (44) embryo 04-06hr  (67) embryo 06-08hr  (60) embryo 08-10hr  (52) embryo 10-12hr    21 embryo 12-14hr    15 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    6 larva L1    2 larva L2    2 larva L3 12hr old    3 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    14 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    6 adult male 30day    4 adult female 01day    7 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    44 embryo 04-06hr    67 embryo 06-08hr    60 embryo 08-10hr    52 embryo 10-12hr    21 embryo 12-14hr    15 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    6 larva L1    2 larva L2    2 larva L3 12hr old    3 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    14 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    6 adult male 30day    4 adult female 01day    7 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    44 embryo 04-06hr    67 embryo 06-08hr    60 embryo 08-10hr    52 embryo 10-12hr    21 embryo 12-14hr    15 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    6 larva L1    2 larva L2    2 larva L3 12hr old    3 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    14 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    6 adult male 30day    4 adult female 01day    7 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    10 embryonic GM2    15 embryonic Kc167    9 embryonic S1    16 embryonic S3    13 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    16 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    13 ovary fGS/OSS    7 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    10 embryonic GM2    15 embryonic Kc167    9 embryonic S1    16 embryonic S3    13 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    16 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    13 ovary fGS/OSS    7 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    10 embryonic GM2    15 embryonic Kc167    9 embryonic S1    16 embryonic S3    13 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    16 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    13 ovary fGS/OSS    7 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    10 embryonic GM2    15 embryonic Kc167    9 embryonic S1    16 embryonic S3    13 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    16 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    13 ovary fGS/OSS    7 ovary OSC    10 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    10 embryonic GM2    15 embryonic Kc167    9 embryonic S1    16 embryonic S3    13 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    16 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    13 ovary fGS/OSS    7 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    10 embryonic GM2    15 embryonic Kc167    9 embryonic S1    16 embryonic S3    13 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    16 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    13 ovary fGS/OSS    7 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    10 embryonic GM2    15 embryonic Kc167    9 embryonic S1    16 embryonic S3    13 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    16 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    13 ovary fGS/OSS    7 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    17 embryonic 1182-4H    10 embryonic GM2    15 embryonic Kc167    9 embryonic S1    16 embryonic S3    13 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    16 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    13 ovary fGS/OSS    7 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • RE55472
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal DetGD4679 lethal | larval stage | male limited (with Df(3R)Exel5780) DetZ2775 viable Dete01527 viable, with Scer\GAL4pnr-MD237 DetGD4679 Sterility Allele fertile Dete01527 Other Phenotypes Allele cytokinesis defective | heat sensitive DetZ2775 cytokinesis defective | heat sensitive (with Df(3R)Exel5780) DetZ2775 cytokinesis defective | male | recessive DetZ2775 meiotic cell cycle defective | heat sensitive DetZ2775 meiotic cell cycle defective | male | recessive DetZ2775 mitotic cell cycle defective (with Df(3R)Exel5780) DetZ2775 mitotic cell cycle defective | male | recessive DetZ2775 neuroanatomy defective | larval stage DetGD4679 visible, with Scer\GAL4pnr-MD237 DetGD4679 Phenotype manifest in Allele chaeta, with Scer\GAL4pnr-MD237 DetGD4679 contractile ring (with Df(3R)Exel5780) DetZ2775 contractile ring & meiotic cell cycle | male DetZ2775 embryonic/larval neuroblast | larval stage DetGD4679 ganglion mother cell | larval stage DetGD4679 mitochondrial derivative | heat sensitive DetZ2775 mitochondrial derivative | heat sensitive (with Df(3R)Exel5780) DetZ2775 Nebenkern DetZ2775 neuroblast | heat sensitive (with Df(3R)Exel5780) DetZ2775 nucleus | ectopic | heat sensitive DetZ2775 nucleus | ectopic | heat sensitive (with Df(3R)Exel5780) DetZ2775 onion stage spermatid | heat sensitive DetZ2775 spermatid & nucleus | supernumerary DetZ2775 spermatid | heat sensitive DetZ2775 spermatid | heat sensitive (with Df(3R)Exel5780) DetZ2775 spindle & meiotic cell cycle | male DetZ2775 testis | heat sensitive DetZ2775 trichogen cell, with Scer\GAL4pnr-MD237 DetGD4679
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Det Class Mutagen Stocks Known lesion Dete01527 piggyBac transposase 2 -- DetZ2775 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Det Class Mutagen Stocks Known lesion DetGD4679 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes DetGL00560 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DetGL00572 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DetKK108638 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Det+t2.5 in vitro construct - genomic fragment 0 Yes DetCterm.IE1 in vitro construct - regulatory fusion 0 Yes DetIE1.PJ in vitro construct - regulatory fusion 0 Yes DetIE1.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes DetN.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes DetQ83E.P86S.t2.5 in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK108638} NA P{TRiP.GL00560} NA P{TRiP.GL00572} NA characterization construct P{Det.t2.5} NA P{GFP-survivin} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Dete01527 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytokinesis inferred from mutant phenotype (Szafer-Glusman et al., 2011) cytokinesis, actomyosin contractile ring assembly inferred from mutant phenotype (Giansanti et al., 2004) cytokinesis after meiosis I inferred from mutant phenotype (Giansanti et al., 2004) cytokinesis after meiosis II inferred from mutant phenotype (Giansanti et al., 2004) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) negative regulation of apoptotic process inferred from mutant phenotype AND inferred from sequence or structural similarity with human BIRC5 (Jones et al., 2000) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) spindle assembly inferred from mutant phenotype (Giansanti et al., 2004) spindle organization inferred from mutant phenotype (Szafer-Glusman et al., 2011)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Jones et al., 2000)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
negative regulation of apoptotic process inferred from sequence or structural similarity with EMBL:AF007769 (FlyBase, 1992-) inferred from sequence or structural similarity with NCBI_gi:6647543 (Vernooy et al., 2000) traceable author statement (Tittel and Steller, 2000, Gorski and Marra, 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Det allele Gene References DetIE1.T:Avic\GFP rpr (Jones et al., 2000)
External Data
Linkouts	SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VEM2
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6NKCG6 Dipteran inclusive ortholog search EOG64MZ2G Insect inclusive ortholog search EOG61JX8V Arthropod inclusive ortholog search EOG6ZCRN2 Metazoa inclusive ortholog search EOG6QCD1N
Orthologs in Drosophila Species (EOG6NKCG6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Det     Drosophila simulans   Dsim\GD19147 Y   Drosophila sechellia   Dsec\GM15217 Y   Drosophila erecta   Dere\GG22093 Y   Drosophila yakuba   Dyak\GE10116 Y   Drosophila ananassae   Dana\GF18137 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11519 Y   Drosophila persimilis   Dper\GL23676 Y   Drosophila willistoni   Dwil\GK11633 Y   Drosophila virilis   Dvir\GJ24423 Y   Drosophila mojavensis   Dmoj\GI24770 Y   Drosophila grimshawi   Dgri\GH13432 Y
Orthologs in non-Drosophila Dipterans (EOG64MZ2G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014251   Anopheles gambiae Malaria mosquito  Agam\IAP5   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006694
Orthologs in non-Dipteran Insects (EOG61JX8V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Det   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000792   Atta cephalotes Leafcutter ant  Acep\ACEP10590   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12715   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19214   Linepithema humile Argentine ant  Lhum\LH15438   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10089   Solenopsis invicta Red fire ant  Sinv\SINV25204   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000677   Acyrthosiphon pisum Pea aphid  Apim\ACYPI21920   Bombyx mori Silkmoth  Bmor\BGIBMGA003946   Tribolium castaneum Red flour beetle  Tcas\TC002709
Orthologs in non-Insect Arthropods (EOG6ZCRN2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Gtse1   Ixodes scapularis Deer tick  Isca\ISCW012508
Orthologs in non-Arthropod Metazoa (EOG6QCD1N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\bir-2   Caenorhabditis elegans Nematode  Cele\bir-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021282gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008878gn   Danio rerio Zebrafish  Drer\birc5a   Danio rerio Zebrafish  Drer\birc5b   Xenopus tropicalis Western clawed frog  Xtro\birc5.1   Xenopus tropicalis Western clawed frog  Xtro\birc5.2   Gallus gallus Domestic chicken  Ggal\LOC768589   Gallus gallus Domestic chicken  Ggal\BIRC5   Mus musculus House mouse  Mmus\Birc5   Homo sapiens Human  Hsap\ENSG00000089685
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000089685
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19147 Drosophila sechellia Dsec\GM15217 Drosophila erecta Dere\GG22093 Drosophila yakuba Dyak\GE10116 Drosophila ananassae Dana\GF18137 Drosophila pseudoobscura pseudoobscura Dpse\GA11519 Drosophila persimilis Dper\GL23676 Drosophila willistoni Dwil\GK11633 Drosophila virilis Dvir\GJ24423 Drosophila mojavensis Dmoj\GI24770 Drosophila grimshawi Dgri\GH13432
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	17963 w1118; PBac{RB}Dete01527 36600 y1 sc* v1; P{TRiP.GL00560}attP2 36612 y1 sc* v1; P{TRiP.GL00572}attP2
Harvard	- PBac{RB}Dete01527
VDRC	v105741 P{KK108638}VIE-260B v43112 w1118; P{GD4679}v43112 v43113 w1118; P{GD4679}v43113
Genomic Clones ( 2 )
	BACR01E04 BACR02L16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE55472
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM18522 LP03704 RE02176 SD11462 SD12181 SD17827 SD27043
Other clones	42857 63855 154050 163197 166295 214307.35 214501.39 Dmel_dig_014101_0682_3296 EC22916 EK166618 EK190858 EK228602 EK258042 EK266940 EP02156 EP11649 FGC027E12 RP01363 RP001003090 RP001003421 RP001019843 RP001020176 RP001023847 RP001024038 RP001043937 RP001048097 RP001051599
RNAi & Array Information
Linkouts
Antibody Information
	monoclonal (Szafer-Glusman et al., 2011) polyclonal (Szafer-Glusman et al., 2011, Jones et al., 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Det CG12265 (Jones et al., 2000) Source for merge of: Det scpo (Szafer-Glusman et al., 2011)
Additional comments
Other Comments
	Loss of Det function during anaphase affects localisation of the centralspindlin component pav but not the microtubule-bundling protein feo in spermatocytes. (Szafer-Glusman et al., 2011) Det acts as an apoptosis inhibitor. (Jones et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142351 RefSeq (Proteins) • NP_650608 DDBJ / EMBL / GenBank • AAF55399 AAL49109 AI260030 AY071487 BI369328 CZ479340 Entrez Gene - A searchable database of RefSeq genes. • 42077 UniProtKB/TrEMBL • Q9VEM2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Baculoviral inhibition of apoptosis protein repeat (IPR001370) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE55472
Linkouts
	SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VEM2
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG12265 (Ni et al., 2011.7.19, Ying et al., 2011, Keleman et al., 2009.8.5, Munoz-Soriano et al., 2012) Det   scpo (Szafer-Glusman et al., 2011, )
Name Synonym	CG12265   deterin (Szafer-Glusman et al., 2011, Reed and Bischoff, 2000) Deterin (Neumüller et al., 2011, Jones et al., 2000, Capalbo et al., 2012) dSurvivin (Szafer-Glusman et al., 2011) scapolo (Szafer-Glusman et al., 2011, Giansanti et al., 2004) Survivin (Szafer-Glusman et al., 2011)
Secondary FlyBase IDs
	FBgn0038489 FBgn0042948 FBgn0083063 FBgn0259784
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 6 ) Review  ( 7 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Capalbo et al., 2012, Open Biol. 2(5): 120070 The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. [FBrf0218656] Munoz-Soriano et al., 2012, J. Mol. Neurosci. 48(1): 136--143 Septin 4, the Drosophila Ortholog of Human CDCrel-1, Accumulates in parkin Mutant Brains and is Functionally Related to the Nedd4 E3 Ubiquitin Ligase. [FBrf0219099] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Szafer-Glusman et al., 2011, Mol. Biol. Cell 22(20): 3779--3790 Role of Survivin in cytokinesis revealed by a separation-of-function allele. [FBrf0216422] Ying et al., 2011, PLoS ONE 6(9): e23863 Comprehensively Surveying Structure and Function of RING Domains from Drosophila melanogaster. [FBrf0215242] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...