FB2020_06, released Dec 22, 2020

Gene: Dmel\Ca-α1T

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General Information
Symbol
Dmel\Ca-α1T
Species
D. melanogaster
Name
Ca2+-channel protein α1 subunit T
Annotation Symbol
CG15899
Feature Type
protein_coding_gene
FlyBase ID
FBgn0264386
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Snapshot
Ca[2+]-channel protein α[[1]] subunit T (Ca-α1T) encodes an α 1 subunit of a T-type like voltage gated calcium channel. It mediates a low voltage activated transient calcium current in antennal lobe projection neurons and wing motoneurons that is sensitive to amiloride. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As

Ca1G

Key Links
Genomic Location
Cytogenetic map
5D5-5D7
Sequence location
X:6,104,085..6,192,483 [-]
Recombination map

1-15

RefSeq locus
NC_004354 REGION:6104085..6192483
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables low voltage-gated calcium channel activity
inferred from mutant phenotype
(Ryglewski et al., 2012)
inferred from direct assay
(Jeong et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables low voltage-gated calcium channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000799039
(assigned by GO_Central )
(Gaudet et al., 2011)
enables voltage-gated sodium channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000004137
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in calcium ion transmembrane transport via low voltage-gated calcium channel
inferred from direct assay
(Jeong et al., 2015)
involved_in calcium ion transmembrane transport
inferred from mutant phenotype
(Ryglewski et al., 2012)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in calcium ion import
inferred from biological aspect of ancestor with PANTHER:PTN000799039
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in membrane depolarization during action potential
inferred from biological aspect of ancestor with PANTHER:PTN000004140
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in neuronal action potential
inferred from biological aspect of ancestor with PANTHER:PTN000799039
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred by curator from GO:0008332
(Jeong et al., 2015)
located_in neuron projection
inferred from biological aspect of ancestor with PANTHER:PTN000799039
(assigned by GO_Central )
(Gaudet et al., 2011)
part_of voltage-gated calcium channel complex
inferred from electronic annotation with InterPro:IPR005445
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
part_of voltage-gated sodium channel complex
inferred from biological aspect of ancestor with PANTHER:PTN000004137
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
VOLTAGE-GATED CALCIUM CHANNEL SUBUNITS -
Voltage-gated Ca2+ channels (CACN) allow the influx of extracellular Ca2+ in response to plasma membrane depolarization. CACNs are hetero-oligomeric assemblies of a pore-forming α1 subunit plus other structural and accessory subunits. (Adapted from FBrf0218524 and PMID:21746798).
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\Ca-α1T for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ca-α1T-RB
FBtr0089393
NM_132068
10842
3188
Ca-α1T-RC
FBtr0112953
NM_001103419
10893
3205
Ca-α1T-RD
FBtr0304609
NM_001258615
10818
3180
Ca-α1T-RE
FBtr0304610
NM_001258616
10878
3200
Ca-α1T-RF
FBtr0334984
NM_001272338
13025
3218
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ca-α1T-PB
FBpp0088415
352.2
3188
9.02
NP_572296
AAF46127
Ca-α1T-PC
FBpp0111866
354.2
3205
8.96
NP_001096889
ABW09342
Ca-α1T-PD
FBpp0293151
351.3
3180
9.00
NP_001245544
AFH07258
Ca-α1T-PE
FBpp0293152
353.5
3200
8.91
NP_001245545
AFH07259
Ca-α1T-PF
FBpp0306997
355.8
3218
9.00
NP_001259267
AGB95113
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ca-α1T using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ca-α1T in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 19 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ca-α1T
Transgenic constructs containing regulatory region of Ca-α1T
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
behavior defective | adult stage
circadian rhythm defective | adult stage
locomotor behavior defective | adult stage | male limited | progressive
neurophysiology defective | adult stage
short lived
sleep defective | adult stage
sleep defective | adult stage, with Ca-α1TGal4, Scer\GAL4Ca-α1T
sleep defective | adult stage, with Ca-α1TGD3252, Scer\GAL4Ca-α1T
sleep defective | adult stage, with Scer\GAL4104Y
sleep defective | adult stage, with Scer\GAL4elav-C155
sleep defective | adult stage (with Ca-α1TΔ3)
sleep defective | adult stage (with Ca-α1TΔ115)
sleep defective | adult stage (with Ca-α1TΔ135)
sleep defective | adult stage | RU486 conditional, with Scer\GAL4elav.Switch.PO
Phenotype manifest in
Allele
adult heart
indirect flight muscle motor neuron MN5
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CACNA1I
11 of 15
Yes
Yes
Hsap\CACNA1G
9 of 15
No
Yes
Hsap\CACNA1H
9 of 15
No
Yes
Hsap\CACNA1A
2 of 15
No
No
5  
Hsap\CACNA1B
2 of 15
No
No
Hsap\CACNA1C
2 of 15
No
No
Hsap\CACNA1D
2 of 15
No
No
Hsap\CACNA1E
2 of 15
No
No
Hsap\CACNA1F
2 of 15
No
No
Hsap\CACNA1S
2 of 15
No
No
Hsap\NALCN
2 of 15
No
No
Hsap\SCN5A
2 of 15
No
No
1  
Hsap\SCN8A
2 of 15
No
No
Hsap\SCN10A
2 of 15
No
No
Hsap\SCN11A
2 of 15
No
No
Hsap\CATSPER1
1 of 15
No
Yes
Hsap\CATSPER2
1 of 15
No
Yes
Hsap\CATSPER3
1 of 15
No
No
Hsap\CATSPER4
1 of 15
No
Yes
Hsap\SCN1A
1 of 15
No
No
Hsap\SCN2A
1 of 15
No
No
1  
Hsap\SCN3A
1 of 15
No
No
Hsap\SCN4A
1 of 15
No
No
Hsap\SCN7A
1 of 15
No
No
Hsap\SCN9A
1 of 15
No
No
Hsap\TPCN1
1 of 15
No
Yes
Hsap\TPCN2
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (26)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cacna1i
11 of 15
Yes
Yes
Mmus\Cacna1g
9 of 15
No
Yes
Mmus\Cacna1h
9 of 15
No
Yes
Mmus\Cacna1a
2 of 15
No
No
Mmus\Cacna1b
2 of 15
No
No
Mmus\Cacna1c
2 of 15
No
No
Mmus\Cacna1d
2 of 15
No
No
Mmus\Cacna1f
2 of 15
No
No
Mmus\Cacna1s
2 of 15
No
No
Mmus\Nalcn
2 of 15
No
No
Mmus\Scn5a
2 of 15
No
No
Mmus\Scn8a
2 of 15
No
No
Mmus\Scn10a
2 of 15
No
No
Mmus\Scn11a
2 of 15
No
No
Mmus\Cacna1e
1 of 15
No
No
Mmus\Catsper1
1 of 15
No
Yes
Mmus\Catsper2
1 of 15
No
Yes
Mmus\Catsper3
1 of 15
No
No
Mmus\Catsper4
1 of 15
No
Yes
Mmus\Scn1a
1 of 15
No
No
Mmus\Scn3a
1 of 15
No
No
Mmus\Scn4a
1 of 15
No
No
Mmus\Scn7a
1 of 15
No
No
Mmus\Scn9a
1 of 15
No
No
Mmus\Tpcn1
1 of 15
No
Yes
Mmus\Tpcn2
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (24)
Rnor\Cacna1h
6 of 13
Yes
Yes
Rnor\Cacna1i
6 of 13
Yes
Yes
Rnor\Cacna1g
5 of 13
No
Yes
Rnor\Cacna1b
2 of 13
No
No
Rnor\Cacna1d
2 of 13
No
No
Rnor\Cacna1e
2 of 13
No
No
Rnor\Cacna1f
2 of 13
No
No
Rnor\Cacna1s
2 of 13
No
No
Rnor\Scn5a
2 of 13
No
No
Rnor\Scn8a
2 of 13
No
No
Rnor\Scn10a
2 of 13
No
No
Rnor\Scn11a
2 of 13
No
No
Rnor\Cacna1a
1 of 13
No
No
Rnor\Cacna1c
1 of 13
No
No
Rnor\Catsper2
1 of 13
No
Yes
Rnor\Catsper3
1 of 13
No
Yes
Rnor\Catsper4
1 of 13
No
Yes
Rnor\LOC102553311
1 of 13
No
Yes
Rnor\Nalcn
1 of 13
No
No
Rnor\Scn3a
1 of 13
No
No
Rnor\Scn4a
1 of 13
No
No
Rnor\Scn7a
1 of 13
No
No
Rnor\Scn9a
1 of 13
No
No
Rnor\Tpcn2
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (19)
Xtro\cacna1i
5 of 12
Yes
Yes
Xtro\cacna1g
4 of 12
No
Yes
Xtro\cacna1h
4 of 12
No
Yes
Xtro\cacna1a
2 of 12
No
No
Xtro\cacna1e
2 of 12
No
No
Xtro\cacna1f
2 of 12
No
No
Xtro\cacna1s
2 of 12
No
No
Xtro\nalcn
2 of 12
No
No
Xtro\scn5a
2 of 12
No
No
Xtro\cacna1c
1 of 12
No
No
Xtro\cacna1d
1 of 12
No
No
Xtro\LOC100489231
1 of 12
No
No
Xtro\LOC101733681
1 of 12
No
Yes
Xtro\nadsyn1
1 of 12
No
No
Xtro\scn1a
1 of 12
No
No
Xtro\scn2a
1 of 12
No
No
Xtro\scn3a
1 of 12
No
No
Xtro\scn4a
1 of 12
No
No
Xtro\scn8a
1 of 12
No
Yes
Danio rerio (Zebrafish) (29)
Drer\cacna1hb
6 of 15
Yes
Yes
Drer\cacna1ia
6 of 15
Yes
Yes
Drer\cacna1ha
5 of 15
No
Yes
Drer\cacna1g
4 of 15
No
Yes
Drer\cacna1aa
2 of 15
No
No
Drer\cacna1ab
2 of 15
No
No
Drer\cacna1ba
2 of 15
No
No
Drer\cacna1bb
2 of 15
No
No
Drer\cacna1da
2 of 15
No
No
Drer\cacna1eb
2 of 15
No
No
Drer\cacna1e
2 of 15
No
No
Drer\cacna1fa
2 of 15
No
No
Drer\cacna1fb
2 of 15
No
No
Drer\cacna1sa
2 of 15
No
No
Drer\cacna1sb
2 of 15
No
No
Drer\nalcn
2 of 15
No
No
Drer\scn8aa
2 of 15
No
No
Drer\scn8ab
2 of 15
No
No
Drer\cacna1c
1 of 15
No
No
Drer\cacna1db
1 of 15
No
No
Drer\scn1laa
1 of 15
No
No
Drer\scn1lab
1 of 15
No
No
Drer\scn4aa
1 of 15
No
No
Drer\scn4ab
1 of 15
No
No
Drer\scn5lab
1 of 15
No
No
Drer\scn12aa
1 of 15
No
No
Drer\tpcn1
1 of 15
No
Yes
Drer\tpcn2
1 of 15
No
Yes
Drer\tpcn3
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\cca-1
14 of 15
Yes
Yes
Cele\egl-19
2 of 15
No
No
Cele\F17C8.6
2 of 15
No
No
Cele\nca-2
2 of 15
No
No
Cele\unc-2
2 of 15
No
No
Cele\unc-77
2 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\TPC1
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CCH1
4 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\cch1
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900BJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006830
Drosophila simulans
Dsim\GD16210
Drosophila sechellia
Dsec\GM12593
Drosophila erecta
Dere\GG17693
Drosophila yakuba
Dyak\GE16481
Drosophila ananassae
Dana\GF20312
Drosophila pseudoobscura pseudoobscura
Dpse\GA25721
Drosophila persimilis
Dper\GL10483
Drosophila willistoni
Dwil\GK17712
Drosophila virilis
Dvir\GJ16667
Drosophila mojavensis
Dmoj\GI16177
Drosophila grimshawi
Dgri\GH24843
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501WW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008536
Musca domestica
House fly
Mdoa\17004774
Musca domestica
House fly
Mdoa\17025150
Glossina morsitans
Tsetse fly
Gmor\GMOY010152
Mayetiola destructor
Hessian fly
Mdes\Mdes006110
Mayetiola destructor
Hessian fly
Mdes\Mdes006111
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL018125
Anopheles darlingi
American malaria mosquito
Adar\ADAC008040
Anopheles gambiae
Malaria mosquito
Agam\AGAP002505
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018672
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01KL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007009
Danaus plexippus
Monarch butterfly
Dple\DPOGS205910-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014218
Heliconius melpomene
Postman butterfly
Hmel\HMEL005206
Apis florea
Little honeybee
Aflo\2147631155
Apis mellifera
Western honey bee
Amel\GB55059
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18415
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18414
Bombus terrestris
Buff-tailed bumblebee
Bter\15202325
Linepithema humile
Argentine ant
Lhum\LH24674
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003013
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007669
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12005
Tribolium castaneum
Red flour beetle
Tcas\TC034186
Pediculus humanus
Human body louse
Phum\PHUM422550
Rhodnius prolixus
Kissing bug
Rpro\RPRC008269
Rhodnius prolixus
Kissing bug
Rpro\RPRC001387
Cimex lectularius
Bed bug
Clec\CLEC011236
Cimex lectularius
Bed bug
Clec\CLEC011234
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI068494
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI54073
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11283
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01IJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011172
Ixodes scapularis
Black-legged tick
Isca\ISCW013161
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60667.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76570.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60665.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60666.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60660.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60659.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g00060
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g00020
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g00010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur29g01770
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_20439
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_47321
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02L1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_1672
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cacna1gL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ttvgcac
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cacna1h
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ttvgcac_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004031
Gallus gallus
Domestic chicken
Ggal\CACNA1I
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000005215
Gallus gallus
Domestic chicken
Ggal\Gga.31827
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Ca-α1D
4 of 10
cac
4 of 10
NaCP60E
4 of 10
para
4 of 10
na
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CACNA1I; calcium voltage-gated channel subunit alpha1 I
    11 of 15
    608230
        CACNA1G; calcium voltage-gated channel subunit alpha1 G
        9 of 15
        604065
        CACNA1H; calcium voltage-gated channel subunit alpha1 H
        9 of 15
        607904
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Interactions Browser
          Summary of Genetic Interactions
          esyN Network Diagram
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          X
          Recombination map

          1-15

          Cytogenetic map
          5D5-5D7
          Sequence location
          X:6,104,085..6,192,483 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          5D5-5D7
          Limits computationally determined from genome sequence between P{EP}EP1457EP1457&P{EP}CG5928EP1083 and P{EP}EP1311&P{EP}EP1384
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          1-15

          (FlyBase, 2016)

          1-15.9

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (17)
          Genomic Clones (45)
          cDNA Clones (18)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                  RNAi and Array Information
                  Linkouts
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Jeong et al., 2015)
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: Ca-α1T CG4222 CG15899

                  (Mittman, 2001.4.17)
                  Source for database merge of

                  Source for merge of: Ca-α1T Ca1G

                  (Ryglewski et al., 2012)
                  Additional comments

                  Annotations CG15899, CG4222 and CG12544 merged as CG15899 (which corresponds to Ca-α1T) in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)
                  Other Comments
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 47 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  Synonyms and Secondary IDs (15)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (76)