DNApol-epsilon, DNApol-ε, DNA polymerase ε, DNApol-ε255, l(3)pl10
Differences between protein sequence and SWP:Q9GV40 are in the center of a long ORF and may correspond to strain differences.
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit DNApol-epsilon255/DNApolE1 and the accessory subunits DNApol-epsilon58/DNApolE2, Chrac-14/DNApolE3 and Mes4/DNApolE4.
The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for maintenance of the complex.
The C-terminal domain (1001-2236 aa) is required for mitotic DNA replication in the eye but not for DNA endoreplication in salivary glands.
The CysA-type zinc finger is required for PCNA-binding.
The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PolE1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\PolE1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: DNApol-ε CG6768
Source for merge of: DNApol-ε l(3)pl10