CK2, CKII, CK2α, Tik, Timekeeper
Gene model reviewed during 5.55
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
1.467 (longest cDNA)
Purified CkII protein kinases were able to phosphorylate acid-soluble proteins from Drosophila Kc cells.
Tetramer of two alpha and two beta chains.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CkIIα using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\CkIIα in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Complementation tests and recombinational mapping suggest the CkIIα mutant maps to a novel circadian rhythm gene.
Source for merge of CkIIα anon-WO02059370.53 was sequence comparison ( date:051113 ).
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells, a whole range of mitotic abnormalities, centrosome abnormalities and lagging chromatids are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
A dominant mutant, which has a long period phenotype as a heterozygote. Homozygotes die during the third larval instar stage. The recessive lethal is not separable from the circadian phenotype, suggesting a vital role for the CkIIα gene.
Identification: screen for circadian locomotor behavior mutants.
In vivo activity of Antp is modified by CkIIα-mediated phosphorylation. Phosphorylation of Antp by CkIIα is important for preventing inappropriate activities of this homeotic protein during embryogenesis.
Casein kinase II specifically phosphorylates a set of serine residues within the cact PEST domain.
Casein kinase II phosphorylates Ser468 (a residue in the PEST domain) of cact in vitro.
Recombinant CkII in vitro binds to spermine and this interaction is concomitant with a striking effect on the structural polymeric organisation on the kinase which in the presence of the polyamine exhibits a ring-like structure.
Casein kinase II reconstituted from heterologous subunits displays properties similar to those of the homologous protein.
Casein kinase II-mediated phosphorylation of Top2 stimulates its activity by enhancing the ability of the enzyme to hydrolyse its high energy ATP cofactor.
Isolation and sequencing of cDNA clones encoding both subunits of casein kinase II.