clueless, clu
Please see the JBrowse view of Dmel\ab for information on other features
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Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.48
Gene model reviewed during 5.45
5.1 (northern blot)
904, 894 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ab using the Feature Mapper tool.
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
ab is expressed in all the cells of the ventral midline starting in stage 9. The only other site of nervous system expression is the stomatogastric nervous system and its precursors. Epidermal expression begins in stage 11 in a pattern of stripes and is uniform by stage 12. ab is expressed in all 30 embryonic abdominal muscles with the highest concentrations in the ventral longitudinal, ventral oblique, and segmental border muscles. ab is also expressed in all imaginal discs.
Comment: 0h APF
ab is expressed in all the cells of the ventral midline starting in stage 9. The only other site of nervous system expression is the stomatogastric nervous system and its precursors. Epidermal expression begins in stage 11 in a pattern of stripes and is uniform by stage 12. ab is expressed in all 30 embryonic abdominal muscles with the highest concentrations in the ventral longitudinal, ventral oblique, and segmental border muscles. ab is also expressed in all imaginal discs.
Comment: homogeneously distributed
GBrowse - Visual display of RNA-Seq signals
View Dmel\ab in GBrowse 22-44
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: ab CG4807
Source for merge of: ab B2149
Source for merge of: ab CG32830
Annotations CG4807 and CG32830 merged as CG43860 in release 5.45 of the genome annotation. Merge supported by second tier modENCODE RNA-seq junction (FBrf0217580).
ab is a repressor of ecdysone signalling and border follicle cell migration.
dsRNA has been made from templates generated with primers directed against this gene. ab RNAi causes an increase in dendrite arborization of ddaD and ddaE neurons. There is an increase in the number and length of lateral branches, which results in an expansion of the coverage field, most noticeably along the anteroposterior (AP) axis. In addition to these defects,ab RNAi also causes frequent cell death, defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.
New annotation (CG32830) in release 3 of the genome annotation.
ab encodes a BTB-zinc finger regulatory protein that controls the specificity of neuromuscular connections.
Identification: Mutations affecting neuromuscular connectivity, using an antibody to Fas2.
Mutations in ab affect individual longitudinal veins: vein specific effects.
kni, tg, tt, ab, cv, cv-2, cv-c and cv-d belong to the radius incompletus phenotypic group within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutants of this group have additive phenotypes suggesting the genes are vein-specific, and small lanceolate wings. Therefore involved in whole vein-region specification rather than vein differentiation. ab alleles may have pleiotropic effects on leg development or be embryonic lethal.
Loss of function is lethal, with effects on connectivity of segmental nerves; hypomorphic alleles affect the development of wing veins, especially wing vein L5, with effects in coxa, male genitalia and bristles.
Bridges, 16th Oct. 1916.