Gene Dmel\Atg6

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General Information

Symbol

Dmel\Atg6

Species

D. melanogaster

Name

Autophagy-specific gene 6

Annotation symbol

CG5429

Feature type

protein_coding_gene

FlyBase ID

FBgn0264325

Gene Model Status

Current

Stock availability

5 publicly available

Also Known As

l(3)00096

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

95D10-95D10

Sequence location

3R:19,874,902..19,876,504 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene Autophagy-specific gene 6 is referred to in FlyBase by the symbol Dmel\Atg6 (CG5429, FBgn0264325). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: autophagic cell death; salivary gland cell autophagic cell death. 13 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Beclin family. Gene sequence location is 3R:19874902..19876504.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

95D10-95D10

Limits computationally determined from genome sequence between P{PZ}l(3)04684⁰⁴⁶⁸⁴ and P{PZ}Atg6⁰⁰⁰⁹⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

95D10-95D11

(determined by in situ hybridisation)

(Spradling et al., 1999)

95D10-95D11

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Atg6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Atg6-RA

FBtr0084590

NM_142952

1493

422

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Atg6-PA

FBpp0083975

48.9

422

4.53

NP_651209

AAF56227

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Beclin family (IPR007243)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VCE1

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		8
central nervous system, pupae P8		6
head, virgin 1-day female		7
head, virgin 4-day female		8
head, virgin 20-day female		8
head, mated 1-day female		8
head, mated 4-day female		8
head, mated 20-day female		6
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		13
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		13
digestive system, larvae L3 wandering		18
digestive system, 1-day adult		6
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		2
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		12
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		6
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		16
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		8
central nervous system, pupae P8		6
head, virgin 1-day female		7
head, virgin 4-day female		8
head, virgin 20-day female		8
head, mated 1-day female		8
head, mated 4-day female		8
head, mated 20-day female		6
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		13
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		13
digestive system, larvae L3 wandering		18
digestive system, 1-day adult		6
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		2
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		12
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		6
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		16
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		8
central nervous system, pupae P8		6
head, virgin 1-day female		7
head, virgin 4-day female		8
head, virgin 20-day female		8
head, mated 1-day female		8
head, mated 4-day female		8
head, mated 20-day female		6
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		13
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		13
digestive system, larvae L3 wandering		18
digestive system, 1-day adult		6
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		2
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		12
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		6
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		16
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		8
central nervous system, pupae P8		6
head, virgin 1-day female		7
head, virgin 4-day female		8
head, virgin 20-day female		8
head, mated 1-day female		8
head, mated 4-day female		8
head, mated 20-day female		6
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		13
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		13
digestive system, larvae L3 wandering		18
digestive system, 1-day adult		6
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		2
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		12
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		6
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		16
accessory gland, mated 4-day male		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		8
central nervous system, pupae P8		6
head, virgin 1-day female		7
head, virgin 4-day female		8
head, virgin 20-day female		8
head, mated 1-day female		8
head, mated 4-day female		8
head, mated 20-day female		6
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		13
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		13
digestive system, larvae L3 wandering		18
digestive system, 1-day adult		6
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		2
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		12
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		6
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		16
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		8
central nervous system, pupae P8		6
head, virgin 1-day female		7
head, virgin 4-day female		8
head, virgin 20-day female		8
head, mated 1-day female		8
head, mated 4-day female		8
head, mated 20-day female		6
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		13
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		13
digestive system, larvae L3 wandering		18
digestive system, 1-day adult		6
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		2
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		12
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		6
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		16
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		8
central nervous system, pupae P8		6
head, virgin 1-day female		7
head, virgin 4-day female		8
head, virgin 20-day female		8
head, mated 1-day female		8
head, mated 4-day female		8
head, mated 20-day female		6
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		13
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		13
digestive system, larvae L3 wandering		18
digestive system, 1-day adult		6
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		2
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		12
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		6
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		16
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		8
central nervous system, pupae P8		6
head, virgin 1-day female		7
head, virgin 4-day female		8
head, virgin 20-day female		8
head, mated 1-day female		8
head, mated 4-day female		8
head, mated 20-day female		6
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		13
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		13
digestive system, larvae L3 wandering		18
digestive system, 1-day adult		6
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		2
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		12
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		6
ovary, virgin 4-day female		14
ovary, mated 4-day female		14
testis, mated 4-day male		16
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		20
embryo 02-04hr		17
embryo 04-06hr		21
embryo 06-08hr		18
embryo 08-10hr		15
embryo 10-12hr		17
embryo 12-14hr		14
embryo 14-16hr		12
embryo 16-18hr		14
embryo 18-20hr		17
embryo 20-22hr		15
embryo 22-24hr		17
larva L1		12
larva L2		10
larva L3 12hr old		8
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		18
white prepupae new		17
white prepupae 12hr		15
white prepupae 24hr		15
pupae 2d postWPP		13
pupae 3d postWPP		10
pupae 4d postWPP		15
adult male 01day		11
adult male 05day		13
adult male 30day		13
adult female 01day		12
adult female 05day		15
adult female 30day		16
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		20
embryo 02-04hr		17
embryo 04-06hr		21
embryo 06-08hr		18
embryo 08-10hr		15
embryo 10-12hr		17
embryo 12-14hr		14
embryo 14-16hr		12
embryo 16-18hr		14
embryo 18-20hr		17
embryo 20-22hr		15
embryo 22-24hr		17
larva L1		12
larva L2		10
larva L3 12hr old		8
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		18
white prepupae new		17
white prepupae 12hr		15
white prepupae 24hr		15
pupae 2d postWPP		13
pupae 3d postWPP		10
pupae 4d postWPP		15
adult male 01day		11
adult male 05day		13
adult male 30day		13
adult female 01day		12
adult female 05day		15
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		20
embryo 02-04hr		17
embryo 04-06hr		21
embryo 06-08hr		18
embryo 08-10hr		15
embryo 10-12hr		17
embryo 12-14hr		14
embryo 14-16hr		12
embryo 16-18hr		14
embryo 18-20hr		17
embryo 20-22hr		15
embryo 22-24hr		17
larva L1		12
larva L2		10
larva L3 12hr old		8
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		18
white prepupae new		17
white prepupae 12hr		15
white prepupae 24hr		15
pupae 2d postWPP		13
pupae 3d postWPP		10
pupae 4d postWPP		15
adult male 01day		11
adult male 05day		13
adult male 30day		13
adult female 01day		12
adult female 05day		15
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		20
embryo 02-04hr		17
embryo 04-06hr		21
embryo 06-08hr		18
embryo 08-10hr		15
embryo 10-12hr		17
embryo 12-14hr		14
embryo 14-16hr		12
embryo 16-18hr		14
embryo 18-20hr		17
embryo 20-22hr		15
embryo 22-24hr		17
larva L1		12
larva L2		10
larva L3 12hr old		8
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		18
white prepupae new		17
white prepupae 12hr		15
white prepupae 24hr		15
pupae 2d postWPP		13
pupae 3d postWPP		10
pupae 4d postWPP		15
adult male 01day		11
adult male 05day		13
adult male 30day		13
adult female 01day		12
adult female 05day		15
adult female 30day		16
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		20
embryo 02-04hr		17
embryo 04-06hr		21
embryo 06-08hr		18
embryo 08-10hr		15
embryo 10-12hr		17
embryo 12-14hr		14
embryo 14-16hr		12
embryo 16-18hr		14
embryo 18-20hr		17
embryo 20-22hr		15
embryo 22-24hr		17
larva L1		12
larva L2		10
larva L3 12hr old		8
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		18
white prepupae new		17
white prepupae 12hr		15
white prepupae 24hr		15
pupae 2d postWPP		13
pupae 3d postWPP		10
pupae 4d postWPP		15
adult male 01day		11
adult male 05day		13
adult male 30day		13
adult female 01day		12
adult female 05day		15
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		20
embryo 02-04hr		17
embryo 04-06hr		21
embryo 06-08hr		18
embryo 08-10hr		15
embryo 10-12hr		17
embryo 12-14hr		14
embryo 14-16hr		12
embryo 16-18hr		14
embryo 18-20hr		17
embryo 20-22hr		15
embryo 22-24hr		17
larva L1		12
larva L2		10
larva L3 12hr old		8
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		18
white prepupae new		17
white prepupae 12hr		15
white prepupae 24hr		15
pupae 2d postWPP		13
pupae 3d postWPP		10
pupae 4d postWPP		15
adult male 01day		11
adult male 05day		13
adult male 30day		13
adult female 01day		12
adult female 05day		15
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		20
embryo 02-04hr		17
embryo 04-06hr		21
embryo 06-08hr		18
embryo 08-10hr		15
embryo 10-12hr		17
embryo 12-14hr		14
embryo 14-16hr		12
embryo 16-18hr		14
embryo 18-20hr		17
embryo 20-22hr		15
embryo 22-24hr		17
larva L1		12
larva L2		10
larva L3 12hr old		8
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		18
white prepupae new		17
white prepupae 12hr		15
white prepupae 24hr		15
pupae 2d postWPP		13
pupae 3d postWPP		10
pupae 4d postWPP		15
adult male 01day		11
adult male 05day		13
adult male 30day		13
adult female 01day		12
adult female 05day		15
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		20
embryo 02-04hr		17
embryo 04-06hr		21
embryo 06-08hr		18
embryo 08-10hr		15
embryo 10-12hr		17
embryo 12-14hr		14
embryo 14-16hr		12
embryo 16-18hr		14
embryo 18-20hr		17
embryo 20-22hr		15
embryo 22-24hr		17
larva L1		12
larva L2		10
larva L3 12hr old		8
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		14
larva L3 puffstage 7-9		18
white prepupae new		17
white prepupae 12hr		15
white prepupae 24hr		15
pupae 2d postWPP		13
pupae 3d postWPP		10
pupae 4d postWPP		15
adult male 01day		11
adult male 05day		13
adult male 30day		13
adult female 01day		12
adult female 05day		15
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		35
Schneider line 2 Sg4		16
embryonic 1182-4H		17
embryonic GM2		22
embryonic Kc167		15
embryonic S1		19
embryonic S3		11
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		17
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		17
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		16
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		21
CNS ML-DmBG1-c1		16
CNS ML-DmBG2-c2		16
tumorous blood cells mbn2		11
ovary fGS/OSS		22
ovary OSC		16
ovary OSS		12
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(35)
Schneider line 2 Sg4		16
embryonic 1182-4H		17
embryonic GM2		22
embryonic Kc167		15
embryonic S1		19
embryonic S3		11
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		17
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		17
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		(27)
eye-antennal disc ML-DmD11		16
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		21
CNS ML-DmBG1-c1		16
CNS ML-DmBG2-c2		16
tumorous blood cells mbn2		11
ovary fGS/OSS		22
ovary OSC		16
ovary OSS		12
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		35
Schneider line 2 Sg4		16
embryonic 1182-4H		17
embryonic GM2		22
embryonic Kc167		15
embryonic S1		19
embryonic S3		11
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		17
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		17
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		16
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		21
CNS ML-DmBG1-c1		16
CNS ML-DmBG2-c2		16
tumorous blood cells mbn2		11
ovary fGS/OSS		22
ovary OSC		16
ovary OSS		12
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		35
Schneider line 2 Sg4		16
embryonic 1182-4H		17
embryonic GM2		22
embryonic Kc167		15
embryonic S1		19
embryonic S3		11
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		17
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		17
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		16
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		21
CNS ML-DmBG1-c1		16
CNS ML-DmBG2-c2		16
tumorous blood cells mbn2		11
ovary fGS/OSS		22
ovary OSC		16
ovary OSS		12
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		35
Schneider line 2 Sg4		16
embryonic 1182-4H		17
embryonic GM2		22
embryonic Kc167		15
embryonic S1		19
embryonic S3		11
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		17
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		17
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		16
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		21
CNS ML-DmBG1-c1		16
CNS ML-DmBG2-c2		16
tumorous blood cells mbn2		11
ovary fGS/OSS		22
ovary OSC		16
ovary OSS		12
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(35)
Schneider line 2 Sg4		16
embryonic 1182-4H		17
embryonic GM2		22
embryonic Kc167		15
embryonic S1		19
embryonic S3		11
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		17
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		17
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		16
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		21
CNS ML-DmBG1-c1		16
CNS ML-DmBG2-c2		16
tumorous blood cells mbn2		11
ovary fGS/OSS		22
ovary OSC		16
ovary OSS		12
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		35
Schneider line 2 Sg4		16
embryonic 1182-4H		17
embryonic GM2		22
embryonic Kc167		15
embryonic S1		19
embryonic S3		11
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		17
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		17
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		16
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		21
CNS ML-DmBG1-c1		16
CNS ML-DmBG2-c2		16
tumorous blood cells mbn2		11
ovary fGS/OSS		22
ovary OSC		16
ovary OSS		12
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		35
Schneider line 2 Sg4		16
embryonic 1182-4H		17
embryonic GM2		22
embryonic Kc167		15
embryonic S1		19
embryonic S3		11
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		17
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		12
wing disc ML-DmD21		17
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		27
eye-antennal disc ML-DmD11		16
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		21
CNS ML-DmBG1-c1		16
CNS ML-DmBG2-c2		16
tumorous blood cells mbn2		11
ovary fGS/OSS		22
ovary OSC		16
ovary OSS		12
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		4
heat shock, 4-day adult		11
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		8
Cadmium 100 mM 48 hrs, 4-day adult		10
Copper 0.5 mM 12 hrs, larvae L3		11
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		14
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		13
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		14
Paraquat 10 mM 48 hrs, 4-day adult		12
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		4
heat shock, 4-day adult		11
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		8
Cadmium 100 mM 48 hrs, 4-day adult		10
Copper 0.5 mM 12 hrs, larvae L3		11
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		14
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		13
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		14
Paraquat 10 mM 48 hrs, 4-day adult		12
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		4
heat shock, 4-day adult		11
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		8
Cadmium 100 mM 48 hrs, 4-day adult		10
Copper 0.5 mM 12 hrs, larvae L3		11
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		14
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		13
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		14
Paraquat 10 mM 48 hrs, 4-day adult		12
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		4
heat shock, 4-day adult		11
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		8
Cadmium 100 mM 48 hrs, 4-day adult		10
Copper 0.5 mM 12 hrs, larvae L3		11
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		14
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		13
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		14
Paraquat 10 mM 48 hrs, 4-day adult		12
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		4
heat shock, 4-day adult		11
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		8
Cadmium 100 mM 48 hrs, 4-day adult		10
Copper 0.5 mM 12 hrs, larvae L3		11
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		14
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		13
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		14
Paraquat 10 mM 48 hrs, 4-day adult		12
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		4
heat shock, 4-day adult		11
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		8
Cadmium 100 mM 48 hrs, 4-day adult		10
Copper 0.5 mM 12 hrs, larvae L3		11
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		14
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		13
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		14
Paraquat 10 mM 48 hrs, 4-day adult		12
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		4
heat shock, 4-day adult		11
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		8
Cadmium 100 mM 48 hrs, 4-day adult		10
Copper 0.5 mM 12 hrs, larvae L3		11
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		14
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		13
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		14
Paraquat 10 mM 48 hrs, 4-day adult		12
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		4
heat shock, 4-day adult		11
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		8
Cadmium 100 mM 48 hrs, 4-day adult		10
Copper 0.5 mM 12 hrs, larvae L3		11
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		14
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		13
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		14
Paraquat 10 mM 48 hrs, 4-day adult		12
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

LD35669

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | pupal stage | recessive

Atg6⁰⁰⁰⁹⁶

lethal | recessive

Atg6⁰⁰⁰⁹⁶

partially lethal - majority die

Atg6⁰⁰⁰⁹⁶

partially lethal - majority die | recessive

Atg6⁰⁰⁰⁹⁶

viable, with Scer\GAL4^pnr-MD237

Atg6^GD11647

Phenotype manifest in

Allele

Classical Alleles ( 5 )

For All Classical Alleles Show

Allele of Atg6	Mutagen	Stocks	Known lesion
Atg6⁰⁰⁰⁹⁶	P-element activity	1	--
Atg6^G3772		0	--
Atg6^G6654		0	--
Atg6^G6854	P-element activity	0	--
Atg6^GS3199		0	--

Alleles Carried on Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Atg6	Mutagen	Stocks	Known lesion
Atg6^GD11647	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
Atg6^HMS01483	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Atg6^JF02897	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Atg6^{dsRNA.Scer\UAS}	in vitro construct - RNAi	0	Yes
Atg6^KK102460	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
Atg6^NIG.5429R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
Atg6^Scer\UAS.cJa	in vitro construct - regulatory fusion	0	Yes
Atg6^{Scer\UAS.T:Hsap\MYC}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(3R)Exel6197

(Ryder, 2004.4.26)

Not disrupted in

Df(3R)crb87-4

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

Insertions

Type of insertions

Name

Expression data

insertion of enhancer trap

P{PZ}Atg6⁰⁰⁰⁹⁶

insertion of mobile activating element

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

Terms Based on Experimental Evidence ( 2 terms )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

autophagic cell death

inferred from expression pattern

(Gorski et al., 2003)

salivary gland cell autophagic cell death

inferred from expression pattern

(Gorski et al., 2003)

Cellular Component ( 0 terms)

Terms Based on Predictions or Assertions ( 1 term )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

autophagy

inferred from electronic annotation with InterPro:IPR007243

(FlyBase Curators et al., 2004-)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

Interactions & Pathways

Summary of Physical Interactions

protein-protein

Interacting group

Assay

References

Atg6 - Uvrag

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23)

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Atg6 allele

Gene

References

unspecified

bchs

(Simonsen et al., 2007)

Prosβ2

(Pandey et al., 2007)

External Data

Linkouts

Orthologs

OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6XSM8Q

Dipteran inclusive ortholog search

EOG6QZ7VF

Insect inclusive ortholog search

EOG608M4H

Arthropod inclusive ortholog search

EOG6WH726

Metazoa inclusive ortholog search

EOG6M0SV5

Orthologs in Drosophila Species (EOG6XSM8Q)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18874

Drosophila persimilis

Dper\GL24151

Drosophila willistoni

Dwil\GK11938

Drosophila virilis

Dvir\GJ14539

Drosophila mojavensis

Dmoj\GI22959

Drosophila grimshawi

Dgri\GH19099

Orthologs in non-Drosophila Dipterans (EOG6QZ7VF)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010427

Anopheles gambiae

Malaria mosquito

Agam\AGAP012793

Anopheles gambiae

Malaria mosquito

Agam\AGAP003858

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ011087

Orthologs in non-Dipteran Insects (EOG608M4H)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\Atg6

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011696

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH15517

Atta cephalotes

Leafcutter ant

Acep\ACEP17713

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO20580

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL15137

Linepithema humile

Argentine ant

Lhum\LH14136

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB24583

Solenopsis invicta

Red fire ant

Sinv\SINV18556

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004000

Bombyx mori

Silkmoth

Bmor\BGIBMGA000092

Pediculus humanus

Human body louse

Phum\PHUM420440

Tribolium castaneum

Red flour beetle

Tcas\TC009816

Orthologs in non-Insect Arthropods (EOG6WH726)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\MT-ND3

Ixodes scapularis

Deer tick

Isca\ISCW014200

Orthologs in non-Arthropod Metazoa (EOG6M0SV5)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\bec-1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_000256gn

Danio rerio

Zebrafish

Drer\becn1

Xenopus tropicalis

Western clawed frog

Xtro\becn1

Gallus gallus

Domestic chicken

Ggal\BECN1

Mus musculus

House mouse

Mmus\Becn1

Rattus norvegicus

Norway rat

Rnor\RGD1563293

Rattus norvegicus

Norway rat

Rnor\Becn1

Homo sapiens

Human

Hsap\BECN1

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\BECN1

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18874

Drosophila persimilis

Dper\GL24151

Drosophila willistoni

Dwil\GK11938

Drosophila virilis

Dvir\GJ14539

Drosophila mojavensis

Dmoj\GI22959

Drosophila grimshawi

Dgri\GH19099

Stocks & Reagents

Stocks Listed in FlyBase ( 5 )

Bloomington

28060

y¹ v¹; P{TRiP.JF02897}attP2

35741

y¹ sc^* v¹; P{TRiP.HMS01483}attP2

11487

ry⁵⁰⁶ P{PZ}Atg6⁰⁰⁰⁹⁶/TM3, ry^RK Sb¹ Ser¹

VDRC

v22122

w¹¹¹⁸; P{GD11647}v22122

v22123

w¹¹¹⁸; P{GD11647}v22123

Genomic Clones ( 1 )

BACR15J11

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 24 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LD35669

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for identity of: Atg6 CG5429

(Scott et al., 2004)

Source for database merge of

Source for merge of: Atg6 beclin

(FlyBase, 1992-)

Source for merge of: CG5429 l(3)00096

(Scott et al., 2004)

Additional comments

FlyBase curator comment: Correspondence with author Naps revealed that 'Beclin1' = 'CG5429'.

(Naps and Neufeld, 2008)

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_142952

RefSeq (Proteins)

•

NP_651209

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

42850

UniProtKB/Swiss-Prot

•

Q9VCE1

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Beclin family (IPR007243)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

LD35669

Linkouts

Synonyms & Secondary IDs ( 10 )

Reported As

Symbol Synonym

Atg6

(Demontis and Perrimon, 2010, Monserrate et al., 2007, Kadandale et al., 2010, Juhász et al., 2008, Martin et al., 2007, Liu and Lehmann, 2008, Cronin et al., 2009, Kim et al., 2010, Midorikawa et al., 2010, Érdi et al., 2012, Japanese National Institute of Genetics, 2012.5.21)

atg6

(Pandey et al., 2007, Pandey et al., 2007, Simonsen et al., 2007, Shelly et al., 2009, Shen and Ganetzky, 2009)

ATG6

(Lee et al., 2007, Wu et al., 2009)

beclin

(Shin and Yoo, 2007)

Beclin-1

(Kadandale et al., 2010)

Beclin1

(Lee et al., 2007)

CG5429

(Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Lee et al., 2003, Gorski et al., 2003, Laviolette et al., 2005, Chittaranjan et al., 2009, Perkins et al., 2009, Juhász et al., 2008, Érdi et al., 2012)

DmAtg6

(Chittaranjan et al., 2009)

l(3)00096

(Berkeley Drosophila Genome Project, 1993.6.1, Spradling et al., 1999, BDGP Project Members, 1994-1999, )

Name Synonym

Autophagy-specific gene 6

(Scott et al., 2004)

beclin

(Shin and Yoo, 2007)

Beclin1

(Naps and Neufeld, 2008, Juhász et al., 2008)

Secondary FlyBase IDs

FBgn0010709
FBgn0039144
FBgn0086211

References ( 46 )

Generate a list of

All references relating to this gene ( 46 )

List References by type

Research paper ( 22 )
Supplementary material ( 5 )
Personal communication to FlyBase ( 11 )
Abstract ( 4 )
FlyBase analysis ( 1 )
Stock list ( 1 )
DNA/RNA sequence record ( 1 )

Recent research papers ( 2 )

Érdi et al., 2012, Autophagy 8(7): 1124--1135: Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila. [FBrf0219844]
Ambegaokar and Jackson, 2011, Hum. Mol. Genet. 20(24): 4947--4977: Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. [FBrf0217690]

Show all research papers ...