General Information
Symbol
Dmel\orb2
Species
D. melanogaster
Name
orb2
Annotation Symbol
CG43782
Feature Type
FlyBase ID
FBgn0264307
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Genomic Location
Cytogenetic map
Sequence location
3L:8,937,100..8,954,463 [-]
Recombination map
3-27
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Summaries
UniProt Contributed Function Data
Required in mushroom body gamma neurons for long-term memory in male courtship (PubMed:17965711, PubMed:23083740). Binds to mRNA 3'-UTRs (PubMed:20547833, PubMed:26638074, PubMed:24830287, PubMed:26095367). In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover (PubMed:20547833, PubMed:26638074). In its amyloid-like oligomeric form, acts as a translational activator (PubMed:26638074). The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA (PubMed:26638074). Isoform A is required for initial memory acquisition and, following subsequent late dopaminergic pathway activation, isoform A recruits isoform B into a complex to activate translation of CaMKII which is required for long-term memory consolidation (PubMed:26095367). Involved in asymmetric cell division in the central nervous system (PubMed:21900268). Required for the progression of spermatogenesis through meiosis and for sperm differentiation (PubMed:23209437). During sperm differentiation, required to asymmetrically localize and activate the translation of protein kinase aPKC mRNAs which is necessary for spermatid cyst polarization (PubMed:24830287). Also required during spermatid cyst polarization for localization and translation of its own mRNA (PubMed:24830287).
(UniProt, Q9VSR3)
Interactive Fly
cytoplasmic polyadenylation element-binding protein - RNA binding protein - forms amyloid-like oligomers enriched in the synaptic membrane - critical for the persistence of long-term memory
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\orb2 or the JBrowse view of Dmel\orb2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Genes with CDS overlap: isoforms of orb2 and CG43783 share two different promoters, 5' UTR exons, and N-terminal coding sequences (162 residues); overlapping structure not conserved outside of Drosophila.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
gene_with_stop_codon_read_through ; SO:0000697
Double stop-codon suppression (UAA, UAG) postulated; FBrf0234051 and FlyBase analysis.
Gene model reviewed during 6.25
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0331511
2098
551
FBtr0331512
3116
704
FBtr0331513
4187
704
FBtr0331514
6425
704
FBtr0331515
8400
704
FBtr0474158
4187
769
FBtr0474159
4187
709
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0303901
59.7
551
7.74
FBpp0303902
74.5
704
7.63
FBpp0303903
74.5
704
7.63
FBpp0303904
74.5
704
7.63
FBpp0303905
74.5
704
7.63
FBpp0423157
81.5
769
8.20
FBpp0423158
75.2
709
7.98
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

704 aa isoforms: orb2-PB, orb2-PC, orb2-PD, orb2-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Domain
Isoform A: The N-terminal Gln/His-rich domain is necessary and sufficient for long-term memory and is required for formation of amyloid-like oligomers with isoform B (PubMed:17965711, PubMed:23083740). Isoform B: The N-terminal Gln/His-rich domain is both dispensable and insufficient for long-term memory and for formation of amyloid-like oligomers with isoform A (PubMed:23083740). Isoform A: The RNA-binding region is not essential for long-term memory. Isoform B: The RNA-binding region is essential for long-term memory.
(UniProt, Q9VSR3)
Subunit Structure (UniProtKB)
Monomer (PubMed:22284910, PubMed:23083740). Upon neuronal stimulation, forms stable amyloid-like oligomers composed of isoform A and isoform B which are required for formation of persistent long-term memory (PubMed:22284910, PubMed:23083740). Isoform A is critical for oligomer formation (PubMed:22284910, PubMed:23083740). Phe-5 of isoform A is required for amyloid-like oligomerization (PubMed:22284910, PubMed:26812143). Rapidly forms amyloids and toxic intermediates are extremely transient (PubMed:26812143). Interacts with the translational regulator bol (PubMed:23209437). Interacts with Tob; the interaction is enhanced by neuronal stimulation, stabilizes isoform A and induces oligomerization (PubMed:24523662).
(UniProt, Q9VSR3)
Post Translational Modification
Phosphorylation regulates interaction with Tob and oligomerization. Protein phosphatase 2A keeps both Orb2 and Tob in an unphosphorylated form. Following synaptic activation, unphosphorylated Orb2 is bound and stabilized by unphosphorylated Tob. Tob recruits activated LimK which phosphorylates both Orb2 and Tob and enhances Orb2 oligomerization.
(UniProt, Q9VSR3)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\orb2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (29 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q9VXJ9
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
inferred from sequence or structural similarity
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
non-traceable author statement
(assigned by UniProt )
inferred from sequence model
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
Biological Process (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
Cellular Component (11 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: 2-4h AEL. Expression specific to orb2 isoforms orb2-RB,RC,RD.

organism

Comment: 9-12h AEL. Expression specific to orb2 isoforms orb2-RB,RC,RD.

organism

Comment: 18-24h AEL. Expression specific to orb2 isoforms orb2-RB,RC,RD.

adult head

Comment: Expression specific to orb2 isoforms orb2-RB,RC,RD.

ovary

Comment: Expression specific to orb2 isoforms orb2-RB,RC,RD.

testis

Comment: Expression specific to orb2 isoforms orb2-RA,RB,RC,RD.

Additional Descriptive Data
The transcript isoforms RB, RC and RD of orb2 are detected in embryos and in the head and gonads of adult flies. The isoform RA is only detected in the testis. In embryos, orb2 transcript is enriched in the central nervous system in the extended germ band stage. In the ovary, orb2 is weakly expressed in the cytoplasm of all germline cells in previtellogenic stage chambers. From oogenesis stages S8 to S10, orb2 transcript is expressed more strongly and excluded from the oocyte, unlike the orb2 protein.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: 0-16h AEL. Expression specific to orb2 isoforms orb2-PB,PC,PD.

adult head

Comment: Expression specific to orb2 isoforms orb2-PB,PC,PD.

organism | restricted

Comment: In body. Expression specific to orb2 isoforms orb2-PB,PC,PD.

ovary | faint

Comment: Expression specific to orb2 isoforms orb2-PB,PC,PD.

testis | intense

Comment: Expression specific to orb2 isoforms orb2-PA,PB,PC,PD.

organism

Comment: Polypeptides PB,PC,PD

Additional Descriptive Data
orb2 protein is deposited maternally and expressed throughout embryogenesis with a decrease in expression between 4-8h AEL. Expression of orb2 protein is detected in the cell bodies of neurons in the CNS and PNS, being excluded from longitudinal and commissural axon tracts. orb2 protein labels the lineage of the Even-skipped positive neuroblast NB4-2. It also labels the cytoplasm of mesodermal cells, in which it co-localises with Scer\GAL4twi.PU. Western blot analysis indicates that in adults, the isoform orb2-PA is restricted to the testis, while the other isoforms orb2-PB,PC and PD are detected in ovaries and testis. orb2 protein is detected in the cell bodies of a subset of neurons in the larval brain and ventral nerve cord. In the adult, orb2 protein is expressed in the ellipsoid body, in two unindentified and symmetrical structures dorsal to the ellipsoid body, in an unpaired structure on the left hemisphere, lateral to the ellipsoid body and in the fan-shaped body. In adult neurons, orb2 protein seems to be localised to the synaptic terminals. In the ovaries, in previtellogenic stage chambers, orb2 protein is detected in all of the cells but enriched in a cap posterior to the oocyte. At oogenesis stages S8 to S10, orb2 protein is enriched in the cortex of the oocyte, similarly to orb protein. orb2 protein is expressed around the nucleus of the nurse cells, unlike the orb2 transcript. It is also detected in a gradient in the cytoplasm of the nurse cells, with expression being strongest in the most posterior cells (closest to the oocyte). orb2 protein is released from these cells into the oocyte via ring canals.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\orb2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 28 )
For All Classical and Insertion Alleles Show
 
Allele of orb2
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Other relevant insertions
miscellaneous insertions
Name
Expression Data
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of orb2
Allele of orb2
Mutagen
Associated Transgenic Construct
Stocks
Transgenic constructs containing regulatory region of orb2
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
8 of 15
No
Yes
7 of 15
No
Yes
4 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Mmus\Cpeb2
10 of 15
Yes
Yes
8 of 15
No
Yes
8 of 15
No
Yes
5 of 15
No
Yes
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
6 of 13
Yes
Yes
5 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
6 of 12
Yes
Yes
4 of 12
No
Yes
4 of 12
No
Yes
Danio rerio (Zebrafish) (7)
7 of 15
Yes
Yes
6 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
7 of 15
Yes
Yes
6 of 15
No
Yes
5 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (2)
1 of 9
Yes
Yes
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
1 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908HS )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila sechellia
Drosophila yakuba
Drosophila persimilis
Drosophila willistoni
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506VZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Glossina morsitans
Tsetse fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W072P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06XT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0AO9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 1 )
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please look at the Interaction Group reports for full details of the physical interactions
    protein-protein
    Interacting group
    Assay
    References
    RNA-protein
    Interacting group
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Monomer (PubMed:22284910, PubMed:23083740). Upon neuronal stimulation, forms stable amyloid-like oligomers composed of isoform A and isoform B which are required for formation of persistent long-term memory (PubMed:22284910, PubMed:23083740). Isoform A is critical for oligomer formation (PubMed:22284910, PubMed:23083740). Phe-5 of isoform A is required for amyloid-like oligomerization (PubMed:22284910, PubMed:26812143). Rapidly forms amyloids and toxic intermediates are extremely transient (PubMed:26812143). Interacts with the translational regulator bol (PubMed:23209437). Interacts with Tob; the interaction is enhanced by neuronal stimulation, stabilizes isoform A and induces oligomerization (PubMed:24523662).
    (UniProt, Q9VSR3 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-27
    Cytogenetic map
    Sequence location
    3L:8,937,100..8,954,463 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    66E4-66E4
    Limits computationally determined from genome sequence between P{PZ}l(3)0162901629&P{PZ}mRpL1210534 and P{EP}Hsp26EP3336&P{EP}Hsp26EP3315
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (18)
    Genomic Clones (26)
    cDNA Clones (216)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      Other clones
      RNAi and Array Information
      Linkouts
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: orb2 CG5735
      Source for database merge of
      Source for merge of: orb2 anon-WO0140519.222
      Source for merge of: orb2 CG5741
      Additional comments
      Annotation CG43113 split into CG43782 (corresponds to orb2) and CG43783 in release 5.45 of the genome annotation. CG43782 is a reinstatement of the CG5735 annotation and CG43783 is a reinstatement of the CG5741 annotation (CG5735 and CG5741 were merged in release 5.32 to produce CG43113).
      Annotations CG43782 and CG43783 share some exons at the 5' end, including some coding sequence.
      Annotations CG5735 and CG5741 merged as CG43113 in release 5.32 of the genome annotation.
      Source for merge of orb2 anon-WO0140519.222 was sequence comparison ( date:051113 ).
      Other Comments
      The orb2 protein has two distinct physical states: a monomer and an amyloid-like oligomer. The monomeric form represses translation, whereas the oligomeric form activates translation.
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 64 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Linkouts
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      KEGG Genes - Molecular building blocks of life in the genomic space.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (10)
      Reported As
      Name Synonyms
      cg43782 gene product from transcript cg43782-rh
      Secondary FlyBase IDs
      • FBgn0262573
      • FBgn0035938
      • FBgn0044649
      • FBgn0264304
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (93)