FlyBase Gene Report: Dmel\CG43867

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG43867 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG43867 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG43867

View exonic expression by tissue for Dmel\CG43867

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264449

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12467

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 40 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG43867

Transgenic constructs containing regulatory region of CG43867

Deletions and Duplications ( 1 )

Disrupted in

Df(1)Exel6223

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

CG43867^EY07245

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

fertile

CG43867^EY07245

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PLEKHH1

13 of 15

Yes

Hsap\PLEKHH2

11 of 15

Yes

Hsap\C1GALT1C1L

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Plekhh1

12 of 15

Yes

Mmus\Plekhh2

11 of 15

Yes

Rattus norvegicus (Norway rat) (2)

Rnor\Plekhh1

12 of 13

Yes

Rnor\Plekhh2

2 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\plekhh2

6 of 12

Yes

Danio rerio (Zebrafish) (2)

Drer\plekhh1

13 of 15

Yes

Drer\plekhh2

6 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\max-1

13 of 15

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\AT5G05710

1 of 9

Yes

Atha\PH1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900KZ )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA22263

Drosophila persimilis

Dper\GL14431

Drosophila willistoni

Dwil\GK10179

Drosophila virilis

Dvir\GJ15365

Drosophila mojavensis

Dmoj\GI15011

Drosophila grimshawi

Dgri\GH12423

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500TD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17013478

Glossina morsitans

Tsetse fly

Gmor\GMOY003026

Glossina morsitans

Tsetse fly

Gmor\GMOY009274

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00062

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08264

Mayetiola destructor

Hessian fly

Mdes\Mdes006448

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009375

Anopheles darlingi

American malaria mosquito

Adar\ADAC005937

Anopheles gambiae

Malaria mosquito

Agam\AGAP001935

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ008405

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00TO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA008378

Danaus plexippus

Monarch butterfly

Dple\DPOGS208530-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL017519

Apis florea

Little honeybee

Aflo\2643544052

Apis mellifera

Western honey bee

Amel\GB51041

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP12000

Bombus terrestris

Buff-tailed bumblebee

Bter\15213596

Linepithema humile

Argentine ant

Lhum\LH13710

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002518

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG000520

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG036919

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_02228

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_02229

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_08185

Pediculus humanus

Human body louse

Phum\PHUM606460

Rhodnius prolixus

Kissing bug

Rpro\RPRC014389

Cimex lectularius

Bed bug

Clec\CLEC011192

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008313

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_02316

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00SG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR009076

Ixodes scapularis

Black-legged tick

Isca\ISCW000929

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60753.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68545.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60754.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68543.1

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_308469

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PLEKHH1; pleckstrin homology, MyTH4 and FERM domain containing H1

13 of 15

PLEKHH2; pleckstrin homology, MyTH4 and FERM domain containing H2

11 of 15

612723

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264449

MIST (protein-protein) - An integrated Molecular Interaction Database

CG43867

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0

Cytogenetic map

1D2-1D2

Sequence location

X:808,217..927,975 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

1D2-1D2

Limits computationally determined from genome sequence between P{EP}EP1600&P{EP}EP1498 and P{EP}EP1615&P{EP}EP964

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-0

(FlyBase, 2016)

1-0.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (21)

Bloomington

17227

w¹¹¹⁸ P{EP}CG43867^EP1498

83064

y¹ v¹; M{WKO.1-H10}ZH-86Fb

51230

y¹ Mi{MIC}CG43867^MI08433 w^*

v102547

v102954

v105096

v108508

v110590

v11112

w¹¹¹⁸; P{GD1605}v11112

v41377

w¹¹¹⁸; P{GD6432}v41377

v46883

w¹¹¹⁸; P{GD17188}v46883

v46884

w¹¹¹⁸; P{GD17188}v46884/CyO

More stocks available...

Genomic Clones (49)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (123)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

LD26268

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264449

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31031

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG12467 CG14633

(FlyBase Genome Annotators, 2008)

Source for merge of: CG42248 CG14632

(FlyBase Genome Annotators, 2012)

Additional comments

Annotations CG42248 and CG14632 merged as CG43867 in release 5.45 of the genome annotation. Merge supported by RNA-seq junction data.

(FlyBase Genome Annotators, 2012)

Annotations CG12467 and CG14633 merged as CG42248 in release 5.7 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 68 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31031

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W5D0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JDC1

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264449

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264449

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12467

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31031

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008185

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG43867

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264449

MIST (protein-protein) - An integrated Molecular Interaction Database

CG43867

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG12467

(Regnard et al., 2011)

CG14632

(Ashwal-Fluss et al., 2014, Keleman et al., 2009.8.5, Manak et al., 2006)

CG14633

(Japanese National Institute of Genetics, 2012.5.21)

CG42248

(Jiang et al., 2016, Ashwal-Fluss et al., 2014, Vernes, 2014, Wasbrough et al., 2010, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2008)

CG43867

(Cho et al., 2020, Khoroshko et al., 2020, Meltzer et al., 2019, Zhimulev et al., 2016, FlyBase Genome Annotators, 2012, Perkins et al., 2009)

EG:34F3.1

(Benos et al., 2001, Benos, 2000.12.13, Benos and Whitfield, 2000.6.2)

EG:34F3.2

(Benos et al., 2001, Benos, 2000.12.13, Benos and Whitfield, 2000.6.2)

Name Synonyms

CG12467

CG14633

Secondary FlyBase IDs

FBgn0259100
FBgn0025623
FBgn0029537
FBgn0025622
FBgn0029538

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (55)

The following external sites may use different assemblies or annotations than FlyBase.

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