FlyBase Gene Report: Dmel\CG43776

General Information

Symbol

Dmel\CG43776

Species

D. melanogaster

Name

Annotation Symbol

CG43776

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264298

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:24,123,167..24,126,630 [-]

Recombination map

2-106

RefSeq locus

NT_033778 REGION:24123167..24126630

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (2 terms)

Molecular Function (0 terms)

There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2012-02-23 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

There is no information supporting a Biological Process term for this gene. (Based on a review of available data on: 2012-02-23 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in extracellular region

inferred from sequence model

(FlyBase Curators, 2011-)

located_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000036124

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG43776 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

gene_with_polycistronic_transcript

(FlyBase Genome Annotators, 2012)

protein_coding_gene

(FlyBase Genome Annotators, 2012)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG43776-RA

FBtr0331501

NM_001274233

2959

270

CG43776-RB

FBtr0343439

NM_001299895

1961

270

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG43776-PA

FBpp0303891

30.9

270

9.63

NP_001261162

AGB93692

CG43776-PB

FBpp0310083

30.9

270

9.63

NP_001286824

AHN56619

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

270 aa isoforms: CG43776-PA, CG43776-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

A0A0B4KFH2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG43776 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG43776_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG43776 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG43776

View exonic expression by tissue for Dmel\CG43776

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264297

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13569

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG43776

Transgenic constructs containing regulatory region of CG43776

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

CG43776^GD2198

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PI16

4 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Crisp1

4 of 15

Yes

Mmus\Crisp3

4 of 15

Yes

Mmus\Glipr1l1

4 of 15

Yes

Mmus\Pi16

4 of 15

Yes

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Rattus norvegicus (Norway rat) (13)

Rnor\Crisp3

4 of 13

Yes

Rnor\Glipr1l1

4 of 13

Yes

Rnor\Pi16

4 of 13

Yes

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Xenopus tropicalis (Western clawed frog) (17)

Xtro\crisp2

4 of 12

Yes

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Yes

Xtro\LOC100490275

1 of 12

Yes

Xtro\LOC100492430

1 of 12

Yes

Xtro\LOC100497187

1 of 12

Xtro\LOC101732829

1 of 12

Yes

Xtro\LOC105947480

1 of 12

Yes

Xtro\pi15

1 of 12

Xtro\pi16

1 of 12

Yes

Danio rerio (Zebrafish) (13)

Drer\LOC100536500

4 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (36)

Cele\scl-23

4 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

Cele\T12A7.10

1 of 15

Yes

Cele\Y39G8B.10

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (22)

Atha\AT1G01310

2 of 9

Yes

Atha\AT1G50050

2 of 9

Yes

Atha\AT1G50060

2 of 9

Yes

Atha\AT2G19970

2 of 9

Yes

Atha\AT2G19980

2 of 9

Yes

Atha\AT3G09590

2 of 9

Yes

Atha\AT3G19690

2 of 9

Yes

Atha\AT4G07820

2 of 9

Yes

Atha\AT4G25790

2 of 9

Yes

Atha\AT4G30320

2 of 9

Yes

Atha\AT4G31470

2 of 9

Yes

Atha\AT4G33710

2 of 9

Yes

Atha\AT4G33720

2 of 9

Yes

Atha\AT4G33730

2 of 9

Yes

Atha\AT5G02730

2 of 9

Yes

Atha\AT5G26130

2 of 9

Yes

Atha\AT5G57625

2 of 9

Yes

Atha\AT5G66590

2 of 9

Yes

Atha\PR1

2 of 9

Yes

Atha\PR-1-LIKE

2 of 9

Yes

Atha\PRB1

2 of 9

Yes

Atha\AT4G25780

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\PRY1

3 of 15

Yes

Scer\PRY2

3 of 15

Yes

Scer\PRY3

3 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190DOS )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila simulans

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila erecta

Drosophila erecta

Drosophila yakuba

Drosophila yakuba

Drosophila yakuba

Drosophila ananassae

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA24364

Drosophila persimilis

Dper\GL10419

Drosophila willistoni

Dwil\GK23199

Drosophila virilis

Dvir\GJ22140

Drosophila mojavensis

Dmoj\GI19264

Drosophila grimshawi

Dgri\GH21914

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508C7 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17023585

Glossina morsitans

Tsetse fly

Gmor\GMOY008544

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09816

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_14282

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ACQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR001362

Strigamia maritima

European centipede

Smar\SMAR001361

Strigamia maritima

European centipede

Smar\SMAR002664

Strigamia maritima

European centipede

Smar\SMAR010832

Ixodes scapularis

Black-legged tick

Isca\ISCW008900

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_312470

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_307125

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_97193

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_305416

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_312473

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_91992

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_312469

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (37)

Gene Symbol

Score

Source

Alignment

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PI16; peptidase inhibitor 16

4 of 15

CLEC18A; C-type lectin domain family 18 member A

3 of 15

616571

CLEC18B; C-type lectin domain family 18 member B

3 of 15

616572

CRISP1; cysteine rich secretory protein 1

3 of 15

601193

CRISP2; cysteine rich secretory protein 2

3 of 15

187430

CRISP3; cysteine rich secretory protein 3

3 of 15

618062

GLIPR1L1; GLIPR1 like 1

3 of 15

610395

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-106

Cytogenetic map

60B11-60B11

Sequence location

2R:24,123,167..24,126,630 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60B11-60B11

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-106

(FlyBase, 2016)

2-110.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Bloomington

26113

w¹¹¹⁸; Mi{ET1}CG3257^MB08418 CG43775^MB08418 CG43776^MB08418 CG43777^MB08418

VDRC

v102546

P{KK111959}VIE-260B

v3611

w¹¹¹⁸; P{GD2198}v3611

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (7)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264298

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

bs68c08

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

14462630

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Annotation CG13569 split into CG43775, CG43776 and CG43777 in release 5.45 of the genome annotation. The three release 5.45 annotations each represent a non-overlapping open reading frame which are encoded by a tricistronic processed transcript.

(FlyBase Genome Annotators, 2012)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 17 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

14462630

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KFH2

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264297

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264298

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG43776_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13569

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

14462630

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG43776

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG13569

(Dickson et al., 2007.7.18)

CG13569-2

(Kovalick and Griffin, 2005)

CG43776

Name Synonyms

Secondary FlyBase IDs

FBgn0034979

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (20)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections